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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Jurnal Kesehatan Melayu JBN (Jurnal Bedah Nasional) Acta Biochimica Indonesiana Health and Medical Journal Unri Conference Series: Community Engagement Bioscientia Medicina : Journal of Biomedicine and Translational Research JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit)
TB Odih Rhomdani Wahid
Universitas Riau
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Putative and pretreatment drug resistance mutations in reverse transcriptase gene among untreated chronic hepatitis B patients at Arifin Achmad Regional District Hospital, Riau, Indonesia Arfianti Arfianti; Fauzia Andrini Djojosugito; Maisaroh Maisaroh; Hendra Asputra; Dita Kartika Sari; Tubagus Odih Rhomdani Wahid
Acta Biochimica Indonesiana Vol. 5 No. 1 (2022): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.68

Abstract

Background: Mutations within the hepatitis B virus (HBV) reverse transcriptase (RT) gene have been associated with drug resistance against nucleos(t)ide analogs (NAs). Objective: This study aimed to identify mutations in the RT gene among patients with chronic hepatitis B (CHB) before receiving antiviral therapy and its relationship with the HBV genotypes. Methods: A total of 26 HBV DNA was extracted from the blood plasma of CHB patients. HBV RT gene was amplified and sequenced using the Sanger dideoxy sequencing method. The HBV genotype was determined through phylogenetic analysis using the Maximum Likelihood method. Results: The study subjects comprised 14 CHB patients without complications and 12 CHB patients with cirrhosis/hepatoma. CHB patients with cirrhosis/hepatoma were older than those without complications. The HBV genotypes comprised 15 (57.7%) genotype C and 11 (42.3%) genotype B. All treatment-naïve CHB patients did not demonstrate any classical NA resistance mutations within the RT gene. However, several putative and pretreatment resistance mutations, including F221Y, N238H, and V224I, were high frequency in more than 40% of study subjects. In addition, F221Y and N238H/Q mutations were frequently observed in genotype B, while V224 I was only found in patients infected with genotype C (p=0.000). Conclusions: There was no evidence of classical RT gene mutations associated with NA resistance in treatment-naïve patients with CHB. However, several putative and pretreatment mutations were identified as genotype-specific mutations and may contribute to antiviral resistance against NAs.
Penanaman Mangrove di Kawasan Ekoeduwisata Bandar Bakau Dumai Sebagai Upaya Pencegahan Masalah Kesehatan Febrian Syahputra; Timotius Agung Soripada; Tubagus Odih Rhomdani Wahid; Muhammad Faiz Adli; Annisa Salsabila Ramadhanti; Irviana Tri Adinda; Rabiatul Adawiyah; Reta Amelia Putri; Nabila Nabila; Citra Lestari Indarwati; Melinda Desvira; Zellina Shaqueela Aleem; Noor Zakiyah Khaifah; Darrel Vania Putri Vidi
Unri Conference Series: Community Engagement Vol 7 (2025): Seminar Nasional Pemberdayaan Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/unricsce.7.165-168

Abstract

Dumai City is located on the east coast of Sumatra, facing the Strait of Malacca. Dumai's coastal location puts it at risk of disasters such as tidal flooding. Tidal flooding is a phenomenon caused by sea tides exceeding normal levels, resulting in flooding. This disaster can be very detrimental because it causes infrastructure damage and can even lead to loss of life. Furthermore, this disaster can also significantly impact the health of coastal communities. One cause is dirty floodwater mixed with waste, which can have negative health effects, especially on skin health due to direct contact with polluted water. Some examples of problems that arise include itching, irritation, bacterial or fungal infections, and other skin diseases. Various efforts can be made to prevent this incident. One effort that can be done is to prevent tidal flooding by planting mangroves and educating coastal communities about various skin problems that arise from tidal flooding. Planting mangroves is one form of prevention against seawater overflowing onto land. Mangrove ecosystems are forests that grow in coastal areas with brackish or salty water. Mangroves have strong roots that extend into the mud, providing a remarkable natural defense against tidal flooding and coastal erosion. Therefore, actions such as planting mangrove seedlings in areas adjacent to the sea can be taken as a form of environmental awareness and to anticipate tidal flooding. Based on these issues, a community service activity was carried out, namely planting 12 mangrove seedlings as a form of effort to prevent skin diseases and tidal flooding.
Co-Authors Abdur Rahman Hamid Annisa Salsabila Ramadhanti Arfianti Arfianti Ari Alvaren Citra Lestari Indarwati Darrel Vania Putri Vidi Dedi Affandi Dita Kartika Sari Fauzia Andrini Febrian Syahputra Filza Rifqi Aufa Aslam Guntur Surya Alam Hendra Asputra Heru Ardila Putra Huriatul Masdar Indra Jaya Indrajaya Irviana Tri Adinda Ismar Ibrahim Ismar Ismar Laode Burhanuddin Laode Burhanuddin Mursa Lofina Mutia Dewi Maisaroh Maisaroh Melinda Desvira Mitra Mitra Muhammad Faiz Adli Nabila Nabila Noor Zakiyah Khaifah Putri Sari Rabiatul Adawiyah Reta Amelia Putri Rohadi Rohadi Salamullah Timotius Agung Soripada Valentino, Andrea Wahyu Jati Wibowo Wendy Desrullah Prada Widya Cahya Purnama Wiwit Ade Fidiawati Yolla Fitri Elmi Yuliaji Narendra Putra Zainal Abidin Zellina Shaqueela Aleem