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All Journal JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Lantanida Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Journal Of Carbazon
Maghfirah, Ruhul
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Physics

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Characterization of Thermophilic Novel-Rare Actinobacteria from Hot Springs and Compost as an Unique Secondary Metabolite Producer Maghfirah, Ruhul; Kemala, Pati; Astryna, Syarifah Yanti
Journal of Carbazon Vol 2, No 2 (2024): December 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jocarbazon.v2i2.42883

Abstract

This review aims to explain in more detail about the Actinobacteria and it secondary metabolites. Some species of Actinobacteria can live in extreme environments such as high acid, high base, high salt and even high temperatures. Actinobacteria mainly of the genus Streptomyces sp. has been known to produce bioactive compounds such as antibacterial, antifungal, anticancer, antitumor, anticytotoxic, anti-inflammatory, anti-parasitic, anti-malarial, antiviral and antioxidant. This study reviews various research findings on Actinobacteria species and their ability to thrive in extreme environments. It also reviews the findings of bioactive compounds isolated from Actinobacteria and their potential applications. Some species in the genera Streptomyces, Thermonospora, and Thermoactinomyces have optimal growth temperatures above 55C and are categorized as thermophilic. More than 30,000 bioactive compounds that have been isolated are derived from Actinobacteria and 80% are from the genus Streptomyces sp. Benzastatin C and 3-Chloro-Tetrahidroquinolon are new antivirals isolated from Streptomyces nitrosporeus. Essramycin is a novel antibiotic that shows activity against Gram positive and Gram negative bacteria. Chandrananimycin A isolated from Actinomadura sp. and N-(2-hydroxyphenyl)-2-Phenazinamin (NHP) isolated from Nocardia dassonvillei are novel antibiotics that can be used as antifungals, antialgas, antibacterials and anticancer. The potential of Actinobacteria in producing bioactive compounds can advance the field of science and technology in the future and become an alternative to overcome the problem of resistance to pathogenic microorganisms are increasing.
UJI SKRINING FITOKIMIA EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L. ) Astryna, Syarifah Yanti; Samaniyah, Siti; Nurhayati, Nurhayati; Asyura, Syarifah; Maghfirah, Ruhul
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 10, No 2 (2024): OKTOBER 2024
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v10i2.4718

Abstract

Bunga telang (Clitoria ternatea L.) merupakan tanaman yang dikenal memiliki berbagai manfaat dalam pengobatan tradisional. Tanaman ini mengandung berbagai senyawa fitokimia yang diduga memiliki aktivitas farmakologis yang bermanfaat untuk kesehatan. Penelitian ini bertujuan untuk mengidentifikasi kandungan senyawa fitokimia pada ekstrak etanol bunga telang melalui uji skrining fitokimia. Ekstraksi dilakukan menggunakan pelarut etanol 70%, dan hasil ekstrak diuji terhadap senyawa alkaloid, flavonoid, saponin, tanin, dan terpenoid menggunakan metode reaksi kimia spesifik. Hasil penelitian menunjukkan bahwa ekstrak etanol bunga telang mengandung senyawa flavonoid, saponin, dan terpenoid, yang memiliki potensi sebagai bahan baku obat alami. Namun, alkaloid dan tanin tidak terdeteksi dalam ekstrak. Temuan ini menunjukkan pentingnya bunga telang sebagai sumber fitokimia dengan potensi terapeutik. 
UJI EFEKTIVITAS GEL EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L. ) TERHADAP PENYEMBUHAN LUKA BAKAR PADA HEWAN UJI KELINCI (Oryctolagus cuniculus) Astryna, Syarifah Yanti; Samaniyah, Siti; Ridjna, Hilal Zulikram; Rosdiana, Eva; Maghfirah, Ruhul
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 10, No 2 (2024): OKTOBER 2024
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v10i2.4765

Abstract

Luka bakar disebabkan oleh perpindahan energi dari sumber panas ke tubuh melalui konduksi atau radiasi elektromagnetik. Data dari Riset Kesehatan Dasar Kementrian Kesehatan tahun 2019 menyatakan angka luka bakar di Indonesia menempati peringkat kedua pada golongan proporsi jenis cidera luka bakar dengan besar 1,3% setelah cedera lainnya dengan presentase sebesar 2,6%. Bunga telang merupakan salah satu tanaman yang memiliki senyawa antioksidan yang dapat memberikan perlindungan tubuh dari serangan radikal bebas yang dapat menyebabkan luka bakar. Senyawa pada bunga telang dapat berperan dalam penyembuhan luka bakar antara lain flavonoid dan saponin. Tujuan Penelitian untuk mengetahui ekstrak etanol bunga telang berpengaruh terhadap penyembuhan luka bakar pada kelinci dan untuk mengetahui tingkat konsentrasi paling efektif pada ekstrak etanol bunga telang yang terbaik memberikan efek penyembuhan luka bakar. Metode Penelitian berupa ekstrak yang diformulasikan menjadi sediaan gel dengan konsentrasi 5%, 10% dan 15%. Pengujian yang dilakukan meliputi standarisasi simplisia, skrinning fitokimia, evaluasi sediaan, uji efektivitas luka bakar pada kelinci dan uji statistik One Way ANOVA. Hasil penelitian menunjukkan bahwa ekstrak etanol bunga telang memiliki pengaruh terhadap penyembuhan luka bakar pada kelinci. 
AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI N-HEKSANA KULIT BUAH KAKAO (Theobroma cacao L.) Purnama, Agnia; Ginting, Binawati; Yahya, Mustanir; Afifi, Muhammad Ridho; Maghfirah, Ruhul; Farida, Mutia; Hamdiyati, Hamdiyati
Lantanida Journal Vol 13 No 1 (2025): January-June 2025
Publisher : UIN AR-RANIRY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/lj.v13i1.29989

Abstract

This study aims to evaluate the antibacterial activity of the n-hexane extract and fraction of cocoa pod husk against Staphylococcus aureus. The antibacterial was tested using the paper disc diffusion method. The results showed that the extract inhibited bacterial with inhibition zones of 7.13 ± 0.29; 8.58 ± 0.14; 9.60 ± 0.87; and 10.97 ± 0.08 mm at concentrations of 1%, 5%, 10%, and 20%, respectively. The fractionation process produced 9 fractions and the 9th fraction showed the greatest inhibitory activity with inhibition zone diameters of 7.42 ± 0.03; 9.22 ± 0.03; 10.43 ± 0.03; and 11.83 ± 0.03 mm at concentrations of 1%; 5%; 10%; and 20% respectively. Phytochemical analysis and thin-layer chromatography (TLC) showed the presence of terpenoid and steroid compounds. Based on the antibacterial activity exhibited by the extract and fraction, this plant shows potential to be developed as a source of natural antibacterials.
The Effect of doses of Natural Super Phospate Fertilizer and Potassium on the Growth and Yield of Peanut Plants (Arachis hypogaea L.) Yusuf, Husainah; Jailani; Apriana, Evi; Elvitriana; Maghfirah, Ruhul
Jurnal Penelitian Pendidikan IPA Vol 10 No 12 (2024): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i12.7898

Abstract

The purpose of the study was to determine the proper dosage of natural phosphate and potash fertilizers for peanut growth and yield. This research was conducted in Tanjung Village, Darul Hasanah District, Southeast Aceh Regency from October to December 2020. This study used 3x3 factorial randomized block design (RBD) with 3 repeats. The results showed that the dose of Natural Super Phosphat fertilizer had a significant effect on the weight of 100 dry seeds of peanut plants.  The highest growth and soaking of dried peanut seeds tends to be obtained at a dose of Natural Super Phospat 100 kg P205 I ha. The dose of potash fertilizer had no significant effect on plant height at the age of 15, 30 and 45 watersheds, the number of well-fused pods per clump, the number of empty pods per clump, the weight of dry pods per clump, the weight of 100 dry seeds, the weight of dry seeds per net plot and the weight of dry seeds per hectare. Better growth and yield of dry seeds in peanut plants tend to be obtained with a dose of potash fertilizer of 75 kg K20 I ha. There is an insignificant interaction between the dose treatment of Natural Super Phosphate fertilizer and the dose of potassium fertilizer.
Co-Authors Afifi, Muhammad Ridho Astryna, Syarifah Yanti Binawati Ginting Elvitriana Evi Apriana Hamdiyati, Hamdiyati Jailani Kemala, Pati Mutia Farida, Mutia Nurhayati Nurhayati Purnama, Agnia Ridjna, Hilal Zulikram Rosdiana, Eva Samaniyah, Siti Syarifah Asyura, Syarifah Yahya, Mustanir Yusuf, Husainah