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All Journal Majalah Kedokteran Bandung Sari Pediatri Paediatrica Indonesiana Narra J
Darnifayanti, Darnifayanti
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Paediatrica Indonesiana

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Risk factors for progression of chronic kidney disease in children with nephrotic syndrome Adrian, Riki; Sovira, Nora; Haris, Syafruddin; Andid, Rusdi; Darnifayanti, Darnifayanti; Yusuf, Sulaiman
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.291-6

Abstract

Background Nephrotic Syndrome (NS) is a progressive kidney disease in children that can lead to chronic kidney disease (CKD). Understanding the interactions between various risk factors is critical in developing new strategies to prevent the progression of CKD in pediatric patients with NS. Objective To determine the risk factors for the progression of CKD in children with nephrotic syndrome at Dr. Zainoel Abidin Public Hospital, Banda Aceh. Methods This analytical observational study with a cross-sectional approach was conducted from September 2021 to September 2023. Data were obtained from medical records of 52 children aged 2 to 18 years in the inpatient and outpatient wards of Dr. Zainoel Abidin Public Hospital, Banda Aceh who met the inclusion criteria. Bivariate analysis using the Chi-square and Fisher's tests and multivariate analysis using logistic regression test were performed. Results Of 52 subjects, most were male and over ten years of age; 53.8% of subjects had Stage 1 CKD. The majority of stage 3-5 of CKD cases had immunosuppressive toxicity and anemia, while the majority of all subjects had hyperfiltration and proteinuria. Risk factors for CKD progression in children with NS are Hypertension (OR 2.54; 95%CI 0.32 to 20.1; P=0.003), immunosuppressant toxicity with (OR 33.67; 95%CI 2.59 to 437.5; P=0.007) and anemia (OR 33.92; 95%CI 2.77 to 414.5; P=0.006). Conclusion Hypertension, immunosuppressant toxicity and anemia for CKD progression in children with NS.
Co-Authors Adrian, Riki Akbar, Zaki Anidar Anidar, Anidar Arsa, Iwan Sabardi Azzaki Abubakar, Azzaki Bakhtiar Bakhtiar Dewi Karlina Rusly Dora Darussalam, Dora Fariyasni, Fariyasni Fauzi Yusuf, Fauzi Heru Noviat Herdata, Heru Noviat Maghfirah, Desi Mulya Safri, Mulya Muslim Akmal Nora Sovira, Nora Rusdi Andid, Rusdi Sri Rezeki Sulaiman Yusuf Syafruddin Haris, Syafruddin Syahrun Nur Utami, Maharani Risiska