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All Journal Pharmaciana: Jurnal Kefarmasian The Journal of Pure and Applied Chemistry Research Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Farmasi Sains dan Komunitas JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal JKFT Jurnal Insan Farmasi Indonesia Sainsbertek Jurnal Ilmiah Sains & Teknologi Prosiding Seminar Nasional Universitas Ma Chung
Monica, Eva
Ma Chung University
Arts Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Other

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Journal : The Journal of Pure and Applied Chemistry Research

 1 
Antimicrobial, antioxidant, and cytotoxic activities of endhopitic fungi Chaetomium sp. isolated from Phyllanthus niruri Linn: in vitro and in silico studies Rollando Rollando; Dion Notario; Eva Monica; Martanty Aditya; Rehmadanta Sitepu
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1433.715 KB) | DOI: 10.21776/ub.jpacr.2017.006.01.317

Abstract

Endophytic fungi Chaetomium sp isolated from Phyllanthus niruri Linn. Mycelium powder was extracted by using ethyl acetate. Extract was fractionated using n-hexane, dichloromethane and ethanol 96%. The antimicrobial test was carried out using disc diffusion and microdilution methods. The antioxidant activity of the fraction was determined using hydrogen peroxide free radical scavenging and reducing power capacity activities. The cytotoxicity assay of the fraction against T47D breast cancer cell was carried out using dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide method (MTT). The in silico prediction of chemical substances which are reported exist in Chaetomium sp. performed using AutoDockVina embedded in PyRx version 8.0. Dichloromethane fraction was found as the most active sample against Escherichia coli (IC50 20.76 mg/mL), Staphylococcus aureus (IC50 70.15 mg/mL), Salmonella typhi (49.13 mg/mL) and was found as the most high phenolic content with value 47.44 mg GAE/g fraction, whereas the best antioxidant activity was performed by ethanol 96% fraction (85%). Cytotoxicity assay against T47D cell line showed dichloromethane fraction have highest activity with IC50 10.76 mg/mL. The docking studies showed that compounds bearing xanthone structure were potential for maltose binding periplasmic and human aromatase associating with their potencies as antibacteria and anticancer. Endophytic fungi Chaetomium sp. was isolated from Phyllanthus niruri using n-hexane, dichloromethane and ethanol fractions was studied its various biological activities as antimicrobial, antioxidant and cytotoxic agent against breast cancer cell. 
Physical Properties Investigation on Sunscreens with Colloidal Gold and Moringa oleifera Extract Ruth Febriana Kesuma; Eva Monica; Rokiy Alfanaar
The Journal of Pure and Applied Chemistry Research Vol 9, No 1 (2020): Edition January-April 2020
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/jpacr.ub.2020.009.01.464

Abstract

Botanicals were known as active ingredients in sunscreens due to their dermal protecting. Gold in colloidal form has a completely unique property for the reason that it may be used as photoaging material. The exposure of UV radiation to skin can cause erythema and skin cancer. The aim of this study was to determine the physical properties of the sunscreens made from Au/ZnO and antioxidant from Moringa oleifera extract such as the sun protection factor (SPF), pH, spreadability, and adhesion. The Moringa oleifera were extracted by maceration. Maceration with 70% ethanol of dried leaves exhibited DPPH scavenging activity (EC50 235.01 μg/mL). Diffuse reflectance UV-Vis spectra of ZnO and Au/ZnO revealed absorption at λex of 385 nm which were equivalent to a bandgap energy of 3.22 eV. Au/ZnO posed a localized state at λex of 385 (3.65 eV). The sunscreens with formulations F1, F2, F3, and F4 showed high SPF number of 20.1479, 21.0008, 22.3872, and18.4631. Kruskal-Wallis test showed significant differences between sunscreen formulations.
Co-Authors Alfanaar, Rokiy Basu Swastha Dharmmesta Bunga Leonita Manurung Charina Halim Sugiono Chresiani Destianita Yoedistira Chresiani Destianita Yoedistira Dion Notario Elvin Febriyanti Hardi F.X. Haryanto Susanto Fibe Yulinda Cesa Gytha Novella Ongkowijoyo Leny Yuliati Martanty Aditya, Martanty Mifta Devin Suwandi Muhammad Setiyawan Nancy Isnawati Simbolon Putri Rahayu Rehmadanta Sitepu Rehmadanta Sitepu Rehmadenta Sitepu Roll ando Rollando, Rollando Ruth Febriana Kesuma Sandra Dewi Tansil Setiawan, Hendry Suci Paramitasari Syahlani Toni Tri Cahyono Yandriyani, Devilke Yuniati, Yuyun