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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Health and Medical Journal Andalas obstetrics and gynecology journal Science Midwifery Scientific Journal
Mayorita, Pamelia
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Ko-Insiden Rhinosinusitis Kronis dengan Polip Hidung dan Neurofibroma Irfandy, Dolly; Budiman, Bestari Jaka; Ikhlas, Khairani Ayunanda; Mayorita, Pamelia
Oto Rhino Laryngologica Indonesiana Vol. 53 No. 2 (2023): VOLUME 53, NO. 2 JULY - DECEMBER 2023
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v53i2.611

Abstract

Background: Nasal polyps are painless inflammatory lesions originated from around the middlemeatus or paranasal sinus cavity; while neurofibroma is benign peripheral nerve sheath tumor. Purpose:To report a rare case of neurofibroma concurrently with nasal polyps in chronic rhinosinusitis. Casereport: A 64-year-old female with chief complaint congestion on the right nose cavity. There was a mass on both nasal cavities. Patient diagnosed with benign mass at right nasal cavity and chronic rhinosinusitis with nasal polyps at left nasal cavity; with a differential diagnosis of chronic rhinosinusitis with bilateral nasal polyps. Computer tomography scan results showed homogeneous isodense lesion in the right nasal cavity, and mucosal thickening in left nasal cavity and maxillary sinus. Patient was managed with total extirpation of the bilateral nasal cavity mass and functional endoscopic sinus surgery. Pathological examination revealed neurofibroma in the right nasal cavity and polyps in the left nasal cavity. Clinical question: “How to differentiate inflammation with tumor of nasal and paranasal sinuses? Is there a causal relationship?” Review method: Literature searching was performed with the keywords “nasal cavity neurofibroma”, AND “nasal polyps”, AND ”chronic rhinosinusitis” through database Google Scholar, PubMed, and hand searching/e-book. Result: There were 11 literatures published in the last 5 years, and 7 articles relevant with the subject. Conclusion: Chronic rhinosinusitis with nasal polyps, along with neurofibroma on nasal cavity is a rare co-incidence, and there was no correlation between those lesions. Pathological examination is a gold standard in differentiating a definite diagnosis of neurofibromas and polyps.Keywords: nasal cavity neurofibroma, nasal polyps, chronic rhinosinusitis
Giant Cell of the Bone: Laporan Kasus dan Tinjauan Pustaka: Laporan Kasus dan Tinjauan Pustaka Oktora, Meta Zulyati; Mayorita, Pamelia
Scientific Journal Vol. 4 No. 1 (2025): SCIENA Volume IV No 1, January 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i1.192

Abstract

Giant Cell Tumor of the Bone (GCTB) adalah neoplasma tulang yang jarang terjadi namun bersifat agresif secara lokal dan sering mengenai epifisis tulang panjang. Laporan kasus ini menggambarkan seorang pria berusia 39 tahun dengan massa yang membesar secara progresif pada lutut kanan selama dua tahun. Pasien memiliki riwayat trauma pada lutut kanan. MRI femur dengan kontras menunjukkan lesi osteolitik ekspansif pada epifisis femur distal. Pemeriksaan histopatologik mengonfirmasi diagnosis GCTB dengan adanya sel multinukleasi raksasa dalam latar belakang stroma mononuklear. Pasien menjalani kuretase intralesional dengan cangkok tulang untuk mengurangi risiko kekambuhan. Patofisiologi GCTB melibatkan interaksi RANK/RANKL yang mendorong resorpsi tulang yang dimediasi osteoklas. Meskipun jinak, GCTB memiliki tingkat kekambuhan yang tinggi dan dalam kasus yang jarang dapat mengalami transformasi ganas. Analisis perbandingan dengan kasus lain menyoroti pentingnya terapi adjuvan dan pendekatan pengobatan bertarget seperti denosumab dalam meningkatkan hasil klinis pasien.
Bone Metastasis Disease from Mucinous Carcinoma of the Breast: A Rare Case Report with Immunohistochemical Confirmation Novianti, Hera; Mayorita, Pamelia; Oktora, Meta Zulyati; Hafizhah, Ataya; Muhammad, Almu
Scientific Journal Vol. 4 No. 1 (2025): SCIENA Volume IV No 1, January 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i1.194

Abstract

Background: Mucinous carcinoma of the breast (MCB) is a rare histological subtype of invasive breast cancer, comprising 1-7% of all breast carcinomas. It is generally associated with a favorable prognosis due to its indolent course and low metastatic potential. However, distant metastases, including to the bone, are exceptionally rare and pose diagnostic and therapeutic challenges. Case Presentation: We present a case of a 64-year-old woman with a history of MCB who developed progressive back pain and lower limb weakness. MRI showed multiple osteolytic lesions with spinal cord compression. A CT-guided biopsy confirmed metastatic mucinous carcinoma, and immunohistochemical (IHC) staining demonstrated GATA3 positivity, confirming breast origin. The patient received denosumab, aromatase inhibitors, and palliative radiotherapy. Conclusion: This case highlights the importance of considering bone metastases in patients with a history of MCB presenting with skeletal-related events. IHC, particularly GATA3, is crucial in confirming the metastatic origin and guiding targeted treatment strategies.
Mycosis Fungoides dengan Gambaran Klinis Eritroderma yang Menyerupai Dermatitis Seboroik Tofrizal; Mayorita, Pamelia; Aini, Julpa Nurul; Nelzima, Maisyah; Oktora, Meta Zulyati
Scientific Journal Vol. 4 No. 2 (2025): SCIENA Volume IV No 2, March 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i2.200

Abstract

Mycosis fungoides (MF) merupakan limfoma T-sel kulit primer yang paling sering ditemukan, termasuk dalam kategori Cutaneous T-cell Lymphomas (CTCL). MF ditandai dengan proliferasi sel T epidermotropik yang sebagian besar terdiri dari sel CD4+. Penyakit ini memiliki perjalanan klinis yang umumnya lambat, diawali dengan lesi berupa patch atau plak eritematosa yang secara bertahap dapat berkembang menjadi tumor atau eritroderma pada stadium lanjut. Eritroderma, yang melibatkan lebih dari 80% permukaan kulit, sering kali sulit dibedakan dari dermatitis inflamasi lainnya, seperti dermatitis seboroik, psoriasis, atau penyakit sistemik lainnya. Oleh karena itu, pengenalan dini dan diagnosis akurat sangat penting untuk menentukan terapi yang tepat dan memperbaiki prognosis pasien. Laporan ini memaparkan kasus seorang pria berusia 53 tahun dengan gejala eritroderma yang awalnya menyerupai dermatitis seboroik. Pemeriksaan fisik dan laboratorium awal menunjukkan adanya lesi kulit meluas disertai skuama kasar, sehingga diduga eritroderma akibat Cutaneous T-cell Lymphoma (CTCL). Hasil biopsi eksisi kulit mengungkapkan infiltrasi sel limfosit atipikal yang menunjukkan epidermotropisme dan pembentukan Pautrier microabscesses, yang mengarah pada diagnosis MF. Pemeriksaan imunohistokimia menunjukkan hasil positif untuk CD3 dan CD4, yang semakin memperkuat diagnosis tersebut. Pasien direncanakan menjalani kemoterapi sebanyak enam siklus, namun pada saat akan menjalani kemoterapi siklus ketiga, kondisi pasien memburuk dengan penurunan kesadaran akibat hiponatremia dan komplikasi lain, hingga akhirnya meninggal dunia. Diagnosis MF pada tahap awal sering kali menjadi tantangan karena manifestasi klinisnya yang menyerupai penyakit kulit inflamasi lainnya. Oleh karena itu, kombinasi pemeriksaan klinis, histopatologi, dan imunohistokimia sangat diperlukan untuk membedakan MF dari diagnosis banding lainnya. Penatalaksanaan yang tepat dan pemantauan jangka panjang menjadi kunci dalam memperbaiki prognosis pasien, terutama pada stadium lanjut MF yang memerlukan terapi sistemik agresif.
Challenges in diagnosing schwannoma mimicking thyroid neoplasms on frozen section Ramadhani, Rahmi; Mayorita, Pamelia; Asri, Aswiyanti; Mulyani, Henny; Novianti, Hera
Science Midwifery Vol 13 No 2 (2025): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i2.1977

Abstract

Schwannoma is a benign soft tissue tumor of the nerve sheath, composed of neoplastic cells with Schwann cell differentiation. It predominantly arises from peripheral nerves in the head, neck, and extremities, with a peak incidence in the fourth to sixth decades. Schwannoma is typically a solitary and sporadic lesion, affecting individuals of all ages, with an incidence rate of 4.4-5.23 cases per 100,000 people. The prevalence is around 7% of all primary nervous system tumors, often occurring in the head and neck (20-50%) and affecting cranial nerves such as N. Vagus and N. Sympathetic. This case report involves a 50-year-old female patient presenting with a right neck lump that had been present for 23 years, initially small but growing rapidly in the last 10 years with occasional pain. Initial imaging suggested a thyroid complex cyst, but further investigation, including a CT scan and intraoperative frozen section examination, raised suspicion for a malignant thyroid tumor. However, histopathological analysis confirmed the diagnosis of Schwannoma, distinguishing it from other potential malignant lesions, such as Anaplastic Thyroid Carcinoma (ATC). This case highlights the importance of intraoperative cytology and frozen section techniques for diagnosing Schwannoma. Although Schwannomas share morphological similarities with other tumors, particularly in the thyroid region, a multidisciplinary approach combining clinical, radiological, and histopathological findings is essential for an accurate diagnosis. This case also underscores the need for careful differential diagnosis in nerve sheath tumors located in the neck.
Malignant Peripheral Nerve Sheath Tumor di Regio Bahu yang menyerupai Undifferentiated Carcinoma: Tantangan Diagnostik Handriyani, Fitri Nur; Tofrizal, Tofrizal; Mayorita, Pamelia
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.90-95

Abstract

Malignant peripheral nerve sheath tumor (MPNST) is a rare and aggressive group of neoplasms arising from the peripheral nervous system sheath cells (Schwann cells or perineurial cells). Malignant peripheral nerve sheath tumors are typically seen in patients aged 20–50 years, and the most common sites are the trunk and extremities. This case highlights the diagnostic complexity and distinguishes MPNST from undifferentiated carcinoma. We present a case report of a 59-year-old male patient who presented with a rapidly growing mass in the right shoulder for six months. Clinical examination on his shoulder showed a solid mass, lobulated and ulcerated, and an irregular margin measuring 16x12x5 cm. A thoracic MRI revealed a large mass, fusiform and lobulated, with dimensions of 15.02 x 15.81 x 12.65 cm. The patient underwent surgical incision biopsy of the mass. Histopathological and immunohistochemical examinations with S100 and cytokeratin (CK) markers were performed on this patient with MPNST results. The immunoprofile of MPNST showed focal positive staining for S100 marker and negative staining for CK marker. The diagnosis of malignant peripheral nerve sheath tumor can be more challenging if the histopathological examination resembles a feature of undifferentiated carcinoma, like lobulated pattern and clustering of cells with round-oval nuclei. The role of immunohistochemical examination is very important to rule out differential diagnoses.
A Rare Case of Multiple Hereditary Exostosis: Making The Correct Diagnosis with Triple Diagnosis Ramadhani, Rahmi; Hilbertina, Noza; Yenita; Tofrizal; Mayorita, Pamelia; Devianti, Loli; O ktora, Meta Zulyati
Scientific Journal Vol. 4 No. 4 (2025): SCIENA Volume IV No 4, July 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i4.248

Abstract

Background: A rare genetic disorder characterized by the development of multiple benign bone tumors called osteochondromas. This condition is primarily hereditary and follows an autosomal dominant pattern of inheritance, with mutations in the EXT1 and EXT2 genes being the most common genetic. Case report: This case report describes an 12-year-old boy with lumps in all four extremities accompanied by intermittent pain. Femur x-rays concluded MHE of the femur, tibia, and bilateral fibula. Histopathological examination shows that the cartilage tissue contains chondrocyte cells that form the cartilage cap. There is a transition of cartilage to bone trabeculae through endochondral ossification and bone marrow between the bone trabeculae. Discussion and Conclusion: MHE is a rare condition, with an incidence of approximately 1 in 50,000 to 100,000 live births. MHE is closely related to genetic mutations that occur in the EXT1, EXT2, and EXT3 genes. These genes code for enzymes involved in the biosynthesis of heparan sulfate, which is necessary for normal bone growth. Mutations in any of these genes disrupt the regulation of bone growth and lead to osteochondroma formation. Symptoms of MHE can range from mild to severe, and they tend to appear in childhood or adolescence. The main clinical manifestations include the formation of a hard lump on the bone, which can cause deformity, pain, and limitation of movement. Osteochondroma can also compress nerves or blood vessels, causing complications such as circulatory disorders or paralysis. We report a rare case emphasizing the typical morphology of multiple hereditary exostosis of the long bones to establish the final diagnosis without immunohistochemistry and molecular examination. In low-resource settings where molecular analysis is not available, histopathological examination are key tools to establish a correct diagnosis.
Sarkoma Ewing Sinonasal dengan Klinis dan Pencitraan Jinak: Pentingnya Pemeriksaan IHK Berlapis dalam Menentukan Diagnosis Akurat Mayorita, Pamelia; Oktora, Meta Zulyati
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.256

Abstract

Sarkoma Ewing merupakan tumor ganas dari kelompok tumor sel kecil bulat yang umumnya ditemukan pada tulang panjang anak dan remaja. Keterlibatan regio sinonasal sangat jarang dan dapat menyerupai lesi jinak, baik secara klinis maupun radiologis, sehingga berpotensi menyebabkan keterlambatan diagnosis. Kami melaporkan kasus sarkoma Ewing primer di regio sinonasal dengan manifestasi yang menyerupai polip jinak, serta menekankan pentingnya pendekatan diagnostik histopatologi dan imunohistokimia berlapis dalam kasus dengan presentasi tidak khas. Seorang laki-laki usia 18 tahun datang dengan keluhan hidung tersumbat, epistaksis, dan penurunan penciuman. Pemeriksaan CT menunjukkan massa hipervaskuler sinonasal dengan kesan awal angiomatous polyp. Pasien menjalani embolisasi dan endoscopic sinus surgery (ESS). Histopatologi awal menunjukkan proliferasi sel bulat kecil dengan pleomorfisme dan mitosis atipik, dengan dugaan awal Sinonasal Undifferentiated Carcinoma. Pemeriksaan imunohistokimia CK dan CD45 menunjukkan hasil negatif. Pemeriksaan lanjutan menunjukkan CD99 positif kuat dan difus pada membran sel, Ki-67 positif >30%, dan desmin negatif. Hasil ini mendukung diagnosis sarkoma Ewing. Pasien dirujuk untuk tatalaksana radioterapi. Sarkoma Ewing sinonasal sering kali tidak dikenali karena lokasinya yang tidak umum dan presentasinya yang menyerupai lesi jinak seperti polip atau angiofibroma. Pemeriksaan imunohistokimia, khususnya ekspresi CD99, merupakan penanda penting dalam membedakan sarkoma Ewing dari entitas lain dalam spektrum tumor sel kecil bulat. Diagnosis yang akurat sangat penting untuk menentukan terapi multimodal yang tepat, termasuk kemoterapi dan radioterapi. Sarkoma Ewing di regio sinonasal merupakan kasus langka dengan manifestasi klinis dan radiologis tidak khas. Pemeriksaan histopatologi dan imunohistokimia berperan penting dalam menegakkan diagnosis, terutama pada lokasi yang tidak lazim.
Diagnosis dan Tatalaksana Limfoma Non Hodgkin Tipe Sel B Sinonasal Octavia, Tri Aryati; Irfandy, Dolly; Budiman, Bestari Jaka; Mayorita, Pamelia
Majalah Kedokteran Andalas Vol. 46 No. 4 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p1103-1117.2023

Abstract

Pendahuluan: Limfoma Non Hodgkin (LNH) sinonasal merupakan tumor ganas ekstranodal yang jarang terjadi. Lokasi paling sering adalah sinus maksilaris, sinus ethmoid dan rongga hidung. Diagnosis pasti imfoma ditegakkan berdasarkan hasil pemeriksaan histopatologi dan imunohistokimia. Tatalaksana kasus berdasarkan stadium dengan menggunakan stagging Ann Arbor. Laporan Kasus: Dilaporkan satu kasus LNH sinonasal pada laki–laki usia 56 tahun dengan keluhan hidung kanan tersumbat dan keluar darah dari hidung kanan. Pemeriksaan kavum nasal dekstra ditemukan adanya massa yang memenuhi kavum nasal disertai sekret mukopurulen. Kemudian dilakukan tindakan medial maksiektomi dengan pendekatan endoskopik dan didapatkan hasil histopatologi limfoma maligna tipe sel sedang serta imunohistokimia (IHK) dengan hasil limfoma maligna tipe sel B. Kesimpulan: Dilaporkan satu kasus LNH sinonasal pada laki–laki usia 56 tahun dengan keluhan hidung kanan tersumbat dan keluar darah dari hidung kanan. Pemeriksaan kavum nasal dekstra ditemukan adanya massa yang memenuhi kavum nasal disertai sekret mukopurulen. Kemudian dilakukan tindakan medial maksiektomi dengan pendekatan endoskopik dan didapatkan hasil histopatologi limfoma maligna tipe sel sedang serta imunohistokimia (IHK) dengan hasil limfoma maligna tipe sel B.Kata kunci: Limfoma Non Hodgkin sinonasal, Limfoma tipe Sel B, Kemoterapi.
Teknik Pewarnaan dan Diagnosis Sputum pada Kanker Paru Hardian, Sonny; Yenita, Yenita; Mayorita, Pamelia
Health and Medical Journal Vol 5, No 2 (2023): HEME May 2023
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v5i2.1259

Abstract

Kanker paru merupakan penyebab kematian yang paling umum di seluruh dunia. Deteksi awal untuk kanker paru bisa menggunakan teknik pemeriksaan sitoligi sputum. Teknik sitologi sputum menggunakan pewarnaan Papanicolaou dan May Grunwald Giemsa. Kedua teknik pewarnaan ini memiliki kelebihannya masing – masing dalam mendiagnosis kanker paru. Beberapa jenis kanker paru yang sering bisa dinilai dari sampel sputum adalah squamous cell carcinoma, adenocarcinoma, dan small cell carcinoma. Kanker paru jenis large cell carcinoma tidak adekuat untuk dinilai dari sampel sputum.
Co-Authors Aini, Julpa Nurul Aswiyanti Asri Bestari Jaka Budiman Devianti, Loli Dolly Irfandy Hafizhah, Ataya Handriyani, Fitri Nur Hardian, Sonny henny Mulyani Ikhlas, Khairani Ayunanda Kusumardani, Dini Muhammad, Almu Nelzima, Maisyah Novianti, Hera Noza Hilbertina, Noza O ktora, Meta Zulyati Octavia, Tri Aryati Oktora, Meta Zulyati Pemuda, Haris Rahmi Ramadhani Setiawati, Yessy Syamel Muhammad Tofrizal Yenita .