Garuda - Garba Rujukan Digital

Studi In Vitro Aktivitas Antibakteri Ekstrak Etanol Penawar Sampai (Tinospora crispa L.) terhadap Staphylococcus epidermidis Martani, Natalia Sri; Turnip, Oktaviani Naulita; Hanasia, Hanasia; Nawan, Nawan
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1074

Kulit merupakan jaringan terluar di tubuh manusia yang menjadi pertahanan pertama dari masuknya patogen. Kulit dihuni oleh berbagai flora normal, salah satunya adalah Staphylococcus epidermidis. S. epidermidis adalah patogen oportunistik yang menjadi penyebab infeksi nosokomial yang menetap pada perangkat medis. Kasus infeksi nosokomial banyak terjadi baik di negara maju maupun negara berkembang. Infeksi nosokomial karena S. epidermidis tergolong sulit diatasi karena adanya kemampuan spesies ini dalam membentuk biofilm dan resistensi antibiotik yang menyebabkan kasus nosokomial berujung kematian. Penelitian ini mengujikan ekstrak dari tanaman penawar sampai atau brotowali terhadap S. epidermidis guna mendeteksi adanya aktivitas antibakteri. Batang penawar sampai dimaserasi dan diuapkan menjadi ekstrak kental dengan konsentrasi 20, 50, 75, dan 100%. Ekstrak kental batang penawar sampai diujikan terhadap S. epidermidis dengan metode difusi cakram. Interpretasi kemampuan ekstrak dalam menekan pertumbuhan S. epidermidis dapat diamati dari diameter zona hambat yang terbentuk di sekitar cakram. Konsentrasi terendah dalam menekan pertumbuhan S. epidermidis dihasilkan pada penelitian ini adalah konsentrasi ekstrak 20%. Hal ini mengindikasikan adanya potensi dari ekstrak penawar sampai sebagai antibakteri terhadap S. epidermidis yang tergolong dalam bakteri Gram positif.The skin is the outermost tissue in the human body and the first line of defense against pathogen entry. The skin is inhabited by a variety of normal flora, one of which is Staphylococcus epidermidis. S. epidermidis is an opportunistic pathogen that causes nosocomial infections that persist in medical devices. Cases of nosocomial infections are common in both developed and developing countries. Nosocomial infections due to S. epidermidis are relatively difficult to overcome due to the ability of this species to form biofilms and antibiotic resistance which causes nosocomial cases to lead to death. This study tested extracts from the antidote to brotowali plant against S. epidermidis to detect antibacterial activity. The stem was macerated and evaporated into thick extracts with concentrations of 20%, 50%, 75%, and 100%. The thick extracts were tested against S. epidermidis using disc diffusion method. Interpretation of the ability of the extract to suppress the growth of S. epidermidis can be observed from the diameter of the inhibition zone formed around the disc. The lowest concentration in suppressing the growth of S. epidermidis produced in this study was 20% extract concentration. This indicates the potential of the extract as an antibacterial against S. epidermidis which is classified as Gram-positive bacteria.

Current Understanding of Mycobacterium tuberculosis Drug Resistances and Diagnostics in Indonesia: A Review Rahayu, Ayu; Rovik, Anwar; Turnip, Oktaviani Naulita
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1121

Tuberculosis is a significant global infectious disease cause of mortality, with 25% of the world's population caused by Mycobacterium tuberculosis (Mtb). The highest case recorded was 821,200 cases in 2023 over one decade. Drug resistance significantly impacts tuberculosis treatment and has been observed since the first drug discovery, streptomycin. In Indonesia, drug-resistant tuberculosis (DR-TB) is a significant public health issue, with an estimated 24,666 cases recorded in 2022. A comparative literature search was conducted using various articles, including research studies, guidelines, narrative reviews, reports, and meta-analyses, with the inclusion criteria for reference sources including ten years of published articles. Drug resistance in TB can reduce treatment success rate and increase therapy duration. In the result, several general mechanisms proposed for drug resistance in Mtb include efflux pump, enzyme inactivation, permeability barrier, mutations in drug-target genes, and epigenetics. Currently, TB treatment in Indonesia involves combination therapy using three or more types of drugs, such as rifampicin and isoniazid. The International Standard for TB Care (ISTC) serves as the basis for TB diagnosis in Indonesia, which involves a combination of clinical and laboratory tests. Early diagnosis and universal access to the Drug Susceptibility Test (DST) are crucial for TB resistance. In Indonesia, several diagnostic methods, such as sequencing, PCR testing, Gene Xpert, and culture, can be used to identify TB resistance. Understanding the mechanisms of drug resistance and developing effective diagnosis strategies for TB resistance is crucial for managing global infection.

Oral Klebsiella sp. Involved in Dental Caries: A Case of Individuals Gargling with Peatwater Turnip, Oktaviani Naulita; Frethernety, Agnes; Hanasia; Panjaitan, Desimaria; Damayanti, Elvina; Rovik, Anwar; Malik, Handayani
Jurnal Sumberdaya Hayati Vol. 10 No. 3 (2024): 2024
Publisher : Departemen Biologi, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jsdh.10.3.122-127

Most of the microbes inhabiting the oral cavities are harmless but can cause disturbance and discomfort if the microbial population increases significantly. One of the oral disorders that is often experienced by children, is dental caries. Dental caries is causedby various factors, including eating and brushing habits. The people of Central Kalimantan who live in the watershed use peat water in their daily activities, including for gargling and brushing their teeth. The acidic characteristics of peat water and the high content of organic substances trigger the development of microbes that cause dental caries.This study used dental caries swab samples of patients who rinsed their mouths with peat water. Bacteria were identified molecularly with 16SrRNA markers with primers 63F and 1387R. The similarity of nucleotide sequences was analyzed with BLAST on GeneBank. A phylogenetic tree was built with Maximum Likelihood. Both isolates have a fairly high level of similarity to Klebsiella pneumoniae, namely 91% and 93%. Both isolates are in the same clade, Klebsiella spp., and are close to various commonly found bacteria in the oral cavity, such as Streptococcus mutans and Lactobacillus salivarius.

Hubungan kadar ureum terhadap kejadian mortalitas pasien sirosis di RSUD dr. Doris Sylvanus Palangka Raya Rejeki, Fransiska Caesaria Silvi; Alexandra, Francisca Diana; Palupi, Didin Retno Endah; Handayani, Septi; Turnip, Oktaviani Naulita
Barigas: Jurnal Riset Mahasiswa Vol. 2 No. 3 (2024): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/barigas.v2i3.12089

The mortality rate of liver cirrhosis is increasing globally, including in Indonesia. Child-Turcotte-Pugh score as a widely used scoring system is difficult to performed in all health facilities in Indonesia. Innovative prognostic screening assessment that is more accessible, and accurate, such as ureum levels, is needed. This research aims to analyze the correlation between ureum levels and mortality of cirrhosis patients. It applied analytic observational study with a cross-sectional design. Data were taken from the patient’s medical records who were hospitalized at RSUD dr. Doris Sylvanus Palangka Raya for the period 2020-2022. Statistical analysis using the Chi-Square test. The p-value = 0.004 (p < 0.05) and OR = 4.54 were obtained, it showed that there was a significant correlation between ureum levels and mortality events in patients with cirrhosis, and patients with high ureum levels were 4.54 times more likely to develop mortality than patients with normal ureum levels.

Penerapan Perilaku Hidup Sehat dan Bersih dalam Penurunan Angka Stunting di Sekolah Dasar Wilayah Tangkiling Palangka Raya Turnip, Oktaviani Naulita; Hanasia, Hanasia; Nawan, Nawan; Martani, Natalia Sri; Praja, Rian Ka; Furtuna, Dewi Klarita
Kontribusi: Jurnal Penelitian dan Pengabdian Kepada Masyarakat Vol. 5 No. 1 (2024): November 2024
Publisher : Cipta Media Harmoni

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53624/kontribusi.v5i1.487

Latar Belakang: Seratus lima puluh satu juta anak di seluruh dunia terlaporkan mengalami stunting. Selain disebabkan karena faktor kurang gizi, sanitasi juga menjadi faktor penyebab stunting. Sanitasi yang buruk dan tidak menerapkan Perilaku Hidup Bersih dan Sehat (PHBS) akan menyebabkan mudah tertular penyakit yang apabila berkelanjutan dapat mengganggu pertumbuhan dan perkembangan anak-anak. Lebih dari separuh jenis penyakit dan kematian pada anak dan balita disebabkan oleh kuman yang masuk ke dalam mulut melalui makanan, air, dan tangan yang kotor. Tujuan: Melalui kegiatan pengabdian masyarakat ini diharapkan dapat memberikan pemahaman pada pelajar akan pentingnya PHBS yang dapat berdampak terhadap kejadian stunting. Metode: Metode yang dilakukan yaitu penyuluhan PHBS, diskusi, praktik cuci tangan dan pemasangan banner langkah-langkah mencuci tangan menurut pedoman WHO. Hasil: Hasil yang didapat yaitu mayoritas pelajar belum mengetahui tentang PHBS dalam kehidupan sehari-hari dan juga belum dapat menerapkan cara mencuci tangan yang benar dan konsisten. Kesimpulan: Edukasi PHBS yang dilakukan meningkatkan pemahaman dan pengetahuan dari pelajar akan pentingnya PHBS khususnya penerapan mencuci tangan dalam kehidupan sehari-hari yang dapat meningkatkan risiko kejadian stunting. Selanjutnya, yang dapat dilakukan adalah melakukan monitoring efektivitas PHBS terhadap kejadian penyakit pada anak-anak yang akan berujung pada kasus stunting.

Peningkatan Pemahaman Osteoporosis pada Wanita di Kelurahan Kereng Bangkirai Kota Palangka Raya Toemon, Angeline Novia; Carmelita, Austin Bertilova; Turnip, Oktaviani Naulita
Jurnal Pengabdian Masyarakat Nusantara (JPMN) Vol. 5 No. 1 (2025): Februari - Juli 2025
Publisher : Lembaga Otonom Lembaga Informasi dan Riset Indonesia (KITA INFO dan RISET)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35870/jpmn.v5i1.3484

Osteoporosis is a disease characterised by a decrease in bone density, leading to the risk of fractures, especially in the elderly and post-menopausal women. Although it can be prevented and managed, many people are not aware of the importance of prevention and early detection of osteoporosis. This community service activity aims to increase community understanding and knowledge related to osteoporosis, as well as provide information on the prevention and management of the disease. This activity was carried out in Kereng Bangkirai village, involving people from various age groups, especially the elderly and post-menopausal women. Activities included counselling on the causes, symptoms, and prevention of osteoporosis, light exercise, and physical examination to detect osteoporosis risk. Evaluation showed a significant increase in participants' knowledge about osteoporosis after participating in this activity. Overall, this activity showed high enthusiasm for the material presented and triggered participants to lead a healthy lifestyle to prevent osteoporosis. This activity has a positive impact in increasing public awareness of the importance of maintaining bone health, and is expected to be held on an ongoing basis to reach more individuals, especially those at high risk.

Sosialisasi Kreasi Pangan Lokal “AKANG” (Kelakai dan Ikan Saluang) sebagai Cemilan pada Penderita Diabetes: Socialization of Local Food Creations "AKANG" (Kelakai and Saluang Fish) as Snacks for Individuals with Diabetes Yuliani, Ni Nyoman Sri; Ahmad, Farah Fauziyah Radhiyatulqalbi; Turnip, Oktaviani Naulita; Hanasia, Hanasia; Komara, Nisa Kartika; Agustira, Dewanti; Sayyidinoor, Muhammad Alif; Sadek, Yitro Tuah HR; Safitri, Andini; Mudatama, Yusuf; Efendy, Dennisya Azzahra; Upel, Dean Antoni
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 2 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i2.8507

Training on the Use of Learning Management Systems (LMS) is essential for enhancing the quality of academic services in an era of increasingly adopting technology. Integrating LMS with conventional methods, known as blended learning, which combines distance learning, regular classes, and LMS, results in a more effective and efficient learning process. With the shift towards digital learning, LMS use becomes crucial for improving the efficiency, accessibility, and quality of academic services. Through e-learning, students not only listen to lectures but also actively observe, perform, demonstrate, and more. Teaching materials can be virtualized in various formats to create more engaging and dynamic content, motivating students to delve deeper into the learning process. This training aims to equip educators and administrative staff with LMS features and potential, enabling them to maximize its use for content delivery, facilitating teacher-student interaction, and enhancing course management and evaluation. The training methods include presentations on basic LMS concepts, demonstrations of key features, and hands-on practice sessions that allow participants to actively engage in the learning process. Additionally, interaction between participants and facilitators is enhanced through discussions and Q&A sessions, ensuring deep understanding and practical skills in LMS usage to improve academic service quality. Consequently, this training is expected to provide a solid foundation for educational institutions to meet challenges and leverage the opportunities offered by the digital era in providing quality academic services.

Potential of Ciplukan Leaf Extract (Physalis angulata L.) Against Streptococcus pneumoniae Growth in Vitro Rakhman, Farizky; Widayati, Ratna; Turnip, Oktaviani Naulita; Fatmaria, Fatmaria; Hanasia, Hanasia
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 1 (2025): February 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i1.1314

Pneumonia is a disease that infects the lungs, and antibiotics such as tetracycline show a high degree of resistance. Therefore, the use of alternative natural materials, such as ciplukan leaves (Physalis angulata L.), which the Dayak people commonly use to treat lung diseases, is necessary. This study aimed to prove that the extract of ciplukan leaves can inhibit Streptococcus pneumoniae by measuring the diameter of the clear zone and determining the Minimum Inhibitory Concentration (MIC). The extract was obtained by maceration using 96% ethanol, and then concentrations of 5%, 10%, 15%, 20%, and 25% were prepared. The positive control was levofloxacin 5 µg, and the negative control was DMSO 1%. The average inhibition zone diameters of the ciplukan leaf extract were 5% (0 mm), 10% (0.17 mm), 15% (0.45 mm), 20% (1.95 mm), 25% (2.67 mm). Antibacterial test using the disk diffusion method. From the Kruskal-Wallis and Mann-Whitney Post Hoc statistical test, a significance value of <0.05 was obtained. Therefore, There is an effect of ciplukan leaf extract on Streptococcus pneumoniae at concentrations of 15%, 20%, and 25%, with the MIC 15%.

Peningkatan Pemahaman Siswa-siswi dalam Penanganan dan Perawatan Kucing yang Efektif Mencegah Infeksi Toxoplasmosis: Improving Students Understanding on Effective Cat Handling and Caring to Prevent Toxoplasmosis Infection Augustina, Indria; Toemon, Agnes Immanuela; Turnip, Oktaviani Naulita
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 5 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i5.8419

Approximately 2 billion people, equivalent to half of the world's population, suffer from toxoplasmosis. Toxoplasmosis is a disease caused by the parasite Toxoplasma gondii that infects cats as its definitive host. Not only cats, T. gondii can also infect animals such as chickens, cows, goats, pigs, and sheep that act as intermediate hosts, including humans. Both feral and pet cats have the potential to be infected with T. gondii. Toxoplasmosis infection in humans can cause various disorders and diseases such as obertus, encephalomyelitis, chorioretinitis, hydrocephalus in newborns, and infertility in women. This activity aims to improve the participants' understanding in terms of pet cat care and effective handling of stray cats in preventing toxoplasmosis infection. The stages of activities carried out began with pretest, socialisation, discussion, posttest, and documentation of activities. The results of this activity showed an increase in participants' knowledge and understanding related to toxoplasmosis, which can be seen from the increase in post-test scores compared to the pre-test scores.

Peningkatan Pemahaman Osteoporosis pada Wanita di Kelurahan Kereng Bangkirai Kota Palangka Raya Toemon, Angeline Novia; Carmelita, Austin Bertilova; Turnip, Oktaviani Naulita
Jurnal Pengabdian Masyarakat Nusantara (JPMN) Vol. 5 No. 1 (2025): Februari - Juli 2025
Publisher : Lembaga Otonom Lembaga Informasi dan Riset Indonesia (KITA INFO dan RISET)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35870/jpmn.v5i1.3484

Osteoporosis is a disease characterised by a decrease in bone density, leading to the risk of fractures, especially in the elderly and post-menopausal women. Although it can be prevented and managed, many people are not aware of the importance of prevention and early detection of osteoporosis. This community service activity aims to increase community understanding and knowledge related to osteoporosis, as well as provide information on the prevention and management of the disease. This activity was carried out in Kereng Bangkirai village, involving people from various age groups, especially the elderly and post-menopausal women. Activities included counselling on the causes, symptoms, and prevention of osteoporosis, light exercise, and physical examination to detect osteoporosis risk. Evaluation showed a significant increase in participants' knowledge about osteoporosis after participating in this activity. Overall, this activity showed high enthusiasm for the material presented and triggered participants to lead a healthy lifestyle to prevent osteoporosis. This activity has a positive impact in increasing public awareness of the importance of maintaining bone health, and is expected to be held on an ongoing basis to reach more individuals, especially those at high risk.

Title

Found 17 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 17 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 17 Documents
Search