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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Berkala Epidemiologi Jurnal Farmasi Klinik Indonesia Pharmacon Sinkron : Jurnal dan Penelitian Teknik Informatika Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JFIOnline Jurnal Kesehatan PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan

Endang Darmawan

Fakultas Farmasi Universitas Ahmad Dahlan, Jl. Prof. Dr. Soepomo S.H., Janturan Umbulharjo, Yogyakarta

Author-ID : 250034

Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Pengaruh Pemberian Edukasi Obat terhadap Kepatuhan Minum Obat Warfarin pada Pasien Sindrom Koroner Akut dan Fibrilasi Atrium di Rumah Sakit PKU Muhammadiyah Yogyakarta Pusmarani, Jastria; Mustofa, Mustofa; Darmawan, Endang
Indonesian Journal of Clinical Pharmacy Vol 4, No 4 (2015)
Publisher : Indonesian Journal of Clinical Pharmacy

Peningkatan kepatuhan minum obat warfarin pada pasien sindrom koroner akut (SKA) dan fibrilasi atrium (FA) salah satunya dapat diberikan melalui edukasi dengan pemberian leaflet. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian edukasi dengan leaflet oleh apoteker terhadap kepatuhan minum obat warfarin pada pasien SKA dan FA. Penelitian ini menggunakan metode uji sebelum dan sesudah menggunakan pembanding. Pengambilan data dilakukan secara prospektif selama 8 minggu periode JuniâJuli 2014 pada pasien rawat jalan SKA dan FA di poliklinik RS PKU Muhammadiyah Yogyakarta. Data diambil melalui rekam medik pasien dan kuesioner Morisky Medication Adherence Scale (MMAS) yang diberikan pada pasien. Analisis statistik menggunakan uji Wilcoxon. Hasil penelitian pada kelompok pembanding â uji sebelum dan sesudahâ sebesar p=0,194 dan kelompok perlakuansebesar p=0,058. Berdasarkan hasil tersebut menunjukkan bahwa tidak ada perbedaan signifikan (p>0,05) setelah diberikan edukasi dengan leaflet. Pemberian edukasi dengan leaflet tidak memengaruhi kepatuhan minum obat warfarin pada pasien SKA dan FA di RS PKU Muhammadiyah Yogyakarta.Kata kunci: Fibrilasi atrium (FA), kepatuhan, sindrom koroner akut (SKA), warfarinThe Effect of Medicinal Education on Adherence Taking Warfarin in Acute Coronary Syndrome (ACS) and Atrial Fibrilation (AF) Patients at PKU Muhammadiyah Yogyakarta HospitalIn order to improve warfarin medication adherence in patient with Acute Coronary Syndrome (ACS) and Atrial Fibrillation (AF), giving education with leaflet administration is one of the solutions. This study was aim to know the impact of pharmacist education with using prepared leaflet on the adherence to warfarin in ACS and AF patients. This study used pre test and post test with control group design. Data were collected prospectively during 8 weeks in JuneâJuly 2014 at the ambulatory ACS and AF patients at PKU Muhammadiyah Yogyakarta hospital, Indonesia. Data were collected by medical record and the questionnaire using Morisky Medication Adherence Scale (MMAS). Wilcoxon test was used for statistical analysis. The results shows pre test and post test value in the control group was p=0.194 and pre and post test value in the test group was p=0.058. There was no significant difference (p>0.05) after giving education with leaflet. The education with leaflet had no effect to adherence in warfarin in ACS and AF patients at PKU Muhammadiyah Yogyakarta hospital.Keywords: Acute coronary syndrome, adherence, atrial fibrilation, warfarin

Pengaruh Pemberian Steroid sebagai Terapi Tambahan terhadap Rata-Rata Lama Pasien Dirawat di Rumah Sakit dan Tanda Klinis pada Anak dengan Pneumonia Ardyati, Sulistia; Kurniawan, Nurcholid U.; Darmawan, Endang
Indonesian Journal of Clinical Pharmacy Vol 6, No 3 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Terapi steroid pada anak dengan pneumonia merupakan terapi tambahan yang memiliki aktivitas sebagai penghambat inflamasi yang menekan ekspresi sitokin proinflamasi dan berpotensi mencegah respon inflamasi. Beberapa penelitian menunjukkan pemberian steroid tidak memberikan pengaruh dalam pengobatan pada pasien pneumonia, tetapi pada penelitian lain menunjukkan pemberian steroid mengurangi rata-rata lamanya pasien dirawat di rumah sakit. Tujuan dari penelitian ini adalah untuk melihat pengaruh pemberian steroid terhadap rata-rata lamanya pasien dirawat di rumah sakit (LoS) dan tanda klinis pasien anak dengan pneumonia. Penelitian yang dilakukan merupakan penelitian observasional dengan metode prospektif yang dilakukan di Rumah Sakit PKU Muhammadiyah Bantul Yogyakarta pada bulan September 2015 hingga Januari 2016. Lima puluh satu pasien digunakan sebagai subjek penelitian. Penelitian ini terdiri dari 2 kelompok yakni kelompok non-steroid terdiri dari 25 pasien dan kelompok steroid terdiri dari 26 pasien. Kelompok non-steroid dan steroid masing-masing memiliki nilai rata-rata lamanya pasien dirawat di rumah sakit 5 (3â10) hari dan 4 (3â10) hari. Durasi tanda klinis pasien kelompok steroid dan kelompok non-steroid berturut-turut adalah 2 (0â6) hari dan 2 (0â7) hari untuk demam, batuk 4 (1â10) hari dan 5 (2â10) hari, sesak 1 (0â5) hari dan 1 (0â10) hari, retraksi 1 (0â5) hari dan 1 (0â9) hari. Kesimpulan dari penelitian ini adalah steroid sebagai terapi tambahan memberikan efek yang tidak berbeda bermakna terhadap nilai length of stay dan tanda klinis pasien anak dengan pneumonia.Kata kunci: Anak, length of stay, pneumonia, steroid Steroids Effect as Adjuvant Therapy toward Length of Stay and Clinical Symptoms in Pediatric with PneumoniaSteroid therapy in children with pneumonia is an adjuvant therapy that has inhibitor inflammatory activity which can suppress the expression of proinflammatory cytokines and potentially prevent the inflammatory response. Some studies showed that steroids did not give beneficial effects in the treatment of patients with pneumonia, while the other studies showed that steroids can reduce the length of stay in hospital. The purpose of this study was to observe the effect of steroid on the length of stay and clinical symptoms in pediatric patients with pneumonia. This was an observational study with a prospective method in patients with pneumonia in PKU Muhammadiyah Bantul Hospital Yogyakarta from September 2015 until January 2016. Fifty one patients participated as subjects of this study. This study consisted of two groups, which were non-steroid group (n=25) and steroid group (n=26). Group of non-steroid and steroid had average value of length of stay of 5 (3â10) days and 4 (3â10) days, respectively. The duration of clinical symptoms of patients in the steroid and non-steroid group in a row was 2 (0â6) days and 2 (0â7) days for symptoms of fever, 4 (1â10) days and 5 (2â10) days for symptoms of cough, 1 (0â5) days and 1 (0â10) days for symptoms of shortness, and 1 (0â5) days and 1 (0â9) days for symptoms of retraction. The conclusion of this study is steroid has not given significant effects on the length of stay and clinical symptoms in pediatric patients with pneumonia.Keywords: Length of stay, pediatric, pneumonia, steroid

Improving Outpatientâs Quality of Life Through Patient Adherence of Antihypertensive Therapy Using âMobile Phone (SMS) and Brief Counselingâ5Aâ in Polyclinic of Internal Medicine at PKU Muhammadiyah Bantul Hospital, Yogyakarta Saputri, Ginanjar Zukhruf; Akrom, Akrom; Darmawan, Endang
Indonesian Journal of Clinical Pharmacy Vol 6, No 2 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Â The Health-Related Quality of Life (HRQoL) is one of the important psycho-social characteristics that can affect patientâs ability to manage therapy. Poor of knowledge of hypertension and the changing lifestyle can affect the quality of life of patients. One of the pharmacistâs interventions in hypertension management is to conduct counseling. Motivational counseling helps health service to assess patientâs understanding and patientâs readiness to change patientâs behavior. Some motivational counseling methods still need to be developed. Therefore, this study aims to find the influence of the "brief counseling-5A" and "motivational SMS" by a pharmacist on the quality of life and blood pressure control in hypertension patients in the internal disease polyclinic, PKU Muhammadiyah Bantul Hospital, Yogyakarta. The study has been done by using the quasi-experimental method with prospective data collection during the period of January until April 2013. Sixty patients have met inclusion criteria and were divided into two groups. Thirty patients (50%) received "brief counseling-5A" and "motivational SMS" as intervention group and the other thirty patients (50%) received usual care as a control group. The data collection was done by interviewing patients. Medication adherence and QoL were assessed by using Morisky Medication Adherence Scale (MMAS) and SF-36. The values of blood pressure are taken from patientâs medical records. Patientâs quality of life showed a good improvement during post study. It is shown in 8 different domains including pain, fatigue, physical function, emotional function, social function, role physical, mental health, and general health. In intervention group, physical function, emotional function, and pain showed highly significant improvement (p<0.05). Systolic and diastolic blood pressure in the intervention group decreased significantly (p<0.05) (systolic p=0.001 and diastolic p=0.018) in the post study. From this study, it is concluded that the "brief counseling-5A by pharmacist" and "motivational SMS" had a positive impact on patientâs QoL and patientâs blood pressure, hence, the therapy outcome has been achieved.

Factors relate to the hypercreatininemia event of patients at the risk of metabolic syndrome in Jetis I public health center Akrom, Akrom; Darmawan, Endang; Maulida, Nuril
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Metabolic syndrome (MS) is a risk factor for chronic kidney disease (CKD). Adherence to drug therapy is one of the keys to achieving therapeutic targets in MS. Hyperuricemia (>7mg/dL in men &>5.4mg/dL in women) and hypercreatininemia (>1.3 mg/dL) is a sign of kidney function deficiency. Kidney function deficiency is the result of uncontrolled blood pressure and blood sugar levels in MS patients. The objective of the study was to know the description of the incidence of hypercreatininemia and factors related to the incidence of hypercreatininemia in outpatientÂ at risk of Â MS at Jetis Public health center (PHC) I, Bantul, Yogyakarta. The analytical observational research with cross sectional design was performed on 99 MS outpatient at Jetis I Public Health Center (PHC) who fulfilled the inclusion criteria and approved the participation in the study. Blood urea and creatinine levels were determined by spectrophotometer 5010. Demographic, diagnosis and treatment data were colleccted Â from medical record. Patient adherence data were collected by interview. Patient compliance was measured by a medication compliance questionnaire. Demographic and clinical Â data are presented descriptively. Bivariate analysis with chisquare was performed to determine the value of the relationship between sex, age, hyperuricemia and adherence to the incidence of hypercreatininemia. Â About 30.3% of total of outpatients at risk of MS at Jetis I PHC, Bantul, is non-adherence and 69.7% is adherence to the treatment. As many as 44.4% of respondents have hypercreatininemia and 8.1% of respondents have hyperuricemia. There was a relationship between adherence and female sex with the prevalence of hypercreatininemia with an odds ratio of 3.8, 0.26 and 7.1 respectively. Based on the data of the study concluded that non-adherence, male sex and hyperuricemia are associated with the prevalence of hypercreatininemia in patients at risk of MS in Jetis I PHC.

PENGGUNAAN POTENTIALLY INAPPROPRIATE MEDICATIONS (PIMs) PADA PASIEN GERIATRI RAWAT INAP OSTEOARTHRITIS DI RS PKU MUHAMMADIYAH YOGYAKARTA Namirah Muh. Syuaib AS, Andi; Darmawan, Endang; Mustofa, Mustofa
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Potentially inappropriate medications (PIMs) use among elderly is a serious public health problem because it is intrinsically linked to increased morbidity, mortality, and healthcare costs. This studyÂ aims to determine the association between number of drug prescribed, duration of hospital stay and PIMs use among elderly hospitalized patients at PKU Muhammadiyah Yogyakarta General Hospital. This study was analytic observational with cross-sectional study. Beers criteria 2012 were used to identify PIMs use among elderly hospitalized patients with osteoarthritis. Logistic regression analysis were used to determine association between number drugs of prescribed, duration of hospital stay and PIMs use. The results showed that 7 (38.9%) out of 18 hospitalized elderly patients were identified PIMs use and all of patients received atleast one PIM. The most common agents involved in PIMs were estazolam (11.1%), and metoclopramide (11.1%). Polypharmacy is a major predictor factor of PIMs use in this study.

PENINGKATAN SISTEM IMUN OLEH KOMBINASI EKSTRAK ETANOL DAUN AWAR â AWAR (Ficus septica burm. F) DAN EKSTRAK ETANOL DAUN KELOR (Moringa oleifera) SEBAGAI KO-KEMOTERAPI KANKER PADA TIKUS PUTIH BETINA GALUR SPRAGUE DAWLEY YANG DIINDUKSI DOKSORUBISIN Anovia, Rizka Angerti; Sari, Dewi Indah; Yazin, Annisa Hardikasari; Ismayani, Ulfa; Darmawan, Endang
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Use of the drug doxorubicin for cancer therapy causes decreasing of immune system reported. Leaves of Ficus septica Burm. F and leaves of Moringa oleifera as immunostimulatory agents. The purpose of this study, among others, determine the combined effects of ethanol extract of Ficus septica Burm. F leaves and ethanol extract of Moringa oleifera leaves as co-chemotherapy for in female rats Sprague Dawley strain induced doxorubicin. Eighteen Sprague Dawley rats were divided into six treatment groups, normal group was given 0.9% NaCl 10ml / kgBB, positive control group were given by doxorubicin with dose of 4.67 mg / kgBB, single-dose treatment group were each given ethanol extract of Ficus septica Burm F leaves dose of 750 mg / kgBB and ethanol extract of Moringa oleifera leaves 500 mg / kgBB, treatment groups were given by combination of ethanol extract Ficus septica Burm. F leaves and Moringa oleifera leaves with a dose of 1.25 g / kgBB and a dose of 1 , 75 g / kgBB. treatment carried out for 7 days. On days 1 and 4 of each treatment groups except the normal group induced by doxorubicin 4.67 mg / kgBB intramuscularly. Blood sampling performed on day 0 and 7 th for lymphocytes CD3+ and lymphocytes CD8+ test. The results showed that the combination of ethanol extract Ficus septica burm. F leaves and Moringa oleifera leaves dose of 1.25 g / kgBB and the dose of 1.75 g / kgBB can enhanched immune system relative small which was not statistically significantly different (p> 0.05). However, a single dose of ethanol extract Moringa oleifera leaves dose of 500 mg/kg have immunostimulatory activity as lymphocytes CD3+ and lymphocytes CD8+ were more effective than a single dose of ethanol extract of Ficus septica Burm. F leaves dose of 750 mg/kgBB.

EFEK ANTI INFLAMASI KITOSAN DARI CANGKANG UDANG PANTAI TRISIK PADA TIKUS MODEL RHEUMATOID ARTHRITIS Hanifah, Nurul; Darmawan, Endang
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

This research was conducted to investigate the effect of chitosan as anti-inflammatory in rheumatoid arthritic in reduction of paw edema using plethysmometer. Chitosan was isolated from the shrimp shell on the Trisik Coastal were administered orally on 17-32th day with CMC 0,5%. This research using repeated measure design. To evaluate anti-inflammatory effect of the suspension, an arthritic rats model was developed using Complete Freund`s Adjuvant (CFA) on 1-16th day. In addition, the research was divided into 5 groups (n=6) including normal control groups, positive control groups, negative control groups, 1 group were treated by chitosan suspension at 50 mg/200 gram BW doses and the other group were treated by chitosan suspension at 100 mg/200 gram BW doses. The reduction of paw edema were determined every 3 day after 17th days then analyzed using general linear repeated measure test (p<0,05). The results showed that paw edema of arthritic rats were evidently decreased by chitosan suspension at 100 mg/200 gram BW doses (142,66%) better than chitosan suspensionÂ at 50 mg/200 gram BW doses (117,23%). In conclusion, the chitosan from shrimp shell of Trisik coastal is found to be effective as anti-inflammatory in rheumatoid arthritic rats model.

HUBUNGAN JUMLAH OBAT YANG DIRESEPKAN DENGAN POTENSIAL PENGGUNAAN OBAT YANG TIDAK TEPAT PADA PASIEN PENYAKIT GINJAL KRONIS DI RS PKU MUHAMMADIYAH YOGYAKARTA Mulyani, Evi; Darmawan, Endang; Mustofa, Mustofa
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Age-related decrease of physiological function caused some healt problem in elderly, so the problem of treatment in the elderly is also not uncommon found as polypharmacy and Potentially Inappropriate medication (PIMs). The purpose of this study to determine the relationship of the number of drug prescribed with PIMs in elderly patients with CKD in PKU Muhammadiyah Yogyakarta Hospital. PIMs identification by STOPP criteria, while the number of drugs prescribed seen by drugs control books. To assess the patients medical history by interviews and search records. Patient characteristics were analyzed descriptively, correlations between variables were analyzed with chi square test. From 53 samples, PIMs identified 17% and average one sample got one PIMs, while of the 410 drugs that prescribed average patient receivingÂ 8 drugs (> 6). Bivariate test results showed that no significant relationship between the number of drug prescribed with PIMs.

PENGARUH KITOSAN DARI CANGKANG UDANG TERHADAP RED BLOOD CELL, HEMOGLOBIN, DAN TROMBOSIT PADA MODEL RHEUMATOID ARTHRITIS YANG DIINDUKSI CFA Sah Putra, Suyandra; Darmawan, Endang
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The research was conducted the effect of chitosan on rats blood alteration that induced arthtritis. In addition, the research used pre-post test group control design. than used Â was divided into groups (n=6) including normal groups, positive control, negatif control, and Â groups were treated byÂ khitosan at varian 50 mg/200gBB and 100 mg/200gBB doses. Adjuvant-induced was developed using complete Freundâs Adjuvant on 1st day, than 17-47th days after treated given appropriate their groups. To evaluate did blodd counter on 0, 16th,and 47th days after treated with otomatic optic dan electronic resisten method. Than analyzed using ANOVA test and paired t-test (p<0,05). Result of the research is Chitosan 50 mg/200gBW fit to reduce of eritrocid 6,1% (p<0,05), hemoglobin 7,77% (p<0,05) and PLCR 35,29% (p<0,05), meanwhile of Chitosan 100 mg/200gBW fit to reduce of trombocyte 40,49% (p>0,05) and PLCR 35,66% (p<0,05). In additional research, khitosan 50 mg/200gBW fit to complete blood of the rheumatoid arthritic mouse well.

EVALUASI IMPLEMENTASI PELAYANAN KONSELING OBAT DI APOTEK KOTA YOGYAKARTA baroroh, farida; darmawan, endang
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 3 No 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Therefore, it is important to give counseling for patients and their family. This study is to evaluate the counseling service implementation at several pharmacy in Yogyakarta Indonesia. This study was a cross-sectional design. The result showed that the implementation counseling service at pharmacy was 59,00% of 96,00% patients who required counseling service. The several pharmacy patient were out-patient who responsible to their therapeutical management. There was 55,93% patients experienced that the room for counseling service was comfortable. So, the communication aspects of counseling service at pharmacy in Yogyakarta had been well conducted. Based on the communication technique, the pharmacist communicated with body language such as practicing how to use the drug in counseling services was 64.41%. In conlusion, the implementation counseling service at pharmacy in Yogyakarta Indonesia was 59,00% of 96,00% patients who required counseling service. A number of 94.83% of patients stated that pharmacists use an understandable language in counseling services. It can be concluded that although only 58.59% of respondents who had received counseling but the desire to get counseling services of pharmacy in Yogyakarta is very high, reaching 95.96% of respondents

Co-Authors Agamasi, Amalia Akrom, Akrom Ananda Muhammad Naafi, Ananda Muhammad Anastasya, Yolanda Andi Namirah Muh. Syuaib AS, Andi Angella, Widi Anggriani, Hesti Annisa Hardikasari Yazin, Annisa Hardikasari Anovia, Rizka Angerti Ardyati, Sulistia Astuti Wulandari, Nur Dewi Indah Sari, Dewi Indah Dewi Isnaini, Ratna Dyah Aryani Perwitasari Evi Mulyani Fahrian Hipmi, Ahmad Farida Baroroh, Farida Grin Fariah Hariadi Wijaya, Made Insani, Pratamasari Noor Iskak, Iskak Jamhari Jamhari Jastria Pusmarani Kurniati, Tripeni Kurniawan, Nurcholid U. Kurniawan, Nurcholid Umam Kusumawati, Leny Witaning Lailatul Hidayah Maulida, Nuril Meki Pranata Mustofa Mustofa Noerhidayati, Elly Nur Rahmatiya Abas, Siti Nurul Hanifah Ramdani, Dewi Riza Alfian Rizky Budi Santoso RR. Ella Evrita Hestiandari Santi Yuliani, Santi Saputri, Ginanjar Zukhruf Sri Mulyaningsih Sri Sulistyorini Sugiyarto Sugiyarto Sugiyarto Surono, Sugiyarto Suyandra Sah Putra, Suyandra Ulfa Ismayani, Ulfa Umam Kurniawan, Nurcholid Uswatun Hasanah Woro Supadmi Yovita Dewi, Fransiska

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