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All Journal Folia Medica Indonesiana MAHESA : Malahayati Health Student Journal Jurnal Farmasi Indonesia
Widya, Reta Anggraeni
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Other

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Analysis of ANC Levels after Filgrastim Therapy in Acute Leukemia Children with Neutropenia Widya, Reta Anggraeni; Nugroho, Susanto; Winarsih, Sri; Yulistiani, Yulistiani
Folia Medica Indonesiana Vol. 55 No. 1 (2019): March
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (292.058 KB) | DOI: 10.20473/fmi.v55i1.24287

Abstract

Cytotoxic chemotherapy suppresses the hematopoietic system, and the most serious hematologic toxicity is neutropenia. This can decrease a risk of infection that causes delays in treatment and reduction of dose intensity, which reduces therapeutic outcome. Filgrastim is used to increase neutrophils level whose therapeutic effect is unknown. The effectiveness of filgrastim is based on the ANC level pre- and post-therapy. This study aimed to analyze the use of filgrastim on ANC level changes in acute leukemia children with neutropenia, and to analyze the patient that achieve ANC level's targeted therapy = 1000 cell/mm3. A prospective observational study with a longitudinal design was conducted from June to October 2016. The inclusion criteria of the study were patients who diagnosed acute leukemia with neutropenia and received filgrastim 10 µg/kgBW for 3, 4, 5 days. Patients' ANC levels were measured before and after filgrastim therapy. This study has been approved its ethical clearance by Dr. Saiful Anwar Hospital, Malang. Data were obtained on the basis of neutropenic episodes, followed by 7 episodes of obtaining filgrastim for 3 days, 1 episode of obtaining filgrastim for 4 days, and 7 episodes of obtaining filgrastim for 5 days. Thus, it consists of 15 episodes. In 3 days, ANC levels increased by 9.5 fold from 381.3 ± 91.8 cell/mm3 to 3984.9 ± 426.8 cell/mm3, but in 5 days, ANC levels decreased by 0.9 fold from 200.9 cell/mm3 ± 98.2 to 189.7 ± 14.2 cell/mm3. Filgrastim was able to increased the ANC levels around nine fold for 3 days of theraphy. There were 53% neutropenia patients who achieved the goal of therapy. Filgrastim therapy with dose 10 µg/kgBW for 3 to 5 days has been able to reach the therapeutic target of 53% in acute leukemia children with neutropenia. The increased levels of ANC maximum was reached on the third day with increased levels of 9.5 fold.
Analisis Persepsi Kemampuan Mahasiswa dengan Asesmen Mandiri dalam Pembelajaran Praktik Kerja Profesi Apoteker (PKPA) di Instalasi Farmasi RSUD Dr. Saiful Anwar Badriyah, Rani Nur; Puspitasari , Vicky; Widya, Reta Anggraeni
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.270

Abstract

Praktik Kerja Profesi Apoteker (PKPA) merupakan proses pembelajaran yang dirancang untuk membantu mahasiswa mengembangkan kemampuan dasar dalam pelayanan kefarmasian. Persepsi mahasiswa merupakan aspek penting yang perlu dipertimbangkan dalam pengembangan kurikulum PKPA di Instalasi Farmasi RSUD Dr. Saiful Anwar. Tujuan dari penelitian adalah untuk mengevaluasi kemampuan dasar mahasiswa dalam pelayanan kefarmasian selama proses PKPA. Persepsi mahasiswa dinilai melalui asesmen mandiri dengan menggunakan kuesioner yang terdiri dari 7 pertanyaan, yaitu mengenai kemampuan rekonsiliasi obat, analisis kesesuaian obat, analisis pemilihan obat, analisis Drug Related Problems (DRP), penyiapan obat, Komunikasi, Informasi, dan Edukasi (KIE), serta Pemantauan Terapi Obat (PTO) sebelum PKPA dimulai (Pre) dan setelah PKPA selesai (Post) pada 76 mahasiswa. Hasil asesmen mandiri memberikan hasil dalam kategori melebihi ekspektasi (86,2%), namun terdapat beberapa kemampuan yang menjadi prioritas utama untuk ditingkatkan, yaitu analisis kesesuaian obat dan KIE. Berdasarkan hasil ini, dapat disimpulkan bahwa mahasiswa memiliki persepsi positif terhadap kemampuan mereka dalam pelayanan kefarmasian secara keseluruhan, meskipun perlu dilakukan penilaian lebih lanjut untuk menguji kesesuaian antara persepsi dan kemampuan yang dimiliki oleh mahasiswa.
Implementasi Lean Hospital dalam Menurunkan Waktu Tunggu Obat Pasien Rawat Jalan Instalasi Farmasi RSUD Dr Saiful Anwar (RSSA) Jawa Timur Widyastuti, Indri; Widya, Reta Anggraeni; Hamidah, Rif'atul; Risnawati, Vina
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.343

Abstract

The minimum service standards (MSS) for drug service- waiting time (26,16%) has not been achieved and the low usage of free delivery services (RAOS SAE) led Pharmacy Department to improve the services with lean hospital management approach. This research aimed to shorten the drug service waiting time at JKN outpatient pharmacy unit with lean hospital management concept. This research was designed with Participation action research (PAR) approach. The data obtained through observations and interviews, analyzed by comparing the waiting time of prescription screening and drug service time with independent t-test comparison.  There were 4 wastes resolved out of 8 wastes that successfully identified, They were; flow of personnel and prescriptions which did not match the process (motion and transportation), The time for  prescriptions screening (waiting) is too long, and the officer could not do the job effectively because of the slowness of online system. (Non Uti talent). The result of implementation decreased the waiting time of prescription screening from 73 minutes to 61 minutes, and the mean of drug service waiting time decreased from 101 minutes to 63 minutes. Comparing the data before and after lean management application for prescription screening waiting time did not statistically different p>0,05 (p=0,057), this activity increased the usage of RAOS SAE, reducing the number of overtime officer at JKN outpatient pharmacy unit. The implementation of lean hospital management reduced drug service waiting time, even though unachieved the MSS yet. There were external factors that could not be controlled causing insignificant decreases. Several improvements need to be done to achieve the established standards.
Laporan Kasus: Keamanan Kombinasi Terapi Nimodipine dan Nicardipine pada Pasien Cerebrovascular Accident Subarachnoid Hemorrhage (CVA SAH) Hayati, Syafira Nur; Badriah, Rani Nur; Widya, Reta Anggraeni; Pratama, Jainuri Erik; Setiadi, Antonius Adji Prayitno; Herawati, Fauna; Gondokesumo, Marisca Evalina
MAHESA : Malahayati Health Student Journal Vol 4, No 10 (2024): Volume 4 Nomor 10 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i10.15815

Abstract

ABSTRACT Hemorrhage stroke is caused by injury due to acute extravasation of blood into the brain parenchyma from rupture of small cerebral blood vessels. One of the etiologies of hemorrhage stroke is hypertension. Hypertension is a disease in which the blood pressure value exceeds normal, namely if the systolic blood pressure value is ≥ 140mmHg and/or the diastolic blood pressure value is ≥ 90mmHg. Giving calcium channel blocker drugs has good benefits. This research is a descriptive case study, namely describing the problem of the safety of using a combination of Nimodipine and Nicardipine therapy in Cerebrovascular Accident Subarachnoid Hemorrhage (CVA SAH) patients. Below we present a case of hypertension in a 59 year old female patient who was admitted to hospital with complaints of decreased consciousness, a history of diabetes mellitus, and a history of hypertension. The patient received combination therapy of Nicardipine (drip) 5-15mg and Nimodipine PO 4x60mg. For five days the patient was treated in hospital with the administration of two anti-hypertension drugs from the same class, namely the calcium channel blocker class. It can be seen from the patient's blood pressure profile that the patient's blood pressure tends to be stable so it is safe not to cause hypotension side effects that are harmful to the patient. Keywords: Case Report, Hypertension, Nimodipine, Nicardipine  ABSTRAK Stroke hemorrhage atau stroke perdarahan disebabkan oleh cedera karena ekstravasasi darah akut ke dalam parenkim otak dari pecahnya pembuluh darah otak kecil. Salah satu etiologi dari munculnya stroke hemorrhage adalah kondisi hipertensi. Hipertensi merupakan penyakit yang mana nilai tekanan darah melebihi normal, yaitu apabila nilai tekanan darah sistolik ≥ 140mmHg dan/atau nilai tekanan darah diastolik ≥ 90mmHg. Pemberian obat golongan calcium channel blocker memiliki manfaat yang baik. Penelitian ini merupakan studi kasus deskriptif mendeskripsikan kasus dari keamanan penggunaan kombinasi terapi Nimodipine dan Nicardipine pada pasien Cerebrovascular Accident Subarachnoid Hemorrhage (CVA SAH). Berikut ini kami presentasikan sebuah kasus hipertensi pada pasien perempuan berusia 59 tahun yang masuk rumah sakit dengan keluhan penurunan kesadaran, riwayat penyakit diabetes mellitus, dan riwayat penyakit hipertensi. Pasien mendapat terapi kombinasi Nicardipine (drip) 5-15mg dan Nimodipine PO 4x60mg. Selama lima hari pasien dirawat di rumah sakit dengan pemberian dua obat anti hipertensi dari golongan yang sama yaitu golongan calcium channel blocker, maka dapat dilihat dari profil tekanan darah pasien bahwa tekanan darah pasien cenderung stabil sehingga aman tidak menyebabkan munculnya efek samping hipotensi yang membahayakan pasien. Kata Kunci: Motivasi, Gaya Kepemimpinan, Perilaku Perawat, Sampah Medis
Co-Authors Badriah, Rani Nur Badriyah, Rani Nur Hamidah, Rif'atul Hayati, Syafira Nur Herawati, Fauna Marisca Evalina Gondokesumo, Marisca Evalina Pratama, Jainuri Erik Puspitasari , Vicky Risnawati, Vina Setiadi, Antonius Adji Prayitno Sri Winarsih Susanto Nugroho Widyastuti, Indri Yulistiani Yulistiani, Yulistiani