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All Journal Waste Technology AKSIOMA: Jurnal Program Studi Pendidikan Matematika Journal of Mathematical and Fundamental Sciences Indonesian Journal of Pharmaceutical Science and Technology Jurnal SOLMA Indonesian Journal of Chemistry PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat SEMAR (Jurnal Ilmu Pengetahuan, Teknologi, dan Seni bagi Masyarakat) Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry

Supandi

Department Of Pharmacy, Faculty Of Pharmacy And Science UHAMKA, Jl. Delima II Klender Jakarta 13460, Indonesia

Author-ID : 1749234

Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Tyrosinase Inhibition from Green Tea (Camellia sinensis (L.) Kuntze) gel Hanifah Rahmi; Supandi Supandi; Naniek Setiadi Radjab; Tiara Julianti
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 2 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i2.27145

Green tea (Camellia sinensis (L.) Kuntze) leaf has polyphenol substance that able to inhibit tyrosinase enzyme. Tyrosinase enzyme is one of the essential components that can be initiated melanin formation on the skin (melanogenesis). The natural inhibitory enzyme can be utilized in cosmetics and medicinal industries as depigmentation agent. Green tea leaf was formulated in the dosage form of a gel with carbomer 934 as a gelling agent. This study aimed to determine the optimum concentration of carbomer 934 on green tea leaf extract gel that has an inhibitory tyrosinase activity. This research used three carbomer 934 concentration, there was 0.5%, 0.75%, and 1% respectively. Which every formula was evaluated during six weeks involve organoleptic, homogeneity, viscosity, pH, centrifuge, and freeze-thaw test (during six cycles). The optimum formula was evaluated tyrosinase activity used a spectrophotometer-vis. The results showed that the great concentration of carbomer 934 was contained on the first formula, which has not phase separation and 49.62 ppm of IC50 value. This research showed that green tea leaf extract gel with 0,5% carbomer 934 prevented tyrosinase activity. Keywords: Carbomer 934, gel, green tea leaf extract, inhibitory of tyrosinase

CARBON QUANTUM DOTS (CQDS) from RAMBUTAN and PANDAN LEAVES for CU2+ DETECTION Laksmi Dewi Kasmiarno; Andini Fikarda; Reforny Kristianti Gunawan; Isnaeni Isnaeni; Supandi Supandi; Nonni Soraya Sambudi
Waste Technology Vol 9, No 1 (2021)
Publisher : Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/9.1.1-10

A facile and eco-friendly process for the synthesis of carbon quantum dots (CQDs) was carried out via hydrothermal and microwave treatment using Rambutan and Pandan leaves as carbon sources. The effects of synthesis methods on the optical and physical properties of CQDs, and the sensing activity of CQDs through Cu2+ detection are presented in this study. From the analysis, the band-gap energies of CQDs are found to be ranging from 2.52 to 3.51 eV. The CQDs solutions exhibit significant fluorescence property, in which bright cyan fluorescence can be detected under Ultraviolet (UV) light irradiation at wavelength of around 405 nm. The CQDs synthesized from Pandan and Rambutan leaves using hydrothermal method show quantum yield (QY) values at around 2.46% and 2.70%, respectively. The FT-IR analysis recorded existing functional groups on the surface of CQDs to be of hydroxyl and carbonyl groups, which can serve as adsorption sites for the detection of Cu2+. Furthermore, this study indicates that CQDs emission from Pandan and Rambutan leaves using hydrothermal method shows the best turn-off behavior when detecting the presence of Cu2+ with minimum limit of detection (LoD) as low as 123 µM.

Docking Studies and Molecular Dynamics Simulation of Compounds Contained in Kaempferia Galanga L. to Lipoxygenase (LOX) for Anti-Inflammatory Drugs Supandi; Yeni; Lusi Putri Dwita
Journal of Mathematical and Fundamental Sciences Vol. 53 No. 2 (2021)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2021.53.2.4

Inflammation is a self-protective response to start the healing process. An anti-inflammatory target worth developing are lipoxygenase inhibitors, which have been studied for several diseases, including severe respiratory disease. This research had the goals of estimating the activity of 21 compounds from K. galanga to inhibit the lipoxygenase (LOX) and estimating the bond stability of the ligand-LOX complex. Based on the compound’s affinity for LOX, the compounds in K. galanga were selected by utilizing the PLANTS docking software, with zileuton as the reference ligand. The GROMACS application was used to simulate the molecular dynamics of the LOX-ligand complex at 310 K. Based on the chemPLP score, most of the 21 K. galanga compounds showed a higher affinity towards 5-LOX compared to zileuton. δ-3-carene had the best affinity for 5-LOX. In the simulation of molecular dynamics until 20 ns, the RMSD of δ-3-carene and 5-LOX was not more than 0.03 nm or 0.3 Å, indicating that the whole system showed decent stability and had ‑1.67392 x 106 kcal/mol as the average potential energy. The results showed that K. galanga contains active components of 5-LOX inhibitors that could be developed.

WORKSHOP PEMBUATAN HANDSANITIZER SPRAY GEL Pramulani Mulya Lestari; Ani Pahriyani; Supandi Supandi
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol 1 No 4 (2020)
Publisher : Universitas Majalengka

Permasalahan kesehatan yang sistemik dan saling berkaitan masih menjadi tantangan mitra, anak – anak yang sering sakit seperti diare, batuk flu, demam seringkali menjadi masalah dalam lingkungan RPTA dan RW 03 kemanggisan Jakarta Barat, karena penularan yang begitu cepat dan terjadi secara terus menerus sehingga dianggap menghambat aktivitas motorik anak – anak yang sedang berkembang. dalam upaya mencapai kualitas kesehatan yang baik dan kesejahteraan yang merata bagi seluruh penduduk serta minimnya pengetahuan dan ide masyarakat terhadap pembuatan produk yang dapat digunakan untuk memelihara kebersihan. Pemecahan masalah yang ada pada masyarakat tersebut dalam mendukung pemeliharaan kesehatan yaitu perlu dilalukan workshop mengenai pembuatan hand satizer gel spray. Tanaman yang dapat dimanfaatkan sebagai bahan alami pembuatan hand sanitizer yaitu Belimbing Wuluh (Averhoa belimbii). Belimbing Wuluh (Averhoa belimbii) mengandung unsur-unsur senyawa kimia yang bemanfaat, salah satunya flavonoid diduga merupakan senyawa aktif anti bakteri. Kegiatan ini diharapkan dapat meningkatkan kesadaran, kemauan dan kemampuan individu, maupun masyarakat untuk peduli akan masalah kesehatan serta berperan aktif dalam segala bentuk upaya kesehatan

Penyuluhan Tentang Bahaya Penyalahgunaan Narkotik, Psikotropika dan Zat Aditif Bagi Siswa Siswi SMA dan SMK Mutiara 17 Agustus Dwitiyanti Dwitiyanti; Kriana Efendi; Supandi Supandi
SEMAR (Jurnal Ilmu Pengetahuan, Teknologi, dan Seni bagi Masyarakat) Vol 8, No 1 (2019)
Publisher : LPPM UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/semar.v8i1.18136

The community services which was carried out entitled " Counseling About The Danger Of Narkotic, Psychotropics and Aditive Subtance Abuse For High School Students Mutiara 17 Augustus", aimed to increase students' knowledge and awareness of negative impact of drug abuse and to direct teenagers to channel energy in positive activities, as well as raising awareness raising and establishing self-defense against the dangers posed by drug abuse. The targets achieved were improving understanding and providing information regarding the use, dangers and impacts of drug abuse. Method of implementation of Empowerment Activities and Community Service to partners in the form of mapping of students by way of data the number of students, gender, age, hobbies, smoking/not. The counseling was done by describing psychotropic narcotic drugs and other additives, negative impacts of drug abuse, discussion and questioning, distribution of leaflets aware of drug abuse and evaluation. The result of this dedication shows the students have an increased understanding compared to before being given counseling about the drug and its harmful effects, thereby increasing students' awareness of the impact that can be generated.

Pembuatan Karbol sebagai Desinfektan Lantai Pramulani Mulya Lestari; Supandi Supandi; Ani Pahriyani
Jurnal SOLMA Vol. 8 No. 2 (2019)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Sehat adalah impian semua manusia, tubuh manusia memiliki pertahanannya sendiri, dengan cara-cara tertentu bagian dari tubuh sudah mampu untuk bertahan dan melawan penyakit.Mencegah suatu penyakit dan penyebarannya dapat dilakukan mulai dari diri sendiri dan lingkungan sebagai sarana untukmengurangi penyebaran penyakit karena mikroorganisme. Untuk menunjang kesehatan maka perlu dilakukan pembekalan kepada ibu-ibu dalam pengenalan kerbersihan dan pelatihan pembuatan karbol. Produk karbol ini dibuat dengan metode sederhana sesuai dengan kemampuan Perumahan Villa Mutiara Gading 3. Pembuatan diawali dengan melarutkan arpus ke dalam cairan NaOH hingga larut, kemudian tambahkan campuran antara pine oil, teepol dan propilenglikol hingga semua tercampur homogen.Karbol siap digunakan. Produk yang dihasilkan merupakan karbol desinfektan lantai. Karbol yang baik adalah yang dapat membersihkan sekaligus dapat membunuh kuman, tidak licin dan aman digunakan.

Simultaneous Analysis of 6-Mercaptopurine, 6-Methylmercaptopurine, and 6-Thioguanosine-5’-monophosphate in Dried Blood Spot Using Ultra Performance Liquid Chromatography Tandem Mass Spectrometry Supandi Supandi; Yahdiana Harahap; Harmita Harmita; Rizka Andalusia
Indonesian Journal of Chemistry Vol 18, No 3 (2018)
Publisher : Universitas Gadjah Mada

6-Mercaptopurine is a chemotherapeutic agent of the antimetabolite class. This study aims to analyze simultaneous validation of 6-mercaptopurine (6-MP), 6-methylmercaptopurine (6-MMP), and 6-thioguanosine-5’-monophosphate (6-TGMP) in dried blood spot (DBS) using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). An accurate volume of 60 μL blood was spotted onto DBS-CAMAG paper and then extracted using methanol 90% (v/v) containing an internal standard of 5-fluorouracil (5-FU). Separation was performed using a Waters Acquity UPLC BEH AMIDA column 1.7 μm (2.1 x 100 mm) with a mobile phase mixture of 0.2% (v/v) formic acid in water−0.1% (v/v) formic acid in acetonitrile-methanol with gradient elution and flow rate of 0.2 mL/min. Mass detection was done using Waters Xevo TQD with positive electrospray ionization (ESI) for 6-MP, 6-MMP, 6-TGMP and negative ESI for 5-FU, in multiple reaction monitoring mode. Detection rates of 6-MP, 6-MMP, 6-TGMP and 5-FU were m/z 153.09 > 119.09; 167.17 > 126.03; 380.16 > 168.00); 129.09 > 42.05, respectively. This method is linear across the range 25.5–1020 ng/mL for 6-MP, 6-MMP and 6-TGMP. This method is valid for the in vitro simultaneous analysis of 6-MP, 6-MMP and 6-TGMP in DBS, based on European Medicine Agency guidelines.

Analisis In-Silico Senyawa Diterpenoid Lakton Herba Sambiloto (Andrographis Paniculata Nees) Pada Reseptor Alpha-Glucosidase Sebagai Antidiabetes Tipe II Rizky Arcinthya Rachmania; Supandi Supandi; Oetari Anggun Larasati
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 12 No. 02 Desember 2015
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar

ABSTRAK Diabetes mellitus (DM) tipe II merupakan penyakit kronis dengan jumlah penderita jutaan orang di dunia. Diabetes mellitus tipe II disebabkan oleh hormon insulin yang tidak mencukupi atau tidak efektif, sehingga tidak dapat bekerja secara normal. Enzim α-glukosidase bekerja pada dinding usus halus, dimana α-glukosidase akan memecah oligosakarida atau polisakarida menjadi glukosa yang dapat diserap oleh usus halus sehingga terjadi peningkatan kadar gula dalam darah. Herba sambiloto memiliki banyak senyawa diterpenoid lakton yang mampu menurunkan kadar glukosa dalam darah. Senyawa diterpenoid lakton dapat menghambat penyerapan glukosa melalui penghambatan enzim α-glukosidase dan α-amilase. Penelitian ini bertujuan untuk mendapatkan kandidat obat yang berasal dari senyawa diterpenoid lakton herba sambiloto yang diharapkan mampu menurunkan kadar glukosa dalam darah dengan metode molecular docking. Sepuluh senyawa aktif diterpenoid lakton sambiloto akan dibandingkan dengan acarbose. Hasil dari penelitian ini, dua senyawa diterpenoid lakton yang memiliki energi bebas terendah dan residu asam amino yang sesuai adalah 14-deoksiandrografolida dengan nilai energi -8,0 kkal/mol dan 19-O-asetilanhidroandrografolida dengan nilai energi -8,7 kkal/mol, sedangkan acarbose memiliki nilai energi -7,6 kkal/mol. Bioavaibilitas oral menurut aturan Lipinski, ligan 14-deoksiandrografolida dan 19-O-asetilanhidroandrografolida juga memiliki bioavaibilitas oral yang tinggi dibandingkan acarbose. Dapat disimpulkan bahwa 14-deoksiandrografolida dan 19-O-asetilanhidroandrografolida dapat menurunkan kadar glukosa dalam darah. Kata kunci: α-glukosidase, diterpenoid lakton, sambiloto. ABSTRACT Diabetes mellitus type II is a chronic disease with the high prevalence worldwide. Diabetes mellitus is caused by insulin insufficiency or infectivity, so it cannot work normally. Sambiloto herb is one of medicinal herbs used to prevent diabetes mellitus. Sambiloto herb contained many diterpenoid lactone compounds that is active in lowering blood glucose levels. A diterpenoid lactone compound inhibits the absorption of glucose through inhibition of α-glucosidase and α-amilase enzymes. This research aims to obtain drug candidate derived from diterpenoid lactone compounds of sambiloto with molecular docking method. Ten active diterpenoid lactone compounds of sambiloto will be compared to acarbose. The result, two diterpenoid lactone compounds have the lowest free energy and suitable residue of amino acid, they are 14-deoxyandrographolide and 19-O-acetilanhydroandrographolide with the value of energy are -8,0 kcal/mol and -8,7 kcal/mol, respectively. Acarbose has the value of energy -7,6 kcal/mol. Oral bioavailability according to Lipinski rules, 14- deoxyandrographolide and 19-O-acetilanhydroandrographolide are also have high oral bioavailability compared to acarbose. The conclusion is, 14-deoxyandrographolide and 19-O-acetylanhydroandrographolide can lower glucose blood levels. Key words: α-glucosidase, diterpenoid lactone, docking, sambiloto.

ANALISIS PENAMBATAN MOLEKUL SENYAWA FLAVONOID BUAH MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl.) PADA RESEPTOR α-GLUKOSIDASE SEBAGAI ANTIDIABETES Rizky Arcinthya Rachmania; Supandi Supandi; Frisca Ananda Dwi Cristina
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 13 No. 02 Desember 2016
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar

Mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl.) merupakan buah yang banyak mengandung flavonoid yang dapat digunakan sebagai obat antidiabetes. Senyawa flavonoid yang berkhasiat antidiabetes pada buah mahkota dewa belum diketahui jenisnya sehingga perlu diteliti. Penelitian ini bertujuan untuk melihat interaksi senyawa flavonoid buah mahkota dewa terhadap enzim α-glukosidase melalui nilai energi bebas (binding affinity/ΔG˚) dan untuk mendapatkan jenis flavonoid yang sesungguhnya dari buah mahota dewa sebagai tahap pencarian kandidat obat antidiabetes yang baru. Pelaksanaan penelitian ini diawali dengan mencari struktur dari enzim α-glukosidase di RCSB kemudian dilakukan proses penambatan molekul, diamati visualisasinya melalui Pymol dan penentuan pocket cavity. Hasil penambatan molekul terhadap 10 senyawa flavonoid menunjukkan senyawa yang memiliki energi bebas terendah adalah fevicordin A dengan nilai -10,8 kcal/mol, sementara itu hasil visualisasi dari fevicordin A terdapat 5 residu asam amino yaitu; Leu 286, Phe 535, Ile 523, Ser 521, Arg 520. Phaleria (Phaleria macrocarpa (Scheff.) Boerl.) is a fruit that contains flavonoids which can use as antidiabetic. Flavonoid compounds type in Phaleria is unknown, so it is need to be investigated. Purpose of this study were to see the interaction of flavonoids of Phaleria with α-glucosidase enzyme by binding affinity and to find out the most potent flavonoid of Phaleria as new drug candidate for antidiabetes. Implementation of this study begins with the search for the structure of the α-glucosidase enzyme in RCSB and then docking process, observed visually with Pymol and determination of pocket cavity. Results of molecular docking of 10 flavonoids, showed that the flavonoid with lowest free energy was fevicordin A with the value of 10.8 kcal/mol. The results visualization showed that fevicordin A have 5 amino acid residues.

MEMAHAMI BAGAIMANA SISWA LAKI-LAKI DAN PEREMPUAN MEMECAHKAN MASALAH MATERI SISTEM PERSAMAAN LINEAR Khoerul Umam; Dedi Hidayat; Supandi Supandi
AKSIOMA: Jurnal Program Studi Pendidikan Matematika Vol 10, No 4 (2021)
Publisher : UNIVERSITAS MUHAMMADIYAH METRO

Kemampuan pemecahan masalah matematika dipengaruhi oleh kemampuan siswa dalam mematematisasi masalah. Dalam memahami bagaimana proses itu terjadi dapat dieksplorasi, salah satu cara mengeksplorasi kemampuan pemecahan masalah matematika dapat menggunakan materi sistem persamaan linear. Materi ini memungkinkan siswa untuk mengembangkan pengetahuan matematika melalui pemecahan masalah. Metode penelitian yang digunakan metode deskriptif kualitatif guna untuk mendeskripsikan kemampuan pemecahan masalah pada siswa dalam materi persamaan linier ditinjau dari kamampuan matematis. Instrumen penelitian ini menggunakan materi system persamaan linear yang mengharuskan siswa mengembangkan kemampuan pemecahan masalah matematisnya. Data penelitian divalidasi dengan menggunakan triangulasi waktu dan sumber agar didapatkan data penelitian yang reliabel dan valid. Analisis data menggunakan analisis deskriptif berdasarkan indikator pada kemampuan pemecahan masalah. Hasil Penelitian ini menunjukkan bahwa siswa telah memahami urutan dalam langkah-langkah memecahkan masalah pada persoalan system persamaan linear dua variabel. Perbedaan mendasar dapat dilihat ketika siswa perempuan lebih mendetailkan seluruh informasi yang didapatkan sedangkan siswa laki-laki cenderung menghabiskan waktu untuk membaca masalah tetapi tidak mendetailkan informasi yang didapatkan. Kecenderungan yang berbeda bagaimana siswa perempuan dan laki-laki mengawali proses pemecahan masalah matematika dapat membantu guru untuk tahapan dan langkah apa yang diperlukan dalam mengembangkan kualitas pembelajaran matematika yang lebih berkelanjutan.

Co-Authors Andini Fikarda Ani Pahriyani Ani Pahriyani Anisa Amalia Dedi Hidayat Dwitiyanti Dwitiyanti Fith Khaira Nursal Frisca Ananda Dwi Cristina Hanifah Rahmi Harmita Harmita Isnaeni Isnaeni Khoerul Umam Kriana Efendi Laksmi Dewi Kasmiarno Lusi Putri Dwita Naniek Setiadi Radjab Nining, Nining Nonni Soraya Sambudi Oetari Anggun Larasati Pramulani Mulya Lestari Reforny Kristianti Gunawan Rizka Andalusia Rizky Arcinthya Rachmania Rizky Arcinthya Rachmania Siska Siska Slamet Slamet Tahyatul Bariroh Tiara Julianti Tri Wintolo Apoko Yahdiana Harahap Yeni Yeni Yeni Yulianindra Khalishah

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