Article Per Year (5 Year)
p-Index From 2021 - 2026
0.659
P-Index
This Author published in this journals
All Journal Plexus Medical Journal Indonesian Journal of Pharmacology and Therapy
Riza Novierta Pesik
Unknown Affiliation
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Pengaruh Ekstrak Etanolik Lidah Buaya (Aloe vera) Terhadap Tingkat Maturasi Sel Sperma pada Testis Tikus Wistar (Rattus norvegicus) Model Sindrom Metabolik Terinduksi Nadzifah Nur Firdaus; Setiawan, Novan Adi; Budiani, Dyah Ratna; Riza Novierta Pesik
Plexus Medical Journal Vol. 3 No. 5 (2024): Oktober
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jhfbgj54

Abstract

Pendahuluan: Sindrom metabolik memunculkan gangguan spermatogenesis, akibat adanya peningkatan ROS. Peningkatan ROS mengganggu maturasi sel sperma. Ekstrak etanolik daun lidah buaya memiliki potensi sebagai antioksidan. Tujuan penelitian ini mengetahui pengaruh ekstrak etanolik daun lidah buaya (Aloe vera) terhadap tingkat maturasi sel sperma menggunakan Johnson score. Metode: Penelitian eksperimental laboratorik dengan pretest-posttest control group design. Dua puluh lima tikus Wistar jantan dibagi menjadi 5 kelompok, masing-masing kelompok sebanyak 5 tikus. K1-kelompok kontrol, K2-kelompok sindrom metabolik, K3, K4, dan K5 adalah kelompok tikus dengan sindrom metabolik yang diberi ekstrak etanolik daun lidah buaya dosis 200, 250, dan 300 mg/KgBB/hari. Penghitungan Johnson score menggunakan perparat histopatologi dengan pengecatan Hematoxilin Eosin (HE) setelah terminasi pada hari ke-57. Analisis data menggunakan uji one-way ANOVA, dilanjutkan dengan uji post-hoc Tukey HSD, dan uji korelasi Pearson, untuk mengetahui hubungan antara dosis ekstrak etanolik Aloe vera dengan tingkat maturasi sperma. Hasil:. Berdasarkan hasil uji korelasi Pearson’s kenaikan Johnson score (tingkat maturasi sel sperma) sejalan dengan peningkatan dosis ekstrak etanolik daun lidah buaya dengan R2= 0,783. Hasil uji beda one-way ANOVA terdapat perbedaan antar kelompok p<0,05. Uji post-hoc Tukey HSD K1 secara signifikan berbeda dengan K2. K1 tidak berbeda dengan kelompok K3, K4 dan K5. K2 secara signifikan berbeda dengan K3,K4 dan K5. Rata-rata skor Johnson K1 9,92 0,05, K2 7,04±1,49, K3 8,93 0,76, K4 9,50 0,23, dan K5 9,56 0,53. Kesimpulan: Pemberian ekstrak etanolik daun lidah buaya (Aloe vera) dosis 200 mg/KgBB/hari, 250 mg/KgBB/hari dan 300 mg/KgBB/hari berpengaruh positif terhadap maturasi sperma tikus Wistar model sindrom metabolik.
The Liver histopathology structure of Wistar rats on the acute toxicity test of Kapulaga Seeds extract (Amomum cardamomum) Ratih Dewi Yudhani; Rizka Hendriyani; Riza Novierta Pesik
Indonesian Journal of Pharmacology and Therapy Vol 1 No 2 (2020)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.717

Abstract

One-third of the Indonesian population uses herbs for alternative medicine empirically. One of them is Kapulaga (Amomum cardamomum) which known as a spice and traditionally used for the treatment of rheumatic, fever, cough, sore throat, and mouth odor. The clinical use of herbs must be supported by scientific evidenced-based and its safety profile. The risk of exposure to a substance in humans can be identified through the toxicity tests on animals. The liver histopathological structure is one of the parameters of the acute toxicity test. This study to determine the acute toxicity of Kapulaga seeds extract (Amomum cardamomum) based on the liver histopathological structure of Wistar rats. The sample selection based on inclusion and exclusion criteria in the OECD 420 guideline. The research consisted of a preliminary and the main test. One rat was used in the preliminary test with an initial dose of cardamom seed extract 300 mg/kg BW and followed by a maximum dose of 2000 mg/kg BW after 48 hours. The main test used 10 rats that were randomly divided into control and treatment groups. Based on the result of the preliminary test, the treatment group was given a single dose of cardamom seed extract 2000mg /kg BW, whilst the control group was given distilled water. Observations of any toxic signs or dead were conducted every 30 minutes in the first 4 hours and continued once per day until 14thday. Assessment of the degree of liver damage was done using the liver damaged scoring and compared using the Mann Whitney test (α = 0.05). The average liver damage score of control and treatment groups is 0.96 ± 0,856 and 0.96 ± 0,604, respectively, and did not show any statistically significant differences (p>0,05). Kapulagaseeds (Amomum cardamomum) had no acute toxic effect based on the liver histopathological structure of Wistar rats.
Ethanolic Extract of Moringa oleifera Leaves Reduces The Expression of ICAM-1 in Aortic Tissues of Metabolic Syndrome Induced Rattus norvegicus Ikhsan, Muhammad Nouval; Riza novierta pesik; Dyah Ratna Budiani; Novan Adi Setyawan
Plexus Medical Journal Vol. 2 No. 4 (2023): Agustus
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v2i4.866

Abstract

Introduction: Metabolic syndrome poses a risk for the development of atherosclerotic lesions, which are associated with various cardiovascular diseases. Moringa leaves are known for their antioxidant and anti-inflammatory properties. ICAM-1 serves as an early marker of atherosclerosis. This study aims to investigate how the dosage of ethanolic extract from Moringa leaves affects the expression of ICAM-1 in the aortic tissue of Wistar rats with metabolic syndrome. Methods: This study employed a laboratory experimental design with a posttest only control group. The research involved 30 Wistar rats, divided into five groups: the normal control group (G1), the positive control group (G2), and three experimental groups (G3, G4, and G5). The experimental groups (G3, G4, and G5) were induced with metabolic syndrome and administered ethanolic extract of Moringa leaves at doses of 150 mg/kg, 250 mg/kg, and 350 mg/kg, respectively. The expression of aortic ICAM-1 was evaluated using the Intensity Distribution Score (IDS) and analyzed using one-way ANOVA and Post-hoc Tukey HSD test. Results: Increasing the dosage of ethanolic leaf extract of Moringa oleifera reduces the IDS value of ICAM-1 in the aortic tissue of Wistar rats with a significance of p<0.05.. Conclusion: The higher dosage of ethanolic leaf extract from Moringa oleifera Lamk has the potential to decrease ICAM-1 expression in the aortic tissue of Wistar rats with metabolic syndrome. The author hopes that Moringa leaf extract can be utilized as a supplement to prevent the formation of atherosclerotic plaques and cardiovascular diseases resulting from atherosclerotic plaques, such as thromboembolism and stroke.  
Co-Authors . Muthmainah Adam Haviyan Nasrullah Brian Wasita Dono Indarto Dyah Ratna Budiani Dzulfiar Nasir Umam Ega Caesaria Pratama Putra Ikhsan, Muhammad Nouval Kristanto Yuli Yarso Mugi Tri Sutikno Nadzifah Nur Firdaus Nanang Wiyono Niluh Ayu Anissa Hanum Novan Adi Setyawan R. Aj. Sri Wulandari Rachmi Fauziah Rahayu Ratih Dewi Yudhani Ratna Kusumawati Rizka Hendriyani Setiawan, Novan Adi Sintin Khotijah Pribadi Suyatmi Suyatmi