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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Kesehatan Masyarakat (JKM) CENDEKIA UTAMA JMM (Jurnal Masyarakat Mandiri) Jurnal Kreativitas PKM PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Medical Sains : Jurnal Ilmiah Kefarmasian Ahmad Dahlan Medical Journal Eduvest - Journal of Universal Studies Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Amaliyah Dina Anggraeni
Universitas Muhammadiyah Malang
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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The Comparative Antioxidant Efficacy from Different Fractions of Clinacanthus nutans Leaves Anggraeni, Amaliyah Dina; Sadatiyah, Sadatiyah; Lestari, Nadia A.; Afifah, Salmahikaru; Paramitha, Alfina I.
Indonesian Journal of Pharmaceutical Science and Technology 2025: Vol. 12 Suppl. 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s1.57433

Abstract

Indonesia is a tropical country whose population is potentially exposed to ultraviolet (UV) radiation. Continuous exposure to UV radiation triggers the formation of free radicals that cause damage at the cell, tissue and organ levels. Dandang gendis (Clinacanthus nutans) is known for its diverse pharmacological activities, including its role as a source of antioxidants. This study aims to evaluate the antioxidant activity of specific fractions of dandang gendis plant through experimental methods. The fractionation process was carried out by stepwise maceration method. Antioxidant activity test was conducted using DPPH (2,2-diphenyl-1-picrylhydrazyl) method, which measures the ability of the extract to capture DPPH free radicals. The results obtained were IC50 values for vitamin C control at 1.25 μg/mL, ethanol fraction at 36.63 μg/mL, ethyl acetate fraction at 5.07 μg/mL, and n-hexane fraction at 40.19 μg/mL. These findings indicate that the ethyl acetate fraction of Dandang gendis has very strong antioxidant activity. Therefore, it can be concluded that the ethyl acetate fraction of Clinacanthus nutans leaves shows very strong potential antioxidant activity, with the lowest IC50 value compared to the ethanol fraction and the n-hexane fraction, so it has a great opportunity to be utilized as an external antioxidant.
A Literature Review on the Antihyperglycemic Effect of Nanoencapsulated Etlingera eatior Extract in Type 2 Diabetes Mellitus Salsabiella, Elok; Anggraeni, Amaliyah Dina; Prastiyo, Muhammad Dodik
Ahmad Dahlan Medical Journal Vol. 6 No. 1 (2025): May 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/admj.v6i1.12966

Abstract

Diabetes mellitus Type 2 (T2DM) is characterized by hyperglycemia due to pancreatic β-cell damage, leading to impaired insulin production. The International Diabetes Federation (IDF) estimates that by 2021, 537 million people worldwide will have T2DM, with projections reaching 783 million people by 2045. In 2023, Indonesia reported a diabetes prevalence of 9.1%, affecting around 25 million people. Nanocarrier-based drug delivery systems show promise in improving diabetes management by enhancing bioavailability and sustaining drug release. This study tested the effectiveness of a nano drug delivery system using nanoencapsulation of Etlingera elatior extract in T2DM therapy. Etlingera elatior contains flavonoids, polyphenols, saponins, and alkaloids, which exhibit significant antihyperglycemic properties. Nanoencapsulation with biodegradable polymers improves stability and controlled release of bioactive compounds. Using a qualitative document study, data sourced from Google Scholar and Publish or Perish with a range of 2015-2024 were analyzed through NVivo 12 Pro software for MacBook Pro. The findings showed that Etlingera elatior effectively lowered blood glucose, improved insulin sensitivity, and protected β-cells, while nanoencapsulation optimized bioavailability. Thus, nanoencapsulation of Etlingera elatior represents a promising innovation for diabetes management, potentially improving glucose control and patient outcomes in Indonesia.
Co-Authors Afifah, Salmahikaru Aghnia Fuadatul Inayah Ahmad Shobrun Jamil Elly Purwanti Ghassani Shabrina Putri Haryoto Haryoto Heng Yen Khong Hidajah Rachmawati Kurnia Putri Utami Lestari, Nadia A. M. Artabah Muchlisin Moh. Mirza Nuryady Moonike Era Wahyuningati Muhammad Dodik Prastiyo Muhammad Priyadi Nia Yuniar Fitriana Putri Nungki Marlian Yuliadarwati Paramitha, Alfina I. Refie Putri Madiyanti Sadatiyah, Sadatiyah Salsabiella, Elok Septia Devi Amalia Siti Rofida Solly Aryza Tutut Indria Permana Ulfiatul Jannah Yustika Faradhiba Yustika Savira