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Analisis Efektivitas Terapi dan Biaya antara Haloperidol Kombinasi dengan Risperidon Kombinasi pada Terapi Skizofrenia Fase Akut Ranti, Imaniar; Octaviany, Andi Fauziyar; Kinanti, Sekar
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2015)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v15i1.2495

Skizofrenia merupakan gangguan jiwa berat dengan perjalanan penyakit terdiri dari fase akut, fase stabilisasi dan fase stabil. Pemilihan terapi yang tepat pada fase akut akan mempengaruhi prognosis pasien. Penggunaan antipsikotik haloperidol dan risperidon saat ini menjadi pilihan untuk terapi farmakologi skizofrenia. Penelitian ini dilakukan untuk mengkaji efektivitas terapi dan biaya antara haloperidol kombinasi dengan risperidon kombinasi pada terapi skizofrenia fase akut. Penelitian ini merupakan penelitian observasional dengan desain pretest-posttest, non randomised, prospective, dan open label. Total sampel 40 pasien skizofrenia fase akut di RSJ. Ghrasia Yogyakarta yang memenuhi kriteria inklusi dan eksklusi. Analisis efektivitas terapi menggunakan nilai PANSS-EC dan analisis efektivitas biaya menggunakan diagram efektivitas biaya. Hasil penelitian nilai PANSS-EC post-terapi pada uji statistik Mann-Whitney antara kedua kelompok didapatkan nilai p=0.711 yang bearti tidak terdapat perbedaan efektivitas terapi secara statistik. Hasil analisis biaya rata-rata yang dibutuhkan pasien pada kelompok haloperidol kombinasi adalah Rp 11.186,95 Â± Rp 1.163,970, sedangkan kelompok risperidon kombinasi adalah Rp 31.191,40 Â± Rp 8.545,114 yang dengan uji statistik Mann-Whitney didapatkan nilai p=0.010 yang bearti haloperidol kombinasi lebih cost-effective dibanding risperidon kombinasi. Disimpulkan bahwa efektivitas terapi kombinasi haloperidol kombinasi sama dengan risperidon kombinasi, tetapi terapi haloperidol kombinasi lebih cost-effective dibanding risperidon kombinasi.Schizophrenia is a severe mental disorder that consists of three phase, there are acute phase, stabilization phase and stable phase. Selection of appropriate therapy in the acute phase will affect the patient's prognosis. The use of antipsychotic haloperidol and risperidone is a choice for pharmacological treatment of schizophrenia now. This study was conducted to assess the therapeutic and cost effectiveness between haloperidol combination with risperidone combination therapy of acute-phase schizophrenia. This study was an observational study with a pretest-posttest design, non-randomized, prospective, and open label. Total sample is 40 acute phase schizophrenia patients in the Ghrasia Psychiatric Hospital Yogyakarta, who meet inclusion and exclusion criteria. Analysis of therapeutic effectiveness using the PANSS-EC instrument and cost-effectiveness analysis using diagrams of cost effectiveness. The result of therapeutic effectiveness analysis were no statistically significant differences in PANSS-EC score post-treatment between two groups (p value = 0.711). The results of the cost-effectiveness analysis of the average cost in the haloperidol combination is Rp 11.186,95 Â± Rp 1.163,970, while the risperidone combination is Rp 31.191,40 Â± Rp 8.545,114. Based on the Mann-Whitney test (p value = 0.010 ), itâ€™s mean significant difference between the cost of Haloperidol combination therapy and Risperidone combination therapy. Concluded that the therapeutic effectiveness of haloperidol combination with risperidone combination is same, but the combination of haloperidol therapy is more cost-effective than risperidone combination.

PENGARUH KOMBINASI VITAMIN ORAL B1, B6 DAN B12 TERHADAP WAKTU REAKSI PADA SUBJEK DEWASA MUDA YANG SEHAT: STUDI ACAK TERKENDALI Ranti, Imaniar; Jenie, Ikhlas Muhammad
Biomedika Vol 13, No 1 (2021): Biomedika Februari 2021
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v13i1.9883

ABSTRAKWaktu reaksi adalah waktu yang diperlukan oleh mahluk hidup untuk berespon secara sengaja terhadap stimulus yang diberikan. Waktu reaksi ini mampu menunjukkan kemampuan koordinasi sistem saraf motorik dan sensorik.Â Waktu reaksi akan menurun saat terjadi penurunan fungsi sistem saraf. Salah satu vitamin yang dapat menjaga fungsi saraf adalahÂ kombinasi vitamin oral B1, B6 dan B12. Penelitian ini bertujuan untuk mengkaji efek pemberian vitamin oral B1, B6, dan B12 terhadap waktu reaksi. Desain penelitian menggunakan uji acak terkendali double blind.Â Subyek sebanyak 20 orang laki-laki dan perempuan usia 18-20 tahun, yang terbagi secara acak 10 orang sebagai kelompok intervensi dan 10 orang sebagai kelompok kontrol.Â Kombinasi vitamin oral B1 100 mg, B6 200 mg dan B12 200 mcg diberikan dalam bentuk kapsul dan diminum satu kali sehari selama 14 hari.Â Subyek kelompok kontrol diberi kapsul yang berisi amylum lactose sebagai plasebo.Â Pada hari ke-14, dilakukan pengukuran waktu reaksi sederhana dan waktu reaksi pilihan menggunakan alat pengukur kecepatan respon.Â Hasil penelitian ini menunjukkan bahwa tidak ada perbedaan bermakna waktu reaksi sederhana dan waktu reaksi pilihan antara kelompok intervensi dan kelompok kontrol.Â Akan tetapi, pada sub analisis berdasarkan gender, subyek perempuan kelompok intervensi mempunyai waktu reaksi pilihan yang lebih cepat dibandingkan kontrol. Kata Kunci: Waktu Reaksi, Kombinasi Vitamin Oral B1, B6, B12, Uji Acak TerkendaliABSTRACTReaction time is the time it takes for organisme to respond the given stimulus voluntarily. This reaction time is a good indicator of sensorimotor nervous system coordination. The reaction time will decrease when there is a decrease in nervous system function. One of the vitamins that can maintain nerve function is an combination of oral vitamins B1, B6 and B12. This study aimed to examine the effect of oral vitamins B1, B6, and B12 on reaction time. The study design used a double blind randomized controlled trial. Subjects were 20 men and women aged 18-20 years, which were randomly divided 10 people as the intervention group and 10 people as the control group. The combination of oral vitamins B1 100 mg, B6 200 mg and B12 200 mcg were given in capsule form and taken once a day for 14 days. The control group subjects were given a capsule containing amylum lactose as a placebo. On day 14th, a simple and selected reaction time was measured using a response velocity measuring device. The results of this study indicate that there were no significant difference in simple and selected reaction time between the intervention group and the control group. In a further analysis stratified by gender, female subjects in the intervention group had a faster selected reaction time than controls.Â Â Keywords: Reaction Time, Oral Vitamin B1, B6, B12, Randomized Controlled Trial

Education on Legality, Quality Assurance and Sustainability of 'Jamu Jogorogo' Production in Empowering Women Farming Groups Wicaksono, Arko Jatmiko; Wahyuningsih, Mae Sri Hartati; Syarif, Rul Afiyah; Padmawati, Retna Siwi; Lestari, Beni; Ranti, Imaniar
Media Karya Kesehatan Vol 7, No 2 (2024): Media Karya Kesehatan
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mkk.v7i2.58490

Production of ‘Jamu Jogorogo’ herbal medicine product by the Group of Women Farmers (KWT Singosaren), in Kab. Bantul, Yogyakarta is stagnant after receiving a Dana Keistimewaan Provinsi (Yogyakarta Province’s Special Fund), and has passed a halal certificate. Based on the Ishikawa fishbone analysis, basic knowledge of legal aspects, quality, and marketing strategy. This study was designed to evaluate the effectiveness of an educational strategy applied to the members of KWT Singosaren. This strategy was implemented through a ‘one-day training’ that began with a Pretest, Post-test I, and Post-test II. A total of 80 members of KWT Singosaren were involved in this training, and 59 met the eligible criteria. A Pretest was conducted before the training to get the initial. After the training, participants worked on the Post-test I. Before leaving the training location, all participants were given a pocketbook containing training material for self-learning. Two weeks (14 days) later, they were asked to take the Post-test II, so the participant’s final knowledge could be investigated. As a result, it was found that there is a rising knowledge of 113.56 % and 71.96 % regarding the understanding of ‘quality’ and ‘legality’, respectively. Interestingly, the marketing strategy (product appeal) and sustainable production knowledge rose by 15.25%. Even so, after Post-test II an increase in scores still occurred. This indicates that participants successfully conducted the self-learning process. Post actualization period, we found that the SPP-IRT permits (legal permits for food production for the Home Industry) of 3 (three) herbal products were successfully issued. Keywords: Empowerment, women, effectiveness, knowledge, training.

Ethnomedicine Study on Medicinal Plants in Nanggulan District, Kulon Progo Regency Kintoko, Kintoko; Saputri, Ginanjar Zukhruf; Novitasari, Putri Rachma; Desmayanti, Astri; Witasari, Hardi Astuti; Ranti, Imaniar; Yulianto, Yulianto; Febriansah, Rifki; Widyaningrum, Rachmawati; Utami, Febri; Setiyawati, Fitri Indah
Journal of Food and Pharmaceutical Sciences Vol 13, No 1 (2025): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.14189

Despite the advancements in conventional medicine, medicinal plants continue to play an important role in treating different human ailments, particularly in developing nations. This is based on locals' knowledge of medicinal plants for treating various ailments. Ethnomedicine is a branch of research investigating society's local wisdom for maintaining its health. According to diverse field studies, 40 different varieties of plants have been discovered that the native inhabitants of Kulon Progo Regency think are medicinal. The purpose of this research was to identify therapeutic herbs used by the Kulon Progo population. Traditional healers and members of the Kulon Progo village were interviewed as part of this study. The ethnomedicine data was analyzed using Use Value (UV), Frequency of Citation (FC), and Plant Part Value (PPV). The analytical results suggest that turmeric (0.78), galangal (0.67), and ginger (0.67) are the most important plants to society. Rhizomes (38.10%) and leaves (34.52) are the most commonly employed plant parts for medicinal purposes. Boiling it (47.06%) produces herbal medication from the plant extract.

Ethnomedicine Study on Medicinal Plants in Nanggulan District, Kulon Progo Regency Kintoko, Kintoko; Saputri, Ginanjar Zukhruf; Novitasari, Putri Rachma; Desmayanti, Astri; Witasari, Hardi Astuti; Ranti, Imaniar; Yulianto, Yulianto; Febriansah, Rifki; Widyaningrum, Rachmawati; Utami, Febri; Setiyawati, Fitri Indah
Journal of Food and Pharmaceutical Sciences Vol 13, No 1 (2025): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.14189

Despite the advancements in conventional medicine, medicinal plants continue to play an important role in treating different human ailments, particularly in developing nations. This is based on locals' knowledge of medicinal plants for treating various ailments. Ethnomedicine is a branch of research investigating society's local wisdom for maintaining its health. According to diverse field studies, 40 different varieties of plants have been discovered that the native inhabitants of Kulon Progo Regency think are medicinal. The purpose of this research was to identify therapeutic herbs used by the Kulon Progo population. Traditional healers and members of the Kulon Progo village were interviewed as part of this study. The ethnomedicine data was analyzed using Use Value (UV), Frequency of Citation (FC), and Plant Part Value (PPV). The analytical results suggest that turmeric (0.78), galangal (0.67), and ginger (0.67) are the most important plants to society. Rhizomes (38.10%) and leaves (34.52) are the most commonly employed plant parts for medicinal purposes. Boiling it (47.06%) produces herbal medication from the plant extract.

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