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All Journal MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Odonto dental journal
Vincensia Maria Karina
Department Of Periodontics, Faculty Of Dentistry, Universitas Gadjah Mada, Yogyakarta
Dentistry Health Professions Medicine & Pharmacology

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Chicken bone hydroxyapatite enhances collagen density and osteoblast cell number during bone formation of post-extraction socket wound healing process (an in vivo study) Humani, Maria Bonita Cerebrina; Kintani, Dayinta Sekar; Arindra, Pingky Krisna; Karina, Vincensia Maria; Haniastuti, Tetiana
Majalah Kedokteran Gigi Indonesia Vol 11, No 1 (2025): April
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.103626

Abstract

Tooth extraction is a common dental procedure. Osteoblasts (bone-forming cells) and collagen are key indicators of wound healing following tooth extraction. Hydroxyapatite is a calcium-rich material that promotes the secretion of Fibroblast Growth Factor (FGF), Platelet-Derived Growth Factor (PDGF), and Transforming Growth Factor Beta (TGF-β)—all of which play critical roles in the wound healing process. Chicken bones, a natural source of hydroxyapatite, contain approximately 85% calcium phosphate minerals. This study aimed to determine the effect of chicken bone-derived hydroxyapatite on osteoblast cell count and collagen density in post-tooth extraction wounds in Wistar rats. Thirty male Wistar rats were randomly divided into treatment and control groups. Tooth extraction was performed on the lower left incisor of each rat. Hydroxyapatite was prepared by calcining chicken bones at 700 °C to remove organic material. The resulting hydroxyapatite powder was implanted into the tooth sockets of rats in the treatment group, while the control group received no implantation. Both groups were sutured and treated with povidone-iodine. Three rats from each group were sacrificed on days 3, 5, 7, 10, 14, and 21. Histological samples were prepared using hematoxylin-eosin and Mallory’s Trichrome staining. Osteoblast cells (100× magnification) and collagen density (400× magnification) were examined using a light microscope and Optilab Viewer, across five fields of view per sample. Two-way ANOVA showed significant differences in both osteoblast cell counts and collagen density between groups and across observation days (p < 0.05). Least Significant Difference (LSD) post hoc analysis also revealed significant differences between groups on all observation days (p < 0.05). In conclusion, chicken bone-derived hydroxyapatite significantly increases osteoblast numbers and collagen density during the post-extraction wound healing process in Wistar rats.
Comprehensive gummy smile correction: a case report on combined lip repositioning and crown lengthening Nurbaiti, Mentari Salma; Murdiastuti, Kwartarini; Karina, Vincensia Maria
Majalah Kedokteran Gigi Indonesia Vol 11, No 2 (2025): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.104349

Abstract

A gummy smile, or excessive gingival display (EGD), is a clinical condition in which more than 3–4 mm of gingiva is visible during smiling. This condition often raises aesthetic concerns and may negatively affect self-esteem. This report presents the clinical management of a 26-year-old male patient whose gummy smile was attributed to altered passive eruption, compounded by hyperactivity of the upper lip elevator muscles. To address these issues, a combined surgical approach was employed: crown lengthening and lip repositioning. Crown lengthening was performed on teeth 12, 11, and 22 to establish an appropriate tooth–gingiva ratio, while lip repositioning was carried out to limit excessive elevation of the upper lip. Postoperative evaluations revealed a significant correction of the gingival display and improved tooth dimensions. These results highlight the effectiveness of a combined periodontal and soft tissue surgical approach in achieving harmonious and predictable smile aesthetics.
DIFFERENCES IN EFFECTIVENESS OF OCIMUM-SANCTUM 4% GEL AND 25% METRONIDAZOLE GEL POST SCALING ROOT-PLANING IN CHRONIC PERIODONTITIS Karina, Vincensia Maria; Lastianny, Sri Pramestri; Meiliyanawaty, Rina
Odonto : Dental Journal Vol 8, No 1 (2021): July 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (433.76 KB) | DOI: 10.30659/odj.8.1.141-146

Abstract

Background: Chronic periodontitis is a disease that causes inflammation of the tooth supporting tissue, loss of periodontal attachment, and loss of alveolar bone. Root planning scaling treatment is carried out to remove irritants and microorganisms. The use of additional materials is required when the pocket depth is more than 5 mm. One of the herbal ingredients that has the potential as an adjunct to periodontal therapy is the 4% ocinumsanctum.Method: The sample consisted of 20 periodontal pockets with a depth of 4-6 mm which were given scaling root planning which were divided into two groups, namely 10 pockets given 4% maximum sanctum gel and 10 pockets given Metronidazole gel 25%. evaluations of the papillary bleeding index, TNF-α, and IL-β were performed at baseline, and on day 21. TNF-α and IL-β levels were taken through the gingival sulcus fluid and then tested using ELISA.Result: Papillary bleeding index, TNF-α, and IL-β levels showed a significant reduction in both groups but there was no significant difference between the 4% ocimum sanctum group and Metronidazole gel.Conclusion: ocimum sanctum application 4% post scaling root planning was able to lower papillary bleeding index score, TNF-α levels, and IL-β.
DIFFERENCES IN EFFECTIVENESS OF OCIMUM-SANCTUM 4% GEL AND 25% METRONIDAZOLE GEL POST SCALING ROOT-PLANING IN CHRONIC PERIODONTITIS Karina, Vincensia Maria; Lastianny, Sri Pramestri; Meiliyanawaty, Rina
Odonto : Dental Journal Vol 8, No 1 (2021): July 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.8.1.141-146

Abstract

Background: Chronic periodontitis is a disease that causes inflammation of the tooth supporting tissue, loss of periodontal attachment, and loss of alveolar bone. Root planning scaling treatment is carried out to remove irritants and microorganisms. The use of additional materials is required when the pocket depth is more than 5 mm. One of the herbal ingredients that has the potential as an adjunct to periodontal therapy is the 4% ocinumsanctum.Method: The sample consisted of 20 periodontal pockets with a depth of 4-6 mm which were given scaling root planning which were divided into two groups, namely 10 pockets given 4% maximum sanctum gel and 10 pockets given Metronidazole gel 25%. evaluations of the papillary bleeding index, TNF-α, and IL-β were performed at baseline, and on day 21. TNF-α and IL-β levels were taken through the gingival sulcus fluid and then tested using ELISA.Result: Papillary bleeding index, TNF-α, and IL-β levels showed a significant reduction in both groups but there was no significant difference between the 4% ocimum sanctum group and Metronidazole gel.Conclusion: ocimum sanctum application 4% post scaling root planning was able to lower papillary bleeding index score, TNF-α levels, and IL-β.
Co-Authors Ahmad Syaify, Ahmad Handoko, Evan Kurniawan Humani, Maria Bonita Cerebrina Kintani, Dayinta Sekar Kwartarini Murdiastuti Meiliyanawaty, Rina Muhammad Yusuf Nur Rahman Ahmad Seno Aji Nurbaiti, Mentari Salma Osa Amila Hafiyyah Padang, Lastry Ruth Pingky Krisna Arindra Pritia, Mardha Ade Sri Pramestri Lastianny, Sri Pramestri Supriatno Suryahapsari, Nastiti Mayangjati Yosaphat Bayu Rosanto