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All Journal Indonesian Journal of Tropical and Infectious Disease Journal of Clinical Microbiology and Infectious Diseases
Aquaresta, Febriana
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Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Gastric Perforation Associated with Candidiasis and NSAIDS Aquaresta, Febriana; Kawilarang, Arthur Pohan; Endraswari, Pepy Dwi
Indonesian Journal of Tropical and Infectious Disease Vol. 8 No. 3 (2020)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v8i3.16084

Abstract

Invasive candidiasis is an important health-care-associated fungal infection. Candida is often described as an opportunistic pathogen. It is commensal flora in the gastrointestinal tract. Invasive candidiasis can happen usually because of a consequence of increased or abnormal colonization together with a local or generalized defect in host defenses. Candidiasis can occur in patients with HIV, therapy with a broad-spectrum antibiotic, transplant organ, and immunocompromised. Most cases of gastric perforation occur as complications of Peptic Ulcer Disease (PUD), Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and gastric neoplasms, but candidiasis as a cause of gastric perforation is very rare. This study aims to reveal the correlation between gastric perforation with candidiasis and NSAIDs. It was reported that a 57-year-old East Java Indonesian female presented with severe epigastric pain, generalized peritonitis, fever, nausea also vomiting and had a history of NSAIDs used for five years. The patient was taken to the general surgery of Dr. Sutomo Surabaya Hospital and performed exploratory laparotomy. A gastric perforation was discovered in the antrum. Microbiology culture examination from biopsy gastric tissue revealed an intense fungal growth from sabouraudagar medium and there is no other microorganism that grew in aerobic culture. Candida albicans was identified by VITEK® 2 COMPACT. Histopathological examination from biopsy gastric tissue was performed by Olympus CX-21 microscope, showed invasive Candida albicans consisting of numerous fungal yeasts and pseudohyphae invading and destroying the gastric wall. The patient was subsequently treated with fluconazole anti-fungal and discharge home after nine days postoperative period in good condition. From this result, we suggest using an antifungal treatment for patients who use NSAIDs for long periods to prevent candidiasis.
Screening of Legionella pneumophila from Well Water in Magetan Regency, Indonesia Hapsari, Nafisah Nurul; Kurniawan, Muhammad Ridho Hafid; Sucipto, Teguh Hari; Fajar, Nur Syamsiatul; Herupradopo, Eduardus Bimo Aksono; Fauziyah, Shifa; Widya, Alicia Margaretta; Aquaresta, Febriana; Sin War Naw
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 3 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i3.48755

Abstract

Legionellosis is a respiratory infection caused by Legionella pneumophila, a bacterium that can infect protozoa and human lung cells. The disease can be mild or severe, and sometimes fatal, especially in immunocompromised people. Some types of antibiotics that can be used to treat Legionella disease are macrolides such as rifampicin, azithromycin and clarithromycin, as well as fluoroquinolones such as levofloxacin and moxifloxacin. The aim was to investigate the distribution and prevalence of Legionella in well water. This study collected and tested water samples from a different well water in Magetan Regency, East Java, Indonesia using DNA extraction, two-step PCR methods, and visualization with 1.5% agarose gel in UV transluminator. The results were visualized with QGIS 3.28.6 and compared with other tests. The results showed that none of the eight water samples were contaminated with L. pneumophila compared with positive control (403 bp).
Molecular characteristics of the gyrA gene among rifampicin-resistant Mycobacterium tuberculosis isolates Aquaresta, Febriana; Kuntaman, Kuntaman; Dewi, Lisa; Syaiful, Irbasmantini
Journal of Clinical Microbiology and Infectious Diseases Vol. 5 No. 1 (2025): Available online : 1 June 2025
Publisher : Indonesian Society for Clinical Microbiology (Perhimpunan Dokter Spesialis Mikrobiologi Klinik Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jcmid.v5i1.96

Abstract

Background: Drug-resistant tuberculosis (TB) remains a public health threat, especially during this pandemic. Meanwhile, fluoroquinolone is used as a second-line multidrug-resistant TB (MDR-TB) treatment since this drug was previously prescribed for respiratory, urinary, and genital tract infections. However, unregulated and excessive use of fluoroquinolones leads to resistance. Methods: The design of this study is a descriptive observational study with a cross sectional approach. This study aims to determine the pattern of gyrA gene mutation in fluoroquinolone resistance among rifampicin-resistant Mycobacterium tuberculosis isolates during the COVID-19 pandemic in Sumatra, Indonesia. The Mycobacterium tuberculosis isolates were stored in the Palembang Health Center Laboratory as the referral laboratory in Sumatra from January to December 2020. Out of the 233 isolates that were tested phenotypically by BACTEC MGIT, 8 isolates of fluoroquinolone resistance (ofloxacin or moxifloxacin or both) were obtained and sequenced using an ABI PRISM 3730XL analyzer for Single Nucleotide Polymorphism analysis (SNP). Results: Among the six fluoroquinolone-resistant Mycobacterium tuberculosis isolates, the gyrA mutations were identified in 5/6 isolates (84%), A90V (34%), D94A (16%), and D94G (34%), while 1/6 isolates (16%) had no mutation in gyrA gene among Mycobacterium tuberculosis that were fluoroquinolone resistance. Conclusion: The gyrA gene mutation in fluoroquinolone resistance among rifampicin-resistant Mycobacterium tuberculosis was commonly present in codon 90 (2/6 isolates =32%) and 94 (3/6 isolates=68%).
Co-Authors Dewi, Lisa Hapsari, Nafisah Nurul Herupradopo, Eduardus Bimo Aksono kawilarang, Arthur pohan Kuntaman Kuntaman Kurniawan, Muhammad Ridho Hafid Nur Syamsiatul Fajar, Nur Syamsiatul Pepy Dwi Endraswari, Pepy Dwi Shifa Fauziyah Sin War Naw Syaiful, Irbasmantini Teguh Hari Sucipto, Teguh Hari Widya, Alicia Margaretta