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All Journal The Indonesian Biomedical Journal Journal Of Widya Medika Junior Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Community Development Journal: Jurnal Pengabdian Masyarakat AKSONA International Journal of Public Health Excellence (IJPHE) Journal of Medicine and Health Jurnal Widya Medika
Erwin, Ferdinand
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Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Tumor Differentiation is Correlated with Estrogen Receptor Beta (ERβ) Expression but Not with Interleukin-6 (IL-6) Expression in Colorectal Carcinoma Theodora, Imelda; Sudiana, I Ketut; Budipramana, Vicky Sumarki; Erwin, Ferdinand; Dewi, Sianty; Novita, Bernadette Dian
The Indonesian Biomedical Journal Vol 16, No 5 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i5.3324

Abstract

BACKGROUND: Colorectal carcinoma (CRC), the third most common malignant disease worldwide, is associated with estrogen receptor β (ERβ) and interleukin-6 (IL-6). ERβ is known to down-regulate IL-6 in prostate cancer, lung carcinoma, and CRC cell lines; however, its effect on human with CRC remains unclear. Therefore, this study was conducted to investigate the association between ERβ and IL-6 expressions with the clinicopathological features of CRC.METHODS: This was an analytic observational study using 40 paraffin blocks of CRC patients. ERβ and IL-6 expression was measured by immunohistochemistry (IHC) staining. The percentage of immunoreactive tumor cell per 1000 cells was manually recorded and tumor differentiation as well as tumor infiltration were determined. Tumor differentiation was graded according to the World Health Organization (WHO) 2010 criteria, while tumor infiltration was defined based on the American Joint Committee on Cancer (AJCC) 8th edition.RESULTS: Fifty percent of samples were well-differentiated CRC, and 57.5% samples were T3 infiltration tumors. IHC staining showed 35.5% of samples were positive for ERβ expression, while 70.86% were positive for IL-6 expression. There were negative correlation of ERβ expression with tumor differentiation (p=0.018; r=-0.371), but no correlation with tumor infiltration (p=0.836) were found. There was no correlation between ERβ expression with IL-6 expression (p=0.154).CONCLUSION: There is statistically significant correlation between tumor differentiation and ERβ expression, wherein improved tumor differentiation is linked to higher levels of positive ERβ expression. However, there is no discernible relationship between IL-6 and tumor differentiation. These findings suggest that while IL-6 was involved in the growth of the tumor, ERβ expression might have an impact on tumor differentiation.KEYWORDS: colorectal carcinoma, estrogen receptor beta, interleukin-6, cell differentiation
Peran Probiotik Terhadap Perbaikan Gejala Motorik Pada Pasien Dengan Penyakit Parkinson: Sebuah Meta-Analisis Erwin, Ferdinand; Meryana, Meryana; Kurniawati, Nita; Kartikasari, Desy; Supit, Paulus A
Journal of Medicine and Health Vol 6 No 2 (2024)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v6i2.8805

Abstract

Penyakit Parkinson merupakan penyakit neurodegeneratif paling sering diderita kedua setelah penyakit Alzheimer, yang ditandai dengan adanya bradikinesia, tremor saat istirahat, dan rigiditas. Penanda utama dari penyakit Parkinson adalah patologi α-synuclein yang disebut dengan Lewy Body. Beberapa penelitian terbaru menunjukkan peran gut dysbiosis menjadi salah satu faktor dalam patofisiologi penyakit Parkinson. Beberapa penelitan sebelumnya menunjukkan efektivitas probiotik terhadap perbaikan klinis penyakit Parkinson. Tujuan dari penelitian ini adalah untuk menganalisis peran probiotik terhadap gejala motorik pasien dengan penyakit Parkinson. Metode penelitian ini adalah dengan melakukan pencarian studi melalui berbagai database seperti Pubmed, Scopus, Cochrane, dan ProQuest. Studi yang didapatkan kemudian dilakukan skrining, penilaian kualitas studi, dan analisis kuantitatif. Hasil penelitian ini didapatkan total 5 studi yang melibatkan 339 pasien dengan penyakit Parkinson. Meta-analisis penelitian ini menunjukkan penurunan skor Unified Parkinson’s Disease Rating Scale Part III (UPDRS-III) secara signifikan (standardized mean difference: -0,25; interval kepercayaan 95%, -0,44 hingga -0,06) pada pasien dengan penyakit Parkinson setelah pemberian probiotik. Penelitian ini menunjukkan bahwa probiotik dapat memperbaiki gejala motorik secara signifikan pada pasien dengan penyakit Parkinson yang diukur dengan skala UPDRS-III, serta relatif aman dan dapat ditoleransi dengan baik.
Anosmia Sebagai Faktor Prediktor Derajat Keparahan Ringan Pada Penderita COVID-19 Rawat Inap di Rumah Sakit Primasatya Husada Citra Surabaya Hadi, Wiyono; Ernawati, Titiek; Novita, Bernadette; Wibowo, Tjipto; Supit, Vincentius Diamantino; Setiawan, Albert; Samsudin, Kevin; Erwin, Ferdinand
Majalah Kedokteran Indonesia Vol 71 No 2 (2021): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.71.2-2021-379

Abstract

Introduction: Anosmia is one of the clinical characteristics of COVID-19 patients. Anosmia was reported as the first symptom before other symptoms were discovered. Prior studies have shown anosmia implications as a favorable prognostic factor in COVID-19 patients. The research aim is to describe the characteristics of COVID-19 patients with anosmia and its correlation with disease severity.Methods: This study was a descriptive, cross-sectional, retrospective study with a total sample of 149 patients confirmed COVID-19. This research was conducted on hospitalized patients from March 1 to July 31, 2020, at the Primasatya Husada Citra Hospital Surabaya. Our study classified patients into two groups, with and without anosmia. The patient’s clinical characteristics were described in a table and odds ratio was calculated to determine the risk factors incidence of severe degree in COVID-19 patients.Results: The mean age of patients with anosmia was 32 years old, the patient’s gender was dominated with the female (63.2%). Patients with anosmia had lower severity, the odds ratio of having severe degree is 0.479. Patients with anosmia also had other symptoms such as cough, rhinorrhea, sore throat, tightness, headache, and muscle aches (p less than 0.05).Conclusion: COVID-19 patients with anosmia had lower severity than patients without anosmia.
Co-Authors Budipramana, Vicky Sumarki Dyana Sarvasti Ernawati, Titiek Hadi, Wiyono Jaya, David Karunia Kartikasari, Desy Kurniawati, Nita Laksono, Gerardo AK Mayung, Claraiva Meryana, Meryana Meryana, Meryana, Novita, Bernadette Novita, Bernadette Dian Paul L Tahalele Paulus Alexander Supit Paulus Sugianto, Paulus Raymond Desun, Evander Aloysius S.Pd. M Kes I Ketut Sudiana . Samsudin, Kevin Setiawan, Albert Sianty Dewi Supit, Paulus Supit, Paulus A Supit, Vincentius Diamantino Theodora, Imelda Tjahyanto, Teddy Wibowo, Tjipto Wiracakra, I Gusti Lanang Krisna Yohanes, Guntur