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All Journal JOURNAL TEKNIK SIPIL DAN INFRASTRUKTUR REKA GEOMATIKA Cannarium (Jurnal Ilmu-ilmu Pertanian) JURNAL PENELITIAN SAINTIKA Jurnal Medik Veteriner Jurnal Akta Yudisia Jurnal Kacapuri : Jurnal Keilmuan Teknik Sipil Journal of Pharmaceutical and Health Research JOURNAL LA MEDIHEALTICO Interaksi Peradaban: Jurnal Komunikasi dan Penyiaran Islam Prosperity: Journal of Society and Empowerment JIFI (Jurnal Ilmiah Farmasi Imelda) Al-MIKRAJ: Jurnal studi Islam dan Humaniora International Journal of Public Health Excellence (IJPHE) Indonesian Research Journal on Education Jurnal Kebidanan, Keperawatan dan Kesehatan (J-BIKES) Parapemikir Jurnal Ilmiah Farmasi Jurnal Pengabdian Masyarakat Ilmu Kesehatan Lisanul Arab: Journal of Arabic Learning and Teaching

Muhammad Gunawan

Pusat Penelitian Bioteknologi Lembaga Ilmu Pengetahuan Indonesia, Bogor

Author-ID : 270968

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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UJI EFEKTIVITAS ANTIHIPERURISEMIA EKSTRAK AIR DAUN SALAM (Syzygium polyanthum Wight.) TERHADAP MENCIT JANTAN (Mus musculus) YANG DIINDUKSI JUS HATI AYAM DAN KALIUM OKSONAT Hidayah, Nurul; Hasanah, Fenny; Gunawan, Muhammad; Lestari, Anggun
JURNAL PENELITIAN SAINTIKA Vol 18, No 1 (2018): MARET 2018
Publisher : JURNAL PENELITIAN SAINTIKA

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Hiperurisemia disebabkan oleh sintesa purin berlebihan dalam tubuh karena pola makan yang tidak sehat dan proses pengeluaran asam urat dari dalam tubuh yang mengalami gangguan. Penggunaan obat-obat sintesis untuk hiperurisemia bukan tanpa risiko efek samping yang merugikan, sehingga diperlukan terapi alternative dari alam. Daun salam dipercaya dapat menurunkan kadar asam urat. Tujuan dari penelitian ini adalah untuk mengetahui potensi efektivitas ekstrak air daun salam terhadap penurunan kadar asam urat mencit jantan yang diinduksi dengan jus hati ayam 0,2% dan kalium oksonat 250 mg/kg BB. Tahapan penelitian meliputi identifikasi tanaman, pembuatan simplisia dan ekstrak, standarisasi dan skrining fitokimia, serta pengujian efek antihiperurisemia. Hewan uji yang digunakan sebanyak 24 ekor, yang dibagi menjadi 6 kelompok uji. Pembagian kelompok hewan uji terdiri atas kelompok normal, induksi, pembanding, ekstrak air daun salam (EADS) dosis 50 mg/kg BB, 100 mg/kg BB, dan 200 mg/kg BB. Parameter efek antihiperurisemia yang diamati adalah kadar asam urat darah hewan uji. Data yang diperoleh selanjutnya diolah secara statistik dengan interval confidency 95%. Hasil uji skrining fitokimia menunjukkan bahwa simplisia dan EADS mengandung tannin, flavonoid, saponin, glikosida, dan alkaloid. Semua kelompok dosis EADS menunjukkan potensi antihiperurisemia yang tidak berbeda signifikan dengan kelompok pembanding yang digunakan.

KEWENANGAN DEWAN PEMBINA DAN PENGENDALI PENGELOLAAN KOLABOATIF (DP3K) TAMAN NASIONAL KAYAN MENTARANG (TNKM) NASIONAL KAYAN MENTARANG (TNKM) Gunawan, Muhammad
JURNAL AKTA YUDISIA Vol 2, No 1 (2017): Jurnal Akta Yudisia Vol. 2 Nomor 1
Publisher : Universitas Borneo Tarakan

Abstract KMNP (Taman Nasional Kayan Mentarang) collaborative management essentially an innovation in the management of National Parks in Indonesia that promote mutual interests, shared responsibility, the role and benefits between government, local communities and NGOs. In this paper, the issue raised is the authority of the Dewan Pembina dan Pengendali Pengelolaan Kolaboratif (DP3K) KMNP. The aim of this study was to determine and analyze the authority of the Board of Trustees and Collaborative Management Controller (DP3K) Kayan. This type of research is the study of normative juridical approach to legislation and conceptual approach and the use of primary and secondary law with a qualitative analysis approach. Based on the results, the conclusion that the authority DP3K TNKM among others embodies the aspirations of the parties in order to develop and control the implementation of collaborative management KMNP.Keywords: National Parks, collaborative management, Authority.

RASIO HUBUNGAN NILAI DAYA DUKUNG TIANG PANCANG BERDASARKAN PENGUJIAN SONDIR, KALENDERING DAN TES PDA PADA JEMBATAN PELAWA KABUPATEN PARIGI MOUTONG Gunawan, Muhammad; Oktaviana, Ida Sri; B., Arifin
JOURNAL TEKNIK SIPIL DAN INFRASTRUKTUR Vol 4, No 1 (2014)
Publisher : Jurusan Teknik Sipil Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (743.497 KB)

Bearing capacity of pile foundation bearing capacity is influenced by several factors, such as the amount of applied loads and non-homogeneous soil characteristics. To determine the bearing capacity of single pile foundation the static method is used on the basis of CPT data and dynamic methods based on dynamic pile and PDA tests. Pile foundations of the Pelawa bridge used in this study are located in the District of Parigi - Moutong. The study of literatures and secondary data such as the data of driven pile equipment, driven piles , CPT, dynamic pile tests, and PDA tests are used for analyzing the pile bearing capacity . Meyerhof method, Aoki de Alencar, LCPC, Price and Waldre, and Schmertmann are used to determine the bearing capacity of pile based on sondir (CPT) data. The dynamic pile tests data are used to calculate the bearing capacity of the piles by using methods of Hiley, Olsen and Flaate , Enginering News Record (ENR) , Janbu Mansur and Hunter , and AASHTO . The results show thatÂ the lowest dan the highest of the ultimate bearing capacitiesÂ for static methods (CPT data) areÂ 114.096 tons (Aoki De Alencar) and 305.479 tons (Schmertmann) respectively. Kalendering method (dynamic pile data) show that the lowest value of 284.22 tons were obtained from equation given by Hiley and the highest 1450.26 tons were obtained from equation given byÂ Janbu.The range of 171.2 tons - 174.5 tons were given for PDA test data. The ratio between CPT to PDAs results that are closest to the value of 1 which is 0.938 is the value that obtained from Meyerhofâ€™s equation, while the ratio between dynamic method (kalendering) to PDAs results that are closest to the value of 1 which is 1,660 is the value that obtained from Hiley equation Keywords: single pile bearing capacity, CPT, dynamic pile test, PDA test

Pemetaan Psikografis Kependudukan Untuk Kepentingan Kampanye Pilkada (Studi Kasus: Kota Cimahi) Gunawan, Muhammad; Sumarno, -; Indrianawati, -
REKA GEOMATIKA Vol 2016, No 2 (2016)
Publisher : Institut Teknologi Nasional

ABSTRAKPemilihan kepala daerah (pilkada) memberikan kesempatan kepada masyarakat untuk memilih kepala daerahnya tanpa melalui suatu perwakilan. Dalam pelaksanaan pilkada terdapat proses kampanye yang bertujuan meyakinkan pemilih untuk memilih calon pasangan tertentu. Tujuan dari pemetaan psikografis kependudukan untuk kepentingan kampanye adalah memberikan data awal kampanye dan lokasi potensial kampanye. Penelitian ini menggunakan metode analisis statistika spasial dengan metode Global Moranâ€™s I dan Getis Ord-ÂG terhadap data karakteristik kependudukan untuk mengetahui adanya autokorelasi spasial dan bentuk pola kluster antara unit wilayah (kelurahan) di Kota Cimahi. Berdasarkan hasil analisis statistika spasial, dapat diketahui bahwa di seluruh kelurahan Kota Cimahi, data awal kampanye yang relevan adalah data karakteristik pekerjaan dan agama. Karakteristik pendidikan relevan di seluruh kelurahan Kota Cimahi, kecuali Kelurahan Cimahi dan Karangmekar. Karakteristik usia juga relevan di seluruh kelurahan Kota Cimahi, kecuali Kelurahan Cimahi dan Pasirkaliki.Kata kunci: kampanye, statistika spasial, autokorelasi, pola klusterABSTRACTRegional heads election (Pilkada) has given an opportunity to people for choosing their regional heads without any delegation in general election. The general election includes campaign process, which aims to select a certain candidate. In the campaign process, psychographic mapping of demography aims to give preliminary data and potential location of the campaign. This research has used spatial statistical analysis using Global Moran's I and Getis Ord-ÂG methods for analysing demographic characteristics. The methods aim to know spatial autocorrelation as well as cluster pattern between villages in Cimahi District. The analysis result shows the relevant characteristics in all Cimahi villages are job and religion. Meanwhile, education characteristic is relevant in all villages Cimahi, except Cimahi and Karangmekar villages. Age characteristic is also relevant in all villages Cimahi, except Cimahi and Pasirkaliki villages.Keywords: campaign, spatial statistic, autocorelation, cluster pattern

Uji Efektivitas Analgetik Ekstrak Etanol Buah Kundur (Benincasa hispida (Thunb.) Cogn.) Terhadap Tikus Putih Jantan (Rattus norvegicus L.) yang Diinduksi Asam Asetat Gunawan, Muhammad; Fatimah, Cut; Santika, Dewi
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.5015

The class of drugs known as analgesics work by reducing or inhibiting pain. This can be achieved in several ways, such as by preventing the synthesis of prostaglandins, which are mediators of pain perception, or by reducing the sensitivity of pain receptors to mechanical, thermal, electrical stimuli. Interest in using natural-based medicine for therapy is increasing in Indonesian society. Kundur fruit is one of the medicinal plants that can be used as an analgesic. It has been empirically proven that kundur fruit (Benincasa hispida (Thunb.) Cogn.) can reduce pain. The purpose of this study was to ensure that the preparation of simplisia, macroscopic and microscopic analysis, phytochemical screening of simplisia, and analgesic efficacy tests were carried out experimentally in this study. Acetic acid 0.5% was injected intraperitoneally under the abdomen of male white rats to stimulate the male white rats. oral administration of ethanol extract solution of kundur fruit at doses of 100 mg/kgBB, 200 mg/kgBB, 400 mg/kgBB, CMC 0.5% (blank) and metampirone 45 mg/kgBB For one hour the number of writhing animals was counted every ten minutes. In addition, the collected data were statistically examined using Tukey test and SPSS ver. 20 One Way ANOVA. Analysis of simplisia and ethanol extracts of kundur fruit had phytochemical screening for the presence of alkaloids, flavonoids, tannins, saponins, steroids and glycosides. The percentage of writhing reduction increased with increasing doses of bamboo randu herb decoction, indicating an increase in analgesic potential and efficacy. Based on the results of the Tukey test and One Way ANOVA test, a dose of 400 mg/kgBB has the best analgesic potential at the 50th minute and is not statistically different from metampirone 45 mg/kgBB.

Sabun Cair Antiseptik Sari Air Kulit Buah Salak (Salacca zalacca) Gunawan, Muhammad; Fatimah, Cut; Panjaitan, Sariatmaja
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.5327

In addition to removing dirt that sticks to the skin, skin wash soap also functions as an antiseptic to ward off skin diseases caused by germs, many antiseptic soaps on the market contain synthetic antibacterials but often have negative side effects. Therefore, it is important to make soap with natural ingredients. For example, salak (Salacca zalacca) fruit peel contains saponin and polyphenol compounds that are antibacterial. To test the antibacterial activity and make liquid soap containing salak fruit peel juice as a cleanser and antibacterial, this study conducted phytochemical screening on salak fruit peel. The research stages include, phytochemical screening of salak fruit peel, liquid soap formulation with 10%, 20%, and 30% salak fruit peel juice (SKBS), liquid soap assessment related to stability, foam height, pH, irritation, and liking test. Antibacterial activity test against germs from volunteer hand wash water specimens against Escherichia coli, and Staphylococcus aureus bacteria. The results showed that salak fruit peel juice can be used to make liquid soap that meets physical quality standards because it contains alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and glycosides. The strongest antibacterial activity with inhibition diameters against Staphylococcus aureus (18.63 ± 0.33) mm and Escherichia coli (16.17 ± 0.33) mm) made 20% SKBS liquid soap the best choice, which was determined by the results of the study.

Antidiabetic Effectiveness Test of Ethanol Extract of Brown Leaves (Theobroma Cacao L.) Against Mice (Mus Musculus) Gunawan, Muhammad; Safriana; Tanjung, Siti Aisyah; Andilala
International Journal of Public Health Excellence (IJPHE) Vol. 3 No. 2 (2024): January-May
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v3i2.775

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormalities in insulin secretion, insulin action or both. DM sufferers are increasing from year to year, accompanied by increasing costs of therapy, therefore, as an alternative to controlling blood glucose levels, use natural ingredients such as cocoa leaves. The aim of this research was to determine the effectiveness of ethanol extract of cocoa leaves (Theobroma cacao L.) in reducing blood glucose levels in mice that had been induced by Aloxan. The research method used was experimental research. The research stages were sample collection, sample identification, making simpilicia, examining the characteristics of simpilicia, making extracts using maceration using 96% ethanol solvent, and testing the antidiabetic effect of EEDC in mice induced by alloxan at a dose of 175 mg/kg. bb intraperitoneally. Diabetic mice were divided into 5 groups, each group consisting of 5 mice that were given the test material 50 mg/KgBB of ethanol extract of brown leaves; 100 mg/KgBB; and 200 mg/KgBB, Metformin 65 mg/KgBB, and CMC 0.5%. Next, blood glucose levels were measured on days 3, 6, 9, 12, and 15, the percentage reduction in blood glucose levels was calculated, then the data was analyzed using the One-Way ANOVA method and Duncan's test, to see real differences between treatments. The research results showed that simplicia, the ethanol extract of brown leaves contains flavonoids, alkaloids, tannins, steroids/triterpenoids, saponins and glycosides. Cocoa leaf ethanol extract has effectiveness in lowering glucose levels, at the 5th and 6th hours it shows good effectiveness at a dose of 200 mg/KgBW of (72.16 ± 0.1.51)% and (82.80 ± 0.73 )%, not significantly different from metfromin 65 mg/KgBB of (74.45 ± 1.51)% and (83.29 ± 1.01).

Primordial Germ Cells Quality of Chicken Embryo from Post Cryopreservation Blood Samples Azizah, Nurul; Kostaman, Tatan; Tribudi, Yuli Arif; Kusumaningrum, Diana Andrianita; Suyatno, Suyatno; Muttaqin, Zultinur; Koswara, Eko; Gunawan, Muhammad
Jurnal Medik Veteriner Vol. 7 No. 2 (2024): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol7.iss2.2024.292-299

The optimal cellular reservoir for the conservation and propagation of endangered poultry is acknowledged to be primordial germ cells (PGCs). This study aimed to evaluate and compare the efficacy of cryopreserving PGCs derived from purified sources and blood samples. The experimental design encompassed two treatment groups, each iterated six replication. Blood samples that had been filled with 500 µL of phosphate-buffered saline without Ca2+ and Mg2+ (PBS) underwent centrifugation at 1200 rpm for six minutes. The supernatant was discarded and the pellet was mixed with 500 µL 10% FBS-PBS and was then subdivided for cryopreservation and PGCs purification. Cryopreservation included the controlled freezing of blood and purified PGCs samples in Nalgene cryogenic vials with the incorporation of banker cells. Following thawing, statistical analyses revealed no significant variance in the mean PGCs count between purified PGCs and blood samples (p > 0.05). The percentages of PGCs mortality and the recovery rate demonstrated statistical significance (p < 0.05). Further investigations indicated that cryopreserving blood samples significantly increased the recovery rate of PGCs while decreasing post-thaw mortality. Morphology of PGCs from blood cryopreservation showed similar morphology to PGCs in general. The potential application of cell-based cryo-banking will contribute to the preservation of poultry genetic diversity for sustainability and adaptation to future poultry demands.

Toothpaste Formulation Combination of Andaliman Fruit and Kecombrang Flowers as a Cleaner and Antibacterial Gunawan, Muhammad; Safriana, Safriana; Andilala, Andilala; Fitriani, Enny
Journal La Medihealtico Vol. 5 No. 2 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i2.1240

Currently on the market there are many circulating toothpastes for cleaning teeth and treatment, but they contain synthetic chemicals that can cause health problems, such as fluoride and sodium lauryl sulfate (SLS). This material can irritate the gums and mouth, gums feel burning, sensitive teeth and discomfort on the tongue. Traditionally, andaliman fruit has been used as a refreshing and deodorizing agent and prevents tooth decay by gargling for about 10 minutes. One natural ingredient that has been proven to have antibacterial activity and has often been used to eliminate bad breath and body odor is combrang flower (Etlinger elatior Jack). Therefore, the author utilizes the combination of andaliman fruit and combrang flowers in toothpaste formulations with the aim of obtaining a natural toothpaste that is relatively safe and economical. The formulation of toothpaste preparations uses a combination of andaliman fruit and combrang flowers concentrations of 2.5%, 5%, and 10% with a ratio (75:25); (50:50); and (25:75). Evaluation of the preparation includes tests of homogeneity, pH, stability, cleaning power, organoleptic with hedonic test, irritation test of volunteer skin, and antibacterial activity against mutant Streptococcus and Escherichia coli. Toothpaste preparations containing a combination of dry pollen of combrang flowers and andaliman fruit have good cleaning power, no irritation, and can eradicate Streptococcus mutans and Escherichia coli bacteria with strong categories. The best formula is with the content of combrang flowers and andaliman fruit 75:25, because although the cleaning power is smaller, it has the strongest antibacterial, so the resulting toothpaste provides benefits for cleaning and dental care, safe and economical.

FORMULASI SABUN CAIR ANTISEPTIK SARI AIR KULIT BUAH PISANG AMBON (MUSA PARADISIACA VAR SEPIENTUM L.) DAN UJI AKTIVITAS ANTIBAKTERI TERHADAP STAPHYLOCOCCUS AUREUS DAN ESCHERICHIA COLI Ramadani, Muhammad; Gunawan, Muhammad; Fitriani, Enny; Kusumastuti, Melati Yulia
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 1 (2024): Vol. 8 No. 1, September Tahun 2024
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i1.1770

Cleanliness of the skin, hands and body is a state of being free of dirt, dust and microorganisms that can cause infection. The existence of these microorganisms can be overcome by using soap containing chemical compounds that have antibacterial activity. In the market there are many circulating antiseptic soaps containing synthetic antibacterials, but they often cause side effects, so it is necessary to make soaps containing natural antibacterials, for example, Ambon banana peel contains polyphenolic compounds and saponins have antibacterial activity. The study conducted a phytochemical screening of Ambon banana peels, made liquid soap containing water extract of Ambon banana peels as a cleanser and antibacterial and carried out antibacterial activity tests. Research stages: phytochemical screening of Ambon banana peel and water extract, liquid soap formulation containing 10%, 20% and 30% Ambon banana peel water extract (SKPA), evaluation of liquid soap including: stability, foam height, pH, irritation and preference test . Antibacterial activity test against Staphylococcus aureus, Escherichia coli and bacteria from volunteer hand washing water specimens. The results showed that the water extract from Ambon banana peel contains alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and glycosides, which can be formulated into liquid soap (SKPA) fulfilling the physical quality requirements. SKPA 30% liquid soap is the best because it is very liked by researchers, has strong antibacterial activity, diameter of inhibition against Staphylococcus aureus (17.23 ± 0.66) mm, and Escherichia coli (15.83 ± 0.66) mm. The total plate number for volunteer hand washing specimens, 10% SKPA resulted in a reduction of bacterial colonies of 49.78%, 30% SKPA obtained the greatest reduction in bacteria, namely 82.79, almost the same as Dettol liquid soap. What is circulating in the market is 83.02%.

Co-Authors - Indrianawati - Sumarno Ahmed, Tanjeel Albar Albar ana, safri Andilala Ani Nur Aeni, Ani Nur Anwar, Laila Arfan Abrar Arifin B. Arum Setiawan Asep Firmansyah Az Zahra, Nur Auliyah Bagas F, Muhammad Candani, Mella Cantika, Puja Widya Dewi Santika Dewi, Risnawati Diana Andrianita Kusumaningrum, Diana Andrianita Dwi Putranti, Oktora Ekowati, Indah Agustina Fadillah, Rizka Fatimah, Cut Fitriani, Enny Harianti, Evi Hasanah, Fenny Ida Sri Oktaviana Kasmuri Kasmuri, Kasmuri Koswara, Eko Kusumastuti, Melati Yulia Lala, Andi Langgeng Priyanto, Langgeng Lestari, Anggun Lijea, Isma Ae Nafis Azmi Amrullah Nasution, Annio Indah Lestari Ningsih, Afni Sari NURUL AZIZAH Oktora Dwi Putranti Panjaitan, Sariatmaja Pitoyo, Pitoyo PriyantoPriyanto, Langgeng Putri, Alya Rosandiyus Ramadani, Muhammad Riswandi Riswandi Robiah, Minchatur Safriana Safriana Safriana Sari, Secillia May Setianingsih, Eva Siregar, Rizki Marwiyah Susanda, Apriansyah Suyatno Suyatno Tanjung, Siti Aisyah Tatan Kostaman Triansyah, Rizky Ahmad Ulwiyah Wahdah Mufassirin Liana Yuli Arif Tribudi Zukhaira Zultinur Muttaqin

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