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All Journal Pharmaciana: Jurnal Kefarmasian Jambura Medical and Health Science Journal
Iskak, Iskak
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Medicine & Pharmacology

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Pharmacist counseling improves medication compliance of schizophrenia patients Pranata, Meki; Perwitasari, Dyah Aryani; Noerhidayati, Elly; Iskak, Iskak; Darmawan, Endang; Angella, Widi
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.25912

Abstract

Schizophrenia is a disorder characterized by abnormal behavior, impaired thinking, disorganized speech, and a reduced ability to perceive reality. One of the key factors influencing the success of schizophrenia therapy is patient adherence. Pharmacy plays a crucial role in the treatment of schizophrenia patients. This study aimed to determine the effect of pharmacist counseling on drug adherence of schizophrenia patients from the first month to the second month. The method used in this study was a one-group pre-test and post-test design that used quasi-experimental research. The subjects of this study were schizophrenia patients in the outpatient installation of Prof.Dr.Soerojo Mental Hospital, Magelang. This study used the Medication Adherence Rating Scale (MARS) questionnaire to measure the level of adherence and drug use monitoring sheet (pill count) to monitor the amount of patient medication. The population in this study was calculated using the Lameshow formula. Data analysis was performed using the chi-square test and the Wilcoxon test. After analyzing data of 108 patients, it was found that there was a significant difference between before and after counseling conducted by pharmacists on medication adherence in schizophrenia patients, with a significance value of p <0.05. Counseling conducted by pharmacists has a good impact on patient medication adherence and monitoring the amount of medication taken. These results indicate the effect of counseling conducted by pharmacists on adherence to taking medication and the monitoring of the amount of medication taken by patients.
Association Between Serum IL-8 Concentrations and Severity of Knee Osteoarthritis: An Exploratory Cross-Sectional Study Iskak, Iskak; Dewanta, Tunggul Bagus; Santoso, Anna Lewi; Aryanti, Novina; Syahzaqi, Idrus; Njoto, Ibrahim
Jambura Medical and Health Science Journal Vol 5, No 1 (2026): Jambura Medical and Health Science Journal
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jmhsj.v5i1.37399

Abstract

Introduction: Osteoarthritis (OA) is a chronic degenerative disorder of the joints that progresses over time, with inflammation playing a key role in its underlying mechanisms. Interleukin-8 (IL-8), a pro-inflammatory cytokine that participates in immune responses and neutrophil migration, has been associated with the process of cartilage breakdown in OA. This study was conducted to analyze the association between serum IL-8 concentrations and the radiographic severity of knee OA as exploratory evidence to enhance understanding of OA pathophysiology.Method: This exploratory observational research applied a cross-sectional approach in patients diagnosed with knee OA. Seven participants were enrolled through total sampling at the Larasati Pondok Osteoarthritis Elderly Health Center, Faculty of Medicine, Wijaya Kusuma University, Surabaya. Radiographic severity of OA was determined using the Kellgren–Lawrence grading system. Venous blood specimens were obtained to determine serum IL-8 concentrations as an indicator of systemic inflammation.Results: Statistical analysis demonstrated a significant inverse correlation between serum IL-8 concentrations and OA severity (r = −0.866, P = 0.012). These results indicate that IL-8 concentrations in serum are relatively elevated in the early phase of OA and tend to decline as the disease progresses.Conclusion: The findings of this exploratory study indicate that serum IL-8 may represent systemic inflammatory activity during the early stages of knee OA and holds potential as a biomarker candidate for future investigation. Further longitudinal studies involving larger sample sizes are necessary to validate its clinical relevance for OA detection and disease monitoring. Keywords: Cartilage, inflammation, interleukin-8, joint diseases, osteoarthritis, risk factors 
Co-Authors Angella, Widi Anna Lewi Santoso Aryanti, Novina Dewanta, Tunggul Bagus Dyah Aryani Perwitasari Endang Darmawan Ibrahim Njoto, Ibrahim Idrus Syahzaqi Meki Pranata Noerhidayati, Elly