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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Health and Medical Journal Andalas obstetrics and gynecology journal Science Midwifery
Mayorita, Pamelia
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Ko-Insiden Rhinosinusitis Kronis dengan Polip Hidung dan Neurofibroma Irfandy, Dolly; Budiman, Bestari Jaka; Ikhlas, Khairani Ayunanda; Mayorita, Pamelia
Oto Rhino Laryngologica Indonesiana Vol. 53 No. 2 (2023): VOLUME 53, NO. 2 JULY - DECEMBER 2023
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v53i2.611

Abstract

Background: Nasal polyps are painless inflammatory lesions originated from around the middlemeatus or paranasal sinus cavity; while neurofibroma is benign peripheral nerve sheath tumor. Purpose:To report a rare case of neurofibroma concurrently with nasal polyps in chronic rhinosinusitis. Casereport: A 64-year-old female with chief complaint congestion on the right nose cavity. There was a mass on both nasal cavities. Patient diagnosed with benign mass at right nasal cavity and chronic rhinosinusitis with nasal polyps at left nasal cavity; with a differential diagnosis of chronic rhinosinusitis with bilateral nasal polyps. Computer tomography scan results showed homogeneous isodense lesion in the right nasal cavity, and mucosal thickening in left nasal cavity and maxillary sinus. Patient was managed with total extirpation of the bilateral nasal cavity mass and functional endoscopic sinus surgery. Pathological examination revealed neurofibroma in the right nasal cavity and polyps in the left nasal cavity. Clinical question: “How to differentiate inflammation with tumor of nasal and paranasal sinuses? Is there a causal relationship?” Review method: Literature searching was performed with the keywords “nasal cavity neurofibroma”, AND “nasal polyps”, AND ”chronic rhinosinusitis” through database Google Scholar, PubMed, and hand searching/e-book. Result: There were 11 literatures published in the last 5 years, and 7 articles relevant with the subject. Conclusion: Chronic rhinosinusitis with nasal polyps, along with neurofibroma on nasal cavity is a rare co-incidence, and there was no correlation between those lesions. Pathological examination is a gold standard in differentiating a definite diagnosis of neurofibromas and polyps.Keywords: nasal cavity neurofibroma, nasal polyps, chronic rhinosinusitis
Challenges in diagnosing schwannoma mimicking thyroid neoplasms on frozen section Ramadhani, Rahmi; Mayorita, Pamelia; Asri, Aswiyanti; Mulyani, Henny; Novianti, Hera
Science Midwifery Vol 13 No 2 (2025): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i2.1977

Abstract

Schwannoma is a benign soft tissue tumor of the nerve sheath, composed of neoplastic cells with Schwann cell differentiation. It predominantly arises from peripheral nerves in the head, neck, and extremities, with a peak incidence in the fourth to sixth decades. Schwannoma is typically a solitary and sporadic lesion, affecting individuals of all ages, with an incidence rate of 4.4-5.23 cases per 100,000 people. The prevalence is around 7% of all primary nervous system tumors, often occurring in the head and neck (20-50%) and affecting cranial nerves such as N. Vagus and N. Sympathetic. This case report involves a 50-year-old female patient presenting with a right neck lump that had been present for 23 years, initially small but growing rapidly in the last 10 years with occasional pain. Initial imaging suggested a thyroid complex cyst, but further investigation, including a CT scan and intraoperative frozen section examination, raised suspicion for a malignant thyroid tumor. However, histopathological analysis confirmed the diagnosis of Schwannoma, distinguishing it from other potential malignant lesions, such as Anaplastic Thyroid Carcinoma (ATC). This case highlights the importance of intraoperative cytology and frozen section techniques for diagnosing Schwannoma. Although Schwannomas share morphological similarities with other tumors, particularly in the thyroid region, a multidisciplinary approach combining clinical, radiological, and histopathological findings is essential for an accurate diagnosis. This case also underscores the need for careful differential diagnosis in nerve sheath tumors located in the neck.
Malignant Peripheral Nerve Sheath Tumor di Regio Bahu yang menyerupai Undifferentiated Carcinoma: Tantangan Diagnostik Handriyani, Fitri Nur; Tofrizal, Tofrizal; Mayorita, Pamelia
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.90-95

Abstract

Malignant peripheral nerve sheath tumor (MPNST) is a rare and aggressive group of neoplasms arising from the peripheral nervous system sheath cells (Schwann cells or perineurial cells). Malignant peripheral nerve sheath tumors are typically seen in patients aged 20–50 years, and the most common sites are the trunk and extremities. This case highlights the diagnostic complexity and distinguishes MPNST from undifferentiated carcinoma. We present a case report of a 59-year-old male patient who presented with a rapidly growing mass in the right shoulder for six months. Clinical examination on his shoulder showed a solid mass, lobulated and ulcerated, and an irregular margin measuring 16x12x5 cm. A thoracic MRI revealed a large mass, fusiform and lobulated, with dimensions of 15.02 x 15.81 x 12.65 cm. The patient underwent surgical incision biopsy of the mass. Histopathological and immunohistochemical examinations with S100 and cytokeratin (CK) markers were performed on this patient with MPNST results. The immunoprofile of MPNST showed focal positive staining for S100 marker and negative staining for CK marker. The diagnosis of malignant peripheral nerve sheath tumor can be more challenging if the histopathological examination resembles a feature of undifferentiated carcinoma, like lobulated pattern and clustering of cells with round-oval nuclei. The role of immunohistochemical examination is very important to rule out differential diagnoses.
Diagnosis dan Tatalaksana Limfoma Non Hodgkin Tipe Sel B Sinonasal Octavia, Tri Aryati; Irfandy, Dolly; Budiman, Bestari Jaka; Mayorita, Pamelia
Majalah Kedokteran Andalas Vol. 46 No. 4 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p1103-1117.2023

Abstract

Pendahuluan: Limfoma Non Hodgkin (LNH) sinonasal merupakan tumor ganas ekstranodal yang jarang terjadi. Lokasi paling sering adalah sinus maksilaris, sinus ethmoid dan rongga hidung. Diagnosis pasti imfoma ditegakkan berdasarkan hasil pemeriksaan histopatologi dan imunohistokimia. Tatalaksana kasus berdasarkan stadium dengan menggunakan stagging Ann Arbor. Laporan Kasus: Dilaporkan satu kasus LNH sinonasal pada laki–laki usia 56 tahun dengan keluhan hidung kanan tersumbat dan keluar darah dari hidung kanan. Pemeriksaan kavum nasal dekstra ditemukan adanya massa yang memenuhi kavum nasal disertai sekret mukopurulen. Kemudian dilakukan tindakan medial maksiektomi dengan pendekatan endoskopik dan didapatkan hasil histopatologi limfoma maligna tipe sel sedang serta imunohistokimia (IHK) dengan hasil limfoma maligna tipe sel B. Kesimpulan: Dilaporkan satu kasus LNH sinonasal pada laki–laki usia 56 tahun dengan keluhan hidung kanan tersumbat dan keluar darah dari hidung kanan. Pemeriksaan kavum nasal dekstra ditemukan adanya massa yang memenuhi kavum nasal disertai sekret mukopurulen. Kemudian dilakukan tindakan medial maksiektomi dengan pendekatan endoskopik dan didapatkan hasil histopatologi limfoma maligna tipe sel sedang serta imunohistokimia (IHK) dengan hasil limfoma maligna tipe sel B.Kata kunci: Limfoma Non Hodgkin sinonasal, Limfoma tipe Sel B, Kemoterapi.
Teknik Pewarnaan dan Diagnosis Sputum pada Kanker Paru Hardian, Sonny; Yenita, Yenita; Mayorita, Pamelia
Health and Medical Journal Vol 5, No 2 (2023): HEME May 2023
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v5i2.1259

Abstract

Kanker paru merupakan penyebab kematian yang paling umum di seluruh dunia. Deteksi awal untuk kanker paru bisa menggunakan teknik pemeriksaan sitoligi sputum. Teknik sitologi sputum menggunakan pewarnaan Papanicolaou dan May Grunwald Giemsa. Kedua teknik pewarnaan ini memiliki kelebihannya masing – masing dalam mendiagnosis kanker paru. Beberapa jenis kanker paru yang sering bisa dinilai dari sampel sputum adalah squamous cell carcinoma, adenocarcinoma, dan small cell carcinoma. Kanker paru jenis large cell carcinoma tidak adekuat untuk dinilai dari sampel sputum.
Ovarian Yolk Sac Tumor pada Usia Tua ; A Rare Case Kusumardani, Dini; Mayorita, Pamelia; Novianti, Hera
Health and Medical Journal Vol 5, No 2 (2023): HEME May 2023
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v5i2.1267

Abstract

Pendahuluan: Yolk sac tumor  merupakan subtipe paling umum kedua atau sekitar 15-20% dari semua germ cell tumor yang biasanya ditemukan pada wanita usia muda.1Yolk sac tumor  ini jarang terjadi pada wanita usia tua atau postmenopause, dapat berupa komponen yolk sac murni atau campuran dengan komponen tumor epitel lainnya. Laporan Kasus: Kami melaporkan seorang wanita usia 54 tahun dengan keluhan perut membesar seperti full- term pregnancy. Hasil pemeriksaan USG adalah tumor ovarium. Hasil pemeriksaan laboratorium menunjukkan dalam batas normal. Pasien menjalani prosedur optimal debulking. Pemeriksaan histopatologi adalah Ovarian Yolk Sac Tumor. Kesimpulan: Meskipun kasus ini jarang terjadi, Ovarian Yolk Sac Tumor dapat ditemukan pada usia tua atau postmenopause yang umumnya murni atau campuran dengan tumor epitel lainnya, pada kasus  ini ditemukan Yolk Sac Tumor ovarium murni. Diagnosis ditegakkan berdasarkan anamnesis, pemeriksaan fisik, pemeriksaan radiologis dan pemeriksaan histopatologis. Pemeriksaan histopatologis merupakan gold standard untuk diagnosis Ovarian Yolk Sac Tumor. Diagnosis bandingnya adalah Immature Teratoma, Sclerosing Stromal Tumor dan Dermoid Cyst. Kecurigaan klinis yang tinggi, diagnosis dan penatalaksanaan yang cepat dapat memberikan prognosis yang baik.
Difficulty in Diagnosing Peritoneal Fluid Cytology in Ovarian Yolk Sac Tumor Cases Pemuda, Haris; Yenita, Yenita; Mayorita, Pamelia; Setiawati, Yessy; Muhammad, Syamel
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 2 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.2.278-286.2021

Abstract

Objective : This article objective is to describe cytology diagnosis difficulties of yolk sac tumors of the ovary.Method : Case reports and literature review.Case : The author reports the case of a 24 year old woman who complained of an enlarged stomach. Serum AFP increased to 16,519.7 U/mL. Ultrasound examination revealed solid and irregular mass of ovarian, so the conclusion was suspect ovarian carcinoma. Conclusion of CT scan examination was a solid ovarian tumor. The working diagnosis was suspect ovarian carcinoma. Optimal debulking was performed, accompanied by taking a sample from the peritoneal rinse fluid. Microscopic examination of peritoneal fluid showed the distribution and group of cells with pleomorphic nuclei, partly hyperchromatic, partly vesicular with coarse chromatin and prominent nucleoli. There were also cells with polygonal nuclei, small nuclei, basophilic and vacuole cytoplasm with a mucoid background. These cells formed a solid arrangement. Conclusion from these features was carcinoma metastases to the peritoneal fluid. Microscopic examination from tumor tissue sample showed an ovarian yolk sac tumor appearance.Conclusion : Cytologic examination of peritoneal fluid in cases of ovarian yolk sac tumor is quite difficult to determine the diagnosis. This is due to the microscopic appearance of tumor cells which often looks like a carcinoma and limited literature about this tumors in the peritoneal fluid.Keywords: Yolk sac tumor, ovary, 
Ko-Insiden Rhinosinusitis Kronis dengan Polip Hidung dan Neurofibroma Irfandy, Dolly; Budiman, Bestari Jaka; Ikhlas, Khairani Ayunanda; Mayorita, Pamelia
Oto Rhino Laryngologica Indonesiana Vol. 53 No. 2 (2023): VOLUME 53, NO. 2 JULY - DECEMBER 2023
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v53i2.611

Abstract

Background: Nasal polyps are painless inflammatory lesions originated from around the middlemeatus or paranasal sinus cavity; while neurofibroma is benign peripheral nerve sheath tumor. Purpose:To report a rare case of neurofibroma concurrently with nasal polyps in chronic rhinosinusitis. Casereport: A 64-year-old female with chief complaint congestion on the right nose cavity. There was a mass on both nasal cavities. Patient diagnosed with benign mass at right nasal cavity and chronic rhinosinusitis with nasal polyps at left nasal cavity; with a differential diagnosis of chronic rhinosinusitis with bilateral nasal polyps. Computer tomography scan results showed homogeneous isodense lesion in the right nasal cavity, and mucosal thickening in left nasal cavity and maxillary sinus. Patient was managed with total extirpation of the bilateral nasal cavity mass and functional endoscopic sinus surgery. Pathological examination revealed neurofibroma in the right nasal cavity and polyps in the left nasal cavity. Clinical question: “How to differentiate inflammation with tumor of nasal and paranasal sinuses? Is there a causal relationship?” Review method: Literature searching was performed with the keywords “nasal cavity neurofibroma”, AND “nasal polyps”, AND ”chronic rhinosinusitis” through database Google Scholar, PubMed, and hand searching/e-book. Result: There were 11 literatures published in the last 5 years, and 7 articles relevant with the subject. Conclusion: Chronic rhinosinusitis with nasal polyps, along with neurofibroma on nasal cavity is a rare co-incidence, and there was no correlation between those lesions. Pathological examination is a gold standard in differentiating a definite diagnosis of neurofibromas and polyps.Keywords: nasal cavity neurofibroma, nasal polyps, chronic rhinosinusitis
Co-Authors Aswiyanti Asri Bestari Jaka Budiman Dolly Irfandy Handriyani, Fitri Nur Hardian, Sonny henny Mulyani Ikhlas, Khairani Ayunanda Kusumardani, Dini Novianti, Hera Octavia, Tri Aryati Pemuda, Haris Rahmi Ramadhani Setiawati, Yessy Syamel Muhammad Tofrizal Yenita .