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All Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Respirologi Indonesia Narra J
Hidayat, Moulid
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Sinyal Bradikinin Pada Covid-19: Tinjauan Pustaka Nurwidya, Fariz; Zulfiyah, Itsna Arifatuz; Hidayat, Moulid; Baskoro, Hario
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 7 (2024): Volume 11 Nomor 7
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i7.15551

Abstract

Patofisiologi COVID-19 melibatkan jalur persinyalan seluler dan molekuler kompleks terkait inflamasi. Salah satu jalur yang mungkin terlibat adalah jalur bradikinin yang mengalami disregulasi. Bradikinin adalah suatu nonapeptida linear derivat dari kininogen yang terdistribusi di berbagai jaringan dan di plasma. Bukti ilmiah memperlihatkan peningkatan produksi bradikinin pada inflamasi. Manifestasi klinis seperti batuk juga berhubungan dengan aktivitas bradikinin. Memahami patogenesi COVID-19 menjadi penting dalam upaya menemukan pendekatan baru pada terapi efektif yang melibatkan jalur bradikinin. Pada tinjauan pustaka ini, akan dibahas bagaimana peranan bradikinin dan metabolitnya pada patogenesis COVID-19.
Challenges on tuberculosis care in health care facilities during COVID-19 pandemic: Indonesian perspective Winardi, Wira; Wahyuni, Hendra; Hidayat, Moulid; Wirawan, Aditya; Nurwidya, Fariz; Uddin, Mohammad N.; Yusup, Mohamad
Narra J Vol. 2 No. 2 (2022): August 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i2.80

Abstract

Indonesia is among the top three countries globally with the highest tuberculosis  burden. During the past decades, Indonesian health authorities have struggled to improve tuberculosis care quality in health care facilities by optimizing the regulation and strengthening the private sector contributions. The coronavirus disease 2019 (COVID-19) pandemic has hardly affected the Indonesian health care system, including the National Tuberculosis Control Program. While the end of the COVID-19 pandemic in Indonesia is uncertain, the measure to control tuberculosis must not be weakened. Early identification and measurement of the problem size are essential to decide the most appropriate approach to maintain the sustainability of National Tuberculosis Control Program, particularly in health care facilities during the COVID-19 pandemic. This article points out the possible threats to the sustainability of TB care in Indonesia during the COVID-19 pandemic, including some approaches to overcome those problems.
Indonesian Society of Respirology Position Paper on Lung Cancer Control in Indonesia Andarini, Sita; Santoso, Andintia Aisyah; Arfiansyah, Mochammad Aris; Syahruddin, Elisna; Zaini, Jamal; Putra, Andika Chandra; Kurniawan, Ferry Dwi; Ermayanti, Sabrina; Soeroso, Noni Novisari; Munir, Sri Melati; Infianto, Andreas; Setijadi, Ana Rima; Setyawan, Ungky Agus; Wulandari, Laksmi; Haryati, Haryati; Jasminarti, Ida Ayu; Hidayat, Moulid; Santoso, Arif
Jurnal Respirologi Indonesia Vol 44, No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.884

Abstract

Lung cancer is a major health concern in Indonesia due to its increasing prevalence, late-stage diagnosis, younger population, and high mortality. Addressing this issue requires nationwide implementation of comprehensive lung cancer control, which includes risk reduction and prevention strategies, focusing on tobacco control and air pollution mitigation. Screening with low-dose computed tomography (LDCT) and early detection in symptomatic patients, along with TB screening programs and all non-communicable diseases, is strongly recommended to enhance early case findings, treatment effectiveness, and overall patient outcomes. A multidisciplinary team (MDT) approach is important to ensure accurate diagnosis and comprehensive care. Moreover, the integration of palliative care at the early stages of advanced lung cancer is vital, focusing on symptom management and enhancing the quality of life for patients. While national guidelines are available for the diagnosis and treatment of lung cancer, significant disparities in healthcare access remain across Indonesia. Thus, it is essential to improve universal health coverage and referral systems to guarantee equal access to lung cancer care for patients at all levels through advocacy and ease of access.
Co-Authors Aditya Wirawan, Aditya Aldri Frinaldi Ana Rima Setijadi Andarini, Sita Arfiansyah, Mochammad Aris Arif Santoso Baskoro, Hario Elisna Syahruddin Ermayanti, Sabrina Fariz, Nurwidya Haryati Haryati Infianto, Andreas Jasminarti, Ida Ayu Kurniawan, Ferry Dwi Laksmi Wulandari Noni Novisari Soeroso Putra, Andika Chandra Santoso, Andintia Aisyah Setyawan, Ungky Agus Sri Melati Munir Uddin, Mohammad N. Wahyuni, Hendra Wira Winardi, Wira Yusup, Mohamad Zaini, Jamal Zulfiyah, Itsna Arifatuz