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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Majalah Kedokteran Bandung Indonesian Journal of Urology Jurnal Kesehatan Andalas Jurnal Kesehatan Komunitas B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Acta Biochimica Indonesiana Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Narra J Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) Jurnal Sains, Teknologi dan Kesehatan
Cimi Ilmiawati, Cimi
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Langkah - Langkah Progresif dalam Intervensi Reduksi Stigma HIV di Komunitas Tenaga Kesehatan: Scoping Review Triana, Vivi; Effendi, Nursyirwan; Prahastuti, Brian Sri; Ilmiawati, Cimi
Jurnal Kesehatan Komunitas Vol 10 No 1 (2024): Jurnal Kesehatan Komunitas
Publisher : LPPM Hang Tuah Pekanbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25311/keskom.Vol10.Iss1.1785

Abstract

Stigma plays a significant role in creating disparities in health services experienced by PLWHA, thus becoming a barrier for them to access prevention, care, and treatment services. Therefore, the role of health workers is crucial. This study aims to review and critically evaluate the type and scope of interventions that have been conducted to reduce HIV/AIDS-related stigma among health workers. This study is a scoping review using PRISMA guidelines. Journal and article searches were conducted through electronic databases, including ScienceDirect, Cochrane Library, Embase, Garuda Portal, PubMed, Scopus, and Sage Journals. Fourteen articles were discussed in this review. Interventions that successfully reduced stigma were those provided with individual emphasis by disseminating information, interacting, and training. In addition, structural approaches such as developing and disseminating policies in hospitals, providing material to facilitate the practice of universal precautions, and adding curriculum in health schools). The results obtained from the intervention significantly reduced stigma among health workers with a combined approach, which showed higher effectiveness than the single approach. Interventions to reduce stigma need to be sufficiently carried out with an individual-based approach, but interventions with a structural approach must also be considered. Suggest further research by analyzing or exploring potential synergies between these two approaches.
Otoacoustic emission examination results on down syndrome students Fasya, Haidar Haikal; Lestari, Rahmi; Hafiz, Al; Asyari, Ade; Masnadi, Nice Rachmawati; Ilmiawati, Cimi
Oto Rhino Laryngologica Indonesiana Vol. 53 No. 1 (2023): VOLUME 53, NO. 1 JANUARY - JUNE 2023
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v53i1.592

Abstract

Background: Down syndrome (DS) is a genetic disorder that occurs due to an excess of genetic material on chromosome 21. Down syndrome was associated with various congenital abnormalities and dysfunction of several organs, one of which was hearing. DS patients often experience sensorineural hearing loss. Evaluation of sensorineural hearing loss in DS patients could be done in several ways, one of which is the Otoacoustic Emission (OAE) examination. Purpose: This study aimed to describe the results of the OAE examination in elementary school children at special need schools in Padang City in 2022. Methods: This research was a descriptive study, using a cross sectional study design. Data were collected and processed using consecutive sampling technique. The research subjects who met the criteria were 31 samples. Results: The results showed that the majority of DS subjects received “refer” results 25/31 on OAE examination, OAE “refer” results occurred both in one ear or both ears. The “refer” results of the OAE were greater in male DS patients 20/24 than female 5/7 and more common in the 18-21 year old age group. Conclusion: Conclusions based on this study, people with DS are more at risk of having sensorineural hearing loss.
Frekuensi Karier Streptococcus pneumoniae pada Populasi Dewasa Suku Akit Provinsi Riau Rosdiana, Dani; Veronica, R. Merlinda; Harahap, Sari; Esha, Indi; Mardhatilah, Ashifa; Putri, Nabila; Safitri, Nuridha Audinia; Safari, Dodi; Sarassari, Rosantia; Ilmiawati, Cimi; Elliyanti, Aisyah
Jurnal Ilmu Kedokteran Vol 18, No 2 (2024): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v18i2.2024.137-143

Abstract

Stretococcus pneumoniae (S.pneumoniae) is a commonly colonized in healthy people that potentially to be transmitted directly to other individuals through droplets and as an invasive pathogen. The prevalence/ frequency of S. pneumoniae carriage in children is around 20-60%, while data of carriage’s frequency in adult population is still limited. Akit tribe is a tribe who lives in a group in the coastal rural area of Rupat Island. The high incidence of upper respiratory tract infection among Akit tribe and the location can be risk for S. pneumoniae carriage. Study aimed is to identify the frequency of carriage in the adult population of the Akit tribe. Nasopharyngeal swab was collected from healthy adults, then cultivated on agar media. Colonies suspected as S. pneumoniae then selected, then subjected to optochin test. S. pneumoniae confirmation were using automatic machine VITEK. We reported S. pneumoniae carriage rate was 7.8% (12 of 153 participants) among Akit tribe.
PENGARUH PERMEN KARET XYLITOL SETELAH TERAPI SCALING DAN ROOT PLANING TERHADAP SPESIES MIKROBIOTA ORAL DALAM SALIVA ANAK STUNTING Ernesto, Gian; Ilmiawati, Cimi; Desmawati, Desmawati; Juwita, Dinda Ratna; Effendi, Muhammad Dzaky Sayyid; Wirza, Thifla Rafifa; Bobby, Bobby; Abdani, Fathan Alif
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Vol 11, No 2 (2024): Vol. 11,No 2 (Desember 2024)
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v11i2.1711

Abstract

Introduction: Stunting is a condition caused by chronic malnutrition, which affects physical, cognitive, and oral health in children, including gingivitis. Reduced salivary flow in stunted children disrupts oral hygiene and increases the risk of oral infections due to oral microbiota dysbiosis. Aim: This study aimed to evaluate the effect of xylitol chewing gum as an adjunct to Scaling and Root Planing (SRP) therapy in improving oral health and microbiota in stunted children. Methods: Eighteen stunted children aged 6-12 years with gingivitis were randomly assigned to two groups: the SRP group (n=9) and the SRP + xylitol chewing gum group (n=9). SRP was performed to reduce gingival inflammation, and xylitol chewing gum was administered for 14 days following SRP. Clinical parameters were assessed using the Gingival Index (GI) and the Oral Hygiene Index-Simplified (OHI-S). Saliva samples were collected before and after treatment for microbiota profiling using 16S rRNA metagenomic sequencing. Results: In the control group (SRP), the average GI score significantly decreased (p=0.00), but the reduction in OHI-S scores did not show a statistically significant difference (p=0.06). In the SRP + xylitol group, there was a significant reduction in both GI (p=0.00) and OHI-S scores (p=0.00). Microbiota analysis showed an increase in beneficial bacteria and a reduction in pathogenic species, particularly in the SRP + xylitol group. Conclusion: SRP is effective in reducing gingival inflammation in stunted children, and the addition of xylitol chewing gum further improves oral health by enhancing salivary flow and modulating the oral microbiota. This combined therapy may offer a promising strategy for improving oral health in children with stunting
Non-Metallic and Metallic Toxicant Exposures from Personal Care Products in Indonesian Male and Female Medical Students Putra, Alby Dwinanda; Syamsir, Elmatris; Yulistini, Yulistini; Khaira, Fathiyyatul; Asri, Ennesta; Ilmiawati, Cimi
Majalah Kedokteran Bandung Vol 55, No 4 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n4.3254

Abstract

Students can gain various benefits from their daily personal care products. However, the chemicals contained in these products may have adverse health effects. Regardless the inspection performed by regulatory agencies on these products, the products circulating in the market may still contain toxicants thus may jeopardize their safety for use. This study evaluated toxicant ingredients contained in personal care products used by male and female college students. This study was conducted from September to December 2022 on 23 male and 46 female college students of the Faculty of Medicine, Universitas Andalas, Indonesia. Data were collected using a 69-items validated questionnaire. Results were then presented as a distribution of products used categorized by body areas and potentially toxic metallic and non-metallic ingredients identified from their labels. Female college students used at least 10 personal care products, with a median of 19 products. Male students used at least four products and a median of eight products. Investigation on the label of skin, hair, eye, dental and oral, lips, and nail personal care products demonstrated the presence of metallic and non-metallic toxicants. Five metallic toxicants (aluminum, titanium, zinc, copper, and chromium) and 15 non-metallic toxicants (triclosan, talc, fragrance, parabens, butylated hydroxyanisole, butylated hydroxytoluene, diethanolamine, triethanolamine, butylene glycol, propylene glycol, polyethylene glycol, phthalates, benzophenone-3, acetone, and fluoride) were identified. Thus, numerous toxicants are present in marketed personal care products, and females are exposed more than males to these toxicants. Consumers need to be more critical in their choice of personal care products.
Effect of probiotic-fermented milk containing Lactiplantibacillus pentoses strain HBUAS 53657 on serum glutathione peroxidase activity and pancreatic histopathology in hyperglycemic rats Yaswir, Rita; Yerizel, Eti; Suharti, Netti; Ilmiawati, Cimi
Acta Biochimica Indonesiana Vol. 7 No. 2 (2024): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.174

Abstract

Background: Hyperglycemia is characterized by elevated blood glucose levels caused by impaired insulin production or function, leading to oxidative stress. Probiotic-fermented milk containing Lactiplantibacillus pentosus strain HBUAS 53657 (PFM) has antioxidant and antimicrobial properties that may reduce oxidative stress. Objective: This study aimed to investigate the effects of PFM L. pentosus strain HBUAS 53657 on serum glutathione peroxidase (GPx) activity and pancreatic histopathology in hyperglycemic rats. Method: A post-test-only experimental design was conducted using 25 adult male Wistar rats divided into five groups (n = 5 per group): normal control, hyperglycemic control group, and hyperglycemic rats treated with PFM at doses of 1 × 10⁸ CFU/day (P1), 1 × 10⁹ CFU/day (P2), and 1 × 10¹⁰ CFU/day (P3) for 28 days. Serum GPx activity was assessed via spectrophotometry, Langerhans islet area was measured using ImageJ, and islet damage was evaluated using the Ningrum Score. Statistical analysis was performed using One-Way ANOVA and Kruskal-Wallis tests. Results: PFM administration at all doses significantly increased serum GPx activity (p = 0.002), with an optimal dose of 1 × 10⁹ CFU/day (P2). PFM also increased the Langerhans islet area (p = 0.001) and reduced islet damage scores (p < 0.001) in a dose-dependent manner. Conclusion: Probiotic-fermented milk containing Lactiplantibacillus pentosus strain HBUAS 53657 increases serum GPx activity, expands Langerhans islet area, and reduces islet damage in hyperglycemic rats.
Hubungan Kadar 25-Hidroksivitamin D (25(OH)D) Serum pada Ibu Hamil Trimester III dengan Fetal Outcome Delfina, Delfina; Amir, Arni; Ilmiawati, Cimi
Majalah Kedokteran Andalas Vol 46, No 9 (2024): Supplementary Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i9.p1444-1451.2024

Abstract

Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan kadar 25(OH)D serum pada ibu hamil trimester III dengan fetal outcome. Metode: Penelitian ini merupakan penelitian observasional analitik dengan rancangan cohort terhadap 77 ibu hamil trimester III dan bayi baru lahir, penelitian dilakukan di wilayah kerja Puskesmas Andalas. Pengambilan sampel secara purposive sampling. Pengukuran kadar 25(OH)D serum dilakukan dengan metode ELISA secara dupleks. Data fetal outcome (berat badan, panjang badan, lingkar kepala) didapatkan dari buku Kesehatan Ibu dan Anak. Korelasi antar variabel diuji dengan uji korelasi Pearson atau Spearman. Hasil: Kadar 25(OH)D serum ibu hamil trimester III didapatkan nilai median yaitu 21,10 ng/ml dan 32 ibu hamil yang mengalami defisiensi. Kadar 25(OH)D) serum ibu berkorelasi negatif dengan berat badan bayi lahir (uji Pearson; r=-0,239; p=0,036), namun tidak memiliki korelasi yang bermakna secara statistik dengan panjang badan (uji Spearman; r=-0,106; p=0,360) dan lingkar kepala bayi  (uji Spearman; r=-0,031; p=0,788). Kesimpulan: Disimpulkan bahwa sebagian besar ibu hamil mengalami defisiensi 25(OH)D dan hal ini dapat mempengaruhi fetal outcome.
Pengaruh Pemberian Mesenchymal Stem Cells Wharton's Jelly terhadap Ekspresi Gen Sirtuin 1 pada Tikus Model Alzheimer Aizah, Havina Nurul; Yanis, Amel; Ali, Hirowati; Tofrizal, Tofrizal; Ilmiawati, Cimi; Arisanty, Dessy
Jurnal Kesehatan Andalas Vol. 12 No. 1 (2023): Online March 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i1.2140

Abstract

Mesenchymal Stem Cells Wharton's Jelly (MSC-WJ) has become a new hope for Alzheimer's disease due to its capability to suppress Amyloid-beta (Aβ) plaques formation. It is found that people with Alzheimer's disease have a lower expression of Sirtuin-1 because of the oxidative stress that was produced by Aβ plaques. Objective: To observe the Sirtuin-1 gene in Alzheimer's disease rat models that AlCl3 was inducing after being given MSC-WJ. Methods: This was an experimental study with a post-test-only control group design, including three groups with a total sample of 18 samples of Alzheimer RNA rat models. Group-1without AlCl3 and MSC-WJ; Group-2 with AlCl3; Group-3 AlCl3 and MSC-WJ. Mean value of the Sirtuin-1 gene was obtained by the Image-J application using a semiquantitative method which was then tested using the One Way ANOVA test. The study was significant if the p-value < 0,05. Results: This study found that the mean ± standard error value of the Sirtuin-1 gene in three groups were 0.18±0.04; 0.16±0.03; and 0.36±0.06 respectively. The statistical test showed a significant difference between the three groups (p = 0.014). Conclusion: There was an increased Sirtuin 1 gene expression in Alzheimer’s rat Model after being given Mesenchymal Stem Cells Wharton’s Jelly.Keywords:  Alzheimer, MSC-WJ, Sirtuin-1
Korelasi Lama Menjalani Hemodialisis dengan Kualitas Hidup Pasien Penyakit Ginjal Kronik di RSUP Dr. M. Djamil Padang Rashieka, Shaydi Amala; Rasyid, Rosfita; Miro, Saptino; Yulia, Dwi; Ilmiawati, Cimi
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 4 (2024): Desember 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i4.1081

Abstract

Latar Belakang: Penyakit ginjal kronik (PGK) adalah suatu kondisi adanya gangguan struktur dan gangguan fungsi ginjal yang dapat dilihat melalui pemeriksaan laboratorium ataupun pencitraan dan terjadi lebih dari tiga bulan. Pada pasien PGK yang sudah mencapai tahap akhir akan memerlukan terapi pengganti ginjal. Terapi pengganti ginjal yang sering diberikan pada pasien PGK di Indonesia adalah hemodialisis. Akan tetapi pada hemodialisis terdapat beberapa komplikasi yang dapat menurunkan kualitas hidup pasien. Penurunan kualitas hidup pada pasien PGK juga dapat sebagai prediktor dari angka kesakitan dan kematian pada pasien PGK. Objektif: Penelitian ini bertujuan untuk mengetahui korelasi lama menjalani hemodialisis dengan kualitas hidup pasien PGK di RSUP Dr. M. Djamil Padang Metode: Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross sectional dengan jumlah sampel yaitu 93 pasien PGK yang menjalani hemodialisis. Instrumen penelitian yang digunakan yaitu kuesioner KDQOL SFTM 1.3. Uji Statistik yang digunakan yaitu korelasi Spearman. Hasil: Jumlah pasien yang menjalani hemodialisis yang kecil atau sama 60 bulan sebanyak (84,9%) dan setengah dari pasien tersebut (50,5%) mempunyai kualitas hidup yang baik. Pada penelitian ini didapatkan hubungan yang bermakna antara kualitas hidup dan lama hemodialisis dan korelasi yang bernilai positif (r=0,263; p=0,017). Kesimpulan: Semakin lama pasien menjalani hemodialisis maka kualitas hidup pasien akan semakin baik.
Uji Daya Hambat Filtrat Lactobacillus gasseri Terhadap Pertumbuhan Staphylococcus aureus yang Diisolasi dari Genitalia Wanita Husna, Annisa Tamara; Suharti, Netti; Akhyar, Gardenia; Putra, Andani Eka; Muhammad, Syamel; Ilmiawati, Cimi
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 4 (2024): Desember 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i4.1329

Abstract

Latar Belakang: Lactobacillus gasseri merupakan salah satu jenis bakteri terbanyak ditemukan pada vagina wanita yang dapat menghasilkan bakteriosin sebagai senyawa antibakteri. Bakteriosin dijadikan alternatif melawan bakteri yang resisten terhadap antibiotik, salah satunya Staphylococcus aureus. Selain itu, Staphylococcus aureus merupakan salah satu penyebab vaginitis aerobik yang diteliti dapat membahayakan kehamilan hingga persalinan. Objektif: Tujuan penelitian ini adalah mengetahui kadar hambat minimal (KHM) dan kadar bunuh minimal (KBM) sebagai indikator untuk melihat kemampuan filtrat bakteriosin Lactobacillus gasseri dalam menghambat pertumbuhan Staphylococcus aureus. Metode: Penelitian ini dilakukan pada bulan Mei-November 2023 di Laboratorium Mikrobiologi Fakultas Kedokteran Universitas Andalas dan Laboratorium Pusat Diagnostik dan Riset Penyakit Infeksi Fakultas Kedokteran Unand. Sampel penelitian ini adalah Staphylococcus aureus yang diperoleh dari swab vagina yang dikultur di Laboratorium Mikrobiologi Fakultas Kedokteran Universitas Andalas. Penelitian dilakukan dengan teknik dilusi dan Real Time PCR dengan desain penelitian rancangan acak lengkap. Hasil: Nilai KHM dari filtrat bakteriosin Lactobacillus gasseri terhadap Staphylococcus aureus diperoleh pada konsentrasi >20% dan <40%, sedangkan nilai kadar bunuh minimal (KBM) diperoleh pada konsentrasi 40%. Kesimpulan: Filtrat bakteriosin Lactobacillus gasseri memiliki efek bakteriostatik dan bakterisidal terhadap pertumbuhan Staphylococcus aureus yang dipengaruhi oleh konsentrasi dari filtrat bakteriosin Lactobacillus gasseri.
Co-Authors Abdani, Fathan Alif Ade Asyari Aisyah Elliyanti Aizah, Havina Nurul Al Hafiz Alvarino Amel Yanis Andani Eka Putra Arni Amir Asri, Ennesta Bobby, Bobby Brian Sri Prahastuti Dani Rosdiana Delfina, Delfina Desmawati Desmawati Dessy Arisanty Ediwi, Nabila C. Effendi, Muhammad Dzaky Sayyid Elisabet, Adinda Ernesto, Gian Esha, Indi Eti Yerizel Etriyel Myh Fasya, Haidar Haikal Fathiyyatul Khaira, Fathiyyatul Gardenia Akhyar Harahap, Sari Hirowati Ali, Hirowati Husna, Annisa Tamara Julizar, Jullizar Juwita, Dinda Ratna Laila Isrona Lestari, Rahmi Mardhatilah, Ashifa Masnadi, Nice Rachmawati Netti Suharti, Netti Nurhayati Nurhayati Nurrahma, Zuyyina ER. Nursyirwan Effendi, Nursyirwan Perdinan, Alfindy Putra, Alby Dwinanda Putri, Nabila Putri, Rahmi Novira Putri, Rahmi T. Rashieka, Shaydi Amala Rosfita Rasyid Sadewa, Arendhika Sesa Safari, Dodi Safitri, Nuridha Audinia Salim, Aurelia Agantha Saptino Miro, Saptino Sarassari, Rosantia Siregar, Fajri M. Sukri Rahman Syamel Muhammad Syamsir, Elmatris Tofrizal Veronica, R. Merlinda Vivi Triana Wirza, Thifla Rafifa Yaswir, Rita Yulia, Dwi Yulistini, Yulistini Yuniar Lestari