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All Journal SemanTIK : Teknik Informasi JMM (Jurnal Masyarakat Mandiri) Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Pharmacy Kieraha Medical Journal JOMPA ABDI: Jurnal Pengabdian Masyarakat ABDI UNISAP: Jurnal Pengabdian Kepada Masyarakat PharmaCine: Journal of Pharmacy, Medical and Health Science
Sandrawati, Sandrawati
Fakultas Kedokteran,Departemen Farmasi, Universitas Khairun
Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Uji Sitotoksik Ekstrak Clitoria Ternatea L. dari Pulau Ternate terhadap Udang Air Laut (Artemia salina L.) dan Sel Kanker Payudara MCF-7: Cytotoxic Effects of Clitoria Ternatea L. Extract from Ternate Island on Brine Shrimp (Artemia salina L.) and MCF-7 Breast Cancer Cell Line Nur Asma S Somadayo; Sandrawati Sandrawati
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 1 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i1.13162

Abstract

Cancer is a leading cause of death worldwide, with nearly 10 million fatalities reported in 2020, including 2.3 million new cases of breast cancer. Due to its high prevalence, effective treatment options remain a critical priority. Clitoria ternatea L., a medicinal plant widely found in Indonesia, is traditionally used for various therapeutic purposes and may possess anticancer properties. This study aimed to evaluate the cytotoxic effects of ethanol extracts of Clitoria ternatea L. collected from Ternate Island. Cytotoxicity was assessed using two methods: the Brine Shrimp Lethality Test (BSLT) to determine general toxicity, and the PrestoBlue assay to evaluate antiproliferative effects on MCF-7 human breast cancer cells. In the BSLT, Artemia salina larvae were exposed to various concentrations of the extract (7.81-1000 µg/mL) for 24 hours, and LC50 values were calculated using probit analysis. For the PrestoBlue assay, MCF-7 cells were treated with extract concentrations ranging from 7.81 to 1000 µg/mL for 48 hours, followed by measurement of cell viability via absorbance at 570 nm. Results showed that the LC50 for the BSLT was 105.681 µg/mL, indicating low toxicity of the extract. In contrast, the extract did not demonstrate significant cytotoxicity against MCF-7 cells, with an IC50 value exceeding 1000 µg/mL. In conclusion, the ethanol extract of Clitoria ternatea L. exhibits low general toxicity but lacks significant cytotoxic effects on MCF-7 breast cancer cells under the tested conditions. Further studies are warranted to isolate active compounds and explore their potential anticancer mechanisms. Keywords: BSLT; Clitoria ternatea L.; MCF-7; Prestoblue Assay.
PENGUATAN KETAHANAN KESEHATAN MASYARAKAT PASCABENCANA MELALUI INTERVENSI KESEHATAN TERPADU DAN EDUKASI BERBASIS KOMUNITAS DI ACEH TAMIANG Sakti, Aditya Sindu; Toka, Wahyunita Do; Sandrawati, Sandrawati; Nur, Amran; Abdullah, Abulkhair; Imam, Fathul Rizky S.; Yulimanida, Herri; Muhammad, Apriyanti; Hidayat, Ferdian
JMM (Jurnal Masyarakat Mandiri) Vol 10, No 2 (2026): April
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v10i2.37721

Abstract

Abstrak: Banjir di Kabupaten Aceh Tamiang pada akhir 2025 mengganggu akses layanan kesehatan dasar, distribusi logistik, dan meningkatkan risiko penyakit berbasis lingkungan. Kegiatan Pengabdian kepada Masyarakat ini bertujuan mempercepat pemulihan kesehatan pascabencana melalui intervensi kesehatan terpadu berbasis kebutuhan lapangan. Intervensi menekankan peningkatan hardskill masyarakat dalam praktik Perilaku Hidup Bersih dan Sehat (PHBS), pemanfaatan Tanaman Obat Keluarga (TOGA), penggunaan obat rasional, serta pengelolaan sanitasi, disertai penguatan softskill berupa komunikasi kesehatan, kolaborasi komunitas, empati sosial, dan kesiapsiagaan adaptif. Program dilaksanakan di sepuluh desa dengan cakupan 691 penerima layanan kesehatan dan 660 rumah tangga penerima logistik melalui kerja sama dengan Puskesmas Tamiang Hulu, HEOC, dan MTA–DRC. Metode kegiatan meliputi pelayanan kesehatan jemput bola, distribusi logistik, edukasi PHBS, pelatihan TOGA, dukungan psikososial, dan penguatan layanan kesehatan primer. Hasil menunjukkan dominasi kasus ISPA, diare, dan penyakit kulit, sekaligus penguatan fungsi layanan primer. Secara kualitatif, masyarakat menunjukkan peningkatan keterampilan melalui partisipasi aktif, penerapan PHBS dan sanitasi rumah tangga, pemanfaatan TOGA untuk keluhan ringan, serta penggunaan obat yang lebih rasional dan terarah. Evaluasi dilakukan melalui observasi lapangan, pencatatan cakupan layanan, dan umpan balik mitra. Intervensi ini berkontribusi pada penguatan ketahanan kesehatan masyarakat pascabencana.Abstract: Flooding in Aceh Tamiang Regency at the end of 2025 disrupted access to basic health services and logistics distribution, and increased the risk of environment-based diseases. This Community Service activity aims to accelerate post-disaster health recovery through integrated health interventions based on field needs. The interventions emphasize improving community hard skills in the practice of Clean and Healthy Living Behaviors (PHBS), utilization of Family Medicinal Plants (TOGA), rational use of medicines, and sanitation management, accompanied by strengthening soft skills such as health communication, community collaboration, social empathy, and adaptive preparedness. The program was implemented in ten villages, covering 691 health service recipients and 660 households receiving logistics through collaboration with the Tamiang Hulu Community Health Center, HEOC, and MTA–DRC. The methods used included mobile health services, logistics distribution, PHBS education, TOGA training, psychosocial support, and strengthening of primary health services. The results showed a predominance of cases of respiratory tract infections, diarrhea, and skin diseases, as well as a strengthening of primary service functions. Qualitatively, the community showed an increase in skills through active participation, the application of PHBS and household sanitation, the use of TOGA for minor complaints, and more rational and targeted use of medicines. The evaluation was carried out through field observations, service coverage records, and partner feedback. Intervention.
Co-Authors Abulkhair Abdullah Aditya Sindu Sakti Amran Nur Anggaraini, Yessy Puspa Bambang Tjiroso, Bambang Burhan, Hesti Trisnianti Dihir, Sri Defi Hasmah Hasmah, Hasmah Hidayat, Ferdian Imam, Fathul Rizky S. Kasau, Sukirno Lola’ Tulak Rerung Marhamah Marhamah Muhammad Subhan A Sibadu Muhammad, Apriyanti Muhlis, Widyawati Nur Asma S Somadayo Nur, Muh. Ilyas Rachman, Eva Syariefah Rope, Mohammad Reza Vitra Rosdiana Rosdiana Siregar, Khoiryah Miagori Somadayo, Nur Asma S Syamsuri Syakri Togubu, Diana Mirza TOKA, WAHYUNITA DO Yulimanida, Herri Zayra, Andi Ratu