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All Journal Jurnal Farmasi Sains dan Komunitas Molecular and Cellular Biomedical Sciences (MCBS) SULUH ABDI : Jurnal Ilmiah Pengabdian Kepada Masyarakat Holistik Jurnal Kesehatan
Wulandari, Febri
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Exposure of Histone Deacetylase-2 Inhibitor Curcumin and Its Analogues in Self-Nano Emulsifying Drug Delivery System Change Memory and Cognitive Function, Anxiety, and Social Interaction Behavior in Mouse Yuniarti, Nunung; Wulandari, Febri; Azizah, Ulfah Laily; Anas, Yance; Murwanti, Retno
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009660

Abstract

Class 1 and 2 histone deacetylase inhibitors (HDACI) have been reported as novel therapeutic approaches to treat neurodegenerative disorders, depression, anxiety, and cognitive deficits. HDACI ameliorated deficits in cognition and stress-related behaviors in a wide range of neurologic and psychiatric disorders. Preclinically, behavioral bioassay can be used to predict the influence of new compounds for treatment of these illnesses. Curcumin and its new analogues PGV-0 and PGV-1 have been reported to inhibit HDAC2. However, reports regarding the effect of curcumin and its analogues on memory and cognitive function, anxiety, and social interaction behavior are as yet to be examined. Mice were divided into control and treated groups. Brain disorder was induced by oral administration of 10% ethanol in sodium-CMC for 7 days. Curcumin, PGV-0, PGV-1, and sodium butyrate (as positive control) were then given orally once a day for 21 days. The behavior tests of social interaction, open field, radial 8-arm-maze, and passive avoidance were performed on day 29. To increase dissolution and bioavailability of the compounds, they were formulated in a self-nano emulsifying drug delivery system (SNEDDS). Brains were isolated and analyzed using PCR to investigate the expression of genes related to neurobehavioral disorders hdac2, trkB, and bdnf. In different doses, curcumin, PGV-0, and PGV-1 increased social interaction capability, declined anxiety level, and improved long-term memory and cognitive function. The mechanism proposed is: HDACI curcumin and its analogues (PGV-0 and PGV-1) that keep the histone protein in acetylation state increase bdnf expression. The increased trkB expression is increasing the activation of the bdnf gene because trkB is the primary receptor of bdnf that supports the survival of existing neurons and encourages the growth and differentiation of new neurons and synapses. Thus, those mechanisms could improve long-term memory and cognitive function, increase social interaction, and reduce anxiety in ethanol-induced mice with brain disorders.
Pengolahan Sampah Rumah Tangga Dengan Menerapkan Prinsip 3R (Reduce , Reuse, Recycle) Kepada Masyarakat Maftukhah, Nur Afni; Wulandari, Asputri; Wulandari, Febri; Al Falif, Rifqoh; Dwi Eka Paksi, Kartika; Ananda, Dea; Purnama Putri, Aguilira; S, Herlisa; -, Sendagia; Aprilia Putri, Cindy; Ali, RM Farhan
Suluh Abdi Vol 7, No 1 (2025): SULUH ABDI
Publisher : Universitas Muhammadiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sa.v7i1.9460

Abstract

Waste processing using the waste burning method can have an impact on air pollution and health, waste processing using 3R (Reduce, Reuse, Recycle) can be an effort to reduce waste by reusing, reducing, recycling waste so that it has added value and also reduces waste in the community. The methods used are questionnaires and counseling. The results obtained were that many people had a poor level of knowledge about burning waste.
1’- Acetoxychavicol acetate Suppresses Osteosarcoma Cell Proliferation through the PI3K Pathway: A Molecular Docking and Cytotoxicity Study Safitri, Putri Gita Ayu; Da’i, Muhammad; Wulandari, Febri
Molecular and Cellular Biomedical Sciences Vol 9, No 2 (2025)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v9i2.640

Abstract

Background: This study aims to investigate anticancer properties of 1'-Acetoxychavicol acetate (ACA), a phenylpropanoid substance obtained from the rhizomes of the Alpinia genus, which has been extensively studied. However research on its cytotoxic effects, particularly against osteosarcoma cells, has never been donenot been conducted. The purpose of the research is to investigate the anticancer potential of ACA to support the its development as a novel therapeutic candidate.Materials and methods: This study assessed ACA’s initial anticancer potential through in vitro cytotoxic tests on normal human osteoblast cells (hFOB) and osteosarcoma cells (MG-63) using the MTT assay. Additionally, bioinformatics analyses, including target prediction, gene ontology, hub gene identification, protein-protein interactions (PPI) network construction, Kyoto encyclopedia of genes and genomes (KEGG) pathways analysis, disease association analysis, and molecular docking, were performed. Results: The cytotoxicity test on normal hFOB showed an IC50 of 45.05 µM, while in MG-63 osteosarcoma cells, the IC50 was 20.41 µM. In the bioinformatics test, top five target genes identified were SRC, GNAI1, PIK3CD, PIK3CB, PIK3R3. Molecular docking analysis showed that, the native PI3KD ligand showed a strong binding affinity of -10.99 kcal/mol and interacted with more amino acid residues.Conclusion: Overall, ACA exhibits promise as a treatment option to inhibit osteosarcoma cell proliferation by targeting the PI3K pathway. To develop ACA as a potential osteosarcoma therapeutic candidate, extensive in vitro research is needed.   Keywords: 1-Acetoxychavicol acetate, bioinformatics, cytotoxicity, osteosarcoma, PI3K pathway
Triple herbal therapy geriatri terhadap penurunan kecemasan dan tekanan darah dalam pencegahan kegawatdaruratan kardiovaskuler Fadlilah, Maya; Wulandari, Febri
Holistik Jurnal Kesehatan Vol. 19 No. 7 (2025): Volume 19 Nomor 7
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v19i7.1259

Abstract

Background: The urgency of this research is evident in the fact that cardiovascular problems are a leading cause of death in the elderly (geriatric) population. Risk factors for common degenerative and non-communicable diseases, such as hypertension, are common in the community. Hypertension can trigger bodily responses that result in physical symptoms such as heart palpitations, dizziness, and muscle tension. These symptoms can trigger or exacerbate existing anxiety, contributing to an increase in cardiovascular emergencies, such as heart attacks and strokes, and even becoming a leading cause of death worldwide. Pharmacological interventions to address hypertension and anxiety include the use of medications. Purpose: To analyze the effect of three herbal therapies for geriatrics in reducing anxiety and blood pressure in preventing cardiovascular emergencies. Method: This study was a pre-experimental study with a quasi-experimental design: pretest-posttest with multiple groups. The sample for each intervention consisted of 15 participants, who received the intervention in the morning and evening for one week. The analyses used were univariate and bivariate, including the Wilcoxon test to compare two paired data groups, the Kruskall-Wallis test to compare more than two independent groups, and a post hoc test to determine which pairs of groups differed significantly. Results: The post hoc test showed that the combination of bay leaves and soursop leaves had a statistically significant difference in reducing anxiety levels (p = 0.036). Conclusion: There was a significant difference between three geriatric herbal therapies: bay leaf (Syzygium polyanthum) decoction, moringa (Moringa oleifera) leaf decoction, and soursop (Annona muricata L.) leaf decoction in reducing anxiety and blood pressure in the prevention of cardiovascular emergencies. Of the three herbal decoctions, soursop leaf decoction was more effective in reducing anxiety levels than bay leaf decoction. Suggestion: Future researchers are advised to consider other factors that may influence blood pressure and anxiety levels.   Keywords: Anxiety; Blood Pressure; Geriatrics; Herbal Therapy.   Pendahuluan: Urgensi dari penelitian ini dilihat bahwa masalah kardiovaskuler menjadi penyebab utama kematian pada populasi lanjut usia (geriatri). Faktor risiko penyakit degeneratif dan penyakit tidak menular yang umum dimasyarakat seperti hipertensi. Hipertensi dapat memicu respons tubuh yang mengakibatkan gejala fisik seperti jantung berdebar (palpitasi), pusing, dan ketegangan otot, gejala-gejala ini dapat memicu perasaan cemas atau memperburuk kecemasan yang sudah ada hal ini dapat berkontribusi terhadap peningkatan kejadian kegawatdaruratan kardiovaskuler, seperti serangan jantung dan stroke dan bahkan ini penyebab utama kematian di dunia. Intervensi yang dapat dilakukan dalam mengatasi hipertensi dan kecemasan dapat dilakukan secara farmakologi dengan menggunakan obat-obatan. Tujuan: Untuk menganalisis triple herbal therapy geriatri terhadap penurunan kecemasan dan tekanan darah dalam pencegahan kegawatdaruratan kardiovaskuler. Metode: Jenis penelitian ini pra eksperimen dengan Quasi-experimental design: pretest-posttest with multiple groups. Sampel dari masing-masing intervensi adalah 15 partisipan yang diberikan intervensi  pada pagi dan sore hari selama satu minggu. Analisis yang digunakan adalah univariat dan bivariate yakni uji wilcoxon untuk membandingkan dua kelompok data berpasangan, uji kruskall Wallis untuk membandingkan lebih dari dua kelompok independen, uji post hoc untuk mengetahui pasangan mana dari kelompok-kelompok yang berbeda secara signifikan. Hasil: Berdasarkan uji post hoc, menunjukkan bahwa pasangan daun salam vs daun sirsak memiliki perbedaan yang signifikan secara statistik dalam penurunan tingkat kecemasan (p = 0.036). Simpulan: Terdapat perbedaan yang signifikan triple herbal terapi geriatric. air rebusan daun salam (syzygium polyanthum), air rebusan daun kelor (moringa oleifera) serta air rebusan daun sirsak (annona muricata l) terhadap penurunan kecemasan dan tekanan darah dalam pencegahan kegawatdaruratan kardiovaskuler serta dari ketiga rebusan herbal, intervensi rebusan daun sirsak lebih effektif memberikan efek yang lebih besar dalam menurunkan tingkat kecemasan dibandingkan dengan daun salam. Saran: Peneliti di masa depan disarankan untuk mempertimbangkan faktor-faktor lain yang dapat memengaruhi tekanan darah dan tingkat kecemasan.   Kata Kunci: Geriatri; Kecemasan; Tekanan Darah; Terapi Herbal.
Co-Authors -, Sendagia Al Falif, Rifqoh Ali, RM Farhan Ananda, Dea Aprilia Putri, Cindy Azizah, Ulfah Laily Da’i, Muhammad Dwi Eka Paksi, Kartika Maftukhah, Nur Afni Maya Fadlilah Nunung Yuniarti Purnama Putri, Aguilira Retno Murwanti S, Herlisa Safitri, Putri Gita Ayu Wulandari, Asputri Yance Anas