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All Journal Malang Respiratory Journal Indonesian Journal of Cancer
Widiasari, Komang Sri Rahayu
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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Provision of Gefitinib as Targeted Therapy in Lung Adenocarcinoma with EGFR Mutation and Brain Metastatic Widiasari, Komang Sri Rahayu
Malang Respiratory Journal Vol. 1 No. 1 (2019): The Many Faces of Respiratory Disease
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (684.418 KB) | DOI: 10.21776/ub.mrj.2019.001.01.3

Abstract

Adenocarcinoma is a malignant epithelial tumor with glandular differentiation or mucin production. Adenocarcinoma covers 30% of lung cancers in Europe and America. This report described a case of an unusual chronic headache since 3 years ago without any complementing symptom except for nausea. The primary tumor was detected with Thorax CT scan and confirmed by histopathology examination. Patient treated with gefitinib (1 x 250 mg) and showed a satisfying result. Gefitinib, as first-line therapy for patients with epidermal growth factor receptor ( EGFR) mutation, was effective and well-tolerated in this patient.
Intrapulmonary Mature Teratoma Presenting with Trichoptysis: A Rare Case Report Nidzarsyah, Muhammad Mirsa; Hidayat, Moulid; Lestari, Rina; Widiasari, Komang Sri Rahayu; Fathana, Prima Belia; Santosa, Hilda; Kumaladewi, Baiq Ratna; Restuningdyah, Novia Andansari Putri; Arsatt, Maz Isa Ansyori
Indonesian Journal of Cancer Vol 19, No 4 (2025): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i4.1390

Abstract

Introduction: Intrapulmonary teratomas (IPT) are exceptionally rare, with only a handful of cases reported worldwide. The disease may lead to severe outcomes, such as massive hemoptysis, airway compression, and malignant transformation. Several international case reports on IPT focus on the diagnosis and surgical treatment approach. In Indonesia, only one case of intrapulmonary teratoma has been documented and analyzed for its radiological characteristics and anatomical pathology. Here, we present a case of mature IPT treated with surgery and adjuvant chemotherapy. To the best of our knowledge, this case is the second to be reported in Indonesia.Case Presentation: A 28-year-old man presented with a complaint of hemoptysis accompanied by clumps of hair (trichoptysis). Physical examination revealed no abnormalities. Chest X-ray and computed tomography (CT) thorax with contrast showed a right lung mass. The patient underwent lobectomy excision with the postoperative CT scan showing a residual mass. Furthermore, pathological findings confirmed a mature teratoma. Patients were then treated with adjuvant chemotherapy and showed clinical improvement.Conclusions: This case emphasizes the importance of including IPT in the differential diagnosis of hemoptysis, especially when trichoptysis–a rare but distinct symptom–is present. Although imaging tests like contrast-enhanced CT scans are crucial for identifying intrapulmonary masses, histological analysis is necessary for a conclusive diagnosis. The mainstay of treatment persists in surgical removal, and adjuvant chemotherapy may help control any remaining illness. This case emphasizes the importance of early detection and a multidisciplinary approach to enhance patient outcomes because it is one of the few documented IPT cases in Indonesia.
Co-Authors Arsatt, Maz Isa Ansyori Hidayat, Moulid Kumaladewi, Baiq Ratna Nidzarsyah, Muhammad Mirsa Prima Belia Fathana Restuningdyah, Novia Andansari Putri Rina Lestari Santosa, Hilda