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Current Evidence of Platelet-Rich Blood Plasma for Pelvic Organ Prolapse: A Review Fakhrizal, Edy; Simanjuntak, Arya Marganda; Hutapea, Anastasya
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.530

Abstract

Objective: To review the current evidence of the potential use of Platelet-Rich Plasma (PRP) in the field of urogynecology, especially in POP cases.Method: This review used several databases (Google Scholar, Pubmed, and Science Direct) and searched for English and Indonesian articles in the last ten years. Articles were received in the form of case reports, observational studies and clinical trials that discussed the use of Platelet-Rich Plasma in cases of Pelvic Organ Prolapse (POP).Results: A total of three articles were included in this review.Discussion: There were two patient studies and one in vitro study. The POP patient study showed favorable results with low recurrence rates in patients who received Platelet Rich-Plasma compared to those who did not and another study that conducted a one-year evaluation found no recurrences after the patients received Platelet Rich Plasma at the surgical site. The in vitro study showed good cell attachment and proliferation in vaginal tissue biopsies with Platelet-Rich Plasma applied to the tissue.Conclusion: Platelet-Rich Plasma may promote tissue regeneration, hence potentially reduce recurrency after reconstruction.Bukti Terkini Plasma Darah Kaya Trombosit untuk Prolaps Organ Panggul: Sebuah KajianTujuan: Untuk meninjau bukti terkini mengenai potensi penggunaan Platelet-Rich    Plasma di bidang uroginekologi, khususnya pada kasus POP.Metode:Tinjauan ini menggunakan beberapa database Google Scholar, Pubmed, dan Science Direct) dan mencari artikel berbahasa Inggris dan Indonesia dalam sepuluh tahun terakhir. Artikel yang diterima berupa laporan kasus, studi observasional, dan uji klinis yang membahas penggunaan Platelet-Rich Plasma pada kasus Prolaps Organ Panggul (POP).Hasil: Sebanyak tiga artikel termasuk dalam tinjauan ini.Diskusi: Terdapat dua studi pasien dan satu studi in vitro. Studi pasien POP menunjukkan hasil yang baik dengan tingkat kekambuhan yang rendah pada pasien yang menerima PRP dibandingkan dengan mereka yang tidak menerima Platelet-Rich Plasma dan studi lain yang melakukan evaluasi satu tahun tidak menemukan adanya kekambuhan setelah pasien menerima Platelet-Rich Plasma di tempat pembedahan. Studi in vitro menunjukkan perlekatan dan proliferasi sel yang baik pada biopsi jaringan vagina dengan Platelet-Rich Plasma yang diaplikasikan pada jaringan tersebut.Kesimpulan: Platelet-Rich Plasma dapat meningkatkan regenerasi jaringan, sehingga berpotensi mengurangi kekambuhan setelah rekonstruksi.Kata kunci: Platelet-Rich Blood Plasma, Prolaps Organ Panggul, Uroginekologi
Mepolizumab’s (Anti-Interleukin-5) Role in Severe Asthma: A Literature Review Atikanur, Atikanur; Wijaya, Dewi; Esha, Indi; Simanjuntak, Arya Marganda
Jurnal Respirologi Indonesia Vol 44, No 2 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i2.494

Abstract

One type of asthma that is difficult to treat is severe asthma, which is asthma that is uncontrolled even when the patient is taking medication or trigger factors. It can be treated with the finest therapy but will worsen if high-dose treatment is discontinued. Age, gender, obesity, hypersensitivity, and immunological factors are all directly related to the onset of asthma. A complicated illness, severe asthma has many clinical symptoms and treatment choices. Chronic airway inflammation and lung tissue remodeling are its defining features. This literature review aims to describe how mepolizumab works in patients with severe asthma. Mepolizumab mainly inhibits the IL-5 cytokine from binding to IL-5 receptor subunits through the nanomolar potential, which inhibits IL-5 from binding to receptors on the surface of eosinophils. In contrast to the placebo group, patients on mepolizumab had an average 50% decrease from the baseline Prednisone dosage. With Mepolizumab, the yearly exacerbation rate was 1.44 RR, while it was 2.12 RR with placebo. The injection of monoclonal antibodies, such as mepolizumab, as a form of therapy in addition to treating severe eosinophilic asthma is advised by the GINA guideline for 2022. Mepolizumab's mode of action blocks IL-5 from binding to receptors on eosinophil surfaces, which lowers eosinophil recruitment, activation, production, growth, and survival, as well as eosinophil-mediated inflammation.
Profile of Pulmonary Tuberculosis After COVID-19 at Toba District, North Sumatra Province Simatupang, Elvando Tunggul Mauliate; Simanjuntak, Arya Marganda; Yovi, Indra; Simbolon, Rohani Lasmaria; Fauzi, Zarfiardy Aksa
Jurnal Respirologi Indonesia Vol 44, No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.716

Abstract

Background: Worldwide cases of pulmonary tuberculosis (PTB) have significantly increased since the COVID-19 pandemic. Indonesia accounted for 6,811,818 of the 767,518,723 cases reported by the World Health Organization. While the Indonesian Ministry of Health reported 824,000 cases, the Global Tuberculosis Report in 2022 reported 10.6 million cases. The pandemic has hampered the goal of eliminating PTB globally, with cases diagnosed after COVID-19 having a 7.15-fold increased risk of contracting the illness.Methods: This cross-sectional study was conducted using total sampling to identify the profile of patients with PTB after having COVID-19 based on age, gender, classification, and type of PTB, as well as the duration of occurrence of PTB after COVID-19. The data collected were from COVID-19 patients from 2020 to 2022, then compared with PTB data. All data were compared to ensure that COVID-19 and PTB patient data were the same.Results: Of the 2544 patients recorded, 29 (1.1%) were infected with PTB after COVID-19 infection. The mean age of patients was 34±18.9 and was dominated by men (68.9%). Most of the cases were drug-sensitive TB (96.6%) and clinically diagnosed TB (55.2%). Age had a statistically significant association with the occurrence of TB cases after COVID-19 infection (P<0.0001). The mean time from the initial diagnosis of COVID-19 to the diagnosis of confirmed TB was approximately 203±34.3 days (6.7 months).Conclusion: After COVID-19, patients have the potential to be infected with TB. Screening former COVID-19 patients can be one solution to finding early cases of PTB.
Tuberkulosis Paru Asimtomatik dengan Asites yang Disebabkan oleh Tuberkulosis Usus: Laporan Kasus Ginting, Heri Krisnata; Simanjuntak, Arya Marganda; Humairoh, Latifah
Majalah Kedokteran Indonesia Vol 75 No 2 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.2-2025-1161

Abstract

Introduction: Tuberculosis (TB) is usually suspected when the patient has symptoms. Ascites is generally suspected if the patient has liver disease, organ failure or malignancy. In this case, we found something that is not usually found and is an important lesson. Case Report: Mrs. RS, a 58-year-old woman, presented with abdominal swelling worsening 5 days before admission with red bloody stools. Previous USG in another hospital showed no abnormalities were found. On physical examination, a right upper lung with ronchi and weak percussion was discovered. The abdomen was distended, and there was a throbbing pain and dull ache that moved about. The bilirubin, stool analysis, and liver function values were all normal. While GeneXpert sputum was negative, abdominal ultrasound revealed ascites, stool samples were positive for TB bacteria, and chest X-ray revealed cavities in the right upper lung. Following treatment with isoniazid (R), rifampicin (R), pyrazinamide (Z), and ethambutol (E), the patient was released and instructed to await examination by the physician. Case Discussion: Although clinical signs like coughing and shortness of breath are frequently used to diagnose tuberculosis, this case was discovered to be silent pulmonary TB, which Kendall et al characterized as subclinical TB infection. Conclusion: Ascites as a result of intestinal TB is rare but possible. Increased TB suspicion testing is necessary, particularly in locations where the disease is prevalent. Instances of intestinal tuberculosis and pulmonary TB without respiratory symptoms make treating tuberculosis cases more difficult.
Accuracy of Platelet Parameters (PC, MPV, and PDW) as A Predictor of The Severity of Preeclampsia Nababan, Heru Maranatha; S, Donel; Arfianti, Arfianti; Simanjuntak, Arya Marganda
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.858

Abstract

Objective: To evaluate the accuracy of platelet parameters—platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW)—as predictors of preeclampsia severity. Methods:A case-control study was conducted on 153 pregnant women with preeclampsia at Arifin Achmad Hospital from January 2019 to December 2020. Platelet indices (PC, MPV, PDW) were compared between 61 patients with severe preeclampsia and 92 with non-severe preeclampsia. ROC analysis determined predictive accuracy, with sensitivity and specificity calculated for selected cut-off values. Results:Significant differences were found in PC (p=0.000), PDW (p=0.049), and MPV (p=0.012) between groups. ROC analysis showed PDW >12.3% had a sensitivity of 60.7% and specificity of 59.8%, while MPV >10.65 fL had a sensitivity of 62.3% and specificity of 64.1%. AUC values for PDW and MPV were 0.62 and 0.66, respectively, indicating weak predictive accuracy. Conclusion:Although platelet parameters differ significantly between preeclampsia severity groups, their predictive value is limited. They should not be solely relied upon for assessing preeclampsia severity. Akurasi Parameter Trombosit (PC, MPV, dan PDW) sebagai Prediktor Tingkat Keparahan PreeklampsiaAbstrak Tujuan: Penelitian ini dilaksanakan pada pasien preeklampsia untuk mengevaluasi akurasi parameter trombosit—jumlah trombosit (PC), volume trombosit rata-rata (MPV), dan lebar distribusi trombosit (PDW)—sebagai prediktor tingkat keparahan.Metode: Studi kasus-kontrol dilakukan pada 153 ibu hamil dengan preeklamsia di Rumah Sakit Arifin Achmad dari Januari 2019 hingga Desember 2020. Indeks trombosit (PC, MPV, PDW) dibandingkan antara 61 pasien dengan preeklamsia berat dan 92 pasien dengan preeklamsia tanpa gejala berat. Analisis ROC digunakan untuk menentukan akurasi prediktif, dengan perhitungan sensitivitas dan spesifisitas berdasarkan nilai cut-off tertentu. Hasil: Terdapat perbedaan signifikan pada PC (p=0.000), PDW (p=0,049), dan MPV (p=0.012) antara kedua kelompok. Analisis ROC menunjukkan bahwa PDW >12.3% memiliki sensitivitas 60.7% dan spesifisitas 59.8%, sedangkan MPV >10.65 fL memiliki sensitivitas 62.3% dan spesifisitas 64.1%. Nilai AUC untuk PDW dan MPV adalah 0.62 dan 0.66, menunjukkan akurasi prediktif yang lemah. Kesimpulan: Meskipun parameter trombosit menunjukkan perbedaan signifikan antara kelompok preeklamsia berat dan tidak berat, nilai prediktifnya terbatas. Parameter ini tidak dapat digunakan secara mandiri untuk menilai tingkat keparahan preeklamsia. Kata kunci: Preeklamsia, Jumlah Trombosit, Lebar Distribusi Trombosit, Volume Trombosit Rata-rata, Biomarker Prediktif
Quantifying Zoonotic Risk from Cats (Felis catus, Felidae: Carnivora): A Systematic Meta-Analysis of Pathogen Prevalence Handoko, Jully; Simanjuntak, Arya Marganda; Suyanto, Suyanto; Pengsakul, Theerakamol; Susana, Yuli; Maulana, Rian; Asni, Enikarmila; Indarjulianto, Soedarmanto
Jurnal Medik Veteriner Vol. 8 No. 2 (2025): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol8.iss2.2025.489-503

Abstract

Cats are known to be potential reservoirs for a variety of zoonotic pathogens. However, the overall prevalence of zoonotic pathogens in the cat population remains unclear amid growing concerns. This study aimed to measure the combined prevalence of zoonotic pathogens in cats through a systematic review and meta-analysis. Relevant literature reporting the prevalence of zoonotic pathogens in cats, published from 2015 to 2025, was collected from databases. A total of 49 studies met the inclusion criteria, encompassing a total sample size of 18,206 cats. A meta-analysis was performed using a random-effects model. Toxoplasma gondii, Bartonella henselae, and Campylobacter spp. were the most frequently reported pathogens, with pooled prevalence estimates presented with 95% confidence intervals (CIs). The I² statistic was used to assess heterogeneity. The combined prevalence of zoonotic pathogens in cats was estimated at 24% (95% CI: 17–32%). Considerable heterogeneity was observed among the studies (I² = 98.4%, p < 0.001), and this likely reflects differences in geographic region, diagnostic methods, and pathogen type. Individual study prevalences ranged from 0.02 to 0.97, with varying weights according to sample size and variance. This meta-analysis highlights the relatively high prevalence of zoonotic pathogens among cats. The relevance of applying a One Health perspective is emphasized by these findings for the development of evidence-based public health policies to reduce zoonotic risks at the community and global levels.
INFEKSI KUSTA PASCA INFEKSI COVID-19 : ANCAMAN PENYAKIT TROPIS TERABAIKAN PASCA PANDEMI BAGI INDONESIA Simanjuntak, Arya Marganda; Marbun, Patricia Dean Ully; Anggraini, Yuni Eka
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 1 (2023): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 1 Periode M
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i1.513

Abstract

Background: Leprosy is still a health problem in Indonesia and as the third world largest contributor the number of cases ranging from 8% world’s cases. Leprosy has various challenges in Indonesia, such as negative stigma, public reluctance to seek medical treatment and comply with medication and the pandemic. Pandemic COVID-19 seems to cover up leprosy cases in Indonesia. A Population-based study in Brazil showed that the impact of pandemic as increasing the diagnosis of multibacillary leprosy. Correlation studies COVID-19 and Leprosy is still unknown. No article identified about leprosy and COVID-19 related in Indonesia. Researchers are trying to explore more about leprosy infection and COVID-19 mechanisms that may occur and also probable condition that would happen in Indonesia. Methods: This literature review sourced from Pubmed, Science Direct and Google Scholar according to the inclusion criteria and evaluated and studied. Discussion: Patient would had Lymphopenia after COVID-19. This supports growth of leprosy in the patient’s body as the patient contact with other leprosy patient. The growth will be progressive due to decreased immunity in COVID-19 patients that would persist for a certain period of time. Increasing severity of COVID-19, the greater the susceptibility of the patient to be infected with leprosy. This allows for a sudden spike in leprosy cases after the pandemic. Solution that can be carried out by the government, such as education to eradicate stigma, to serological examination of IgM PGL-1 are needed to find leprosy case as early as possible, especially in patients with sublclinical phase. Finding cases of leprosy as early as possible is needed so that it can be treated before the occurrence of disability in the patient. Conclusion: Infection of COVID-19 would make patient more susceptible for leprosy infection to growth progressively hence increasing case of leprosy after the pandemic if the case is not found as early as possible especially in subclinical phase of Leprosy infection.
MILIARY TUBERCULOSIS AND ELEVATED TRANSAMINASE ENZYMES IN AN UNTREATED HUMAN IMMUNIDEFICIENCY VIRUS (HIV) PATIENT: A CASE REPORT: To Identify and Treat It Comprehensively Veronica, R.Merlinda; Azis, Abdurrahman; Indri, R.Melda; Simanjuntak, Arya Marganda
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 2 (2024): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 2 Periode O
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i2.731

Abstract

Introduction Tuberculosis (TB) is closely related to Human Immunodeficiency Virus (HIV) and causes 25% death in HIV patients. Miliary TB is a complication of a focus of tuberculosis infection that is spread hematogenously, in the form of fine spots that are generally evenly distributed throughout the lung fields. Giving Anti Tuberculosis Drugs can have side effects in some TB patients including drug-induced hepatitis, therefore it is necessary to check liver function. Liver function tests that are commonly used are transaminase enzymes, namely SGOT and SGPT levels which will show an increase if there is damage or inflammation in liver tissue. In HIV positive patients, it is recommended to have liver function tests every month. Case illustration Here we report a case of a male patient diagnosed with miliary TB and HIV who had an increase in the transaminases enzyme at the beginning of the diagnosis with chief complainnts of cough with phlegm, fluctuating fever, night sweats, weakness, nausea, vomiting, and weight loss 0f 14 kg since three months before being admitted to the hospital. The patient appeared moderately ill with composmentis consciousness, temperature 38,8C, saturation 98% with oxygen, BMI underweight (13,4kg.m2), anemic conjunctiva and sclera are not icteric. The laboratory finding anemia left shift hypochromic microytic with thrombocytopenia (Hb 9,8g/dl, Hematocrit 28,3%, leukocytes 2470/Ul, platelets 157000/uL MCV 87fl, MCH 28,7pg, MCHC 33,0g/dl), increase transaminase enzymes (SGOT:398U/L SGPT:90U/L), hypoalbuminemia (2,17g/dL), normal kidney function, hiponatremia (124), HbsAg and Anti HCV: non Sputum BTA I/II/II: +1/+2/+2, Gene Xpert: MTB detected, Rifampicin resistance was not detected. Reactive HIV test, CD4: 26 sel/UL. Ro Thorax examination: Inhomogeneous nodular opacity in both lung fields, suspected pneumonia, USG: Chronic liver disease. The patient received Co-trimoxazole therapy, modified Anti Tuberculosis Drugs and Antiretrovirals. After being given modified anti-tuberculosis and antiretroviral therapy, clinical and laboratory improvement occurred. Conclusion The need for monitoring of liver function in patients who show symptoms of hepatitis and examination of liver function.
Penggunaan SGLT2-i Sebagai Inovasi Terapi Preventif Stroke Pada Pasien Diabetes Mellitus Tipe 2 Simanjuntak, Arya Marganda; Marbun, Patricia Dean Ully; Patresia, Putri Leony
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 1 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i1.8347

Abstract

Diabetes merupakan faktor resiko stroke iskemik sebesar 2,5 kali dan 1,5 kali lipat menderita stroke hemoragik. Hal ini memicu meningkatnya angka mortalitas baik yang disebabkan oleh diabetes, stroke maupun diabetes yang berkomplikasi pada stroke. Sodium Glucose cotransporter 2 inhibitor (SGLT2-i) diketahui dapat mengurangi permasalahan kardiovaskular pada diabetes sehingga penulis akan menelaah lebih lanjut mengenai mekanisme SGLT2-i terhadap vaskular yang dihubungkan terhadap stroke. Literature Review ini dilakukan dengan menelusuri artikel penelitian yang terdapat pada mesin pencarian. Mesin pencarian jurnal yang digunakan berupa PubMed dan Science Direct. Dari 551 artikel diidentifikasi berdasarkan judul, duplikasi, abstrak dan kesesuaian dengan kriteria inklusi dan dilaksanakan review untuk artikel terpilih. SGLT2-i memiliki mekanisme untuk menghambat progresivitas atheroma. Mekanisme yang terjadi berupa penurunan reaksi inflamasi sistemik, penurunan stress oksidatif, pengurangan ukuran ateroma hingga menjaga kestabilan plak ateroma. Oleh karena itu SGLT2-i merupakan kandidat terapi yang potensial dalam mengurangi risiko stroke pada pasien DMT2. SGLT2-i dapat digunakan sebagai inovasi terapi preventif untuk stroke pada pasien DMT2.
Lung Cancer In Former Tuberculosis Patients at Arifin Achmad General Hospital, Riau Province Martarita, Evitrie; Erdayani, Rita; Munir, Sri Melati; Fauzi, Zarfiardy Aksa; Simanjuntak, Arya Marganda
Respiratory Science Vol. 4 No. 2 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i2.97

Abstract

Background: There is ongoing discussion over the connection between lung cancer and pulmonary tuberculosis (TB). Future lung cancer cases in Indonesia, which has the second-highest TB case burden, are a cause for concern. The purpose of this study is to ascertain the connection between TB and LC at Arifin Achmad General Hospital in the province of Riau. Method: From 2015 to 2018, we looked back on lung cancer patients at Arifin Achmad General Hospital in Riau Province who had received pulmonary tuberculosis and anti-tuberculosis treatment (ATT). Results: From 203 patients, 24 patients (11.8%) had histories of TB. The patients' ages were from 41 years to 60 years. The most prevalent pathological findings were adenocarcinoma in 13 patients (54.0%). The most common cancer stage was advanced stage IIIB in 7 patients (29.2%) Conclusion: The cases of TB infections were apparent in lung cancer patients, approximately around 11% of lung cancer cases. Therefore, it is necessary to assess the history of TB in lung cancer patients.