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All Journal Science and Technology Indonesia Berita Biologi
Rahayu, Maya Damayanti
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Materials Science & Nanotechnology Physics

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Evaluation of Bioactive Compounds, Antioxidant, and Anti-Diabetic Activities in Hexane and Supercritical Carbon Dioxide Extracts of Sweet Potato (Ipomoea batatas L.) Leaves Nasori, Achmad Sofian; Wiguna, Bangkit; Rahayu, Maya Damayanti; Permatasari, Devi; Kazfia, Hananda; Muhamaludin; Rosyidin, Ahmad Khulafaur; Dewi, Rizna Triana; Fu, Minghai; Atmaji, Priyo; Aji, Galih Kusuma
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.250-261

Abstract

Sweet potato leaves are a rich source of bioactive compounds with potential health benefits. Advanced methods are being explored to harness these beneficial compounds efficiently. Applying the supercritical carbon dioxide (SCO2) technique, as an environmentally friendly extraction technique, offers many advantages over traditional solvent extraction. This study, therefore, aimed to investigate the effect of SCO2 extraction on the bioactive properties of sweet potato leaves, focusing on antioxidant and anti-diabetic activities. Then, the SCO2 extracts were compared with the hexane extract. A completely random design was used, performing 3 pressures (2000, 3000, and 4000 Psi) and 3 temperatures (40, 50, and 60°C) for the SCO2 extraction. In addition, a maceration using hexane solvent was performed in a shaker for 24 hours. Total polyphenol and flavonoid concentrations were quantified, and gas chromatography-mass spectrometry (GCMS) analyses were used to identify the extracted bioactive compounds. Antioxidant and anti-diabetic activities were also assessed. This yield of SCO2 extraction ranged from 0.49% to 0.89%, which was significantly lower in yield, polyphenol, flavonoid concentration, and antioxidant activity compared to hexane extract (P<0.05). Despite the lower yield, this study observed a higher concentration of bioactive terpenoids such as phytol, caryophyllene oxide, and squalene. In terms of anti-diabetic activity, the extracts at SCO2-specific conditions (4000 Psi 40°C, 3000 Psi 60°C, 3000 Psi 40°C, and 60°C, 2000 Psi 60°C) exhibited potent alpha-glucosidase inhibition, with IC50 values comparable to acarbose, and hexane extract. Dipeptidyl peptidase 4 (DPP4) inhibition was the highest in the hexane extract (p < 0.05), followed by SCO2 extracts. Thus, these findings highlight new possibilities for developing anti-diabetic agents derived from sweet potato leaves using the green SCO2 extraction technique.
EFFECT OF STORAGE TIME VARIATION OF ANDALIMAN FRUIT ON FREE RADICAL SCAVENGING AND PROLIFERATION INHIBITION ON MCF-7 CELLS Rosidah, Idah; Kusumastuti, Siska Andrina; Simanungkalit, Grace Sophiwati; Rahayu, Maya Damayanti; Nuralih, Nuralih; Martgrita, Merry Meryam; Kembaren, Roga Florida; Chaidir, Chaidir; Sunaryanto, Rofiq; Wibowo, Agung Eru
Berita Biologi Vol 23 No 2 (2024): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/beritabiologi.2024.3334

Abstract

Andaliman (Zanthoxylum acanthopodium D.C) is a plant widely used by the Batak people in North Sumatera. Several studies demonstrated that Andaliman fruit exhibits antioxidant activities and cytotoxic effects on cancer cells. Quality of Andaliman fruit could affected by post-harvest process including storage time. This research aims to analyze the compound, antioxidant activity and proliferation inhibition on MCF-7 cells of Andaliman fruit extracts (AFE) stored at varying storage time. A series of fresh 250 g Andaliman fruit sealed in a closed container and stored in the oven at 30ºC. After storage at 0, 24, 48, 72, 96, 120 and 144 hours, Andaliman fruit macerated using methanol and obtained successive extract yields of 4.12; 3.70; 12.79; 8.17; 8.15; 3.7 and 2.21. These extracts were analyzed for total phenolic, total flavonoids, free radical scavenging activity and proliferation inhibition on MCF-7 cells. The chemical compound analysis of AFE was performed by ultra performance liquid chromatography (UPLC). Results showed that the AFE stored at zero hours had higher total phenol content (47.32 mg gallic acid equivalent (GAE)/g of extract) and free radical scavenging activity (50.38%) at 500 µg/mL significantly compared to other extracts. The total flavonoid content of all extracts showed no difference level except for the extract at 120 hours of storage. The proliferation inhibition test on MCF-7 cells at 100 µg/mL showed that AFE stored at 72, 96 and 144 hours could inhibit MCF-7 cells above 50%. The storage time variation of Andaliman fruit may affect the total phenolic and flavonoid content, and also activity of free radical scavenging and proliferation inhibition on MCF-7. The UPLC analysis founded the major compound of AFE was predicted as α-sanshool. Analysis of chemicals substance in Andaliman fruit with varying of storage time need to be conducted to evaluated alteration of secondary metabolites contained in Andaliman fruit.
Co-Authors Agung Eru Wibowo Aji, Galih Kusuma Chaidir Chaidir Devi Permatasari Fu, Minghai Idah Rosidah Kazfia, Hananda Martgrita, Merry Meryam Muhamaludin Nasori, Achmad Sofian Nuralih Nuralih, Nuralih Priyo Atmaji Rizna Triana Dewi Rofiq Sunaryanto ROGA FLORIDA KEMBAREN Rosyidin, Ahmad Khulafaur Simanungkalit, Grace Sophiwati Siska Andrina Kusumastuti Wiguna, Bangkit