Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal Journal of General Procedural Dermatology and Venereology Indonesia Plexus Medical Journal
Rachmawati, Yenny
Unknown Affiliation
Health Professions Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The effectiveness of laser therapy in onychomycosis patients: An evidence-based case report Prayogo, Rizky Lendl; Gaol, Evangelina Lumban; Azizah, Fitri; Lusiana, Lusiana; Rachmawati, Yenny; Rahman, Yusnita; Saldi, Siti Rizny
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 2, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Onychomycosis may cause nail discoloration, thickening, nail bed separation, and other serious complications. For some cases, oral antifungal treatment is not tolerable because of its potential side effects and drug interactions. Laser therapy is considered as an alternative treatment, owing to the features of simple and effective, with only minor potential side effects. This EBCR was made to collect and appraise studies regarding the effectiveness of laser therapy for onychomycosis, and to suggest laser as an alternative treatment. Methods: Literature searching strategy was performed using Pubmed and Cochrane Library database to address the clinical problem. Keywords used were “laser” AND “onychomycosis”. Results: Seventy-nine articles were obtained from the search strategy procedure. After selection based on exclusion and inclusion criteria, and full-text availability, four relevant articles remained. Discussion: The study by Xu et al. was considered as the most valid study while compared to other three studies. This study used intention to treat analysis and had no loss of follow-up patients. Xu et al. compared mycological and clinical clearance rate between patients receiving laser, oral terbinafine, or combination of those two. It showed that laser therapy was less effective when compared to oral antifungal (Number Needed to Harm = 17). Conclusions: Laser has a lower level of effectiveness while compared to oral terbinafine as the current gold standard therapy for onychomycosis. However, laser therapy can still be used as an adjunctive therapy along with oral antifungal to achieve a better cure rate. More studies are needed to prove this hypothesis.
Efek Asam Klorogenat pada Ekspresi Mrna IL-6 dan CD86 Lobus Frontal Tikus Model Diabetes Mellitus Munawaroh, Fauziyatul; Hanif , Aisyah Amanda; Ragil Kemuning, Asri; Mutmainah, Iffa; Rachmawati, Yenny; Muharam Nurdin, Naufal
Plexus Medical Journal Vol. 3 No. 4 (2024): Agustus
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v3i4.1815

Abstract

Pendahuluan: Diabetes Mellitus (DM) merupakan penyakit kronik dengan berbagai komplikasi, salah satunya yaitu Encephalopati Diabetikum (ED). Hiperglikemia pada DM akan mengakibatkan neuroinflamasi melalui jalur M1 proinflamatorik. Beberapa agen proinflamatori akan meningkat dengan aktifnya jalur ini, seperti IL-6. Neuroglia kemudian teraktivasi dan mengekspresikan CD86 pada membran sel. Asam klorogenat (CGA) merupakan senyawa polyphenol pada kopi  yang  memiliki  efek antiinflamasi.  Tujuan penelitian ini adalah untuk memperjelas efek CGA pada aktivasi mikroglia jalur M1 dengan melihat ekspresi mRNA IL-6 dan CD86 pada lobus frontal tikus dengan model DM. Metode: 24 ekor tikus jantan secara acak dibagi menjadi enam kelompok yaitu :  kontrol,   DM 1,5 bulan dan DM 2 bulan,  dan kelompok dengan pemberian  CGA dengan  tiga  dosis  berbeda  (CGA1,  CGA2,  CGA3).  Jaringan lobus frontal diambil untuk analisa ekspresi mRNA IL-6 dan CD86 menggunakan RT-PCR. Hasil: Ekspresi mRNA IL-6 lobus frontal berbeda signifikan antara kelompok kontrol dengan DM1,5 (p=0.010); kontrol dengan DM2 (p=0.001); kelompok DM2 dengan CGA2 (p=0.028). Ekspresi mRNA CD86 lobus frontal trdapat perbedaan signifikan antara kelompok kontrol dengan semua kelompok DM, baik dengan CGA atau tanpa CGA (p<0.05). Kelompok DM2 berbeda signifikan dengan kelompok CGA2 (p=0.000) dan kelompok CGA3 (p=0,000). Kesimpulan: Ekspresi mRNA penanda jaras proinflamatorik M1 (IL-6 dan CD86) pada neuroinflamasi lobus frontal akibat DM lebih rendah setelah pemberian CGA dengan dosis 25 mg/KgBB.
Co-Authors Aisyah Amanda Hanif Asri Ragil Kemuning Azizah, Fitri Gaol, Evangelina Lumban Iffa Mutmainah Lusiana Lusiana Munawaroh, Fauziyatul Naufal Muharam Nurdin Prayogo, Rizky Lendl Rahman, Yusnita Saldi, Siti Rizny