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PENGARUH EKSTRAK SEREH (Cymbopogon citratus) TERHADAP PANJANG LUKA MUKOSA LABIAL MENCIT SECARA KLINIS Hairi, Melinda; Dewi, Nurdiana; Khatimah, Husnul
Dentino Vol 1, No 2 (2016)
Publisher : FKG Unlam

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ABSTRACT   Background: Lemongrass is one of the most widely used plants for traditional medicine. Lemongrass has bioactive substances such as phenolic acid, flavonoid, and tannin which act as anti-inflammatory and antioxidant agent which could affect the wound healing process. Purpose: The aim of this study was to assess the effects of 25%, 50%, and 100% lemongrass extract on mice labial mucosa clinical wound length by measuring the wound length. Methods: This study was a true experimental with post test-only with control design. 30 mice were used in this study, which were divided into 5 groups, patent drug containing Aloe vera extract as positive control group, 100% lemongrass extract group, 50% lemongrass extract group, 25% lemongrass extract group, and aquadest as negative control group. Results: One-way ANOVA and Post-hoc LSD tests showed significant difference between Aloe vera extract group, 100% lemongrass extract group, and 50% lemongrass extract group with aquadest group. There was no significant difference between Aloe vera extract group, 100% lemongrass extract group, and 50% lemongrass extract group. There was also no significant difference between 25% lemongrass extract group with aquadest group. Conclusion: Based on the conducted study, it can be concluded that 100% and 50% lemongrass extract could accelerate wound healing process on mice labial mucosa by measuring length of the wound.  Keywords: lemongrass extract, wound healing, wound length, oral mucosa, mice  ABSTRAK   Latar Belakang:Sereh adalah salah satu tanaman yang sering digunakan sebagai obat tradisional.  Sereh mengandung zat bioaktif seperti phenolic acid, flavonoid dan tanin yang berperan sebagai antiinflamasi dan antioksidan yang berpengaruh dalam proses penyembuhan luka.Tujuan:Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak sereh 25%, 50%, dan 100% terhadap panjang luka mukosa labial mencit secara klinis dengan mengukur panjang luka. Metode:Penelitian ini merupakan eksperimental murni dengan rancangan post test-only with control design. Penelitian ini menggunakan 30 ekor mencit yang dibagi menjadi 5 kelompok, yaitu kelompok kontrol positif yang menggunakan obat paten mengandung ekstrak Aloe vera, kelompok ekstrak sereh 100%,  kelompok ekstrak sereh 50%, kelompok ekstrak sereh 25%, dan kelompok kontrol negatif menggunakan akuades.Hasil:Hasil uji One-way ANOVA dan Post-hoc LSD menunjukkan perbedaan yang bermakna antara kelompok ekstrak Aloe vera, kelompok ekstrak sereh 100%, dan kelompok ekstrak sereh 50% dibandingkan dengan kelompok akuades. Tidak terdapat perbedaan yang signifikan antara kelompok ekstrak Aloe vera, kelompok ekstrak sereh 100%, dan kelompok ekstrak sereh 50% serta tidak terdapat perbedaan yang signifikan antara kelompok ekstrak sereh 25% dan kelompok akuades.Kesimpulan:Berdasarkan penelitian yang telah dilakukan dapat disimpulkan bahwa ekstrak sereh 100% dan 50% dapat mempercepat penyembuhan luka mukosa labial mencit dilihat dari panjang luka.  Kata-kata kunci:ekstrak sereh, penyembuhan luka, panjang luka, mukosa mulut, mencit
PERBEDAAN ANGKA KEJADIAN DRY SOCKET PADA PENGGUNA KONTRASEPSI HORMONAL DAN YANG TIDAK MENGGUNAKAN KONTRASEPSI HORMONAL Ananda, Retno Septiana; Khatimah, Husnul; Indra Sukmana, Bayu
Dentino Vol 1, No 1 (2016)
Publisher : FKG Unlam

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ABSTRACT Background: Dry socket (alveolar osteitis) is a postoperative pain around tooth’s socket that can increase from day 1 until day 3 after tooth extraction. One of the factors that can cause dry socket is hormonal contraception utilization. Hormonal contraception is contraception that use estrogen hormone. Estrogen hormone has a role on increasing the lysis of blood clots. Purpose: The purpose of this research is to describe the difference of dry socket incidents on hormonal contraception users and non-users. Methods: The method of this research was study observation of prospective longitudinal study with total sample of 76 samples. Observation conducted on women patients after permanent tooth extraction that use and did not use hormonal contraception. Results: The results hormonal contraception users as many as 38 samples that consist of 3 samples were positive 3,7 % (developed dry socket) and 35 samples were negative 46% (didn’t develop dry socket), whereas the ones that did not use contraception hormonal as many as 38 samples consist of 1 sample was positive 1,3% (developed dry socket) and 37 samples were negative 49% (did not developed dry socket).Conclusion: From alternative test of fisher obtained p value = 0,615 which means there was no difference of dry socket incidence contraception hormonal users and non-users. ABSTRAK Latar Belakang Dry socket (alveolar osteitis) adalah sakit pasca operasi pada sekitar soket gigi yang dapat meningkat tiap waktu antara hari ke 1 sampai hari ke 3 setelah pencabutan gigi. Salah satu faktor yang menyebabkan terjadinya dry socket adalah pengguna kontrasepsi hormonal. Kontrasepsi hormonal adalah kontrasepsi yang menggunakan hormon, progesteron sampai kombinasi estrogen dan progesteron. Estrogen memiliki peran dalam proses fibrinolisis dengan mengaktifkan sistem fibrinolitik dan kemudian meningkatkan lisis bekuan darah. Tujuan:. Penelitian ini bertujuan untuk mengetahui perbedaan angka kejadian dry socket pada pengguna kontrasepsi hormonal dan yang tidak menggunakan kontrasepsi hormonal. Metode: Penelitian ini menggunakan desain penelitian observasi studi longitudinal prospektif dengan jumlah sampel yang diperoleh secara seluruhnya sebanyak 76 sampel. Pengamatan dilakukan terhadap pasien wanita dewasa pasca pencabutan gigi permanen yang menggunakan kontraspesi hormonal dan yang tidak menggunakan kontrasepsi hormonal. Hasil: Hasil penelitian menunjukkan pengguna kontrasepsi hormonal berjumlah 38 sampel yang terdiri dari 3 sampel positif sebesar 3,7% (mengalami dry socket) dan 35 sampel negatif sebesar 46% (tidak mengalami dry socket), sedangkan yang tidak menggunakan kontrasepsi hormonal berjumlah 38 sampel yang terdiri dari 1 sampel positif sebesar 1,3% (mengalami dry socket) dan 37 sampel negatif sebesar 49% (tidak mengalami dry socket).Kesimpulan: Dapat disimpulkan dari hasil uji alternatif fisher diperoleh nilai p = 0,615 artinya tidak terdapat perbedaan angka kejadian dry socket pada pengguna kontrasepsi hormonal dan yang tidak menggunakan kontrasepsi hormonal.
PERBEDAAN KEJADIAN DISFUNGSI SEKSUAL PADA WANITA DENGAN DIABETES MELITUS DAN TANPA DIABETES MELITUS Amelia, Helna; Khatimah, Husnul; Istiana, Istiana
Berkala Kedokteran Vol 12, No 2 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v12i2.1861

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Abstract: Sexual dysfunction in woman with diabetes mellitus has received less attention from the doctors. The study about sexual dysfunction in female is relatively less than sexual dysfunction in male. The aim of this study was to analyze the difference of sexual dysfunction in diabetes and non-diabetes female at Ulin and Dr. H. Moch. Ansari Saleh Hospitals Banjarmasin. This study was an observational analytic study with case control approach. Diabetes and non-diabetes female that came to the subspecialist polyclinic in Ulin hospital and to the internal medicine polyclinic in Dr. H. Moch. Ansari Saleh hospital period July-September 2015 that meet to the inclusion criteria were included as sample of this study. Female sexual dysfunction was assessed using the Female Sexual Function Index (FSFI) questionnaire. From 30 diabetes females, there were 19 females (63,3%) had sexual dysfunction and from 30 non-diabetes females there were 14 females (46,7%) had sexual dysfunction. The data analysis using chi-square was resulted p=0,299 that means there was no significant difference. It was concluded that there was no significant difference of sexual dysfunction in diabetes and non-diabetes female. Keywords:sexual dysfunction, female, diabetes mellitus Abstrak: Disfungsi seksual pada wanita dengan diabetes melitus (DM) belum banyak mendapat perhatian dari dokter. Penelitian tentang disfungsi seksual pada wanita juga relatif sedikit jika dibandingkan dengan disfungsi seksual pada laki-laki. Penelitian ini bertujuan untuk menganalisis perbedaan kejadian disfungsi seksual pada wanita dengan DM dan tanpa DM di RSUD Ulin dan RSUD Dr. H. Moch. Ansari Saleh Banjarmasin. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan case control.Pasien wanita DM dan tanpa DM yang datang ke poliklinik subspesialis RSUD Ulin dan poliklinik penyakit dalam RSUD Dr. H. Moch. Ansari Saleh Banjarmasin periode Juli-September 2015 yang memenuhi kriteria inklusi menjadi sampel pada penelitian ini. Disfungsi seksual wanita dinilai dengan menggunakan kuesioner the Female Sexual Function Index (FSFI). Dari 30 wanita DM yang menjadi subjek penelitian, terdapat 19 orang (63,3%) yang mengalami disfungsi seksual dan dari 30 wanita tanpa DM yang menjadi subjek penelitian, terdapat 14 orang (46,7%) mengalami disfungsi seksual. Analisis data dengan menggunakan uji chi-square didapatkan nilai p=0,299 yang berarti tidak terdapat perbedaan yang bermakna.  Berdasarkan penelitian yang dilakukan dapat diambil kesimpulan bahwa tidak terdapat perbedaan yang bermakna antara kejadian disfungsi seksual pada wanita DM dan tanpa DM. Kata-kata kunci: lingkar pinggang, obesitas sentral, diabetes melitus, disfungsi ereksi
KADAR TESTOSTERON INTRATESTIKULAR TIKUS Rattus novergicus STRAIN Sprague dawley AKIBAT PEMBERIAN KURKUMIN SETELAH STIMULASI hCG Khatimah, Husnul
Berkala Kedokteran Vol 11, No 2 (2015): September 2015
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v11i2.168

Abstract

Curcumin is an active agent on Curcuma longa. Curcumin had so many biologic activities; one of them is anti fertility. Curcumin research in male reproductive system had been done. Curcumin reduced testis weight and serum testosterone. This study is done to know curcumin effect on testosterone intratesticular level in rats. This study was conducted to 15 male Sprague dawley rats aged 90 days. Rats divided into 5 groups treatment : group 1 rats were given aquades, group 2 rats were given a single dose of 50 IU hCG, group 3 rats were given CMC, group 4 rats were given curcumin, group 5 rats were given hCG and curcumin.  Rats were sacrified on age 91 days. Testis was taken, homogenizer and sentrifuge. Supernatant was taken in order to measured intratesticular testosterone level. The result of this study show intratesticular testosterone level from 5 group treatment, each group are n = 3, are (1) 44.36±1.30 (aquades), (2) 41.53±16.44 (hCG), (3) 37.33±9.05 (CMC), (4) 54.16±29.82 (curcumin), (5) 49.36±5.05 (hCG + curcuminStatistic analytic with ANOVA showed there is no significant difference  (p>0.05). This study had a conclusion that curcumin not decreased testosterone intratestikular level in rats. Keywords: curcumin, hCG, intratesticular testosterone
HUBUNGAN KONDISI VENTILASI RUMAH DENGAN KEJADIAN TB PARU DI WILAYAH PUSKESMAS KELAYAN TIMUR Sinaga, Ferdy Ricardo; Heriyani, Farida; Khatimah, Husnul
Berkala Kedokteran Vol 12, No 2 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v12i2.1878

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Abstract : Pulmonary TB is an infectious disease which is transmitted through air contaminated by Mycobacterium tuberculosis. TB remains a main health problem in all over the world and also one of leading causes of death from infectious disease. Enviromental characteristic is the key factor to the risk of transmition. Ventilation condition is one factor that contributes to the house’s environmental characteristic. This research aims to know the correlation between ventilation condition and the incidence of pulmonary TB in working area of Kelayan Timur Community Health Center. This is an analitic observasional research with study design of case control. Subjects were selected using the simple random sampling technique. Subjects were divided into 2 groups, 30 subjects for the case group and 30 subjects for the control group. Data was analyzed using Chi Square test with 95 % confidence interval. The result shows that 29 of 30 houses (96,67 %)  from the case group have an inproper ventilation meanwhile only 9 of 30 houses (30 %) from the control group which have an inproper ventilation. The analysis shows a significant correlation between ventilation condition and the incidence of pulmonary TB with ρ = 0,000.  Keywords: ventilation condition, pulmonary TB, Kelayan Timur Community Health Center. Abstrak : TB paru merupakan penyakit infeksi yang ditularkan melalui udara yang terkontaminasi Mycobacterium tuberculosis. TB masih menjadi masalah utama kesehatan di seluruh dunia dan merupakan salah satu penyebab kematian akibat penyakit infeksi. Keberlangsungan hidup kuman TB ditentukan oleh karakteristik lingkungannya. Kondisi ventilasi rumah merupakan salah satu faktor yang mempengaruhi karakteristik lingkungan dalam rumah. Penelitian ini bertujuan untuk mengetahui hubungan kondisi ventilasi rumah dengan kejadian TB paru di wilayah Puskesmas Kelayan Timur. Penelitian ini adalah penelitian observasional analitik dengan desain studi kasus kontrol. Subjek penelitian dipilih dengan menggunakan teknik simple random sampling. Subjek penelitian terdiri dari 2 kelompok yaitu 30 sampel kelompok kasus dan 30 sampel kelompok kontrol. Data dianalisa menggunakan uji Chi Square dengan tingkat kepercayaan 95 %. Hasil penelitian menunjukkan 29 dari 30 kelompok kasus (96,67 %)  memiliki kondisi ventilasi rumah yang tidak memenuhi syarat, sedangkan hanya 9 dari 30 kelompok kontrol (30 %) yang memiliki kondisi ventilasi rumah yang tidak memenuhi syarat. Hasil analisa mendapatkan nilai ρ=0,000 sehingga dapat disimpulkan bahwa terdapat hubungan yang bermakna antara kondisi ventilasi rumah dengan kejadian TB paru. Kata-kata kunci: kondisi ventilasi, TB paru, Puskesmas Kelayan Timur.
PERBEDAAN KADAR LDL MAHASISWI KEDOKTERAN UNLAM YANG MELAKUKAN DAN TIDAK MELAKUKAN SENAM AEROBIK Fakhrina, Dina Aulia; Arifin, Miftahul; Khatimah, Husnul
Berkala Kedokteran Vol 11, No 2 (2015): September 2015
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v11i2.139

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Low-density lipoprotein (LDL) is a lipoprotein that transports cholesterol from the liver to body tissues. Aerobic gymnastic can lower LDL cholesterol is believed to reduce the risk of cardiovascular disease. This study aim was to know difference between LDL levels of Lambung Mangkurat University medical women students who did and did not do aerobic gymnastic. Method of researchused randomized pretest-posttest control design. These samples included 17 people in training group and 16 in control group. Taking blood samples was performed twice, before and after the study. Training group didgymnastic twice a week, 60 minutes for four weeks. The result of mean in LDL levels in control group was95.38 mg/dL and training group after study was 92.71 mg/dL. Mann-Whitney test between the two groups resulted in 0.787 of the significant value. The conclusion is there is no significant difference between LDL levels in the women college students who did and did not do aerobic gymnastic. Keywords: LDL levels, aerobic gymnastic, women college student
Whorl Pattern and Total Ridge Count on Patient with Essential Hypertension at Ulin Hospital Banjarmasin Khatimah, Husnul; Rosida, Lena
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 2 (2013)
Publisher : Universitas Muhammadiyah Yogyakarta

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Dermatoglypics can used to predicted a disease such as essential hypertension. The aim of this research is to know of summary of whorl pattern and total ridge count on patient with essential hypertension in department of internal medicine of Ulin hospital Banjarmasin period Juli – August 2007. Sample of research from patient with essential hypertension that diagnosed by doctor in department of internal medicine of Ulin hospital Banjarmasin (32 samples), control samples are from normotension person (32 samples). The variables that observed are summary of whorl pattern and total ridge count. The result show that patient with essential hypertension with whorl pattern > 6 is 81,25 %, normotension is 25%. Summary of average of total ridge count in patient with essential hypertension is 147,38, normotension is 129,38. It can be concluded there is difference from patient with whorl pattern > 6 and total ridge count between essential hypertension with control (p<0,05). Dermatoglifi dapat digunakan untuk memprediksi penyakit seperti hipertensi esensial. Tujuan penelitian ini adalah untuk mengetahui pola sidik jari whorl  dan total jumlah rigi sidik jari pada pasien dengan hipertensi esensial di bagian penyakit dalam rumah sakit Ulin Banjarmasin periode Juli – Agustus 2007. Sampel penelitian adalah pasien dengan hipertensi esensial yang didiagnosis oleh dokter di bagian penyaki dalam rumah sakit Ulin Banjarmasin sebanyak 32 sampel, kontrol dari pasien dengan normotensi sebanyak 32. Variabel penelitian adalah pola sidik jari whorl dan total jumlah rigi sidik jari. Hasil penelitian menunjukkan bahwa pasien hipertensi esensial dengan pola whorl > 6 adalah 81,25%, normotensi adalah 25%. Rata-rata jumlah rigi sidik jari pada pasien dengan hipertensi esensial adalah 147,38, normotension adalah 129,38. Disimpulkan bahwa ada perbedaan dari pasien dengan pola whorl > 6 dan total jumlah rigi sidik jari antara hipertensi esensial dengan kontrol (p <0,05).
Cytogenetics profile of student with syndromic mental retardation on special schools in Banjarmasin Siti Wasilah; Husnul Khatimah; Tri Indah Minarni
Biomedical Engineering Vol 2, No 1 (2016)
Publisher : Biomedical Engineering

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Objective:  This descriptive study aims to describe the cytogenetic profile of students with mental retardation disorders on special school in Banjarmasin conducted since 2012-2013.Material and methods:  Cytogenetic profile described based the existence of free trisomy 21, trisomy 21 with translocation, mosaic trisomy 21 and trisomy 21 partially or in the form of numeric aberration and structure of chromosomal abnormalities such as fragile X, specific deletions of chromosomal segments or the presence of a ring chromosome forms.Result:  The results obtained from the study of 22 students with physical signs of mild to severe syndromic mental retardation. The results of cytogenetic examination showed most of the sample (77.78%) with free trisomy 21 (karyotype 47, XX, + 21 or 47, XX, + 21) or a classic type of Down syndrome, 1 sample with mosaic karyotype: 46, XY (1%) / 47, XY, + 21, 1 sample with structural abnormalities of chromosomes 22 (karyotype: 46, XY, ring 22) and 2 samples with normal karyotype (karyotype: 46, XY or 46, XX).Conclusion:  Cytogenetic profile of students with syndromic mental retardation on special school in Banjarmasin are free trisomy 21, mosaic trisomy 21, structure aberration (ring chromosome 22), and a normal karyotype.
Whorl Pattern and Total Ridge Count on Patient with Essential Hypertension at Ulin Hospital Banjarmasin Husnul Khatimah; Lena Rosida
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 2 (2013)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v13i2.1058

Abstract

Dermatoglypics can used to predicted a disease such as essential hypertension. The aim of this research is to know of summary of whorl pattern and total ridge count on patient with essential hypertension in department of internal medicine of Ulin hospital Banjarmasin period Juli – August 2007. Sample of research from patient with essential hypertension that diagnosed by doctor in department of internal medicine of Ulin hospital Banjarmasin (32 samples), control samples are from normotension person (32 samples). The variables that observed are summary of whorl pattern and total ridge count. The result show that patient with essential hypertension with whorl pattern 6 is 81,25 %, normotension is 25%. Summary of average of total ridge count in patient with essential hypertension is 147,38, normotension is 129,38. It can be concluded there is difference from patient with whorl pattern 6 and total ridge count between essential hypertension with control (p0,05). Dermatoglifi dapat digunakan untuk memprediksi penyakit seperti hipertensi esensial. Tujuan penelitian ini adalah untuk mengetahui pola sidik jari whorl  dan total jumlah rigi sidik jari pada pasien dengan hipertensi esensial di bagian penyakit dalam rumah sakit Ulin Banjarmasin periode Juli – Agustus 2007. Sampel penelitian adalah pasien dengan hipertensi esensial yang didiagnosis oleh dokter di bagian penyaki dalam rumah sakit Ulin Banjarmasin sebanyak 32 sampel, kontrol dari pasien dengan normotensi sebanyak 32. Variabel penelitian adalah pola sidik jari whorl dan total jumlah rigi sidik jari. Hasil penelitian menunjukkan bahwa pasien hipertensi esensial dengan pola whorl 6 adalah 81,25%, normotensi adalah 25%. Rata-rata jumlah rigi sidik jari pada pasien dengan hipertensi esensial adalah 147,38, normotension adalah 129,38. Disimpulkan bahwa ada perbedaan dari pasien dengan pola whorl 6 dan total jumlah rigi sidik jari antara hipertensi esensial dengan kontrol (p 0,05).
Differences in Age and Body Mass Index of Women with Polycystic Ovary Syndrome Attending in Vitro Fertilization (IVF) Program Roselina Panghiyangani; Husnul Khatimah; Dwi Anita Suryandari; Budi Wiweko; Mala Kurniati
Berkala Kedokteran Vol 15, No 1 (2019)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (176.991 KB) | DOI: 10.20527/jbk.v15i1.6088

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Abstract: Nutritional status in this case BMI in women is very important in relation to infertility problems in women of reproductive age. Polycystic ovary syndrome (PCOS), is a reproductive problem with hormonal disorders. Infertility Female with PCOS is associated with anovulation, high LH and hyperandrogenism. The purpose of this study was to analyze differences in age and body mass index (BMI) of PCOS women undergoing in vitro fertilization (IVF). This was an observational analytic study. The subjects of the study were women aged 30-40 years who undergoing IVF-assisted fertilization program at Yasmin Clinic - RSCM Kencana who was diagnosed as PCOS. As a comparison are women 30-40 years who have infertility problems but not PCOS  who underwent IVF-assisted fertilization program. Women diagnosed with PCOS based on the Rotterdam 2003 consensus definition, and reinforced with ultrasound examinations that show polycystic ovary symptoms. Diagnosis is performed by a specialist in Obstetrics and Gynecology. Age data is taken from medical record and IMT data is calculated based on formula body weight/height2. Data analysis was done by unpaired t test. Mean age of study subjects: 32.21 ± 0.99 years female PCOS and 32.80 ± 0.516 years of non-PCOS group of women, unpaired t-test results were not significantly different (p> 0.05). Mass Index PCOS group 24.425 ± 0.585 Kg/m2 and 22.840 ± 0.494 Kg/m2 non-PCOS group, unpaired t-test results were significantly different (p <0.05). Conclusion of this research was in the PCOS women group had significantly higher BMI rates than the group non PCOS woman.