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All Journal Jurnal Insan Farmasi Indonesia Jurnal Info Sains : Informatika dan Sains Journal of Pharmaceutical Care and Sciences Jurnal Atma Inovasia Jurnal Bakti Untuk Negeri Prosiding Seminar Nasional Universitas Ma Chung Indonesian Journal of Pharmacy and Natural Product JUKEJ: Jurnal Kesehatan Jompa
Yandriyani, Devilke
Universitas Ma Chung
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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STUDI PREFORMULASI KELARUTAN MINYAK ATSIRI MASOYI (Massoia aromatica Becc.) dalam SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS) Devilke Yandriyani; Eva Monica; Rollando Rollando; Hendry Setiawan; Rehmadenta Sitepu
Jurnal Insan Farmasi Indonesia Vol 2 No 1 (2019)
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

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Abstract

Self-Emulsifying Drug Delivery System (SEDDS) merupakan salah satu metode yang digunakan untuk memperbaiki bioavailabilitas obat yang memiliki kelarutan dan absorpsi buruk dan biasanya digunakan untuk bahan aktif yang termasuk dalam BCS kelas II. Formulasi Self-Microemulsifying Drug Delivery System (SMEDDS) menggunakan beberapa komponen minyak, surfaktan, dan kosurfaktan. Parameter yang digunakan dalam formulasi meliputi studi kelarutan, penetapan kandungan lakton, skrining surfaktan dan kosurfaktan serta diagram fase pseudoterner. Komponen surfaktan, kosurfaktan dan minyak yang dipilih yaitu tween 80, PEG 400 dan minyak jarak. Formula Self-Microemulsifying Drug Delivery System (SMEDDS) terdiri dari 60% surfaktan dan kosurfaktan (4:1), 30% minyak jarak dan 10% minyak masoyi (Massoia aromatica Becc.).
Analisis Nilai Overall Equipment Effectiveness dan Dampaknya pada Biaya Produksi: Studi pada Tingkat Ketersediaan Industri Farmasi PT Z Yandriyani, Devilke; Sitanggang, Maura Linda; Masri, Indah
Prosiding Seminar Nasional Universitas Ma Chung (Informatika & Sistem Informasi Bahasa dan Seni
Publisher : Ma Chung Press

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Abstract

Industri farmasi dalam menjamin sistem mutu memiliki peraturan yang ketat dan harus menerapkan prinsip-prinsip Cara Pembuatan Obat yang Baik (CPOB). Selain itu, untuk menghasilkan kualitas yang konsisten, industri farmasi harus melakukan perbaikan berkelanjutan. Salah satunya adalah dengan menurunkan waktu henti dan menurunkan produk cacat dengan metode Overall Equipment Effectiveness (OEE). Waktu henti ini berhubungan dengan kinerja mesin produksi di industri farmasi dan menyebabkan rendahnya nilai tingkat ketersediaan. Tingkat ketersediaan memengaruhi rendahnya nilai Overall Equipment Effectiveness (OEE) yang dapat berdampak pada biaya produksi di industri farmasi. Penelitian ini menggunakan metode kuantitatif deskriptif dan diikuti dengan kualitatif untuk mencari akar penyebab. Kuantitatif dengan menghitung nilai tingkat ketersediaan, tingkat performa, tingkat kualitas, nilai OEE, dan biaya produksi (direct labor dan factory overhead). Biaya direct material diasumsikan konstan. Kualitatif dengan Focus Group Discussion (FGD). Hasil penelitian ini menunjukkan bahwa rendahnya nilai OEE berdampak pada jam kerja dan biaya produksi (direct labor dan factory overhead), di mana hasil uji T menunjukkan perbedaan yang signifikan antara standar dan aktual. Penyebab utama rendahnya nilai OEE adalah rendahnya nilai ketersediaan yang disebabkan oleh belum adanya standar setting untuk masing-masing produk sehingga proses setting berpedoman pada pengalaman dan proses tunggu buka dan sortir afkir/produk terlalu lama, belum ada pelatihan standar setting untuk masing-masing produk sehingga terdapat perbedaan keterampilan personel, dan adanya ketidakstabilan suhu antara sealing A dan sealing B.
The effect of low oveerall equipment effectiveness (OEE) on working hours and production costs of supplement products Devilke Yandriyani; Maura Linda Sitanggang; Indah Masri
Jurnal Info Sains : Informatika dan Sains Vol. 14 No. 01 (2024): Informatika dan Sains , Edition March 2024
Publisher : SEAN Institute

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Abstract

The pharmaceutical industry has strict regulations and procedures to guarantee a quality system by implementing Good Manufacturing Practices (CPOB) or current Good Manufacturing Process (cGMP). This must be adhered to by the pharmaceutical industry to ensure the safety, efficacy and consistent quality of the products produced. To produce consistent quality, the pharmaceutical industry needs to make continuous or ongoing improvements, one of the improvements that must be made is reducing downtime and reducing defective products. These improvements will increase the effectiveness of the machine. One method that can be used is Overall Equipment Effectiveness (OEE). This research aims to determine the effect of OEE values on working hours and production costs (direct labor & factory overhead) of supplement products by looking at the differences between actual and standard. This research uses descriptive quantitative methods followed by qualitative methods to find the root of the problem. Quantitative by calculating the value of availability level, performance level, quality level, OEE value, working hours and production costs (direct labor & factory overhead). Qualitative with Focus Group Discussion (FGD). The primary packaging production process for supplement products in 2022 shows an availability level of 47.23%, a performance level of 82.50%, a quality level of 95.78%, an OEE value of 37.32%. This shows that the condition of packaging machine X is not in prime condition because the overall OEE value is still below the ideal value of 85%. The low OEE value has an impact on working hours and production costs (direct labor & factory overhead) where the T test results show a significant difference between standard and actual (p-value (1.2829x10-6) ≤ α (0.05).
F Formulasi Sediaan Lip Serum Minyak Argan (Argania spinosa L.) Dan Uji Efektivitas Sebagai Moisturizing Agent Secara In Vitro Yandriyani, Devilke
Jurnal Pelayanan Kefarmasian dan Sains Vol 5 No 1 (2024): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v5i1.669

Abstract

Background: The problem of dry and chapped lips is often experienced by women. This is due to a lack of nutrition and care for the lips, so there is a need for cosmetic products that can be used to moisturize and nourish the lips from the outside and inside. Argan oil is a natural ingredient that has the potential as a moisturizing agent which can be formulated into a lip serum preparation that can moisturize and nourish the lips. This research aims to determine the most optimal formula and concentration of argan oil and its effectiveness as a moisturizing agent.Objective: To determine the effectiveness of argan oil lip serum preparations as a moisturizing agent in vitro.Method: The method used was a true experiment using the Sorption Desorption Test (SDT) and analyzed using a one-way Anova test with p-value <0.05.  The lip serum preparation formula is designed using 5 formulas with different concentrations of argan oil, namely 0%, 15%, 20%, 25% and 30%.Results: The effectiveness value was calculated by the total [AUC] value determined by the amount of weight lost during storage. The smaller the weight lost, the greater the effectiveness of the moisture, and vice versa. The results of observations of effectiveness tests on lip serum preparations of argan oil with a concentration of 30% had the smallest weight loss and the highest total [AUC] value. Based on the results of statistical tests, it shows that there is a significant difference with a p-value of 1.5938E-08 (p-value < 0.05).Conclusion: In this study there were significant differences in the effectiveness of the moisture of 5 (five) formulas. Argan oil lip serum preparations with a concentration of 30% have the best moisturizing ability.
UPAYA MENINGKATKAN KESADARAN MASYARAKAT DALAM MENCEGAH PENYAKIT DIABETES MELITUS DI DESA SUMBERSEKAR Yandriyani, Devilke
Jurnal Bakti untuk Negeri Vol 5 No 1 (2025): Jurnal Bakti Untuk Negeri
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/92tap698

Abstract

The prevalence of diabetes mellitus both in the world and in Indonesia continues to increase every year. Increasing public knowledge is considered to have an influence on efforts to prevent diabetes mellitus. Extension activities in Sumbersekar village, Malang Regency were carried out by presenting material to the community, specifically Women for Family Empowerment and Welfare (PKK). Increasing public understanding can be seen from active two-way discussions between presenters and participants. These results show that the people of Sumbersekar Village have an interest in understanding and preventing diabetes and the dangers of repeated use of cooking oil. It can be concluded that the aim of this community service, namely to increase public knowledge about preventing diabetes mellitus, has been achieved.
Comparative Study of the Antifungal Effectiveness of Massoia Essential Oil-Based SMMDF Formulations with HPMC and PVP Polymers against Candida albicans Devilke Yandriyani; Eva Monica
Indonesian Journal of Pharmacy and Natural Product Vol. 8 No. 02 (2025): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijpnp.v8i02.4319

Abstract

Oral diseases, like oral candidiasis caused by Candida albicans, remain a common and troubling health issue in Indonesia. Massoia essential oil (Massoia aromatica Becc.), which contains C-10 massoialactone, has proven antifungal properties. However, its limited solubility affects how well it is absorbed into the body. This study aimed to evaluate the antifungal effectiveness of Self-Micro-emulsifying Mouth Dissolving Film (SMMDF) formulations that incorporate massoia essential oil, using either HPMC or PVP polymers, against C. albicans in a laboratory setting. The test fungus was cultured on PDA and prepared into a suspension standardized to 0.5 McFarland, followed by antifungal testing using the well diffusion method on PDA medium. Nystatin served as the positive control, while formulations without massoia essential oil served as the negative control. The results showed that the average inhibition zones for SMMDF with HPMC and PVP polymers were 10.85 mm and 11.51 mm, respectively—both considered strong and larger than the positive control (6.68 mm). An independent sample t-test showed no significant difference between the two polymers (p = 0.735), suggesting that the antifungal activity mainly stemmed from the massoia essential oil itself. These results suggest that massoia essential oil-based SMMDF holds significant potential as an effective antifungal solution against C. albicans, with no major difference in effectiveness between HPMC and PVP as the polymers used to form the film.
Aplikasi Metode Biologi Molekuler pada Model Embrio Ikan Zebra (Danio rerio) dalam Pengembangan Obat Kardiovaskular Fibe Yulinda Cesa; Martanty Aditya; Devilke Yandriyani; Reflinda Sindy Puspita; Rizal Bing Garumal Indianta
JUKEJ : Jurnal Kesehatan Jompa Vol 5 No 2 (2026): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol5.Iss2.2698

Abstract

Cardiovascular diseases remain a leading cause of global mortality and morbidity for 6.9 million deaths in 2021 due to conditions like stroke and ischemic heart disease. The high cost of long-term treatment often leads to decreased medication adherence, spurring the development of new, more affordable yet effective drugs. To minimize risk, animal models are crucial in drug development before human trials. Therapy for cardiovascular diseases continues to evolve due to high costs and poor adherence. Zebrafish have emerged as a promising animal model due to their genetic similarity to humans, allowing for the testing of more efficient and affordable novel drugs. This study reviewed articles on cardiovascular disease in zebrafish embryos from MDPI, PubMed, Science Direct, and Springer Link databases, using specific keywords. Inclusion criteria included quantitative research articles in English or Indonesian, open-access, and published between 2015-2025. Following the PRISMA process (identification, screening, eligibility), 14 relevant journals were selected from 5.680 initial articles and subsequently analyzed using JBI Critical Appraisal Tools for further discussion. The findings indicate that various molecular techniques, such as immunostaining, PCR, and western blotting, enable cardiovascular disease research in zebrafish embryos. This model offers speed, accuracy, and cost-efficiency due to its transparent and replicable nature. Despite requiring specialized skills due to their small size, zebrafish embryos present a promising alternative for developing new cardiovascular drugs.
Penanggulangan Anemia pada Remaja di Desa Sumbersekar Malang dalam Mendukung Sustainable Development Goals 3 Bita Parga Zen; Hendry Setiawan; Devilke Yandriyani; Muhammad Nurwegiono
Jurnal Atma Inovasia Vol. 6 No. 1 (2026)
Publisher : Lembaga Penelitian dan Pengabdian pada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/jai.v6i1.12687

Abstract

Adolescent female anemia is a health issue that increases the risk of chronic malnutrition and stunting in children. In Sumbersekar Village, Malang Regency, adolescent girls face limited awareness of the importance of hemoglobin, making prevention efforts challenging. This study aims to improve knowledge, promote early detection, and provide practical anemia prevention strategies. The methods used include interactive education on anemia symptoms and prevention, hemoglobin (Hb) testing to identify at-risk participants, distribution of iron supplement tablets, and demonstration of an app-based anemia monitoring system. Data were collected through Hb testing, participant observations, and satisfaction surveys. The results showed active participation of 160 adolescent girls, an increased in knowledge and awareness about anemia, smooth distribution of iron tablets, and better understanding of health monitoring through the application. Evaluation revealed that 95% of participants were highly satisfied with the program. In conclusion, the initiative effectively enhanced awareness, promoted early detection, and prevented anemia among adolescent girls in Sumbersekar Village
Co-Authors Bita Parga Zen Fibe Yulinda Cesa Indah Masri Martanty Aditya, Martanty Maura Linda Sitanggang Monica, Eva Muhammad Nurwegiono Reflinda Sindy Puspita Rehmadenta Sitepu Rizal Bing Garumal Indianta Rollando, Rollando Setiawan, Hendry Sitanggang, Maura Linda