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All Journal Jurnal Teknologi Industri Pertanian Science and Technology Indonesia
Muhamaludin
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Engineering Environmental Science Industrial & Manufacturing Engineering Materials Science & Nanotechnology Physics

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Evaluation of Bioactive Compounds, Antioxidant, and Anti-Diabetic Activities in Hexane and Supercritical Carbon Dioxide Extracts of Sweet Potato (Ipomoea batatas L.) Leaves Nasori, Achmad Sofian; Wiguna, Bangkit; Rahayu, Maya Damayanti; Permatasari, Devi; Kazfia, Hananda; Muhamaludin; Rosyidin, Ahmad Khulafaur; Dewi, Rizna Triana; Fu, Minghai; Atmaji, Priyo; Aji, Galih Kusuma
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.250-261

Abstract

Sweet potato leaves are a rich source of bioactive compounds with potential health benefits. Advanced methods are being explored to harness these beneficial compounds efficiently. Applying the supercritical carbon dioxide (SCO2) technique, as an environmentally friendly extraction technique, offers many advantages over traditional solvent extraction. This study, therefore, aimed to investigate the effect of SCO2 extraction on the bioactive properties of sweet potato leaves, focusing on antioxidant and anti-diabetic activities. Then, the SCO2 extracts were compared with the hexane extract. A completely random design was used, performing 3 pressures (2000, 3000, and 4000 Psi) and 3 temperatures (40, 50, and 60°C) for the SCO2 extraction. In addition, a maceration using hexane solvent was performed in a shaker for 24 hours. Total polyphenol and flavonoid concentrations were quantified, and gas chromatography-mass spectrometry (GCMS) analyses were used to identify the extracted bioactive compounds. Antioxidant and anti-diabetic activities were also assessed. This yield of SCO2 extraction ranged from 0.49% to 0.89%, which was significantly lower in yield, polyphenol, flavonoid concentration, and antioxidant activity compared to hexane extract (P<0.05). Despite the lower yield, this study observed a higher concentration of bioactive terpenoids such as phytol, caryophyllene oxide, and squalene. In terms of anti-diabetic activity, the extracts at SCO2-specific conditions (4000 Psi 40°C, 3000 Psi 60°C, 3000 Psi 40°C, and 60°C, 2000 Psi 60°C) exhibited potent alpha-glucosidase inhibition, with IC50 values comparable to acarbose, and hexane extract. Dipeptidyl peptidase 4 (DPP4) inhibition was the highest in the hexane extract (p < 0.05), followed by SCO2 extracts. Thus, these findings highlight new possibilities for developing anti-diabetic agents derived from sweet potato leaves using the green SCO2 extraction technique.
EFFECT OF GINGER OLEORESIN CONCENTRATION ON THE ENCAPSULATION PROCESS USING IONIC GELATION Permana, Asep Wawan; Mardiyyah, Annisah; Wiguna, Bangkit; Laksono, Hendrawan; Aji, Galih Kusuma; Mufti, Ayi; Atmaji, Priyo; Muhamaludin; Budiyanto; Kusumasmarawati, Ambar Dwi; Prasetyo, Wegik Dwi; Sulaswatty, Anny; Nasori, Achmad Sofian
Jurnal Teknologi Industri Pertanian Vol. 34 No. 3 (2024): Jurnal Teknologi Industri Pertanian
Publisher : Department of Agroindustrial Technology, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24961/j.tek.ind.pert.2024.34.3.279

Abstract

The primary active components in ginger oleoresin are gingerol and shogaol, with gingerol exhibiting significant pharmacological activities such as anti-inflammatory, antioxidant, and analgesic effects. However, gingerol is heat-sensitive and degrades at elevated temperatures, limiting its functional efficacy when consumed. To overcome this limitation, encapsulation of ginger oleoresin was performed to enhance its physical and functional properties and improve its bioavailability. This study utilized the ionotropic gelation method to encapsulate ginger oleoresin, resulting in the formation of beads. Alginate was employed as the encapsulation matrix. The dried beads were characterized using FTIR, SEM, disintegration tests, and encapsulation efficiency was assessed via UV-Vis spectrophotometry. Results demonstrated that alginate beads containing ginger oleoresin could be successfully synthesized using the ionotropic gelation technique, with alginate as the polymer and CaCl2 as the cross-linking agent. Ginger oleoresin concentrations of 0.9%, 0.7%, 0.5%, and 0.3% were tested. The highest encapsulation efficiency, 72.48%, was obtained with a ginger oleoresin concentration of 0.7%. Surface morphology analysis revealed that the alginate beads exhibited a rough, porous texture with visible folds. Furthermore, the dry beads disintegrated within 30 minutes. Keywords: alginate, beads, encapsulation, ginger oleoresin, ionic gelation method
Co-Authors Aji, Galih Kusuma Anny Sulaswatty, Anny Asep Wawan Permana, Asep Wawan BUDIYANTO Devi Permatasari Fu, Minghai Hendrawan Laksono Kazfia, Hananda Kusumasmarawati, Ambar Dwi Mardiyyah, Annisah Mufti, Ayi Nasori, Achmad Sofian Prasetyo, Wegik Dwi Priyo Atmaji Rahayu, Maya Damayanti Rizna Triana Dewi Rosyidin, Ahmad Khulafaur Wiguna, Bangkit