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All Journal MPI (Media Pharmaceutica Indonesiana) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Ilmu Kefarmasian Indonesia Pharmaceutical Journal of Indonesia Pharmacoscript Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang CERATA
Kesuma, Dini
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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ANTIVIRAL ACTIVITY OF FABACEAE AND ASTERACEAE FLAVONOID COMPOUNDS AGAINST SARS-CoV-2 ON SPIKE PROTEIN, MAIN PROTEASE (Mpro) AND RNA DEPENDENT RNA POLYMERASE (RdRp) RECEPTORS WITH IN SILICO METHOD: ANTIVIRAL ACTIVITY OF FABACEAE AND ASTERACEAE FLAVONOID COMPOUNDS AGAINST SARS-CoV-2 ON SPIKE PROTEIN, MAIN PROTEASE (Mpro) AND RNA DEPENDENT RNA POLYMERASE (RdRp) RECEPTORS WITH IN SILICO METHOD Lekal, Tresia; Kesuma, Dini; Azminah, Azminah
Pharmaceutical Journal of Indonesia Vol. 8 No. 2 (2023)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2023.008.02.2

Abstract

This study was conducted to test the antiviral activity of flavonoid compounds of Fabaceae tribe (Clitoria ternatea, Caesalpinia sappan, Leucaena leucocephala, Indigofera tinctoria) and Asteraceae tribe (Eclipta prostrata, Artemisia vulgaris, Blumea balsamifera, Chromolaena odorata) against SARS-CoV-2 on spike protein, Mpro and RdRp receptors by molecular docking method in silico. The results of molecular docking with AutoDock Vina showed that the flavonoid compounds apigenin and juglanin (Leucaena leucocephala), semiglabrin and glabratephrin (Indigofera tinctoria), apigetrin (Eclipta prostrata), acacetin (Chromolaena odorata) had binding energies close to, equivalent and better than the original ligand and Comparator of each receptor.
Co-Authors Adi Kusuma Suardini, Luh Aditya Trias Pradana Aguslina Kirtishanti Amelia, Marsha Anggita Arina Swastika Maulita, Arina Swastika Azminah Azminah Azminah C, Fadita Trisa Claudya, Maria Dwi Putri, I Gusti Ayu Laksmi Fadhilah Faza, Farah I Gede Ari Sumartha Lekal, Tresia Rahmadinar, Amirah Nabila Rani, Karina Citra Tuga, Maria Claudia Dwiyanti Winantari, Agnes Nuniek Wulansari, Devyani Diah