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All Journal As-syifaa Jurnal Farmasi Jurnal Mandala Pharmacon Indonesia Jurnal Kefarmasian AKFARINDO ad-Dawaa : Journal of Pharmaceutical Sciences Medfarm: Jurnal Farmasi dan Kesehatan Journal of Pharmaceutical Science and Herbal Technology Jurnal Kefarmasian Indonesia
Sitti Rahimah, Sitti
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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UJI AKTIVITAS EKSTRAK BIJI SELASIH (Ocimum basilicum L.) DENGAN BEBERAPA PELARUT SEBAGAI ANTIPIRETIK PADA MENCIT (Mus musculus) Rahimah, Sitti; hendrarti, Wahyu; Ramlah, Sitti
Jurnal Ilmiah As-Syifaa Vol 7, No 2 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.534 KB) | DOI: 10.33096/jifa.v7i2.7

Abstract

Seeds basil (Ocimum basilicum L.) has been known to the publicand is widely used to treat a variety of diseases. One of its benefits as lowering fever but have not been proven scientifically. This study was to determine whether there is an antipyretic effecte basil seeds (Ocimum basilicum L.) and to determine the effectiveness of extracts of basil seeds by using some of the solvent is n-hexane, ethyl acetate and ethanol compared with paracetamol in mice (Mus musculus). This study was an experimental study using RAL. Experimental animals used were 15 mice, stages of research giving treatment af mice in each group who had fasted for 12 hours, measured rectal temperature (initial temperature), then injected with 1 ml peptone/tail subcutaneously. The data obtained were analyzed ANOVA followed BNJ test. Test antipyretic extract basil seeds (Ocimum basilicum) with some solvent, most effectively used as a solvent in the basil seeds that solvent ethyl acetate compared with solvent n-hexane and ethanol. The results oft his study showed that the extract of basil seeds antipyretic effect.
UJI TOKSISITAS TERATOGENIK EKSTRAK ETANOL DAUN ASAM JAWA (Tamarindus indica Linn) TERHADAP TIKUS (Rattus norvegicus) Rahimah, Sitti; Salampe, Mirnawati; Rahmania, Nurbaiti
Jurnal Ilmiah As-Syifaa Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.058 KB) | DOI: 10.33096/jifa.v12i1.588

Abstract

In this study of teratogenic toxicity tests was carried out on the ethanol extract of tamarindus leaves (Tamarindus Indica Linn) on rats (Rattus norvegicus) during the organogenesis period. This study aims to know the safety and toxicity of the administration of ethanol extract of tamarind leaves (Tamarindus indica L.) to fetus rats (Rattus norvegicus) with macroscopic parameters including number, resorption, weight, and skeleton of the fetus. 15 animals were divided into 3 groups, each group consisted of 5 rats. Group I was treated with 0.5% Na CMC as normal control,  group II was treated with ethanol extract of tamarind leaves with a dose of 14 mg / 200 g BW for 10 days and group III was given a simvastatin tab at a dose of 10 mg / kg BW. Treatment was given orally during the organogenesis period on the 5th to 15th day of pregnancy. On the 16th day, laparatomy of the rat and fetus was removed from the uterus. The results showed that the suspension of ethanolic extract of tamarind leaves did not cause teratogenic occurrence in fetal rats, and the control of simvastatin caused teratogenic due to resorption, less fetal weight, hand and foot defect, and death in the fetus, compared to the normal control group.
UJI AKTIVITAS EKSTRAK ETANOL DAUN BIDARA LAUT (Strychnos ligustrina Biume) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KELINCI (Oryctolagus cuniculus) Rahimah, Sitti; Salampe, Mirnawati; Syamid, Ahmad Gufairil; Ismail, Ismail; Nisa, Michrun
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 12 No 2 (2023): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v12i2.201

Abstract

Burns are damage or loss of skin tissue caused by contact with heat sources such as hot water, fire, chemicals, electricity, friction and radiation. Sea lotus (Strychnos ligustrina Blume) is known to contain compounds that have the potential to heal burns such as flavonoids, saponins and tannins. This study aims to determine the activity of ethanol extract of bidara de mer leaves on burn healing as a function of reduction in burn diameter, wound discoloration, edema and crust formation. This study used 5 Oryctolagus cuniculus that received 4 types of treatment after being induced by hot plate, namely wound I (bioplacenton® gel positive control), wound 2 (HPMC 5% negative control), wound 3 (extract concentration 10%) and wound 4 (concentration of extract 10%) 25%). Apply the test sample to the burns twice a day and observe the condition of the wound daily. Burn healing as a function of wound diameter was determined based on the AUC (Area Under Curve) value and statistically analyzed using SPSS 21.0. The test results showed that the mean AUC value at 10% and 25% concentrations was 0.495 cm/day and 0.532 cm/day, respectively. The results of the statistical analysis showed that the ethanol extract of bidara sea leaves gave significant results compared to the negative control. treatment (HPMC). The conclusion obtained is that the ethanolic extract of sea bidara leaves accelerates the healing process of burns in Oryctolagus cuniculus.
PENGUJIAN AKTIVITAS ANALGETIK DAN ANTIPIRETIK EKSTRAK ETANOL DAUN TENDANI (Ganiothalamus macrophyllus (Blume) Hook. F. & Thomson) Rahimah, Sitti; Mirnawati Salampe; Suwahyuni Mus; Ismail Ismail; Michrun Nisa; Supardi
Jurnal Kefarmasian Akfarindo Vol 8 No 1 (2023)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.v8i1.200

Abstract

Nyeri dan demam merupakan kondisi yang dapat dialami oleh semua orang pada segala usia. Salah satu tanaman yang secara empiris telah banyak digunakan sebagai obat untuk penaganan nyeri dan demam khususya oleh masyarakat suku Dayak adalah tendani. Penelitian ini bertujuan untuk menguji aktivitas analgetik dan antipiretik ekstrak daun tendani pada mencit. Hewan coba dibagi menjadi 5 kelompok perlakuan yaitu kelompok 1 sebagai kontrol negative (Na CMC), kelompok 2 sebagai kontrol positif, kelompok 3,4 dan 5 untuk pemberian ekstrak daun tendani masing-masing dengan dosis 100 mg/KgBB, 200 mg/KgBB, dan 300 mg/KgBB. Pada pengujian aktivitas analgetik, hewan coba diinduksi nyeri dengan asam asetat 1% sebelum pemberian sampel uji dengan asam mefenamat sebagai kontrol positif. Pada pengujian Pada pengujian aktivitas antipiretik, hewan coba diinduksi demam dengan pepton 12,5% setelah pemberian sampel uji dengan paracetamol sebagai kontrol positif. Hasil penelitian menujukan bahwa pemberian ektrak daun tendani memiliki aktivitas dalam menghambat terjadinya nyeri dan menurunkan demam setelah induksi. Kesimpulan dari penelitian ini adalah ekstrak daun tendani memiliki aktivitas sebagai analgetik dan antipiretik.
UJI AKTIVITAS ANTIHIPERGLIKEMIA EKSTRAK DAUN JAGUNG MANIS (ZEA MAYS SACCHARATA) PADA MENCIT (MUS MUSCULUS) DIINDUKSI SUKROSA Rahimah, Sitti; Hasmita, Nur
Journal of Pharmaceutical Science and Herbal Technology Vol. 9 No. 2 (2024): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pendahuluan: Kejadian penyakit degeneratif seperti diabetes melitus semakin meningkat seiring perubahan pola hidup dan lingkungan. Pengobatan DM perlu diperhatikan, karena penderitanya memerlukan pengobatan sepanjang hidup untuk mengurangi gejala, mencegah progresivitas penyakit dan mencegah terjadi komplikasi. Jagung merupakan salah satu tumbuhan yang digunakan oleh masyarakat sebagai obat tradisional Salah satu bagian dari jagung yang biasanya hanya dianggap sebagai limbah dan dapat digunakan sebagai antidiabetes yaitu daun jagung. Tujuan penelitian: Penelitian dilakukan untuk mengetahui aktivitas dari ektrak daun jagung manis sebagai antihiperglikemia pada hewan coba yang diinduksi sukrosa. Metode penelitian:Penelitian ini dilakukan dengan mengelompokkan hewan coba mencit yang diinduksi sukrosa menjadi 5 kelompok jenis perlakuan yang terdiri dari kelompok 1 untuk perlakuan Na-CMC 1% sebagai kontrol negatif, kelompok 2 dengan pemberian suspensi Acarbose sebagai kontrol positif, kelompok 3, 4, dan 5 dengan pemberian ekstrak daun jagung manis (Zea mays saccharata) dengan dosis berbeda yaitu 100 mg/KgBB, 300 mg/KgBB, 500 mg/KgBB. Hasil penelitian: penelitian yang telah dilakukan menunjukkan bahwa ekstrak daun jagung dapat menghambat kenaikan kadar glukosa pada mencit yang diinduksi sukrosa. Kesimpulan: ekstrak daun jagung memiliki aktivitas sebagai antihipeglikemia
Pengaruh Fraksi Daun Asam Jawa (Tamarindus indica L.) terhadap Fungsi Hati dan Ginjal Tikus Diinduksi Parasetamol Rahimah, Sitti; Awaluddin, Akbar; Wahyuddin, Nurzadrina
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.5955

Abstract

Liver and kidneys play a role in the metabolism and excretion of substances that enter the body, they become targets for toxicity from xenobiotics and other chemicals including drugs. Exogenous antioxidants are needed to overcome and prevent oxidative stress. Fraction of tamarind leaf extract (Tamarindus indica L) has antioxidant activity, it has the potential to protect the body from free radicals. This study aimed to determine the effect of giving tamarind leaf fractions on AST, ALT and creatinine levels in rats (Rattus norvegicus) induced with paracetamol. Experimental animals were divided into 4 groups. Group I was given paracetamol induction (negative control), group II was given the ethyl acetate fraction and induced paracetamol, group III was given the n-hexane fraction and induced paracetamol, and group IV was without treatment (positive control). Statistical analysis using One Way Anova test and LSD (Post Hoc) showed that the ethyl acetate fraction was not significantly different (p-value >0.05) with the positive control group and the n-hexane fraction group, but significantly different from the negative control group (p -value
Anti-inflammatory Potential of Tithonia diversifolia Leaves in Carrageenan-Induced Edema Model in Mice (Mus Musculus) Indrisari, Maulita; Khairi, Nur; Muslimin, Lukman; Aksa, Rahmat; Amriani, Amriani; Rahimah, Sitti; Rahayu, Riska
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57119

Abstract

Introduction: Edema is a common sign of inflammation characterized by increased tissue volume. Tithonia diversifolia leaves have traditionally been used as anti-inflammatory agents because they contain active compounds such as flavonoids, alkaloids, steroids, terpenoids, tannins, sesquiterpenoids, phenolic acids, and saponins. Aims: Determine the anti-inflammatory effects of ethanol extract of Tithonia diversifolia leaves on rats (Mus musculus) induced by carrageenan. Method: Extraction was carried out using maceration. The experimental design was pre- and post-test with five groups: healthy controls, positive controls (sodium diclofenac), and three treatment groups receiving 12.5 mg/30 gBW, 25 mg/30 gBW, and 37.5 mg/30 gBW of Tithonia diversifolia leaf extract. Edema was induced with carrageenan and measured using a plethysmometer at certain intervals. Result: The results showed that a dose of 37.5 mg/30 gBW significantly decreased edema volume, comparable to the diclofenac group (p>0.05). Conclusion: The ethanol extract of paitan leaves at this dose can function as an effective anti-inflammatory agent.
Uji Aktivitas Antioksidan Ekstrak Daun Murbei (Morus alba) Menggunakan Metode BCB, CUPRAC, dan FRAP Salampe, Mirnawati; Rahimah, Sitti; Nur, Syamsu; Mamada, Sukamto S.; Biring, Frans Syukur; Keyzia, Kurnia; Matandung, Friska Nissa; Payung, Deslin; Rahman, Annisa Amirah; Wahyuddin, Nurzadrina; Ivone P., Velyostri
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.723

Abstract

Morus alba dikenal sebagai sumber senyawa antioksidan alami yang dapat menangkal radikal bebas yang berkontribusi terhadap penyakit degeneratif. Penelitian ini bertujuan untuk mengidentifikasi aktivitas antioksidan dari ekstrak metanol dan fraksi daun M.alba menggunakan metode BCB, CUPRAC, dan FRAP. Ekstraksi dilakukan menggunakan pelarut metanol, kemudian difraksinasi dengan n-heksana, etil asetat, n-butanol, dan air. Metode BCB digunakan untuk menentukan IC50, metode CUPRAC untuk mengukur kapasitas antioksidan dalam GAEAC (Gallic Acid Equivalent Antioxidant Capacity), dan metode FRAP untuk menilai kemampuan reduksi ion besi dalam FeEAC (Ferri Sulfate Equivalent Antioxidant Capacity). Pengujian aktivitas antioksidan pada metode FRAP dilakukan dengan reagen dapar asetat, TPTZ, dan FeCl? yang diukur menggunakan microplate reader pada panjang gelombang 595 nm berdasarkan kemampuan sampel dalam mereduksi ion besi. Metode CUPRAC menggunakan reagen CuCl? 10 mM, neocuproine 7,5 mM, dan ammonium sulfat 1 M. Hasil uji BCB menunjukkan bahwa fraksi n-heksana memiliki aktivitas antioksidan tertinggi dengan IC50 sebesar 64,85 ppm dibandingkan dengan etil asetat (437,23 ppm). Pada CUPRAC, ekstrak metanol menunjukkan kapasitas tertinggi (342,74 µM/g), diikuti oleh etil asetat (342,43 µM/g). Uji FRAP menunjukkan fraksi etil asetat memiliki aktivitas tertinggi (809,28 mmol/g), diikuti oleh metanol (761,03 mmol/g), dan n-butanol (613,03 mmol/g). Ekstrak metanol, fraksi etil asetat, dan n-butanol menunjukkan kemampuan signifikan dalam mereduksi ion Cu²? dan Fe³? dibandingkan dengan n-heksana dan air. Hasil ini menunjukkan bahwa aktivitas antioksidan ekstrak M. alba bervariasi tergantung pada fraksi dan metode yang digunakan. Oleh karena itu, pemilihan metode yang tepat sangat penting dalam mengevaluasi potensi antioksidan dari suatu sampel.
Co-Authors Aksa, Rahmat Amriani Amriani, Amriani Awaluddin, Akbar Biring, Frans Syukur Hasmita, Nur Ismail Ismail Ivone P., Velyostri Keyzia, Kurnia Khairi, Nur Mamada, Sukamto S. Matandung, Friska Nissa Maulita Indrisari, Maulita Michrun Nisa Mirnawati Salampe Muslimin, Lukman Payung, Deslin Rahman, Annisa Amirah Rahmania, Nurbaiti Riska Rahayu Salampe, Mirnawati Sitti Ramlah Supardi Suwahyuni Mus Syamid, Ahmad Gufairil Syamsu Nur, Syamsu Wahyu Hendrarti Wahyuddin, Nurzadrina