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All Journal VALENSI Sinergi Chemistry in Education Indonesian Journal of Chemical Science ABDIMAS SILIWANGI Jurnal Kartika Kimia GERVASI: Jurnal Pengabdian kepada Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Kepada Masyarakat (JPKM) Tabikpun Journal of Science and Technology Research for Pharmacy Bookchapter Alam Universitas Negeri Semarang Indonesian Journal of Chemical Science Journal of Science and Technology Research for Pharmacy
Widhihastuti, Endah
Universitas Negeri Semarang
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Comparison of Lead (Pb) Content Analysis Using Atomic Absorption Spectrophotometry with Wet and Dry Destruction Methods in Body Lotion Preparations in Semarang City Muhammad Shidqi Naufal Athalla; Endah Widhihastuti
Journal of Science and Technology Research for Pharmacy Vol. 5 No. 2 (2025): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v5i2.31998

Abstract

Many body lotions are found in circulation without a BPOM RI registration number, which can raise concerns about lead metal contamination. The lead metal content in body lotion can be sourced from the raw material, namely water. Lead metal levels in water range from 0,011 mg/L to 0,076 mg/L. Determination of lead levels uses an Atomic Absorption Spectrophotometry instrument. The requirement for analysis using Atomic Absorption Spectrophotometry is that the sample must be in solution form, so a destruction process is necessary because the body lotion sample is in semi-solid form. This study aims to compare two commonly used destruction methods, namely wet and dry destruction. The methodology in this study consists of qualitative analysis, method validation, and quantitative analysis. The test results with qualitative analysis showed negative lead metal content. The results of the Atomic Absorption Spectrophotometry method validation were: linearity (R2) of 0,9999; LoD of 0,024 mg/L; LoQ of 0,080 mg/L; precision (%RSD) of 0,61%; accuracy (%Recovery) of 100,09% with quantitative results of the percentage of wet digestion sample content, results were: 1,2264 ± 2,96%; 1,7687 ± 4,24%; 1,5036 ± 3,75%; 1,1807 ± 2,92%; and 1,5606 ± 3,88%. This can happen because the wet destruction method is better to use than the dry destruction method which can be seen from the %Recovery.
Antioxidant Activity of Porang (Amorphophallus muelleri) Leaves Ethanol Extract and Its Application as Cream Preparation Willy Tirza Eden; Erlina Sari; Endah Widhihastuti; Tri Minarsih; Senda Kartika Rakainsa
Jurnal Kartika Kimia Vol 9 No 1 (2026): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v9i1.915

Abstract

Antioxidants are compounds that can overcome the effects of free radicals. One of the plants that has antioxidant activity is the Porang plant (Amorphophallus muelleri). This study aims to determine the antioxidant activity of the Porang leaves’ ethanol extract and fraction using the DPPH method. Porang leaves were extracted using maceration with 96% ethanol and separated by fractionation using n-hexane and ethyl acetate. The ethanol extract and the three fractions were tested for their activity as antioxidants using the DPPH method with ascorbic acid as positive control. Phytochemical screening and Total Flavonoid Content (TFC) assay were also conducted. Phytochemical screening showed the presence of flavonoids, tannins/polyphenols, and terpenoids. Quantitative test for Total Flavonoid Content (TFC) showed that the greatest flavonoid content was found in the ethyl acetate fraction, which was 101.93 ± 2.75 mgQE/g. The results showed that the strongest antioxidant activity was possessed by ethanol extract (IC50 66.39 ± 0.44 µg/mL), followed by the ethyl acetate fraction (IC50 72.19 ± 4.37 µg/mL), ethyl acetate insoluble fraction (IC50 135.48 ± 2.54 µg/mL), and the weakest was n-hexane fraction (IC50 198.31 ± 16.75 µg/mL). Hence, cream was prepared using ethanol extract which possesses the strongest antioxidant activity. Formula 4 (7.5% extract) showed the strongest antioxidant activity (IC50 1,637.12 µg/mL), followed by formula 3 (5% extract) with IC50 of 2590.377 µg/mL, formula 2 (2.5% extract) with IC50 of 3,898.694 µg/mL, and formula 1 (cream base) with IC50 of 110,727.4 µg/mL. All cream formulations which contained porang leaves extract (F2 – F4) had higher antioxidant activity than formula 1 (base), although their antioxidant activity was classified as very weak.
Co-Authors Agustina, Nurul Fajar Ameliyana Anak Agung Gede Sugianthara Artissiani, Maysa Christijanti , Wulan Devi Ajeng Efrilianda Erika Wuryaningsih Erlina Sari F Widhi Mahatmanti Izzania, Rahma Annisa Larasati, Dhatu Sekar M. Kholid Baror Abadi Muhammad Shidqi Naufal Athalla Nanang Fakhrudin, Nanang Ni'ma, Neli Syahida Nuni Widiarti Nurul Fajar Agustina Prisma Detty Nuryana Rakainsa, Senda Kartika Sam'an, Muhammad Senda Kartika Rakainsa Senda Kartika Rakainsa Sigit Priatmoko SIRAIT, Ernessa Indah Rotua Sitarina Widyarini Sri Wahyuni Subhan Subhan Syarif, Deny Lukman Tri Minarsih Willy Tirza Eden, Willy Tirza Woro Sumarni Yahya Nur Ifriza Yuan Maylia Rosanti