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Dewi, Lucia VIta Inandha
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Preliminary identification of N-Acetyltransferase 2 (NAT2) gene polymorphisms in the dayak population Dewi, Lutfiana Aswindra; Peranginangin, Jason Merari; Dewi, Lucia Vita Inandha
Journal of Health Management and Pharmacy Exploration Vol. 3 No. 2 (2025): August 2025
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v3i2.612

Abstract

Polymorphism is a change or mutation in a gene that does not cause a change in the protein structure. The N-Acetyltransferase NAT enzyme is encoded by the N-Acetyltransferase 2 (NAT2) gene, the N-Acetyltransferase 2 (NAT2) gene, several variations of DNA known as single nucleotide polymorphisms (SNPs) that alter the genotype, haplotype, and phenotype. The NAcetyltransferase 2 (NAT2) genotype was classified into three phenotypes, namely fast acetylators, intermediate acetylators, and slow acetylators. The purpose of this study was to determine the type of polymorphism and the type of polymorphism of the NAT2 gene of the Dayak tribe. In this study, blood samples from the Dayak tribe were isolated from the Wizard Genomic DNA Purification kit and then identified Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). With stages 1. Denaturation 2. Anneling and 3. Extension using NAT2 N4 and N5 primers then RFLP with restriction enzymes KpnI, TaqI and BamHI then electrophoresed with 2% agarose gel. The results of the initial identification of the N-Acetyltransferase 2 (NAT2) gene polymorphism in the Dayak tribe obtained 5 types of genotypes NAT2*4/*5B (20%), NAT2*4/*6A (33.3%), NAT2*4/*7B (20%), NAT2*5B/5B (13.3%) and NAT2*7B/7B (13.3%). From the phenotype of the Dayak tribe, there are two medium acetylators (73.3%) and slow acetylators (26.3%).
Co-Authors Andayani , Tri Murti Anggralisa, Mellinia Yunari Anggriani, Indah Putri Dewi, Lutfiana Aswindra endey, joverly Gunawan Pamudji Widodo Hamzani, Yogi Mujizat Harsono, Samuel Budi Inaratul Rizkhy Hanifah Ismi Rahmawati Jason Merari Peranginangin Muchromin, Muchromin Paranginangin, Jason Merari Pasaribu, Ezra Pradesthya, Karinda Wirandani Purnomo, Lenis Sufiya Sakaria, Hamra Tongkonoo, Mutiah Tri Wijayanti Zaqiah, Fiqih