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All Journal MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Odonto dental journal
Vincensia Maria Karina
Department Of Periodontics, Faculty Of Dentistry, Universitas Gadjah Mada, Yogyakarta
Dentistry Health Professions Medicine & Pharmacology

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Comprehensive gummy smile correction: a case report on combined lip repositioning and crown lengthening Nurbaiti, Mentari Salma; Murdiastuti, Kwartarini; Karina, Vincensia Maria
Majalah Kedokteran Gigi Indonesia Vol 11, No 2 (2025): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.104349

Abstract

A gummy smile, or excessive gingival display (EGD), is a clinical condition in which more than 3–4 mm of gingiva is visible during smiling. This condition often raises aesthetic concerns and may negatively affect self-esteem. This report presents the clinical management of a 26-year-old male patient whose gummy smile was attributed to altered passive eruption, compounded by hyperactivity of the upper lip elevator muscles. To address these issues, a combined surgical approach was employed: crown lengthening and lip repositioning. Crown lengthening was performed on teeth 12, 11, and 22 to establish an appropriate tooth–gingiva ratio, while lip repositioning was carried out to limit excessive elevation of the upper lip. Postoperative evaluations revealed a significant correction of the gingival display and improved tooth dimensions. These results highlight the effectiveness of a combined periodontal and soft tissue surgical approach in achieving harmonious and predictable smile aesthetics.
DIFFERENCES IN EFFECTIVENESS OF OCIMUM-SANCTUM 4% GEL AND 25% METRONIDAZOLE GEL POST SCALING ROOT-PLANING IN CHRONIC PERIODONTITIS Karina, Vincensia Maria; Lastianny, Sri Pramestri; Meiliyanawaty, Rina
Odonto : Dental Journal Vol 8, No 1 (2021): July 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (433.76 KB) | DOI: 10.30659/odj.8.1.141-146

Abstract

Background: Chronic periodontitis is a disease that causes inflammation of the tooth supporting tissue, loss of periodontal attachment, and loss of alveolar bone. Root planning scaling treatment is carried out to remove irritants and microorganisms. The use of additional materials is required when the pocket depth is more than 5 mm. One of the herbal ingredients that has the potential as an adjunct to periodontal therapy is the 4% ocinumsanctum.Method: The sample consisted of 20 periodontal pockets with a depth of 4-6 mm which were given scaling root planning which were divided into two groups, namely 10 pockets given 4% maximum sanctum gel and 10 pockets given Metronidazole gel 25%. evaluations of the papillary bleeding index, TNF-α, and IL-β were performed at baseline, and on day 21. TNF-α and IL-β levels were taken through the gingival sulcus fluid and then tested using ELISA.Result: Papillary bleeding index, TNF-α, and IL-β levels showed a significant reduction in both groups but there was no significant difference between the 4% ocimum sanctum group and Metronidazole gel.Conclusion: ocimum sanctum application 4% post scaling root planning was able to lower papillary bleeding index score, TNF-α levels, and IL-β.
DIFFERENCES IN EFFECTIVENESS OF OCIMUM-SANCTUM 4% GEL AND 25% METRONIDAZOLE GEL POST SCALING ROOT-PLANING IN CHRONIC PERIODONTITIS Karina, Vincensia Maria; Lastianny, Sri Pramestri; Meiliyanawaty, Rina
Odonto : Dental Journal Vol 8, No 1 (2021): July 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.8.1.141-146

Abstract

Background: Chronic periodontitis is a disease that causes inflammation of the tooth supporting tissue, loss of periodontal attachment, and loss of alveolar bone. Root planning scaling treatment is carried out to remove irritants and microorganisms. The use of additional materials is required when the pocket depth is more than 5 mm. One of the herbal ingredients that has the potential as an adjunct to periodontal therapy is the 4% ocinumsanctum.Method: The sample consisted of 20 periodontal pockets with a depth of 4-6 mm which were given scaling root planning which were divided into two groups, namely 10 pockets given 4% maximum sanctum gel and 10 pockets given Metronidazole gel 25%. evaluations of the papillary bleeding index, TNF-α, and IL-β were performed at baseline, and on day 21. TNF-α and IL-β levels were taken through the gingival sulcus fluid and then tested using ELISA.Result: Papillary bleeding index, TNF-α, and IL-β levels showed a significant reduction in both groups but there was no significant difference between the 4% ocimum sanctum group and Metronidazole gel.Conclusion: ocimum sanctum application 4% post scaling root planning was able to lower papillary bleeding index score, TNF-α levels, and IL-β.
Caspase-3/-9 as tongue cancer cell apoptosis target induced by ibuprofen Supriatno; Yosaphat Bayu Rosanto; Vincensia Maria Karina
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p355-360

Abstract

Background: Tongue carcinoma is different from oral cancer in other areas because it has a high amount of cell growth, localized migration, and a higher rate of spreading to cervical lymphatic nodes. Therapeutic alternatives, particularly concerning recurrent malignancies, are notably constrained. Nevertheless, it is imperative to explore novel methodologies for refractory neoplasms, one of which may involve the application of ibuprofen. Purpose: The goal of this study was to look at how well caspase-3 and -9 break down proteins as possible targets for apoptosis in tongue cancer cells that were caused by ibuprofen. Methods: A controlled laboratory experiment employing a post-test-only design was executed. We used a colorimetric test for caspase-3 and -9 to check for the induction of apoptosis. The suppression of cellular invasion was verified through the Boyden chamber assay. Western blot analysis was utilized to identify the presence of caspase-3 and -9 proteins. The administered doses of ibuprofen were calibrated at 0, 5, 10, 25, 50, and 100 µg/mL. Data were subjected to analysis using two-way ANOVA followed by post-hoc Least Significant Different (LSD), with a significance threshold set at 95%. Results: It was established that ibuprofen at dosages ranging from 25 to 100 µg/mL significantly facilitated apoptosis in cells through an augmentation of the proteolytic activity of caspase-3 and -9. Notably, caspase-9 exhibited a superior proteolytic activity (1.85-fold) compared to caspase-3 (1.30-fold) (P = 0.038) at the 100 µg/mL concentration. The upregulation of caspase-3 and -9 proteins was observed in cells treated with ibuprofen. Ultimately, ibuprofen demonstrated an ability to inhibit the invasion of tongue carcinoma cells across various dosages. Conclusion: Ibuprofen has been shown to induce the proteolytic activities of caspase-3 and -9 in tongue carcinoma cells. However, the proteolytic activity of caspase-9 surpassed that of caspase-3, suggesting that targeting this protein may constitute a promising novel therapeutic strategy for this cancer variant.
Co-Authors Ahmad Syaify, Ahmad Handoko, Evan Kurniawan Humani, Maria Bonita Cerebrina Kintani, Dayinta Sekar Kwartarini Murdiastuti Meiliyanawaty, Rina Muhammad Yusuf Nur Rahman Ahmad Seno Aji Nurbaiti, Mentari Salma Osa Amila Hafiyyah Padang, Lastry Ruth Pingky Krisna Arindra Pritia, Mardha Ade Sri Pramestri Lastianny, Sri Pramestri Supriatno Suryahapsari, Nastiti Mayangjati Yosaphat Bayu Rosanto