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All Journal Jurnal Sains Materi Indonesia The Journal of Pure and Applied Chemistry Research Jurnal Rekayasa Bahan Alam dan Energi Berkelanjutan Walisongo Journal of Chemistry Acta Biochimica Indonesiana Jurnal Jejaring Matematika dan Sains Jurnal Sains dan Edukasi Sains Indonesian Journal of Cosmetics TeknoKreatif: Jurnal Pengabdian kepada Masyarakat Journal of Chemistry Sciences and Education
Syahjoko Saputra, Iwan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Energy Environmental Science Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Other

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BIOSYNTHESIS AND CHARACTERIZATION OF GOLD NANOPARTICLES AND THEIR INTERACTION STUDY WITH METFORMIN Anggraini, Dian; Suhartati, Siti; Saputra, Iwan Syahjoko; Sudirman, Sudirman
Jurnal Sains Materi Indonesia Vol 21, No 2: JANUARY 2020
Publisher : Center for Science & Technology of Advanced Materials - National Nuclear Energy Agency

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1021.174 KB) | DOI: 10.17146/jsmi.2020.21.2.5591

Abstract

BIOSYNTHESIS AND CHARACTERIZATION OF GOLD NANOPARTICLES AND THEIR INTERACTION STUDY WITH METFORMIN. Synthesis of gold nanoparticles successfully carried using Imperata cylindrica L leaf extract. In this study, the approach used through green synthesis method is a reaction betwen of the HAuCl4 solution (concentration variation as 3; 5; 7 x 10-4 M) with Imperata cylindrica L leaf extract. Results of UV-Vis showed of gold nanoparticles has a maximum wavelength at 530 nm with absorbance value of 1.4. Results of FTIR shows a shift the absorption peak at wavenumber of 3392 cm-1 to 3404 cm-1. PSA and PZC showed the distribution of gold nanoparticles was 48.84 nm with a charge of 20.5 mV. Gold nanoparticles has a spherical shape and an average particle size of 20 nm which can be seen from the results of the characterization using TEM. XRD showed crystalize size average of gold nanoparticles as 20.47 nm. The interaction between of gold nanoparticles with metformin can be seen in the absorbance decrease of 0.38 at a wavelength of 531 nm and the results of PSA shows an average particle size of AuNPs@metformin is 122 nm. From the characterization data can be concluded the gold nanoparticles were successfully synthesized using natural bioreductors by utilizing secondary metabolites from Imperata cylindrica L leaf extract.
Sintesis dan Kararkterisasi Modifikasi Mikropartikel Magnetit (Fe3O4) Dalam Pemanfaatan Karat dengan Ekstrak Daun Ilalang (Imperata Cylindrica L): Synthesis and Characterization of Modified Magnetite Microparticles (Fe3O4) in Rust Utilization with Leaf Extract of Grass (Imperata cylindrica L) Siti Zulaicha, Annisaa; Syahjoko Saputra, Iwan; Puspita Sari, Indah; Annas, Dicky
Jurnal Jejaring Matematika dan Sains Vol. 2 No. 2 (2020): Edisi Desember 2020
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36873/jjms.2020.v2.i2.405

Abstract

The synthesis of magnetite (Fe3O4) microparticles has been successfully carried out using rust and leaf extract of grass (Imperata cylindrica L). The purpose of this research is the synthesis and characterization of Fe3O4 microparticles using the Green Synthesis method. The UV-Vis results showed that the absorption peak was at a wavelength of 273 nm with an absorbance value of 0.75. FTIR analysis shows the shift of the peak at wave number 3356 cm-1 to 3290 cm-1 and the appearance of a new peak at wave number 500 cm-1 which is characteristic of the Fe-O-Fe functional group and indicates the formation of Fe3O4 microparticles. XRD results showed six specific peaks, which were crystallinity of Fe3O4 microparticles at position 2 theta 30.40 °, 35.70 °, 43.30 °, 53.80 °, 57.40 °, and 63.00 °. PSA analysis showed that the mean particle size was > 100 nm, and the PZC results showed a zeta potential of 20 mV. SEM results showed the morphology of Fe3O4 microparticles with 1000x magnification, and EDS analysis results showed Fe and O's elemental composition.
Eco-Friendly Synthesis of Gold Nanoparticles through Gracilaria sp Seaweed Extract for Foam Height Stability in Liquid Hand Soap Formulations Syahjoko Saputra, Iwan; Hermadi Saputro, Anjar; Adliani, Nur; Rahmi, Dwinna; Sudirman, Sudirman; Nopiandi, Yogi
The Journal of Pure and Applied Chemistry Research Vol 10, No 3 (2021): Edition September-December 2021
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2021.010.03.599

Abstract

Gold nanoparticles (G-NPs) were successfully synthesized using Gracilaria sp seaweed extract. Visually, color changes from purple-blue to ruby red and then finally to pink. UV-Vis spectrophotometer showed the optimum condition of G-NPs at 531 nm wavelength with an absorbance value of 1.1. The fourier transform infrared (FTIR) spectroscopy shows the absorption peak of functional groups at the Gracilaria sp seaweed extract like hydroxyl group (-OH), aromatic (C=C), alkane (C-H), and amine (C-N) at the wavenumbers of 3356, 1613, 1456, and 1182 cm-1, respectively. The X-ray diffraction (XRD) shows the crystallinity peaks of G-NPs at 2θ: 38.3o, 44.1o, 64.8o, and 77.8o with miller indices of (111), (200), (220), and (311). The Particle size analyzer (PSA) shows the distribution and particle size average of G-NPs was 11.8 nm. Analysis of particle zeta charge (PZC) confirms the total charge of inter-particles was -24.7 mV. The transmission electron microscopy (TEM) images shows the G-NPs was spherical shape with a particle size was 20 nm. The hand soap@G-NPs have a pH of 6.0 and foam height stability of 4.1 cm for 10 min.
Sintesis dan Kararkterisasi Modifikasi Mikropartikel Magnetit (Fe3O4) Dalam Pemanfaatan Karat dengan Ekstrak Daun Ilalang (Imperata Cylindrica L): Synthesis and Characterization of Modified Magnetite Microparticles (Fe3O4) in Rust Utilization with Leaf Extract of Grass (Imperata cylindrica L) Siti Zulaicha, Annisaa; Syahjoko Saputra, Iwan; Puspita Sari, Indah; Annas, Dicky
Jurnal Jejaring Matematika dan Sains Vol. 2 No. 2 (2020): Edisi Desember 2020
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36873/jjms.2020.v2.i2.405

Abstract

The synthesis of magnetite (Fe3O4) microparticles has been successfully carried out using rust and leaf extract of grass (Imperata cylindrica L). The purpose of this research is the synthesis and characterization of Fe3O4 microparticles using the Green Synthesis method. The UV-Vis results showed that the absorption peak was at a wavelength of 273 nm with an absorbance value of 0.75. FTIR analysis shows the shift of the peak at wave number 3356 cm-1 to 3290 cm-1 and the appearance of a new peak at wave number 500 cm-1 which is characteristic of the Fe-O-Fe functional group and indicates the formation of Fe3O4 microparticles. XRD results showed six specific peaks, which were crystallinity of Fe3O4 microparticles at position 2 theta 30.40 °, 35.70 °, 43.30 °, 53.80 °, 57.40 °, and 63.00 °. PSA analysis showed that the mean particle size was > 100 nm, and the PZC results showed a zeta potential of 20 mV. SEM results showed the morphology of Fe3O4 microparticles with 1000x magnification, and EDS analysis results showed Fe and O's elemental composition.
Pelatihan dan Edukasi Pembuatan Masker Kecantikan di SMKN 7 Bandar Lampung Saputra, Iwan Syahjoko
TeknoKreatif: Jurnal Pengabdian kepada Masyarakat Vol 1 No 2 (2021): TeknoKreatif: Jurnal Pengabdian kepada Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M), Institut Teknologi Sumatera, Lampung, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/teknokreatif.v1i2.601

Abstract

Kosmetik merupakan produk yang dapat digunakan untuk memperindah dan mempercantik diri. Masker kecantikan merupakan salah satu produk kosmetik dan sangat digemari bagi kalangan wanita. Selain dapat digunakan sebagai masker kecantikan, produk kosmetik ini dapat menjadi produk unggulan dalam meningkatkan UMKM di Indonesia. Kegiatan Pengabdian Kepada Masyarakat (PkM) yang dilakukan oleh program studi Rekayasa Kosmetik, Institut Teknologi Sumatera ini bertujuan untuk memberikan pelatihan dan edukasi pembuatan masker kecantikan berbahan dasar alami bagi kalangan siswa-siswi SMKN 7 Bandar Lampung. Peserta yang mengikuti kegiatan PkM ini bejumlah 30 siswa. Hasil pre-test menunjukkan jumlah siswa yang mampu menjawab pertanyaan dengan score diatas 80 sebanyak 5 orang. Setelah dilakukan pelatihan dan edukasi, hasil post-test menunjukkan peningkatan pengetahuan para siswa menjadi 27 orang yang memiliki score > 80. Kegiatan PkM ini memberikan pengetahuan dan menambah wawasan bagi para siswa-siswi SMKN 7 Bandar Lampung dari mulai pembuatan masker kecantikan menggunakan bahan dasar alami sampai regulasi perizinan BPOM.
Utilization of Senduduk Fruit Extract (Melastoma malabathricum) for Natural Color in Lip Cream Zulaicha, Annisaa Siti; Munawaroh, Khoryfatul; Saputra, Iwan Syahjoko; Setiajaya, Arif
Walisongo Journal of Chemistry Vol 6, No 2 (2023): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v6i2.18427

Abstract

Decorative cosmetics function to beautify your appearance with a combination of colors such as blush, hair dye and lip color . A class of cosmetics that women always use to give a more attractive appearance are decorative cosmetics such as lips cream. The coloring ingredients added to lip cream preparations are chosen from an economic perspective, but the optimal level of color stability means that many manufacturers still use dangerous chemical dyes such as Rhodamine B in their products. This dye can cause irritation to the respiratory tract and is carcinogenic. Therefore, the aim of the research is to formulate a lip cream preparation with natural coloring agent from sendunia fruit extract that is safe, useful and of good quality through physical and stability tests. Extraction was carried out using the maceration method for 3x24 hours using 96% ethanol solvent. Senduduk fruit extract lip cream is formulated into 4. The base comparisons carried out were (carnauba wax: microcrystaline wax) F 0 (12.6; 10.6), F1 (9.6; 7.6), F2 (7.6; 9.6), and F4 (9 ;9), physical properties assessed from the organoleptic test, homogeneity test, spreadability test, adhesion, pH test. The results of the hedonic test can be concluded that F2 color is the best formulation interested.
Effect of Adding Basil Leaf Extract (Ocimum basilicum) on Reducing Ag+ Ions to Ag0 by Colorimetry: Pengaruh Penambahan Ekstrak Daun Kemangi (Ocimum basilicum) Terhadap Reduktor Ion Ag+ menjadi Ag0 secara Kolorimetri Ambarita, Petrus Alvin Peter Ambarita; Nurhayati, Veni Putri; Rani, Fella Anindya; Putri, Tia Azzahra; Khansa, Shefia Dhiya; Gultom, Rifka; Rorensya, Chika Ari Dinar; Saputra, Iwan Syahjoko
Jurnal Rekayasa Bahan Alam dan Energi Berkelanjutan Vol. 8 No. 2 (2024)
Publisher : Fakultas Teknik, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.rbaet.2024.008.02.04

Abstract

Nanotechnology has become a significant focus of research in efforts to address various challenges across multiple fields, including the synthesis of metal nanoparticles using natural bioreductors. This study explores the use of basil leaves (Ocimum basilicum) as a natural bioreductor for the synthesis of silver nanoparticles (Ag). The extract from basil leaves is rich in flavonoids, which serve as reducing agents in the green synthesis process of silver nanoparticles. The research methods include the preparation of basil leaves, extraction of simplicia, phytochemical analysis, and testing the bioreduction of Ag+ ions. The results indicate that the addition of basil leaf extract effectively reduces Ag+ ions to Ag⁰, marked by a color change in the solution to yellow-green within 60 minutes. The uniqueness of this study lies in utilizing basil leaves as an environmentally friendly bioreductor in the synthesis of silver nanoparticles. These findings have broad potential applications in catalysis, sensing technologies, and cosmetics.
Molecular docking of ferulic acid, bakuchiol and niazirin on peroxisome proliferator-activated receptor gamma (PPAR-γ) as anti-diabetic agents Saputro, Anjar Hermadi; Fauziyya, Riri; Sarmoko; Saputra, Iwan Syahjoko
Acta Biochimica Indonesiana Vol. 7 No. 2 (2024): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.181

Abstract

Background: Diabetes mellitus remains one of the most dangerous illnesses worldwide. The PPAR-gamma protein plays a crucial role in lipid and carbohydrate metabolism, making it a key target for diabetes therapy. Research into plant-derived active compounds for diabetes treatment is increasingly important. Objective: This study aims to evaluate and analyze the interaction of ferulic acid, niazirin, and bakuchiol with the peroxisome proliferator-activated receptor gamma (PPAR-γ) protein using molecular docking. Methods: Molecular docking was employed to assess the interactions between ferulic acid, niazirin, bakuchiol, and the PPAR-γ protein (PDB ID: 2PRG). The analysis focused on binding free energy values, amino acid residue interactions, the number of hydrogen bonds, and bond distances, comparing these results to those of the native ligand and pioglitazone, a known anti-diabetic drug targeting PPAR-γ. Results: The binding free energies for the ferulic acid-PPAR-γ, bakuchiol-PPAR-γ, niazirin-PPAR-γ, native ligand-PPAR-γ, and pioglitazone-PPAR-γ complexes were -5.54 kcal/mol, -8.47 kcal/mol, -6.56 kcal/mol, -10.08 kcal/mol, and -9.94 kcal/mol, respectively. The amino acid residue similarity percentages with the native ligand were 18.18% for ferulic acid, 27.27% for bakuchiol, 18.18% for niazirin, and 81.82% for pioglitazone. The native ligand-2PRG and pioglitazone-2PRG complexes exhibited superior hydrogen bond numbers and shorter bond distances compared to the other compounds. Conclusion: Although bakuchiol showed the most promising interaction among the tested compounds, none surpassed the binding affinity and stability of the native ligand or pioglitazone. Further research is needed to optimize these compounds for potential anti-diabetic therapy.
Pengaruh Metode Ekstraksi Maserasi, Sonikasi, dan Sokletasi Terhadap Nilai Rendemen Sampel Kulit Buah Naga (Hylocereus polyrhizus) Triyanti, Sinta Bella; Lestari, Fhora Putri; Fitriana, Puti Anisa Nur; Rostiana, Herlita Rahma; Silalahi, Devika Damayanti; Syalsabina, Tria Dara; Putri, Rahma Yenita; Saputra, Iwan Syahjoko
Jurnal Sains dan Edukasi Sains Vol. 8 No. 1 (2025): Jurnal Sains dan Edukasi Sains
Publisher : Faculty of Science and Mathematics, Universitas Kristen Satya Wacana, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24246/juses.v8i1p71-78

Abstract

Ekstraksi merupakan proses pemisahan senyawa aktif simplisia dengan menggunakan pelarut cair tertentu. Simplisia adalah bahan alami yang berasal dari alam dan belum mengalami proses pengolahan kecuali proses pengeringan. Proses pengeringan dilakukan untuk memperpanjang masa simpan dan mempermudah penggunaannya. Simplisia banyak digunakan sebagai bahan dasar ekstraksi. Ada beberapa metode dalam ekstraksi diantaranya adalah maserasi, sonikasi, dan sokletasi. Pada percobaan ekstraksi kulit buah naga, proses ekstraksi dimulai dengan menghancurkan kulit buah naga menjadi potongan kecil, kemudian direndam dalam pelarut untuk memisahkan senyawa senyawa yang diinginkan. Maserasi adalah proses merendam suatu simplisia dalam pelarut pada suhu kamar untuk mendapatkan ekstrak. Sonikasi adalah modifikasi dari metode maserasi yang menggunakan bantuan ultrasound (sinyal dengan frekuensi tinggi, 20 kHz), sedangkan sokletasi melibatkan pemanasan yang cukup pada suhu yang lebih tinggi. Pada kulit buah naga, senyawa senyawa yang dapat dihasilkan juga memiliki beberapa manfaat, diantaranya termasuk antioksidan yang tinggi dan khasiat anti - inflamasi. Dengan memanfaatkan teknik ekstraksi maserasi, sonikasi, dan sokletasi potensi senyawa senyawa bermanfaat dalam kulit buah naga dapat diekstraksi secara efisien untuk aplikasi yang beragam. Pada penelitian ini hasil nilai rendemen maserasi sebesar 16,29%; nilai rendemen sonikasi 3,74%; dan nilai rendemen sokletasi sebesar 29,54%. Adapun hasil uji fitokimia pada ekstrak kulit buah naga metode sokletasi terdapat senyawa metabolit dengan yaitu tanin.
THE EFFECT OF DIFFERENCES IN CHARACTERISTICS OF BIDARA LEAF EXTRACT (ZIZIPHUS MAURITIANA L.) OBTAINED FROM MACERATION, ULTRASONIC, AND SOXHLET METHODS Capah, Agitha Casanova; Sholeha, Aida Febina; Putri, Meysita; Putri, Shinta Eryamana; Akmeltha, Ayesha Dinda; Oktavia, Rika; Dinni, Sabili Rachma; Saputra, Iwan Syahjoko
Indonesian Journal of Cosmetics Vol. 2 No. 2 (2024): Indonesian Journal of Cosmetics
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/ijcos.v2i2.2158

Abstract

Bidara leaves are known to contain alkaloids, flavonoids, steroids, tannins, and saponins. This study aims to analyze how the three extraction methods used can affect the characteristics of bidara leaf extract. The extraction methods used in this study were the maceration method, the ultrasonic method, and the soxhlet method. The calculation of the yield value was carried out and the difference was seen with the largest number in the ultrasonic method 10.37% w/w, the soxhlet method 3.49% w/w, and the maceration method 3.68% w/w, then the stock solution calculation was carried out and the results were obtained ultrasonic method 0.1%, soxhlet method 0.0044%, and maceration method 0.012%. The evaluation used was phytochemical screening. The results of phytochemical screening showed that the leaf extract contained secondary metabolites, namely alkaloids, flavonoids, steroids, tannins, and saponins. It can be concluded that the three extraction methods in bidara leaves did not show differences in the presence of secondary metabolites, but affected their yield values.
Co-Authors Akmeltha, Ayesha Dinda Ambarita, Petrus Alvin Peter Ambarita Anjar Hermadi Saputro Annas, Dicky Annisa Rahma Aryanti Capah, Agitha Casanova Dian Anggraini Dinni, Sabili Rachma Dwinna Rahmi Fauziyya, Riri Fitriana, Puti Anisa Nur Gultom, Rifka Herayati Indah Puspita Sari Khansa, Shefia Dhiya Lestari, Fhora Putri Made Helen Susanti Munawaroh, Khoryfatul Nopiandi, Yogi Nur Adliani Nurhayati, Veni Putri Oktavia, Rika Puspita Sari, Indah Putri, Meysita Putri, Rahma Yenita Putri, Shinta Eryamana Putri, Tia Azzahra Rani, Fella Anindya Rorensya, Chika Ari Dinar Rostiana, Herlita Rahma Sarmoko Sarmoko Sedo Putra, Muhammad Hakiem Setiajaya, Arif Sholeha, Aida Febina Silalahi, Devika Damayanti Siti Suhartati, Siti Siti Zulaicha, Annisaa Sudirman Sudirman Sugeng, Santoso Syalsabina, Tria Dara Triyanti, Sinta Bella Zulaicha, Annisaa Siti