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All Journal Indonesia Medicus Veterinus Media Kedokteran Hewan Jurnal Medik Veteriner ARSHI Veterinary Letters Jurnal Medika Veterinaria
Sewoyo, Palagan Senopati
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

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Journal : Jurnal Medika Veterinaria

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The Role of p53 as the Guardian of the Genome and the Consequences of its Mutation in Cancer Development: A Review Purwitasari, Made Santi; Sewoyo, Palagan Senopati; Astawa, I Nyoman Mantik
Jurnal Medika Veterinaria Vol 19, No 2 (2025): J.Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v19i2.48988

Abstract

The TP53 gene encodes the p53 protein, often referred to as the guardian of the genome due to its critical role in maintaining genomic stability and preventing tumorigenesis. Under normal conditions, p53 expression is tightly regulated by MDM2 and MDMX, which promote its degradation through ubiquitination. In response to endogenous or exogenous stress, this ubiquitination process is inhibited, leading to the stabilization of p53. Once stabilized, p53 forms a tetrameric complex in the nucleus and binds to DNA. It then activates the transcription of genes involved in cell cycle arrest, DNA repair, apoptosis, and senescence, aiming either to repair DNA damage or eliminate cells when the damage is irreparable. Nearly half of all cancer cases involve mutations in the TP53 gene. These mutations may include missense, nonsense, inframe, and splice-site mutations. Mutations in TP53 result in the production of mutant p53 (mutp53) proteins. These mutations can lead to a loss of tumor suppressor function or confer gain-of-function properties that promote tumor progression. Given its central role in cancer development, TP53 is considered a promising therapeutic target. Potential strategies include reactivating suppressed p53, restoring the function of mutp53, or inducing its degradation.
Molecular Detection of the Gene Encoding Second Internal Transcribed Spacer of Sarcoptes scabiei in Rabbits in Several Regions in East Java Rusdiana, Nur; Retno Lastuti, Nunuk Dyah; Aisyah, Siti; Purwanti, Ni Luh Lasmi; Sewoyo, Palagan Senopati
Jurnal Medika Veterinaria Vol 17, No 2 (2023): J.Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v17i2.35273

Abstract

This study aimed to detect the Second Internal Transcribed Spacer (ITS-2) encoding gene of Sarcoptes scabiei from rabbits. ITS-2 is a highly conserved gene and always used to identify and differentiate host species infected by S. scabiei. Isolates of S. scabieiwere collected from samples of rabbit skin scrapings suspected of being infected with S. scabiei. The rabbits were acquired from Surabaya, Sidoarjo, Pasuruan, Mojokerto and Nganjuk. Detection on the presence of S. scabiei was carried out microscopically then further confirmed by PCR method and visualized using electrophoresis. PCR identification results showed DNA bands at 304 base pairs. The results showed that samples were infected by S. scabiei, determined by the presence of ITS-2 encoding gene. The ITS-2 encoding gene was chosen as the main focus in this study because it was easily amplified that made analysis and identification easier. The high cases of scabies in Indonesia can be a warning to prevent infection of S. scabiei, especially in pets that have the potential as a reservoir in spreading diseases.
Co-Authors Anak Agung Ayu Mirah Adi Evan, Samuel I Gusti Agung Gede Putra Pemayun I Ketut Berata I Made Merdana i Nengah Wandia I NYOMAN MANTIK ASTAWA I Putu Cahyadi Putra, I Putu Cahyadi I Wayan Wirata Ida Bagus Kade Suardana Ida Bagus Oka Winaya Luh Made Sudimartini Marson, Fransiska Gratia Sonita Nainggolan, Willy Morris Nur Rusdiana Purbantoro, Steven Dwi Purwanti, Ni Luh Lasmi Purwitasari, Made Santi Putu Henrywaesa Sudipa Retno Lastuti, Nunuk Dyah Siti Aisyah Teja, Putu Tessa Hariys Septianda