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All Journal Jurnal Medik Veteriner Veterinary Biomedical and Clinical Journal
Purwatiningsih, Wawid
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Veterinary

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The Effect of Triponyl Sulphate on Fetuses Development and Placental Abnormalities in Inducing Preeclampsia of Rattus norvegicus animal model Purwatiningsih, Wawid; Aryani, Dhita Evi; Vidiastuti, Dian; Oktanella, Yudit; Firmawati, Aulia
Veterinary Biomedical and Clinical Journal Vol. 1 No. 1 (2019)
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (672.49 KB) | DOI: 10.21776/ub.VetBioClinJ.2019.001.01.6

Abstract

Preeclampsia is one of the obstetrical problems that can cause maternal and fetal morbidity and mortality. Preeclampsia causes the fetus born prematurely and low fetal weight. This is caused by high blood pressure which causes decrease of blood delivery to the placenta, so the supply of oxygen and food to the fetus decreases. As a result, fetal development inhibits and trigger born prematurely. More fatal, this disease cause the release of placental tissue from the uterus prematurely. The aim of this study was to determine the effect of administration of triponyl sulfate as induction of increased blood pressure in preeclampsia animal models, fetal development with alizarin red staining and placental abnormalities. The experimental animals were rats Rattus norvegicus mated with male rats monomating , 4 months old and 250-300 grams body weigh. Pregnant female rats were induced by triponyl sulfate 70 mg / kg BW (k +) and without induced by triponyl sulfate (k-). The results of the study showed that there were formation of the sternal bone in k- and malformation of the sternum bone at k +. Placental abnormalities occured in k +, it could be seen in the presence of ghos villi in blood vessel abnormalities in the preeclampsia placenta caused by there was no invation of trophoblast cells in the whole or partial spiral arteries and the mean of blood pressure increased.
Toksisitas Larutan Perak Nitrat (AgNO3) pada Mencit Balb-c Berdasarkan Kadar SGPT dan SGOT Amri, Indah Amalia; Hendrasmara, Muhamad Ferian; Qosimah, Dahliatul; Aeka, Ajeng; Rickyawan, Nofan; Purwatiningsih, Wawid; Dameanti, Fidi Nur Aini Eka Puji
Jurnal Medik Veteriner Vol. 3 No. 2 (2020): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol3.iss2.2020.251-257

Abstract

Perak Nitrat (AgNO3) sering dimanfaatkan di bidang kesehatan sebagai bahan antimikroba. Efek pada organisme yang terpapar perak nitrat dapat mengakibatkan adanya akumulasi toksik pada hepar. Penelitian ini bertujuan mengetahui dampak toksisitas perak nitrat terhadap kadar SGPT dan SGOT pada mencit Balb-c. Hewan coba yang digunakan pada penelitian ini berjumlah 20 ekor mencit Balb-c dengan berat badan 25-30  gram dan umur 2-3 bulan serta masa pemberian perlakuan selama 14 hari. Perlakuan yang diberikan terdiri dari kelompok K- (tanpa induksi), P1 (100 µg/ml), P2 (200 µg/ml), P3 (300 µg/ml), P4 (400 µg/ml). Kadar SGPT dan SGOT diamati dengan menggunakan metode spektrofotometri. Data dianalisa menggunakan uji One Way ANOVA dengan tingkat kepercayaan 95%. Hasil dan kesimpulan menunjukkan induksi larutan perak nitrat pada mencit Balb-c dengan dosis P4 (400 µg/ml) dan volume induksi 0.5 ml dapat menyebabkan toksisitas pada mencit yang ditandai dengan peningkatan kadar SGPT dan SGOT.
Co-Authors Aeka, Ajeng Amri, Indah Amalia Aryani, Dhita Evi Dameanti, Fidi Nur Aini Eka Puji Dian Vidiastuti, Dian Firmawati, Aulia Hendrasmara, Muhamad Ferian Qosimah, Dahliatul Rickyawan, Nofan Yudit Oktanella, Yudit