Garuda - Garba Rujukan Digital

Silicosis: Mechanisms, Clinical Aspects, and Impacts due to Silica Exposure Esha, Indi; Afdi, Tania Libristina Ambun Suri; Simatupang, Elvando Tunggul Mauliate
Jurnal Respirologi Indonesia Vol 44, No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.644

Silicosis, an occupational lung disease, has significant mortality rates in Indonesia, as reported by Global Health Grove in 2013. The death rate for silicosis stands at 69.3%, with the typical age at death ranging from 40 to 44 years for men and approximately 80 years for women. The pathogenesis of silicosis begins when respirable crystalline silica (RCS) particles enter the airways. These RCS particles bypass the mucociliary defense mechanisms of the respiratory tract and reach the alveoli. Workers frequently exposed to silica are at high risk of developing silicosis, which significantly impacts morbidity and mortality. The diagnosis of silicosis can follow the seven-step principle for determining occupational diseases. Although silicosis is linked to serious conditions such as tuberculosis, autoimmune diseases, and lung cancer, no effective therapy exists. Treatment remains symptomatic, adjuvant, and supportive. To prevent occupational lung diseases, it is essential to involve the government in policy-making for industrial management and workers.

Mepolizumab’s (Anti-Interleukin-5) Role in Severe Asthma: A Literature Review Atikanur, Atikanur; Wijaya, Dewi; Esha, Indi; Simanjuntak, Arya Marganda
Jurnal Respirologi Indonesia Vol 44, No 2 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i2.494

One type of asthma that is difficult to treat is severe asthma, which is asthma that is uncontrolled even when the patient is taking medication or trigger factors. It can be treated with the finest therapy but will worsen if high-dose treatment is discontinued. Age, gender, obesity, hypersensitivity, and immunological factors are all directly related to the onset of asthma. A complicated illness, severe asthma has many clinical symptoms and treatment choices. Chronic airway inflammation and lung tissue remodeling are its defining features. This literature review aims to describe how mepolizumab works in patients with severe asthma. Mepolizumab mainly inhibits the IL-5 cytokine from binding to IL-5 receptor subunits through the nanomolar potential, which inhibits IL-5 from binding to receptors on the surface of eosinophils. In contrast to the placebo group, patients on mepolizumab had an average 50% decrease from the baseline Prednisone dosage. With Mepolizumab, the yearly exacerbation rate was 1.44 RR, while it was 2.12 RR with placebo. The injection of monoclonal antibodies, such as mepolizumab, as a form of therapy in addition to treating severe eosinophilic asthma is advised by the GINA guideline for 2022. Mepolizumab's mode of action blocks IL-5 from binding to receptors on eosinophil surfaces, which lowers eosinophil recruitment, activation, production, growth, and survival, as well as eosinophil-mediated inflammation.

Frekuensi Karier Streptococcus pneumoniae pada Populasi Dewasa Suku Akit Provinsi Riau Rosdiana, Dani; Veronica, R. Merlinda; Harahap, Sari; Esha, Indi; Mardhatilah, Ashifa; Putri, Nabila; Safitri, Nuridha Audinia; Safari, Dodi; Sarassari, Rosantia; Ilmiawati, Cimi; Elliyanti, Aisyah
Jurnal Ilmu Kedokteran Vol 18, No 2 (2024): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v18i2.2024.137-143

Stretococcus pneumoniae (S.pneumoniae) is a commonly colonized in healthy people that potentially to be transmitted directly to other individuals through droplets and as an invasive pathogen. The prevalence/ frequency of S. pneumoniae carriage in children is around 20-60%, while data of carriage’s frequency in adult population is still limited. Akit tribe is a tribe who lives in a group in the coastal rural area of Rupat Island. The high incidence of upper respiratory tract infection among Akit tribe and the location can be risk for S. pneumoniae carriage. Study aimed is to identify the frequency of carriage in the adult population of the Akit tribe. Nasopharyngeal swab was collected from healthy adults, then cultivated on agar media. Colonies suspected as S. pneumoniae then selected, then subjected to optochin test. S. pneumoniae confirmation were using automatic machine VITEK. We reported S. pneumoniae carriage rate was 7.8% (12 of 153 participants) among Akit tribe.

E-Cigarette or Vaping Use-Associated Lung Injury (EVALI): A Literature Review Brahmantyo, Adhimas; Esha, Indi; Yunus, Faisal
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.285-297

Electronic cigarettes (e-cigarettes) are electronic tools designed to produce an inhalable aerosol from a liquid solution. Electronic cigarette or vaping use-associated lung injury (EVALI) describes any lung damage linked to the consumption of e-cigarettes or vaping products. The liquids and aerosols from e-cigarettes can include tobacco-related nitrosamines, aldehydes, metals, volatile organic compounds, phenolic compounds, polycyclic aromatic hydrocarbons, tobacco alkaloids from tobacco, flavor additives, and various medicinal compounds. Substantial evidence indicates that substances like propylene glycol, vitamin E acetate (VEA), and heavy metals such as lead and arsenic are significant constituents of e-cigarettes, contributing to lung harm. Patients with EVALI may present with sudden or gradually developing respiratory disease, presenting with non-specific signs, including breathlessness, coughing, chest discomfort, and sometimes coughing up blood. Radiological findings in EVALI are often non-specific. The most commonly observed pattern in EVALI is parenchymal organizing pneumonia (OP), identified in 56% of cases, whereby bilateral dominant ground-glass opacity (GGO) was identified, located in the inferior sections of the lungs or diffusely distributed with varying degrees of consolidation.

The Impact of Viscose Rayon Fiber Exposure on Lung Function Khairani, Muhammad; Esha, Indi; Suyanto, Suyanto
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.298-306

Viscose rayon fiber is a semi-synthetic material derived from regenerated cellulose. The cellulose used to make viscose rayon is extracted from natural sources, resulting in fibers that are physically similar to cotton and have characteristics such as softness and high absorbency. The viscose manufacturing process involves chemical modification of cellulose using carbon disulfide (CS2), which is dangerous if exposed to humans. Carbon disulfide residues, along with endotoxin biological agents present on rayon fibers, can be inhaled into the respiratory tract. This causes oxidative protein damage, which then activates the oxidative stress response. This response ultimately results in the release of oxidants that induce inflammatory mediators, triggering acute or chronic inflammatory reactions in the airways and alveoli, resulting in decreased lung function. A systematic approach is essential for gathering and interpreting relevant data. This approach can be organized into seven steps to diagnose occupational lung diseases. The use of personal protective equipment (PPE) represents the final but most important defense. Recommended PPE includes respirator masks with suitable particle filters, protective eyewear to prevent eye irritation, chemical-resistant gloves to protect the skin from direct contact, and full-body work clothing.

Association Between Factory Workers’ Profile with Chest X-ray Finding and Spirometry at Industrial Company of X Wijaya, Dewi; Esha, Indi; Adrianison, Adrianison; Simatupang, Elvando Tunggul Mauliate; Amarudin, Amarudin
Respiratory Science Vol. 6 No. 1 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i1.198

Background: Factory workers are a group at high risk of developing occupational lung abnormalities. Continuous exposure to dust, smoke, or gas particles during work processes may lead to progressive lung damage. Chest X-ray and spirometry are essential diagnostic tools for assessing both structural and functional lung changes, allowing early detection and prevention of occupational lung disability, especially among workers exposed to airborne pollutants. Method: This analytical observational study employed a cross-sectional design to analyze the association between factory workers’ profiles and chest X-ray and spirometry findings. Lung function was assessed using spirometry parameters, including Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV₁), and FEV₁/FVC ratio to identify restrictive or obstructive patterns. Data were collected using total sampling during periodic health examinations and analyzed with SPSS version 26.0. Descriptive statistics were used to summarize characteristics, while inferential analysis using Chi-square or Fisher’s exact tests was conducted to determine associations between categorical variables, with a significance level set at P<0.05. Results: A total of 260 factory workers participated, most with ≤5 years of work experience (60.76%). Comorbidities were significantly associated with both chest X-ray findings and lung function (P=0.034 and P=0.004). Smoking history and length of work also showed significant relationships with lung function (P=0.027 and P=0.019). Conclusion: There is a significant association between smoking history and length of work with changes in lung function. Meanwhile, comorbidities have a significant association with lung structure and lung function. Periodic evaluation using spirometry and chest X-ray is essential for early detection and prevention of occupational lung abnormalities among factory workers.

Mepolizumab’s (Anti-Interleukin-5) Role in Severe Asthma: A Literature Review Atikanur, Atikanur; Wijaya, Dewi; Esha, Indi; Simanjuntak, Arya Marganda
Jurnal Respirologi Indonesia Vol 44 No 2 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i2.494

One type of asthma that is difficult to treat is severe asthma, which is asthma that is uncontrolled even when the patient is taking medication or trigger factors. It can be treated with the finest therapy but will worsen if high-dose treatment is discontinued. Age, gender, obesity, hypersensitivity, and immunological factors are all directly related to the onset of asthma. A complicated illness, severe asthma has many clinical symptoms and treatment choices. Chronic airway inflammation and lung tissue remodeling are its defining features. This literature review aims to describe how mepolizumab works in patients with severe asthma. Mepolizumab mainly inhibits the IL-5 cytokine from binding to IL-5 receptor subunits through the nanomolar potential, which inhibits IL-5 from binding to receptors on the surface of eosinophils. In contrast to the placebo group, patients on mepolizumab had an average 50% decrease from the baseline Prednisone dosage. With Mepolizumab, the yearly exacerbation rate was 1.44 RR, while it was 2.12 RR with placebo. The injection of monoclonal antibodies, such as mepolizumab, as a form of therapy in addition to treating severe eosinophilic asthma is advised by the GINA guideline for 2022. Mepolizumab's mode of action blocks IL-5 from binding to receptors on eosinophil surfaces, which lowers eosinophil recruitment, activation, production, growth, and survival, as well as eosinophil-mediated inflammation.

Silicosis: Mechanisms, Clinical Aspects, and Impacts due to Silica Exposure Esha, Indi; Afdi, Tania Libristina Ambun Suri; Simatupang, Elvando Tunggul Mauliate
Jurnal Respirologi Indonesia Vol 44 No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.644

Silicosis, an occupational lung disease, has significant mortality rates in Indonesia, as reported by Global Health Grove in 2013. The death rate for silicosis stands at 69.3%, with the typical age at death ranging from 40 to 44 years for men and approximately 80 years for women. The pathogenesis of silicosis begins when respirable crystalline silica (RCS) particles enter the airways. These RCS particles bypass the mucociliary defense mechanisms of the respiratory tract and reach the alveoli. Workers frequently exposed to silica are at high risk of developing silicosis, which significantly impacts morbidity and mortality. The diagnosis of silicosis can follow the seven-step principle for determining occupational diseases. Although silicosis is linked to serious conditions such as tuberculosis, autoimmune diseases, and lung cancer, no effective therapy exists. Treatment remains symptomatic, adjuvant, and supportive. To prevent occupational lung diseases, it is essential to involve the government in policy-making for industrial management and workers.

Current Lung Asbestosis Approach for Diagnosis, Not Just Histopathology: A Literature Review Purnama, Nori; Esha, Indi; Adrianison, Adrianison; Simanjuntak, Arya Marganda
Jurnal Respirologi Indonesia Vol 45 No 1 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i1.678

Asbestosis is characterized by diffuse interstitial fibrosis in the lungs, which is caused by breathing asbestos fibers from the crystalline or amphibole groups. The diagnosis of asbestosis, a form of pneumoconiosis, is one of the seven steps in identifying an occupational lung disease. Because there is no known cure for this condition, early detection, prevention, and education of workers and anybody in their proximity who has a risk of asbestos fiber exposure is critical. Clinical symptoms of asbestosis include weight loss, decreased appetite, and dyspnea during exertion. Clubbing fingers, cyanosis, and tachypnea are all symptoms of severe asbestosis. Bronchoalveolar lavage (BAL), histology, CT scans, HRCT, and respirometry can all help with the diagnosis. The "shaggy heart border sign" on a chest X-ray, along with the asbestos body observed in the BAL, is a reliable indicator of asbestosis. Because of the dismal prognosis and lifelong consequences, prevention is essential.

Title

Found 9 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 9 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 9 Documents
Search