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All Journal Lantanida Journal Biologica Samudra Narra J Journal Of Carbazon
Purnama, Agnia
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary

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Molecular docking of two cytotoxic compounds from Calotropis gigantea leaves against therapeutic molecular target of pancreatic cancer Purnama, Agnia; Mardina, Vivi; Puspita, Kana; Qanita, Intan; Rizki, Diva R.; Hasballah, Kartini; Iqbal, Mudassar; Sarong, Murniana
Narra J Vol. 1 No. 2 (2021): August 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i2.37

Abstract

The utilization of natural compounds as therapeutic agents to treat pancreatic cancer has recently focused on natural drug research. Calotropis gigantea has long been believed to be a medicinal plant that helps in treating various diseases. The bioactive compounds 9-metoxipinoresinol and isoliquiritigenin isolated from C. gigantea leaves are proven to act as therapeutic agents by inhibiting the cancer cell growth of Panc-1 cells. This study aimed to screen the potential molecular inhibition mechanisms of 9-metoxipinoresinol and isoliquiritigenin against pancreatic cancer development in-silico. We analyzed the activity of the aforementioned two compounds as inhibitors of several proteins that play a role in the growth of pancreatic cancer cells, such as GCNT3, GOT1, c-Met, PPARγ, BUB1, and NF-κβ, through molecular docking investigation. Our data suggested that 9-metoxipinoresinol and isoliquiritigenin were able to have well interaction with the target proteins, in which the predicted affinity energy ranged between -6.8 and 8.7 kcal/mol. The docking scores of 9-metoxipinoresinol and isoliquiritigenin were higher than the standard drug used (gemcitabine). Based on the binding affinity energy, GCNT3 and BUB1 are potentially to be used as target molecules for cancer therapy using 9-metoxipinoresinol and isoliquiritigenin, respectively.
Evaluation of Antifeedant Activity in Methanol Extracts of Zingiberaceae Species Against Epilachna sparsa Purnama, Agnia; Nurdin, Nurdin; Ratna, Ratna; Farida, Mutia
Journal of Carbazon Vol 2, No 2 (2024): December 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jocarbazon.v2i2.42458

Abstract

Cellulosenanofibrils (CNF) is a new generation material that has high performance, good physics and medical properties and is a renewable material that has been developed from various sources using the acid hydrolysis method. CNF synthesis is generally obtained from logs that have a high amount of cellulose fiber. Cellulose nanofibrils (CNF) from arabica coffee skins have great potential to be developed as raw materials for medicines, which function as wound healing agents, surgical sutures, diet medicines, and skin softeners. CNF is produced from Arabica coffee skin through delignification, namely the removal of lignin and hemicellulose by extraction with alkali until -cellulose is obtained, then CNF is synthesized through hydrolysis using dilute acid. From the coffee skin extraction results, a high cellulose yield was obtained, reaching above 24.30% and crystallinity reaching 79.60%. Hydrolysis by 10%, 12% and 15% HCl with a reaction time of 2 hours, the respective crystallinity was 80.66; 79.06; and 77.69%.
AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI N-HEKSANA KULIT BUAH KAKAO (Theobroma cacao L.) Purnama, Agnia; Ginting, Binawati; Yahya, Mustanir; Afifi, Muhammad Ridho; Maghfirah, Ruhul; Farida, Mutia; Hamdiyati, Hamdiyati
Lantanida Journal Vol 13 No 1 (2025): June 2025
Publisher : UIN AR-RANIRY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/lj.v13i1.29989

Abstract

This study aims to evaluate the antibacterial activity of the n-hexane extract and fraction of cocoa pod husk against Staphylococcus aureus. The antibacterial was tested using the paper disc diffusion method. The results showed that the extract inhibited bacterial with inhibition zones of 7.13 ± 0.29; 8.58 ± 0.14; 9.60 ± 0.87; and 10.97 ± 0.08 mm at concentrations of 1%, 5%, 10%, and 20%, respectively. The fractionation process produced 9 fractions and the 9th fraction showed the greatest inhibitory activity with inhibition zone diameters of 7.42 ± 0.03; 9.22 ± 0.03; 10.43 ± 0.03; and 11.83 ± 0.03 mm at concentrations of 1%; 5%; 10%; and 20% respectively. Phytochemical analysis and thin-layer chromatography (TLC) showed the presence of terpenoid and steroid compounds. Based on the antibacterial activity exhibited by the extract and fraction, this plant shows potential to be developed as a source of natural antibacterials.
Quantitative Analysis of Sibutramine Hydrochloride in Slimming Herbal Medicines in Banda Aceh Using UV-Vis Spectrophotometry Ruhul Maghfirah; Farida, Mutia; Purnama, Agnia; Afifi, Muhammad Ridho; MZ, Kartika; Rahmawati, Erda
JURNAL BIOLOGICA SAMUDRA Vol 7 No 1 (2025): Biologica Samudra
Publisher : Program Studi Biologi, Fakultas Teknik, Universitas Samudra

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33059/jbs.v7i1.11763

Abstract

Sibutramine hydrochloride is a chemical compound that was once often used as a weight loss drug. This drug is hazardous if used illegally in herbal medicine because it can cause health problems such as kidney failure, heart attacks, and strokes. BPOM has banned its use in herbal medicine, but until now herbal medicine containing sibutramine hydrochloride is still on the market. This study aims to determine the levels of Sibutramine Hydrochloride contained in slimming herbal medicine. The samples used in this study consisted of four brands of slimming herbal medicine that are not registered with BPOM, coded A, B, C, and D, which were obtained from several shops in Baiturrahman District, Banda Aceh City. Sampling was carried out using the total sampling method and then analyzed quantitatively using UV-Vis spectrophotometry. The results of the analysis showed that the four samples were positive for containing Sibutramine Hydrochloride with an average level of 31.69% of herbal medicine sample A; 39.88% of herbal medicine sample B; 7.09% of herbal medicine sample C; and 36.60% of herbal medicine sample D. Therefore, stricter examination and supervision of the circulation of slimming herbal medicine products in the Banda Aceh city area are needed to protect public health.
Co-Authors Afifi, Muhammad Ridho Binawati Ginting Hamdiyati, Hamdiyati Iqbal, Mudassar Kartini Hasballah Maghfirah, Ruhul Mardina, Vivi Mutia Farida, Mutia MZ, Kartika Nurdin Nurdin Puspita, Kana Qanita, Intan Rahmawati, Erda Ratna Ratna Rizki, Diva R. Ruhul Maghfirah Sarong, Murniana Yahya, Mustanir