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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JCPS (Journal of Current Pharmaceutical Sciences) Jurnal Pengabdian Kepada Masyarakat MEMBANGUN NEGERI Journal of Fundamental and Applied Pharmaceutical Science Prosiding Seminar Nasional Program Pengabdian Masyarakat
Krisridwany, Annisa
Universitas Muhammadiyah Yogyakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The Description Of The Level Of Knowledge About Traditional Turmeric-Tamarind Herbal Drink As A Swamedication Of Dymenorore In Adolescent Women In Batang District Indonesia Hasna Nuansa Sasadara; Annisa Krisridwany; Vella Lailli Damarwati; Salmah Orbayinah
JCPS (Journal of Current Pharmaceutical Sciences) Vol 6 No 2 (2023): March
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Self-medication is an individual's effort to treat a disease that is experienced without medical assistance. Adolescent girls with a history of dysmenorrhea often do pharmacological therapy such as the use of pain relievers with a limited level of knowledge, while there are alternatives to self-medication, namely non-pharmacological therapies such as the use of herbal medicine, turmeric tamarind herbal drink, which is easily obtained and also has many benefits in treating dysmenorrhea to describe the level of knowledge about the herbal medicine turmeric tamarind as a self-medication for dysmenorrhea among adolescents in Batang District Indonesia using a non-experimental observational research design with a cross-sectional approach conducted in Batang District, Central Java in October 2021-February 2022. The population in this study, which are adolescent girls in Batang District who are currently studying for Junior High School, Senior High School with total of 5,705 respondents. The number of samples were 105 respondents. The data analysis used is the presentation technique. Based on the characteristic of respondents, most of the respondents (54.3%) belonged to the category of middle adolescents (13-15 years), and most of the respondents' education level were currently pursuing high school education (65.7%). The level of knowledge shows that most respondents have a high level of knowledge (95.2%), 2.9% respondents have a moderate level of knowledge, and 1.9% respondents have a low level of knowledge. Respondents in Batang District have a high level of knowledge or understand
Bioinformatics and Molecular Docking Study of Amentoflavone and 3,8-Biapigenin as Inhibitors on Cervical Cancer Proteins Dhecella Winy Cintya Ningrum; Triana Arum Kusumaningtyas; Rifki Febriansah; Melisa Juniananda; Sri Tasminatun; Annisa Krisridwany
Indonesian Journal of Cancer Chemoprevention Vol 14, No 2 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss2pp105-116

Abstract

Cervical cancer maintains its second-place ranking for Indonesia's highest number of cancer cases. In 2021, there were 36,633 cases of cervical cancer in Indonesia, with a rising death rate. Commonly, chemotherapy is used to treat cervical cancer and can improve the survival chances of patients, but these therapies imply increased toxicity. Biflavonoid group compounds like amentoflavone and 3,8-Biapigenin have the potential to act as anticancer agents by modulating multiple signaling pathways. This study aims to determine the cervical anticancer potential of amentoflavone and 3,8-Biapigenin based on in silico study. Prediction of anticancer activity in silico using Prediction of Activity Spectra for Active Substances (PASS) online, followed by target protein tracing using STITCH-STRING, then receptor analysis test using Ramachandran plot. A molecular docking test was conducted to determine the binding affinity of the compound with the receptor. Based on the online PASS, the compounds as thought to have low cervical anticancer potential if tested on a laboratory scale. STAT3, EP300, CYP1A1, and AKR1C1 proteins used in this study have met the requirements of a suitable receptor for molecular docking test. The best binding affinity was obtained at the interaction of amentoflavone and STAT3 with a better docking score (-9.3 kcal/mol) than doxorubicin (-7.1 kcal/mol). Overall, the results suggest biflavonoid compounds have the potential to be developed as a chemopreventive agent for cervical cancer.Keywords: bioinformatics, molecular docking, amentoflavone, 3,8-Biapigenin, cervical cancer protein.
Evaluation of Sidr Leaf Ethanol (Ziziphus mauritiana Lam.) Extract-Based Tablets as Antihypercholesterolemia Orbayinah, Salmah; Dewi, Yunita P.; Kurniawan, Fariez; Krisridwany, Annisa
Indonesian Journal of Pharmaceutical Science and Technology 2025: Vol. 12 Suppl. 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s1.57926

Abstract

Sidr leaf extract (Ziziphus mauritiana Lam.) is effective against hypercholesterolemia by blocking the HMG-CoA reductase. This study seeks to identify the characteristics of tablets formulated from the ethanol extract of Sidr leaf and their efficacy in lowering total blood cholesterol levels. The tablets were produced using the wet granulation method and processed into three formulations, F1, F2, and F3, with differing dosages of 100, 150, and 250 mg, along with placebo. The granules produced were evaluated for their physical characteristics. The tablets were evaluated for their physical characteristics and tested for effectiveness in lowering cholesterol levels. The efficacy of tablet-form sidr leaf ethanol extract was assessed by analyzing cholesterol levels in mouse serum samples compared to simvastatin. The data were statistically analyzed using one-way ANOVA and post-hoc Tukey HSD test. In the disintegration time test, F1 and F2 tablets satisfied the criteria. However, F3 exceeded the limit of 60 minutes. Among the three tablet doses, the F2 tablet (150 mg) demonstrated superior efficacy in lowering total cholesterol levels relative to the F1 and F3 tablets. Consequently, tablets containing Sidr leaf extract demonstrate potential for hypercholesterolemia management at an effective dosage of 150 mg, warranting further investigation through clinical trials.
Immunomodulatory Activity of Parijoto Fruit (Medinilla speciosa) on Macrophage Phagocytosis, Lymphocyte Proliferation, and IgG Production Jannah, Asni F.; Winanta, Aji; Anggreani, Ira; Krisridwany, Annisa
Indonesian Journal of Pharmaceutical Science and Technology 2025: Vol. 12 Suppl. 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s1.57948

Abstract

Parijoto fruit (Medinilla speciosa) contains flavonoid compounds that are potentially immunomodulators because they increase macrophage phagocytosis activity and lymphocyte proliferation in vitro. This study aims to determine the phytochemical compound content of parijoto fruit and its potential as an immunomodulatory agent in vivo. Parijoto fruit was extracted using 70% ethanol solvent. The ethanol extract of parijoto fruit (EEPF) was qualitatively identified by phytochemical screening. The immunomodulatory activity test in vivo was conducted using BALB/c mice, which were separated into five groups: untreated, Phyllanthus niruri L. (PN) extract (positive control), and test groups (125mg/KgBW; 250mg/KgBW and 375mg/KgBW). The treatment duration was 18 days, with the induction of the hepatitis B vaccine on days 7 and 14. An immunomodulatory activity test was conducted on the 19th day, which included a macrophage phagocytosis activity test, lymphocyte proliferation, and measurement of IgG levels. The identification results showed that EEPF contains flavonoids, tannins, and saponins. Macrophage phagocytosis activity showed that EEPF increased macrophages' phagocytosis capacity (PC) and phagocytosis index (PI). EEPF increased lymphocyte proliferation activity and IgG levels, significantly different from control and not substantially different from positive control. Collectively, EEPF increases immunomodulatory activity in vivo.
Formulation and Evaluation of Pulp Devitalization Paste Combination of Jatropha Curcas L. and Piper Crocatum Leaves Extract Damarwati, Vella Lailli; Wahid, Rahmat A Hi; Primasari, Dyani; Harimurti, Sabtanti; Labibah, Lana; Syahrani, Syahrani; Krisridwany, Annisa
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.24041

Abstract

Dental caries require operative techniques such as pulp devitalization, but pulp devitalization materials that are often used by dentists have serious adverse effects that need to be considered, such as gingival injury and alveolar bone necrosis. Hence, the aim of the present study was to develop natural ingredients as an alternative to pulp devitalization from a combination of Jatropha curcas (Jatropha curcas L.) and red betel leaf extract (Piper crocatum) in the form of a paste and then conducting physical evaluation tests, Cyclooxygenase-2 (COX-2) tests, and also histopathological picture tests to the sample. The formulation of the pasta sample was carried out by the trituration method.  Formulation I (FI) contained 25% of Jatropha resin, 0.25% red betel leaf extract, and 25% Jatropha resin, 0.5% red betel leaf extract for Formulation II (FII). The paste produced was then evaluated for physical properties which consisted of organoleptic, homogeneity, pH, spreadability, adhesion, and anti-inflammatory power using test animals with COX-2 expression number parameters. The FI and FII treatment groups had met the requirements as paste formula. In the COX-2 expression test, FI has a COX-2 expression percentage value of 0.38% and a COX-2 suppression percentage value of 0.62%, while FII has a COX-2 expression percentage value of 0.59% and a COX-2 expression percentage of 0.59% and suppression of COX-2 of 0.41%. The optimal concentration of the paste formulation is the paste with a combination of 25% jatropha latex and 0.25% red betel leaf extract had been shown to have potential as an alternative to pulp devitalization
Co-Authors Aji Winanta Aji Winanta Aji Winanta Anggreani, Ira Chaessy Yori Anggraini Dewi, Yunita P. Dhecella Winy Cintya Ningrum Dina Latifah Hanum Dyani Primasari Sukamdi Erlangga Jun Prasetya Hasna Nuansa Sasadara Jannah, Asni F. Khrisna Heryanti Kurniawan, Fariez Labibah, Lana Maura Shavira Alamsyah Melisa Juniananda Muhammad Ananda S Muhammad Arif Rizqi Neva Valencia Eka Apriliana Nita Fajar Maharani Pramitha Esha Nirmala Dewi Primasari, Dyani Radhwa Fauztina Rifki Febriansah Rizka Wahyu Septiasih Sabtanti Harimurti Sabtanti Harimurti, Sabtanti Salmah Orbayinah Sayidah Aulia Ul Haque Sri Tasminatun SYAHRANI SYAHRANI Tatsufumi Okino Triana Arum Kusumaningtyas Tsania Khusnul Khotimah Vella Lailli Damarwati Wahid, Rahmat A Hi Wardah Dwi Latifah Zaki Tiffani Lazuardian Zelmi Dwi Novita