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All Journal Jurnal Mandala Pharmacon Indonesia Jurnal Kefarmasian AKFARINDO Jurnal Kefarmasian Indonesia
Wahyuddin, Nurzadrina
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Chemistry Immunology & microbiology Medicine & Pharmacology Social Sciences

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AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN JARAK MERAH (Jatropha gossypiifolia) ASAL KABUPATEN BANTAENG Wahyuddin, Nurzadrina; Ismail, Ismail; Mashar, Harlyanti Muthma'innah; Dali
Jurnal Kefarmasian Akfarindo Vol 7 No 1 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.115

Abstract

Background: In the last few decades there has been an increase in cases of chronic diseases and premature aging which are some of the key factors in influencing public health. This condition is caused by various causes, but the main factor is the number of free radicals that exceed the body's capacity to neutralize them. Antioxidants have an important role as health protective factors because they can neutralize and protect cells from the presence of free radicals. Red castor leaves have been reported to have good activity as an antioxidant. The chemical content of this plant is anthraquinone, flavonoid, saponin, tannin and terpenoid. Objective: This study aimed to evaluate the antioxidant activity of red jatropha leaf extract using the DPPH method. Methods Samples were extracted using 70% ethanol by maceration method. The antioxidant activity test was carried out using the DPPH method (1,1-diphenyl-2-picrylhydrazyl) using a comparison of Vitamin C. Each test used a variation of the concentration of the solution. For red jatropha leaf extract using concentration variations of 20, 40, 60, 80 and 100 g/ml, while for vitamin C using concentration variations of 10, 15, 20, 25, and 30 g/ml. The absorbance of each test solution was measured using a spectrophotometer at a wavelength of 515 nm. The results are reported as IC50 values. Results: The results showed that the IC50 values ​​of red jatropha leaf extract and vitamin C were 47.81 and 14.99 g/ml, respectively. This value indicates that the Chinese jatropha leaf extract has a very strong antioxidant activity (IC50 <50 g/ml). Conclusion: Red jatropha leaf extract showed very strong antioxidant activity with an IC50 value of 47.81 g/ml so it has great potential as an antioxidant that can be used for the development of traditional medicinal raw materials.
Pengaruh Fraksi Daun Asam Jawa (Tamarindus indica L.) terhadap Fungsi Hati dan Ginjal Tikus Diinduksi Parasetamol Rahimah, Sitti; Awaluddin, Akbar; Wahyuddin, Nurzadrina
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.5955

Abstract

Liver and kidneys play a role in the metabolism and excretion of substances that enter the body, they become targets for toxicity from xenobiotics and other chemicals including drugs. Exogenous antioxidants are needed to overcome and prevent oxidative stress. Fraction of tamarind leaf extract (Tamarindus indica L) has antioxidant activity, it has the potential to protect the body from free radicals. This study aimed to determine the effect of giving tamarind leaf fractions on AST, ALT and creatinine levels in rats (Rattus norvegicus) induced with paracetamol. Experimental animals were divided into 4 groups. Group I was given paracetamol induction (negative control), group II was given the ethyl acetate fraction and induced paracetamol, group III was given the n-hexane fraction and induced paracetamol, and group IV was without treatment (positive control). Statistical analysis using One Way Anova test and LSD (Post Hoc) showed that the ethyl acetate fraction was not significantly different (p-value >0.05) with the positive control group and the n-hexane fraction group, but significantly different from the negative control group (p -value
Uji Aktivitas Antioksidan Ekstrak Daun Murbei (Morus alba) Menggunakan Metode BCB, CUPRAC, dan FRAP Salampe, Mirnawati; Rahimah, Sitti; Nur, Syamsu; Mamada, Sukamto S.; Biring, Frans Syukur; Keyzia, Kurnia; Matandung, Friska Nissa; Payung, Deslin; Rahman, Annisa Amirah; Wahyuddin, Nurzadrina; Ivone P., Velyostri
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.723

Abstract

Morus alba dikenal sebagai sumber senyawa antioksidan alami yang dapat menangkal radikal bebas yang berkontribusi terhadap penyakit degeneratif. Penelitian ini bertujuan untuk mengidentifikasi aktivitas antioksidan dari ekstrak metanol dan fraksi daun M.alba menggunakan metode BCB, CUPRAC, dan FRAP. Ekstraksi dilakukan menggunakan pelarut metanol, kemudian difraksinasi dengan n-heksana, etil asetat, n-butanol, dan air. Metode BCB digunakan untuk menentukan IC50, metode CUPRAC untuk mengukur kapasitas antioksidan dalam GAEAC (Gallic Acid Equivalent Antioxidant Capacity), dan metode FRAP untuk menilai kemampuan reduksi ion besi dalam FeEAC (Ferri Sulfate Equivalent Antioxidant Capacity). Pengujian aktivitas antioksidan pada metode FRAP dilakukan dengan reagen dapar asetat, TPTZ, dan FeCl? yang diukur menggunakan microplate reader pada panjang gelombang 595 nm berdasarkan kemampuan sampel dalam mereduksi ion besi. Metode CUPRAC menggunakan reagen CuCl? 10 mM, neocuproine 7,5 mM, dan ammonium sulfat 1 M. Hasil uji BCB menunjukkan bahwa fraksi n-heksana memiliki aktivitas antioksidan tertinggi dengan IC50 sebesar 64,85 ppm dibandingkan dengan etil asetat (437,23 ppm). Pada CUPRAC, ekstrak metanol menunjukkan kapasitas tertinggi (342,74 µM/g), diikuti oleh etil asetat (342,43 µM/g). Uji FRAP menunjukkan fraksi etil asetat memiliki aktivitas tertinggi (809,28 mmol/g), diikuti oleh metanol (761,03 mmol/g), dan n-butanol (613,03 mmol/g). Ekstrak metanol, fraksi etil asetat, dan n-butanol menunjukkan kemampuan signifikan dalam mereduksi ion Cu²? dan Fe³? dibandingkan dengan n-heksana dan air. Hasil ini menunjukkan bahwa aktivitas antioksidan ekstrak M. alba bervariasi tergantung pada fraksi dan metode yang digunakan. Oleh karena itu, pemilihan metode yang tepat sangat penting dalam mengevaluasi potensi antioksidan dari suatu sampel.
Co-Authors Awaluddin, Akbar Biring, Frans Syukur Dali Harlyanti Muthma'innah Mashar Ismail Ismail Ivone P., Velyostri Keyzia, Kurnia Mamada, Sukamto S. Matandung, Friska Nissa Payung, Deslin Rahman, Annisa Amirah Salampe, Mirnawati Sitti Rahimah, Sitti Syamsu Nur, Syamsu