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Hilma, Hilma
Sekolah Tinggi Ilmu Farmasi Bhakti Pertiwi
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Biosynthesis, Characterization of Curcumin-Capped Zno-Cuo and Chitosan-Curcumin-Capped Zno-Cuo based Nanomaterial as Antibacterial Agent of Escherichia coli Fatoni, Ahmad; Umli, Afnita Fatmawati; Sriwijaya, Reza Agung; Hilma, Hilma; Hidayati, Nurlisa
Chimica et Natura Acta Vol 13, No 3 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n3.62946

Abstract

The biofabrication of the chitosan-curcumin-capped ZnO-CuO and curcumin-capped ZnO-CuO nanoparticles, as well as their ability to combat Escherichia coli bacteria, were the focus of this study. Fourier-Transform Infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and Scanning Electron Microscopy (SEM) were used to examine the chitosan-curcumin-capped ZnO-CuO and curcumin-capped ZnO-CuO nanoparticles, respectively. Both were evaluated using the agar diffusion method as antibacterials against Escherichia coli. Results of analysis with FTIR, between 500 and 700 cm⁻¹, the functional group of Cu-O or Zn-O was seen at its highest point. The functional group of Cu-O and Zn-O in curcumin-capped ZnO-CuO was detected at wavenumber of 621 cm⁻¹ and 507 cm⁻¹, respectively. In chitosan-curcumin-capped ZnO-CuO, the wave numbers of the Cu-O and Zn-O groups were observed at 619 and 653 cm-1 respectively.  According to XRD analysis results, the chitosan-curcumin-capped ZnO-CuO and curcumin-capped ZnO-CuO nanoparticles' crystalline shapes are demonstrated by their respective crystallite sizes of 12.58 and 1.88 nm. Based on the results of analysis with SEM, curcumin-capped ZnO-CuO and chitosan-curcumin-capped ZnO-CuO nanoparticles have a dense surface structure. The average diameter of inhibition zone (clear zone) produced by chit-cur-ZnO-CuO nanoparticles is 14.61 mm, while the clear zone produced by cur-ZnO-CuO nanoparticles is 9.52 mm. Chit-cur-ZnO-CuO has superior antibacterial qualities to cur-ZnO-CuO nanoparticles.
Co-Authors Ade Arinia Rasyad Ahmad Fatoni David Darwis Dwi Puspita Sari Egata, Neisa Ensiwi Munarsih, Ensiwi Herlina Herlina J, Tri Kurnia Rahayu. Lasmaryna Sirumapea Martha, Septiani Mauizatul Hasanah Mauizatul Hasanah, Mauizatul Mellinda, Mellinda Nadiyah Atikah Della Putri Nilda Lely Novriyanti, Selly Nurlisa Hidayati Nurlisa Hidayati Ratu Handayani Romsiah Romsiah Sambe Indryasari Selly Novriyanti Sriwijaya, Reza Agung Umli, Afnita Fatmawati