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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia Majalah Patologi Indonesia Ethical Lingua: Journal of Language Teaching and Literature Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of Scientific Research, Education, and Technology Media Dermato-Venereologica Indonesiana Jurnal Riset Multidisiplin Edukasi
Syarif Husin
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Neutrophil-Lymphocyte Ratio as a Novel Biomarker for Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study Pradesta, Rahnowi; Novadian; Yulianto Kusnadi; Nova Kurniati; Syarif Husin
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1235

Abstract

Background: Early detection of diabetic nephropathy (DN) is crucial to prevent progression to end-stage renal disease. The gold standard for diagnosing DN involves urine microalbumin testing and renal biopsy. However, the availability of these diagnostic tools is limited in many healthcare facilities across Indonesia. Consequently, there is a pressing need for an alternative examination that is readily accessible and can effectively monitor the progression of DN. Methods: This cross-sectional study was conducted at Dr. Mohammad Hoesin General Hospital, Palembang, from February 2024 to May 2024. The study aimed to investigate the correlation between neutrophil-lymphocyte ratio (NLR) and urinary albumin levels in type 2 diabetes mellitus (DM) patients. NLR, calculated from complete blood counts, has emerged as a potential inflammatory marker for various conditions. A total of 65 participants diagnosed with type 2 DM were enrolled in the study. Data analysis involved Spearman's correlation test to assess the relationship between NLR and urinary albumin levels. Results: The majority of the 65 subjects were female (58.5%). The study found that 44 subjects had normoalbuminuria, 18 had microalbuminuria, and 3 had macroalbuminuria. A significant positive correlation was observed between NLR and albuminuria levels in type 2 DM patients (r = 0.795; p < 0.01). Conclusion: The study's findings suggest that NLR is a potential cost-effective biomarker for the early detection of DN in type 2 DM patients, especially in resource-limited settings. Further large-scale studies are recommended to validate these findings and establish specific NLR thresholds for predicting DN progression.
Ekspresi Epidermal Growth Factor Receptor dan Karakteristik Klinikohistopatologik pada Karsinoma Kolorektal . Reallyani; Mezfi Unita; Zulkarnain Musa; Syarif Husin
Majalah Patologi Indonesia Vol. 23 No. 1, Januari 2014
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Background Colorectal carcinoma is one of the world's fourth most malignancies. Frequency of colorectal carcinoma malignancy most likely to occur in the gastrointestinal tract and causes the death of close to 15% of all cancers. Heterogeneous of the etiology is associated with many risk factors and molecular changes. Epidermal growth factor receptor is a 170 kDa transmembrane glycoprotein which contribute to carcinogenesis, prognostic impact and specific therapeutic targets. The aims this study to determine the relationship between EGFR expression and the clinicohistopathology characteristics in colorectal carcinoma. Methods This study is an observational study with cross sectional approach. The samples were specimens of the 57 samples that had been diagnosed as colorectal carcinoma from January 2010 to August 2012. Samples from histopathological preparations are reviewed and conducted outward EGFR immunohistochemistry with primary antibodies for the primary tumor. Results EGFR expression to histopathological characteristics are as follows pT3 of 45.6%, positive lymph node status was 52.6% and poorly differentiated histological degree of malignancy of 50.9%. Statistical calculations showed no significant correlation between EGFR expression and histopathologic characteristics of the pT in the TNM system (p=0.037), lymph node status (p=0.000), histological grading of malignancy (p=0.001), and high expression (61.4%). Conclusion EGFR expression affects the pT in TNM system, lymph node staging and histological grading of malignancy. Key words: characteristic clinicohistopathology, colorectal carcinoma, epidermal growth factor receptor.
Co-Authors . Reallyani Achirul Bakri Ardesy Melizah Ardesy Melizah Kurniati Eusabinus Bunau Hasri Salwan Iskandar Lutfi Jayawarsa, A.A. Ketut Khoirunnisak Lisa Ma'rufi Masayu Anisah Mezfi Unita Monica Trifitriana Muhammad Ihsan Abdurrahman Nopriyati Nopriyati Nova Kurniati Novadian Pradesta, Rahnowi Rahmayani Rahmayani Rajendra Ekki Maulana Ramzi Amin, Ramzi Reza Mayasari Rizal Sanif Soenarto Kartowigno Sudarsono Syifa Alkaf Tri Suciati Yanti Sri Rejeki Yulianto kusnadi Zulkarnain Musa