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All Journal CHEMPUBLISH JOURNAL Science and Technology Indonesia Jurnal PAJAR (Pendidikan dan Pengajaran) Pendas : Jurnah Ilmiah Pendidikan Dasar Jurnal Penelitian Fisika dan Terapannya (JUPITER) Public Health and Safety International Journal (PHASIJ) Journal of Biobased Chemicals (JOBC) Kemas Journal:Jurnal Pengabdian masyarakat Journal of Media and Learning Technology
Atina
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Manufacture of Nanofibers for Wound Dressing Applications from Sea Cucumber and Curcuma longa, Turmeric sp. Rahmawati; Wida Fatma Sari; Atina; Parmin Lumban Toruan
JOBC Vol. 5 No. 1 (2025): Journal of Biobased Chemicals
Publisher : University of Jember

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Abstract

The skin is the topmost layer that safeguards the body and can be vulnerable to injuries, such as cuts. Turmeric and sea cucumber are recognized for their effectiveness in healing wounds. The research used natural polymers such as turmeric and sea cucumber, while the synthetic polymer used was polyvinyl alcohol (PVA). Electrospinning equipment is used to produce the nanofibres. The variables investigated in this study were the concentrations of PVA, turmeric, and sea cucumber. Gamat and curcuma are proven to accelerate wound healing, but no literature explains whether they are compatible with PVA in making nanofibres. The nanofibres were analysed using scanning electron microscopy (SEM). The most optimal nanofiber composition for wound dressing applications is PVA with a concentration of 12%, turmeric 2%, and curcuma 0.5%.
Bioactive Metabolites in Melaleuca leucadendra Leaves Extract: Phytochemical Profilling and GC-MS Characterization for Antimicrobial Relevance Atina; Royani, Idha; Assaidah; Setiabudidaya, Dedi; Miksusanti, Miksusanti; Arsyad, Fitri Suryani
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal (January - June)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v10i1.49078

Abstract

The global escalation of antimicrobial resistance (AMR) necessitates the exploration of natural sources of antibacterial agents. This study examined the ethanolic leaf extract of Melaleuca leucadendra's phytochemical composition, chemical profile, and antibacterial activity. Alkaloids, flavonoids, saponins, tannins, phenolics, terpenoids, and steroids were all detected by phytochemical screening. The quantitative total flavonoid content (TFC) of the extract was 17.78 mg QE/g, while the total phenolic content (TPC) was 292.43 mg GAE/g extract. Gas Chromatography–Mass Spectrometry (GC–MS) analysis identified oxygenated esters (18.86%), oxygenated aromatics (15.22%), phenolic derivatives (13.44%), and flavonoids (12.86%), methoxylated aromatics and terpenoids (5.34%), phytol, and fatty acid derivatives. These metabolite classes are widely reported to exert antibacterial effects through multiple mechanisms such as membrane disruption, enzyme inactivation, and inhibition of nucleic acid synthesis. Antibacterial testing against Staphylococcus aureus and Escherichia coli using the agar diffusion method showed a concentration-dependent response, with the highest activity at 80% extract (15.67 ± 0.58 mm and 15.33 ± 0.58 mm inhibition zones, respectively). Raman spectroscopy confirmed the interaction between polymer molecules and secondary metabolite compounds in the extract, thereby potentially enhancing antibacterial properties. These findings highlight that the antibacterial activity of M. leucadendra is mediated by the synergistic interplay of phenolics, flavonoids, methoxylated aromatics, terpenoids, and fatty acids. The findings offer compelling proof that M. leucadendra is a viable natural source for the creation of antibacterial compounds that will lessen antibiotic resistance.
Co-Authors Ananda, Lutfiah Ananda Andi Arif Setiawan Arsyad, Fitri Suryani Assa'idah Assaidah Dayun Riadi Dedi Setiabudidaya eka novitasari Fatma Sari, Wida Idha Royani Joni Iswan Lumban Toruan, Parmin Mardi Fadillah Miksusanti Miksusanti Muhammaf Iqbal Fahlevi Parmin Lumban Toruan Perry Boy Chandra Siahaan QOLBI KHOIRI Rahman, Dui Yanto Rahmawati Sefti Triani Siti Imroatul Latifah Sulistyowati, Rita Suradi, Ahmad Wida Fatma Sari Widyaningsih, Fitria Yanto Rahman, Dui Zakiyuddin