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All Journal International Journal of Educational Research and Social Sciences (IJERSC) Gema Lingkungan Kesehatan JPNM : Jurnal Pustaka Nusantara Multidisiplin Jurnal Riset Multidisiplin Edukasi
Chodidjah
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Religion Humanities Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Public Health Social Sciences Other

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Effect of Turmeric Ethanol Extract (Curcuma Longa Linn) on IL-6, IL-10 Levels and Skin Moisture Anggraeni, Gilda Putri; Sumarawati, Titiek; Chodidjah; Wibowo, Joko Wahyu; Zulaikah, Siti Thomas; Trisnadi, Setyo
Gema Lingkungan Kesehatan Vol. 23 No. 3 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i3.330

Abstract

Ultraviolet B (UVB) radiation is known to induce skin damage, including erythema, roughness, sagging, wrinkles, and reduced skin moisture, contributing to premature aging. Turmeric (Curcuma longa Linn.) contains curcumin, an active compound with potent anti-inflammatory properties. This study investigated the effect of turmeric ethanol extract on IL-6 and IL-10 levels, as well as skin moisture, in UVB-exposed rats. A total of 24 Wistar rats were randomly divided into four groups: healthy controls (K1), UVB-exposed without treatment (K2), UVB-exposed treated with turmeric ethanol extract at 100 mg/kg BW (K3), and 200 mg/kg BW (K4). The extract was administered orally for 14 days. IL-6 and IL-10 levels were measured using ELISA, and skin moisture was assessed macroscopically. Statistical analysis was performed using one-way ANOVA. Rats in groups K2, K3, and K4 exhibited very dry skin, redness, visible wrinkles, and peeling following UVB exposure. IL-6 levels were significantly lower in treated groups, with the lowest levels observed in K4 (1.85 ± 0.24 ng/L), compared to K1 (4.36 ± 0.75 ng/L) and K2 (4.46 ± 0.74 ng/L) (p = 0.000). IL-10 levels increased in the treated groups, notably in K3 (376.48 ± 78.24 pg/mL) and K4 (351.06 ± 78.24 pg/mL), compared to K1 (285.34 ± 45.54 pg/mL) and K2 (306.89 ± 45.54 pg/mL) (p = 0.001). These findings suggest that oral administration of turmeric ethanol extract modulates inflammatory responses by reducing IL-6 and enhancing IL-10 in UVB-exposed skin, although significant dryness persists.
Effect of Turmeric Ethanol Extract (Curcuma Longa Linn.) on Tumor Necrosis Factor alpha (TNFα) and the extent of wound lesions (Experimental Study on Wistar Rats Exposed to UVB Rays) Rahim, Denasa Dwi Sopandita; Sumarawati, Titiek; Chodidjah; Zulaikhah, Siti Thomas; Priyantini, Sri; Trisnadi, Setyo
Gema Lingkungan Kesehatan Vol. 23 No. 3 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i3.331

Abstract

Continuous exposure to ultraviolet B (UVB) radiation can induce photoaging and accelerate premature skin aging. Turmeric (Curcuma longa) is a medicinal plant that contains curcumin, an active compound known for its anti-inflammatory properties and its role in accelerating wound healing. This study aimed to evaluate the effect of turmeric ethanol extract on TNF-α levels and wound lesion areas in Wistar rats exposed to UVB radiation. A post-test-only control group design was employed, involving 24 Wistar rats divided into four groups: a healthy control group (K1), a negative control group (K2), and two treatment groups receiving oral turmeric ethanol extract at doses of 100 mg/kg BW (K3) and 200 mg/kg BW (K4) for 14 days, with concurrent UVB exposure. TNF-α levels were assessed using one-way ANOVA followed by Tukey's post hoc test, while wound lesion areas were analyzed using the Kruskal–Wallis test followed by the Mann–Whitney U test. The results showed that the highest TNF-α levels were observed in the healthy control group (129.14 ng/L), although no statistically significant differences were found between groups (p = 0.538). In contrast, a significant difference was observed in wound lesion areas (p < 0.001), with the largest lesions occurring in the negative control group. In conclusion, oral administration of turmeric ethanol extract did not significantly affect TNF-α levels but was effective in reducing the area of wound lesions caused by UVB exposure.
Pengaruh Pemberian Krim Ekstrak Buah Delima (Punica granatum L.) terhadap Kadar Interleukin-6: Studi Eksperimen pada Tikus Wistar yang Dipapar UVB Hayuning Mentari Justicia; Chodidjah
JPNM Jurnal Pustaka Nusantara Multidisiplin Vol. 4 No. 1 (2026): February : Jurnal Pustaka Nusantara Multidisiplin (ACCEPTED)
Publisher : SM Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59945/jpnm.v4i1.827

Abstract

Ultraviolet B (UVB) adalah sinar UV dengan panjang gelombang 280-320 nm yang dapat mencapai permukaan bumi. Paparan UVB menginisiasi peningkatan stres oksidatif sehingga berisiko pada melasma penyebab hiperpigmentasi kulit, yang terjadi akibat peningkatan produksi Interleukin-6 (IL-6) di keratinosit. Melasma dapat dicegah dengan pengaplikasian krim antioksidan yang berasal dari ekstrak buah delima (Punica granatum L.). Tujuan penelitian mengetahui pengaruh pemberian krim ekstrak buah delima (Punica granatum L.) terhadap kadar IL-6 pada tikus jantan galur wistar yang dipapar UVB. Penelitian eksperimen dengan desain posttest only control group design. Subjek penelitian 25 tikus jantan galur wistar yang dibagi menjadi 5 kelompok (K1: Tikus sehat; K2, K3, K4, dan K5 dipapar UVB tiga kali selama seminggu). K2: Hanya dipapar UVB, K3: diaplikasikan krim retinoid, K4 dan K5 diaplikasikan krim ekstrak buah delima 10% dan 20%. Pengaplikasian krim dilakukan 20 menit sebelum dan 4 jam setelah paparan UVB. Kadar IL-6 diperiksa menggunakan metode ELISA pada panjang gelombang 450 nm, kemudian dianalisis menggunakan uji one way ANOVA dilanjutkan dengan post hoc Tamhane. Hasil rerata kadar IL-6 di K1, K2, K3, K4, dan K5 adalah 80,4±2,89; 152,0±2,35; 94,3±0,76; 98,0±1,43 dan 85,5±2,05 pg/mL. Uji One Way Anova didapatkan perbedaan signifikan antar kelima kelompok dengan nilai p<0,001. Hasil Uji Post Hoc Tamhane juga didapatkan perbedaan signifikan antar dua kelompok (p<0,05), kecuali antara K1 dengan K5 dengan nilai p=0,136. Pemberian krim esktrak buah delima berpengaruh pada kadar IL-6 pada tikus jantan galur wistar yang diinduksi UVB. Krim ekstrak buah delima konsentrasi 20% paling efektif dalam menurunkan produksi kadar IL-6.
PENGARUH PEMBERIAN KRIM EKSTRAK BUAH DELIMA (PUNICA GRANATUM L.) TERHADAP JUMLAH KOLAGEN: Studi Eksperimental Pada Tikus Jantan Galur Wistar Yang Dipapar UVB Anneta Aulia Ismail; Chodidjah; Eni Widayati; Widiana Rachim
Jurnal Riset Multidisiplin Edukasi Vol. 2 No. 12 (2025): Jurnal Riset Multidisiplin Edukasi (Edisi Desember 2025)
Publisher : PT. Hasba Edukasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71282/jurmie.v2i12.1409

Abstract

Ultraviolet B (UVB) exposure can trigger oxidative stress, DNA damage, and decreased collagen synthesis through the activation of inflammatory pathways and degradation of the extracellular matrix. Collagen is the main component of the dermis that maintains skin strength and elasticity, so its damage accelerates skin aging. Pomegranate (Punica granatum L.) contains bioactive compounds such as punicalagin, polyphenols, and ellagic acid, which have antioxidant and anti-inflammatory effects and support collagen regeneration by protecting fibroblasts from oxidative stress and suppressing the expression of collagen-degrading enzymes. This study aimed to determine the effect of pomegranate extract cream on collagen levels in male Wistar rats exposed to UVB. This study was an experiment with a post-test only control group design using 25 rats divided into five groups: normal control (K1), negative control (K2), positive control (K3), treatment 1 (K4), and treatment 2 (K5). The study lasted 14 days, including 7 days of adaptation, 7 days of treatment (UVB exposure and cream application), skin tissue collection, paraffin preparation, and histopathological observation with a 400x magnification microscope. The mean collagen counts for K1-K5 were 52.21 ± 6.40; 0.00 ± 0.00; 57.35 ± 6.20; 57.75 ± 7.27; and 61.30 ± 4.16, respectively. The Kruskal Wallis test showed significant differences between groups (p = 0.007). The Mann-Whitney test showed that K2 was significantly different from K1, K3, K4, and K5 (p = 0.005), while K1, K3, K4, and K5 were not significantly different. This study shows that the application of pomegranate fruit extract cream (Punica granatum L.) has an effect on collagen levels in male Wistar rats exposed to UVB.
Students’ Stage Fright Symptoms in English Public Speaking Class Meinawati, Euis; Purwaningrum, Prapti Wigati; Alawiyah, Sufi; Chodidjah
International Journal of Educational Research & Social Sciences Vol. 4 No. 2 (2023): April 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijersc.v4i2.622

Abstract

The purpose of this research is to find out the symptoms of stage fright in students in English public speaking classes. The study approach uses a qualitative survey consisting of four open-ended questions. The data in this study were taken through direct observation of English public speaking classes, document reports on the progress of students learning public speaking from the teacher and interviews. The data analysis procedure was carried out in three stages, including 1) data reduction, which is the process of collecting data according to the focus of the research, 2) presenting data through the process of categorizing data, classifying and analyzing the process, and 3) drawing conclusions to find out the results. solving research problems. The results of the data analysis concluded that there were two general symptoms associated with student stage fright during public speaking class practice, namely physiological symptoms and cognitive symptoms. Thus, the teacher should be able to direct students to apply strategies to overcome speaking anxiety such as increasing preparation and practice. These findings have implications for teachers' understanding of the concept of the importance of understanding the character of students' anxiety in practicing English public speaking in class, so that teachers can choose learning methods or techniques that are appropriate to students' anxiety levels
Co-Authors Anggraeni, Gilda Putri Anneta Aulia Ismail Eni Widayati Euis Meinawati Hayuning Mentari Justicia Joko Wahyu Wibowo Purwaningrum, Prapti Wigati Rahim, Denasa Dwi Sopandita Setyo Trisnadi Siti Thomas Zulaikhah Sri Priyantini Sufi Alawiyah Titiek Sumarawati Widiana Rachim Zulaikah, Siti Thomas