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All Journal Majalah Obstetri dan Ginekologi Hearty : Jurnal Kesehatan Masyarakat Jurnal Biomedika dan Kesehatan UMI Medical Journal The Avicenna Medical Journal Jurnal Pengabdian Masyarakat Bangsa GEMBIRA (Pengabdian Kepada Masyarakat) Jurnal Kedokteran Meditek Sanus Medical Journal Jurnal Pengabdian Masyarakat Mandira Cendikia (JPKM-MC) Cermin Dunia Kedokteran
Ilona, Florinda
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Journal : Cermin Dunia Kedokteran

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D-dimer sebagai Biomarker Diagnostik Tuberkulosis Paru pada Efusi Pleura: Tinjauan Pustaka Digambiro, Reza Aditya; Ilona, Florinda; Chendrasari, Julian; Lestari, Indah Widya; Parwanto, Edy
Cermin Dunia Kedokteran Vol 52 No 2 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i2.1242

Abstract

Background: Tuberculosis (TB) remains a major health threat, especially in developing countries. Although the lungs are the most affected organ, systemic manifestations are quite significant. D-dimer, as one of the fibrin degradation products and also an indicator of coagulation activity, has been extensively researched for its predictive and diagnostic value in various diseases. This study aims to assess the effectiveness of D-dimer as a diagnostic biomarker for pulmonary tuberculosis (TB) in patients with pleural effusion compared to those with non-TB pleural effusion. Methods: The study was conducted as an observational case-control on 64 patients with pulmonary TB with pleural effusion were compared to 64 non-TB subjects with pleural effusion. Result: In the TB patient group, 62.5% of patients were smokers, 46.9% of patients had been exposed to TB. Patients were assessed based on the TB symptom scale and with radiological lung examinations, either x-rays or CT scans. D-dimer levels were correlated with the TB severity. D-dimer levels above the threshold value were significantly higher in patients with severe TB symptoms. Conclusion: A direct correlation was observed between the size of radiological lung lesions and D-dimer levels. The average D-dimer level in the control group was 220 ± 60 ng/mL, which increased to 450 ± 90 ng/mL in TB patients with severe lesions.
Co-Authors Aryasatiani, Ekarini Cantika, Catalya Christina Chendrasari, Julian Digambiro, Reza Dyonesia Ary Harjanti Fadillah, Ibnu Haris Fiji, Wijaya Taufik Hastuty , Dewi Kartika, Chandra Dewi Lestari, Indah Widya ML Edy Parwanto Monica Dwi Hartanti, Monica Dwi Parwanto, Edy Raymond Surya Reza Aditya Digambiro Saroso, Ade Setianingrum, Dyah Ayu Woro Setyaningrum, Dyah Ayu Woro Sisca Sisca, Sisca Siti Helmyati Sutanto, Hans Tenka, Lisda