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All Journal Journal of Pharmacopolium Pharmacoscript Jurnal Pengabdian kepada Masyarakat Jurnal Buana Farma Mejuajua Journal of Pharmaceutical and Sciences.
Amal, Surya
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Buana Farma

 1 
The STUDI INTERAKSI OBAT ANTIHIPERLIPIDEMIA PADA PASIEN RAWAT JALAN DI SALAH SATU RUMAH SAKIT SWASTA CIKAMPEK Amal, Andi Nurzakiah; Agustini, Dewi Darwati; Amal, Surya
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1209

Abstract

Hyperlipidemia is a lipid metabolism disorder characterized by an increase in total cholesterol levels in the blood, which is a risk factor for various cardiovascular diseases. Treatment of hyperlipidemia is often combined with other drugs, increasing the potential for drug interactions. This study aims to identify the severity of antihyperlipidemia drug interactions in outpatients in private hospitals in Cikampek during the period of June to December 2023. The research uses an analytical survey design with a retrospective approach. Data were obtained from 251 patient prescriptions that met the inclusion criteria and were analyzed univariably using the Stockley Drug Interaction and drugs.com application. The results showed that 67.65% of prescriptions had potential drug interactions, while 32.35% did not. Patients aged 50–59 years were the largest group (42.6%) receiving antihyperlipidemia, with simvastatin being the most frequently prescribed drug and causing drug interactions most often (51.11%). Of the 135 cases of drug interactions identified, moderate severity accounted for 57.03%, while major severity reached 46.97%. No cases with minor severity were found. This study highlights the importance of monitoring drug interactions to prevent more serious risks in hyperlipidemia patients.
SENYAWA ALAMI DAUN BAWANG UNTUK DIABETES: PENDEKATAN IN SILICO TERHADAP PPAR-γ Hidayah, Himyatul; Ruswanto; Mindawati , Erisa; Amal, Surya; Farhamzah
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1466

Abstract

Leek leaves (Allium fistulosum L.) are plants that contain flavonoid compounds with diverse biological activity potential. This study aims to examine the stable interaction of the docking results between the PPAR-γ receptor complex structure and the best candidate flavonoid compounds in leek leaves as antidiabetic candidates. The method used in this study is quantitative and designed using molecular docking techniques based on computational molecular dynamics (MD), which simulates the dynamic behaviour of a molecular system as a function of time, treating each entity in the simulation box (protein, ligand, or water, if present) as flexible. The results of molecular docking on 16 onion leaf flavonoid compounds showed that hesperidin had the smallest Gibbs free energy (ΔG) of -10.0 kcal/mol, which is close to that of natural ligands. The RMSD and RMSF values are sufficiently stable. Hesperidin also has good pharmacokinetic properties and is non-toxic, thus meeting the criteria for drug-likeness as a potential oral drug candidate. These findings indicate the potential for developing flavonoid compounds, particularly hesperidin from onion leaves, as a candidate for an antidiabetic drug by inhibiting the PPARγ receptor. This study provides a foundation for further in vitro and in vivo studies to validate its biological activity.
Co-Authors Abriyani, Ermi Agustini, Dewi Darwati Aliyani Mardiana, Lina Amal, Andi Nurzakiah Astuti, Diany Dedy Frianto Farhamzah Gunarti , Neni Sri Gunarti, Neni Sri Hari Kusumawati, Anggun Hidayah, Himyatul Kusumawati, Anggun Hari Mangunsong , Dhavid Twua Maulana Yusuf Alkandahri Maya Arfania Mindawati , Erisa Mutiaraning Tyas, Fitri Nia Yuniarsih, Nia Ridwanulah, Dadan Ruswanto Sahevtiyani, Sisy Sugiharta, Sudrajat