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All Journal BIOTROPIA - The Southeast Asian Journal of Tropical Biology Global Medical and Health Communication

Arinta, Yukko

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Author-ID : 1789318

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Nursing Public Health Veterinary

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Articles

The Effect of Kerokan to Liver Function of Hepatitis B Patients Hanum, Nur Adiba; Ismalayani, Ismalayani; Juliansyah, Rahmad Aswin; Syokumawena, Syokumawena; Pastari, Marta; Kusuma, Hanna Sari Widya; Arinta, Yukko
Global Medical & Health Communication (GMHC) Vol 7, No 1 (2019)
Publisher : Universitas Islam Bandung

Kerokan is an alternative therapy done by rubbing and pressing the skin surface using oil and a blunt object. This treatment has a hepatoprotective effect as it increases heme oxygenase-1, an essential enzyme in heme catabolism. In hepatitis B, heme oxygenase-1 plays a vital role to fight oxidative stress. Hence the damage on liver cells can be reduced or even prevented. Damaged cells indicate by the production of aspartate aminotransferase (AST/SGOT) and alanine aminotransferase (ALT/SGPT) enzymes that accumulated in the bloodstream. This study aimed to investigate the effect of kerokan to liver function by analyzing SGOT and SGPT levels in hepatitis B patients. These were an experimental study with a pre-test post-test control group design conducted in the public health center in Palembang in October 2016. Statistical analysis used the unpaired t test and paired. The research subjects were 30 patients with inactive carrier and chronic hepatitis B. The levels of SGOT and SGPT were determined using the IFCC method. The levels of SGOT in control (19.53±3.44 U/L) and treatment group (20.46±4.53 U/L, Δ=0.93) after 24–48 hours were not statistically different (p=0.53). Also, the levels of SGPT in control (18.66±5.40 U/L) and treatment group (19.80±9.25 U/L, Δ=1.13) after 24–48 hours were also not statistically different (p=0.68) as well. In conclusion, the liver cells of inactive carrier and chronic hepatitis B patients were not damaged (necrosis) after kerokan therapy, and the levels of SGOT and SGPT were still in the normal range. EFEK KEROKAN TERHADAP FUNGSI HEPAR PASIEN HEPATITIS BKerokan merupakan terapi alternatif yang dilakukan dengan menggosok dan menekan permukaan kulit menggunakan minyak dan benda tumpul. Pengobatan ini bersifat hepatoprotektif, yaitu meningkatkan produksi enzim heme oxygenase-1 dalam katabolisme heme. Pada hepatitis B, heme oxygenase-1 berperan penting dalam menangkal radikal bebas sehingga dapat mengurangi atau mencegah kerusakan sel hepar. Kerusakan sel hepar diindikasikan oleh produksi enzim aspartate aminotransferase (AST/SGOT) dan alanine aminotransferase (ALT/SGPT) yang terakumulasi dalam pembuluh darah. Penelitian ini bertujuan mengetahui pengaruh kerokan pada fungsi hepar dengan menganalisis kadar SGOT dan SGPT pada pasien hepatitis B. Penelitian eksperimental ini menggunakan desain pre-test post-test control group yang dilakukan di puskesmas di Palembang pada Oktober 2016. Analisis statistik menggunakan uji t berpasangan dan tidak berpasangan. Subjek penelitian meliputi 30 pasien inactive carrier dan kronik hepatitis B. Kadar SGOT dan SGPT diukur dengan menggunakan metode IFCC. Kadar SGOT pada kontrol (19,53±3,44 U/L) dan grup perlakuan (20,46±4,53 U/L; Δ=0,93) setelah 24–48 jam tidak terdapat perbedaan signifikan (p=0,53). Selain itu, kadar SGPT pada kontrol (18,66±5,40 U/L) dan grup perlakuan (19,80±9,25 U/L; Δ=1,13) setelah 24–48 jam tidak menunjukkan perbedaan signifikan (p=0,68). Simpulan, sel hepar pada pasien inactive carrier dan kronik hepatitis B tidak mengalami kerusakan setelah terapi kerokan, serta kadar SGOT dan SGPT tetap dalam kondisi normal.

Regulation of Adipogenesis and Key Adipogenic Gene Expression by Mangosteen Pericarp Extract and Xanthones in 3T3-L1 Cells Widowati, Wahyu; Darsono, Lusiana; Suherman, Jo; Afifah, Ervi; Rizal, Rizal; Arinta, Yukko; Mozef, Tjandrawati; Suciati, Tri
BIOTROPIA Vol. 27 No. 1 (2020): BIOTROPIA Vol. 27 No. 1 April 2020
Publisher : SEAMEO BIOTROP

Obesity is one of the risk factors for atherosclerosis, and its occurrence and development are associated with fat accumulation and adipocyte differentiation. Thus, the suppression of adipocyte differentiation can be a potential anti-obesity approach. This study examined the effect of mangosteen pericarp extract (MPE) and xanthones (α-Mangostin (AM) and γ-Mangostin (GM)) on the expression of PPARγ, C/EBPα, SCD1, LPL, aP2, adipoQ, and FAS in 3T3-L1 cells. Concentrations of MPE and xanthones used were based on cytotoxicity assays on 3T3-L1 cells. Three different MPE concentrations (0, 25, and 50 µg/mL), three AM concentrations (0, 25, and 50 µM), and GM concentrations (0, 50, and 75 µM) were used. The expressions of PPARγ, C/EBPα, SCD1, LPL, aP2, adipoQ, and FAS genes were measured using real-time quantitative PCR. Gene expression was downregulated in cells treated with 50 µg/mL MPE and 50 µM GM. However, 25 µM and 50 µM AM did not suppress PPARγ and SCD1 expression. The 50 µM AM treatment also failed to reduce aP2 gene expression. Overall, MPE and GM demonstrated potential anti-adipogenesis and anti-obesity effects by suppressing the expression of PPARγ, C/EBPα, SCD1, LPL, aP2, adipoQ, and FAS in 3T3-L1 cells.

Co-Authors Afifah, Ervi Hanna Sari Widya Kusuma, Hanna Sari Widya Hanum, Nur Adiba Ismalayani, Ismalayani Jo Suherman Lusiana Darsono Pastari, Marta Rahmad Aswin Juliansyah, Rahmad Aswin Rizal Rizal Syokumawena, Syokumawena Tjandrawati Mozef Tri Suciati WAHYU WIDOWATI

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