Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Journal of Dentistry Indonesia Jurnal Kedokteran Gigi Universitas Padjadjaran
Arief Ichwan, Solachuddin Jauhari
Unknown Affiliation
Dentistry Health Professions

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Correlation between blood international normalised ratio (INR) value and saliva prothrombin concentration in patients under warfarin therapy: An observational analytics study Pratama, Rachendra; Sjamsudin, Endang; Tasman Yuza, Abel; Wijaya, Indra; Arief Ichwan, Solachuddin Jauhari
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 36, No 1 (2024): April 2024
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v36i1.52441

Abstract

Introduction: Oromaxillofacial surgery has a bleeding risk complication. Increasing bleeding risk can be caused by the use of blood clotting inhibitors, including warfarin. Warfarin is an anticoagulant that works by inhibiting coagulation factors in the cascade. International normalised ratio (INR) indicates warfarin monitoring and bleeding risk during surgical procedures. INR examination currently uses blood plasma. This research analyses the correlation between blood INR value and salivary prothrombin concentration. Methods: This research was an analytical observational with a correlational design on 19 samples examined using a human prothrombin reagent from Elabscience. The samples used were blood and saliva, and then ELISA tests were carried out on them. Data results were analysed with linear regression and correlation tests. Results: In this study, 19 samples were collected from 6 male and 13 female subjects. The average value of salivary prothrombin concentration in this study was 227.63 (ng/ml), and the blood INR value was 1.85. The normality test result showed that the data distribution was normal; therefore, the correlation and simple linear regression tests can be conducted. The correlation and regression tests showed a positive correlation between blood INR value and salivary prothrombin concentration with a correlation coefficient of r = 0.81 (p < 0.001). Conclusion: There is a positive relationship between blood INR value and salivary prothrombin concentration in oromaxillofacial patients under warfarin therapy.
Flaxseed Ethanolic Extract Modulates Β-Catenin and DKK1 Expressions During Osteoblast Differentiation of Dental Pulp-Derived Stem Cells Nordin, Nur Sazwi; Mokhtar, Khairani Idah; Abdul Qader, Omar Abdul Jabbar; Mustafa, Basma Ezzat; Lestari, Widya; Darnis, Deny Susanti; Kannan, Thirumulu Ponnuraj; Ahmad, Azlina; Arief Ichwan, Solachuddin Jauhari
Journal of Dentistry Indonesia
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: WNT signaling regulates osteogenic differentiation of mesenchymal stem cells (MSC) through the canonical WNT pathway. β-catenin; an important molecule of WNT pathway, and DKK1; a WNT antagonist, play important roles in regulating bone formation. Although flaxseed (Linum usitatissimum) has various health benefits, including promoting bone health, our previous study showed that flaxseed ethanolic extract (FEE) reduced the osteoblast differentiation potential of stem cells from human exfoliated deciduous teeth (SHED). This study aimed to determine the effects of FEE on WNT pathway-related molecules, β-catenin and DKK1, during osteoblast differentiation of SHED. Methods: RNA at Day 7, 14, and 21 was extracted from SHED cultured in osteoblast induction media (OIM) treated with/without FEE and subjected to reverse transcriptase-PCR (RT-PCR) using the specific primers for B-Catenin and DKK1, while GAPDH acted as the internal control. Results: Treatment with FEE at 4 mg/ml significantly reduced β-catenin and DKK1 expression at day 7 (p < 0.01), increased at day 14 (p < 0.01), and later was reduced at day 21 (p < 0.01). Conclusion: Overall, FEE modulates the expressions of WNT-associated molecules: β-catenin and DKK1, during osteoblast differentiation of SHED, hence affecting the normal process of osteogenesis of SHED as demonstrated in the current analysis.
Co-Authors Abdul Qader, Omar Abdul Jabbar Abel Tasman Yuza Azlina Ahmad, Azlina Deny Susanti Endang Sjamsudin Kannan, Thirumulu Ponnuraj Lestari, Widya Mokhtar, Khairani Idah Mustafa, Basma Ezzat Nordin, Nur Sazwi Pratama, Rachendra