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Application of Scoring System Components in Children Diagnosed with Tuberculosis in Jatinangor Primary Health Care, Sumedang Mutiara Azhara Nurwanti; Chrysanti Chrysanti; Sri Sudarwati
Althea Medical Journal Vol 4, No 4 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Diagnosis of tuberculosis in children is very difficult. Scoring system is used to diagnose tuberculosis in children in Indonesia. The aim of this study was to determine the application of scoring system components in children diagnosed with tuberculosis in the primary health care.Methods: This cross-sectional study was conducted in Jatinangor Primary Health Care, Sumedang in September–October 2013. Data were obtained from 59 medical records of pediatric patients diagnosed with tuberculosis in 2010–2012, and recorded on the application of scoring system components including tuberculosis contact history, tuberculin skin test, fever, cough, nutritional status, lymph node enlargement, swelling of bones or joints, and chest X-ray. Results: All scoring system components either with tuberculosis contact history, fever, cough, nutritional status, lymph node enlargement, swelling of bones or joints, and chest X-ray were performed on all of the children diagnosed with tuberculosis, except the tuberculin skin test was performed only on 38 (64%) children. Most frequent clinical symptoms were cough (97%), while fever and malnutrition occurred in 69% and 19% of children, respectively.Conclusions: The application of scoring system components in children diagnosed with tuberculosis in Jatinangor primary health care is not having problems, except for the tuberculosis skin test. Most frequent clinical symptoms of childhood tuberculosis in this study are cough.

Handwashing among Schoolchildren in Jatinangor, West Java Cheryl May Chong Sue Faye; Chrysanti Chrysanti; Sharon Gondodiputro
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (142.135 KB)

Background: Diarrhea and pneumonia accounts for an estimated 40% of all child deaths around the world each year. Handwashing with soap could protect about 1 out of every 3 young children who get sick with diarrhea and almost 1 out of 6 young children with respiratory infections like pneumonia. Although people around the world clean their hands with water, very few use soap to wash their hands. Washing hands with soap removes germs much more effectively. This study was undertaken to determine the level of knowledge and practice regarding proper handwashing among elementary school children.Methods: A descriptive study was conducted from August to October 2014 in Jatinangor using primary data from respondents who are 5th graders from four schools. A total of 49 males and 50 females were chosen using cluster random sampling. Schoolchildren who were present, able and well were given questionnaires after written informed consent was obtained from the schoolchildren and their guardians. Then, respondents demonstrated hand-washing techniques which were evaluated using a checklist.Results: Overall, 52% of the schoolchildren had moderate level of hand washing knowledge and 66% had bad handwashing practices.Conclusions: Despite having a moderate level of handwashing knowledge, the majority still had poor handwashing practices. Handwashing programs should be carried out extensively to improve knowledge and practice.[AMJ.2016;3(2):170–4]DOI: 10.15850/amj.v3n2.795

Streptococcus pneumoniae Drugs Resistance in Acute Rhinosinusitis Chong Jie Hao; Chrysanti Chrysanti; Trias Nugrahadi
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Background: Acute rhinosinusitis that usually caused by Streptococcus pneumoniae becomes the reason why patients seek for medical care. Drugs resistance in Streptococcus pneumoniae is increasing worldwide. This study was conducted to determine drugs resistance of Streptococcus pneumonia from acute rhinosinusitis in Dr. Hasan Sadikin General Hospital.Methods: A descriptive laboratory study was conducted in June–October 2014 at the Laboratory of Microbiology Faculty of Medicine Universitas Padjadjaran. The sample was taken using nasopharyngeal swabbing from 100 acute rhinosinusitis patients in Dr. Hasan Sadikin General Hospital and planted on tryptic soy agar containing 5% sheep blood and 5 μg/ml of gentamicin sulphate and then incubated in 5% CO2 incubator at 37°C for 24 hours. The identification of Streptococcus pneumonia was performed by optochin test. The susceptibility test against Streptococcus pneumoniae was done using disk diffusion method.The antibiotic disks were trimethoprim-sulfamethoxazole, oxacillin, levofloxacin, azithromycin, and doxycycline.Results: Out of 100 samples, 8 of them were tested positive for Streptococcus pneumoniae. Three of Streptococcus pneumoniae isolates died with unknown reason after it were stored at -80 .The drugs resistance test showed the resistance of Streptococcus pneumonia to oxacillin, azithromycin and trimethoprim were 6, whereas levofloxacin and doxycycline are 4.Conclusions: Streptococcus pneumonia drugs resistance in acute rhinosinusitis shows the resistance of Streptococcus pneumoniae to oxacillin, azithromycin and trimethoprim are 6, whereas the resistance to levofloxacin and doxycycline are 4. [AMJ.2016;3(1):64–8]DOI: 10.15850/amj.v3n1.722

Efektivitas Filtrat Utuh Lactobacillus Bulgaricus Ks1 dalam Soyghurt Menurut Konsentrasi Terhadap Besar Daerah Hambat Korespondensi: Pertumbuhan Berbagai Strain Klebsiella Pneumoniae Prima Nanda Fauziah; Jetty Nurhajati; Chrysanti Chrysanti
BIOTIKA Jurnal Ilmiah Biologi Vol 11, No 2 (2013): BIOTIKA DESEMBER 2013
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/bjib.v11i2.10054

Gambaran Perilaku Masyarakat dalam Pencarian Pengobatan Infeksi Saluran Pernapasan Akut di Wilayah Kejadian Luar Biasa Avian Influenza Pada Unggas di Jawa Barat Tahun 2014 widyani rachim; kuswandewi Mutiara; Chrysanti Murad
Jurnal Sistem Kesehatan Vol 2, No 1 (2016): Volume 2 Nomor 1 September 2016
Publisher : Universitas Padjadjaran

Infeksi Saluran Pernapasan Akut (ISPA) masih menjadi penyebab utama morbiditas pada anak di dunia, dengan insidensi sebesar 17% pertahun di Indonesia. Virus utama penyebab ISPA adalah virus Influenza, yang memiliki daya mutasi yang cepat dan dapat menyebabkan penyakit endemik seperti infeksi Avian Influenza. Cara masyarakat dalam mencari pengobatan berpengaruh terhadap morbiditas dan mortalitas penyakit ini, sehingga penting untuk diketahui agar dapat dilakukan intervensi. Penelitian ini bertujuan untuk melihat pemilihan pengobatan pada masyarakat dengan ISPA di daerah endemik Avian Influenza pada unggas. Penelitian ini menggunakan desain survey potong lintang deskriptif kuantitatif dengan wawancara menggunakan kuesioner. Jenis data yang digunakan adalah data sekunder pada penelitian di Kabupaten Indramayu dan Majalengka bulan Juli-Desember 2014. Pola pengobatan responden sangat bervariasi. Lebih dari setengah responden (50-70%) memilih mengobati sendiri penyakit mereka dan ke tenaga medis saat penyakit tidak sembuh atau gejala yang dirasakan berat. Pengobatan tahap pertama yang paling banyak dipilih adalah pengobatan sendiri menggunakan obat bebas. Sebagian besar (±80%) mengakhiri pengobatan setelah menemui tenaga medis. Tidak terdapat perbedaan dalam pola pengobatan antar kategori umur balita, anak, dan dewasa. Faktor yang mempengaruhi pemilihan pengobatan antara lain faktor biaya, jarak, dan kondisi sakit keluarga.Kata Kunci. Avian Influenza, Infeksi Saluran Pernapasan Akut, pola pencarian pengobatan.

Gambaran Pengetahuan Masyarakat mengenai Influenza pada Manusia di Kabupaten Indramayu dan Majalengka sebagai Wilayah Kejadian Luar Biasa H5N1 pada Unggas di Jawa Barat Tahun 2014 shofia safira rahma; kuswandewi Mutiara; Chrysanti Murad
Jurnal Sistem Kesehatan Vol 1, No 3 (2016): Volume 1 Nomor 3 Maret 2016
Publisher : Universitas Padjadjaran

Berdasarkan data WHO tahun 2015, Indonesia merupakan negara dengan kasus influenza A H5N1 pada manusia yang terbanyak kedua setelah Mesir. Virus H5N1 dikhawatirkan dapat menimbulkan pandemi berikutnya karena kemampuan virus dalam bermutasi secara cepat dan mengalami perubahan gen. Kurangnya pemahaman dan kesadaran masyarakat mengenai flu burung dan kemungkinan risikonya perlu ditangani untuk mencegah terjadinya pandemi. Penelitian ini bertujuan untuk menilai pengetahuan masyarakat mengenai influenza pada manusia di Kabupaten Indramayu dan Majalengka. Penelitian ini menggunakan desain survei potong lintang deskriptif kuantitatif. Peneliti menggunakan data sekunder pada penelitian yang sudah dilaksanakan di Kabupaten Indramayu dan Majalengka pada Juli – Desember 2014. Subjek penelitian ini adalah penghuni rumah dengan kasus indeks di daerah KLB flu burung dan rumah tangga yang berada di area 200 meter dari rumah tersebut. Teknik pengumpulan data yang digunakan adalah wawancara terstruktur berdasarkan kuesioner pengetahuan mengenai influenza dan kuesioner pengetahuan mengenai flu burung pada manusia. Mayoritas responden memiliki tingkat pengetahuan kurang mengenai influenza (65,5%) dan flu burung pada manusia (74,5%). Banyak responden yang tidak mengetahui penyebab influenza dan flu burung pada manusia, serta gejala flu burung pada manusia. Pemerintah masih perlu meningkatkan pendidikan kesehatan mengenai influenza dan flu burung pada manusia melalui televisi dan penyuluhan.Kata kunci: flu burung, influenza, pengetahuan

Microbiota profile in sinonasal mucosa of chronic rhinosinusitis as an indicator for therapeutic outcome Imam Megantara; Muhammad Fadhil Ihsan Yazid; Gita Widya Pradini; Melati Sudiro; Chrysanti Murad
Oto Rhino Laryngologica Indonesiana Vol 51, No 2 (2021): VOLUME 51, NO. 2 JULY - DECEMBER 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i2.423

ABSTRACTBackground: Chronic rhinosinusitis (CRS) is characterized by persistent inflammation of the sinonasal mucosa, which often requires surgical and additional post-operative therapy. Microbial dysbiosis due to the imbalance of commensal bacteria and pathogens plays a crucial role in the inflammatory process within the sinonasal mucosa and in therapy outcome. Further knowledge about the microbiota profile in CRS is needed to improve the management strategy for CRS patients. Purpose: To review recent studies on the microbiota profile in sinonasal mucosa of CRS patients, and its potential as an indicator for therapeutic outcome. Literature review: Recent data from several studies has documented increased microbiota richness and diversity in post-operative CRS patients’ sinonasal mucosa, as well as good post-operative outcomes. Increased genus Corynebacterium abundance was also consistently associated with good post-operative outcomes. Conclusion: There was a difference in microbiota profiles in pre and post-operative CRS patients, indicating an association with clinical improvement. Corynebacterium was associated with better post-operative outcomes. Thus, the presence of these bacteria potentially could be used as an indicator for therapeutic outcome.Keywords: chronic rhinosinusitis, microbiota, endoscopic sinus surgery, therapeutic outcomeABSTRAKLatar belakang: Rinosinusitis kronis (RSK) merupakan kondisi inflamasi yang menetap pada mukosa sinonasal dan sering memerlukan operasi dan terapi tambahan pasca-operasi. Kondisi disbiosis mikrobiota akibat ketidakseimbangan bakteri komensal dan patogen diduga memengaruhi proses inflamasi pada mukosa sinonasal dan luaran terapi. Diperlukan pengetahuan tentang profil mikrobiota pada RSK sehingga diharapkan dapat meningkatkan strategi penanganan pasien RSK. Tujuan: Mempelajari studi terkini tentang profil mikrobiota pada mukosa sinonasal pasien RSK, dan potensinya sebagai indikator luaran terapi. Tinjauan pustaka: Data terkini dari beberapa penelitian menemukan peningkatan kekayaan dan keragaman mikrobiota pada mukosa sinonasal pasien RSK pasca-operasi dan memiliki hubungan dengan luaran operasi yang baik. Peningkatan kelimpahan genus Corynebacterium ditemukan secara konsisten berkaitan dengan luaran operasi yang baik. Kesimpulan: Terdapat perbedaan profil mikrobiota pada pasien RSK pra dan pasca-operasi yang mengindikasikan kaitannya dengan perbaikan klinis. Corynebacterium adalah bakteri yang ditemukan memiliki hubungan dengan luaran operasi yang lebih baik, sehingga keberadaan bakteri ini berpotensi untuk dapat dimanfaatkan sebagai indikator luaran terapi.Kata kunci: rinosinusitis kronis, mikrobiota, operasi sinus endoskopik, luaran terapi

DAYA ANTIBAKTERI Lactobacillus bulgaricus KS1 DALAM SOYGHURT TERHADAP Klebsiella pneumoniae STRAIN ATCC 700603, CT1538 DAN S941 Prima Nanda Fauziah; Chrysanti - -; Jetty - Nurhajati
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 4, No 2 (2015)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58327/jstfi.v4i2.45

AbstrakSalah satu usaha untuk menghasilkan antibiotik alami dengan melakukan pengujian daya antibakteri Lactobacillus bulgaricus KS1 dalam soyghurt terhadap berbagai strain Klebsiella pneumoniae telah dilakukan di Laboratorium Mikrobiologi Rumah Sakit Pendidikan Universitas Padjadjaran Bandung. Penelitian ini bertujuan untuk mendapatkan perlakuan terbaik antara konsentrasi L. bulgaricus dalam soyghurt terhadap nilai MIC (Minimum Inhibitory Concentration) dan daya hambat pertumbuhan berbagai strain K.pneumoniae. Penelitian ini terdiri dari 2 tahap yaitu tahap pertama menguji MIC L.bulgaricus dalam soyghurt terhadap berbagai strain K.pneumoniae; tahap kedua menguji daya antibakteri L.bulgaricus dalam soyghurt terhadap besar daerah hambat pertumbuhan berbagai strain K.pneumoniae. Hasil penelitian tahap pertama diketahui bahwa konsentrasi 80% filtrat L.bulgaricus dalam soyghurt mampu bersifat bakterisidal terhadap berbagai strain K.pneumoniae. Hasil penelitian tahap kedua diketahui bahwa L.bulgaricus dalam soyghurt mampu memberikan efek terhadap peningkatan daerah hambat berbagai strain K.pneumoniae. Daerah hambat sebesar 19,167 mm ditunjukkan oleh K.pneumoniae strain ATCC 700603 pada konsentrasi 90% filtrat L.bulgaricus dalam soyghurt. Besar daerah hambat pertumbuhan berbagai strain K.pneumoniae dipengaruhi oleh konsentrasi filtrat L.bulgaricus dalam soyghurt dan strain bakteri K.pneumoniae. Kata Kunci : Antibakteri, Klebsiella pneumoniae, Lactobacillus bulgaricus, MIC, Soyghurt. AbstractAn attempt to produce of natural antibiotic though the observation of the antibacterial activities of Lactobacillus bulgaricus in soyghurt according of concentration against inhibitory zone growth of Klebsiella pneumoniae strains has been done in Microbiology Laboratory, Teaching Hospital, Padjadjaran University,Bandung. This research aimed to get the best treatment among concentration of filtrate of L.bulgaricus in soyghurt against the MIC value and growth inhibition zones of K.pneumoniae strains. This research consists of two phases: first examine the MIC of filtrate of L.bulgaricus in soyghurt against K.pneumoniae strains; the second phase is testing the antibacterial activities of L.bulgaricus in soyghurt against inhibitory zones growth of K.pneumoniae strains. Results of the first research showed the concentration 80% of filtrate of L.bulgaricus in soyghurt can bactericidal tend against K.pneumoniae strains. The second phases of the research results showed the antibacterial activities of L.bulgaricus in soyghurt can give the effect against increasing of inhibition zones of K.pneumoniae strains. The inhibition zones about 19,167 mm was demonstrated by K. pneumoniae ATCC 700603 in the concentration 90% of intact filtrate. The inhibitory zone growth of K.pneumoniae strains depending on the concentration of L.bulgaricus in soyghurt, and strains of bacteria. Keywords : Antibacterial, Klebsiella pneumoniae, Lactobacillus bulgaricus, MIC, Soyghurt.

Risk Factors for Patients with Gonococcal Urethritis at Dr. Hasan Sadikin General Hospital Bandung, Indonesia in 2013–2019 Pati Aji Achdiat; Jefferson Basta Erguna Ginting; Chrysanti Chrysanti
Althea Medical Journal Vol 10, No 1 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n1.2537

Background: Gonorrhea is the second most common sexually transmitted infection in Southeast Asia. Many factors cause gonococcal urethritis, and each region has its characteristics. This study aimed to determine the risk factors among patients with gonococcal urethritis at Dr. Hasan Sadikin General Hospital Bandung. Methods: This was a descriptive study with a retrospective and total sampling method, reviewing the gonococcal urethritis patient medical records obtained from Dr. Hasan Sadikin General Hospital Bandung from 2013 to 2019. Sociodemographic, clinical manifestations, and sexual or risky behaviors data were collected.Results: Among 97 males with gonococcal urethritis, unmarried males (54.6%) and the age category of 20–24 years (35.1%) were predominant, with high school education/equivalent (58.8%). Based on their sexual behavior, the majority had more than one sexual partner in the past month (63.9%) and had never used a condom when having sex (55.7%). Additionally, there was also a group of man who had sex with man (MSM) (14.4%) and illicit drug users (19.5%).Conclusions: Males in the young adult age group, single, have a high education level, have multiple sexual partners, and never used a condom during having sex, have a higher risk of having gonococcal urethritis. Identifying these most reported risk factors may help health care providers design effective prevention strategies. Unmarried young adults should be a primary focus in receiving educational programs. They should be informed regarding the impact of multiple sexual partners, condom usage, and illicit drug on gonococcal urethritis infection among men.

Microbiota profile in sinonasal mucosa of chronic rhinosinusitis as an indicator for therapeutic outcome Imam Megantara; Muhammad Fadhil Ihsan Yazid; Gita Widya Pradini; Melati Sudiro; Chrysanti Murad
Oto Rhino Laryngologica Indonesiana Vol. 51 No. 2 (2021): VOLUME 51, NO. 2 JULY - DECEMBER 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i2.423

ABSTRACTBackground: Chronic rhinosinusitis (CRS) is characterized by persistent inflammation of the sinonasal mucosa, which often requires surgical and additional post-operative therapy. Microbial dysbiosis due to the imbalance of commensal bacteria and pathogens plays a crucial role in the inflammatory process within the sinonasal mucosa and in therapy outcome. Further knowledge about the microbiota profile in CRS is needed to improve the management strategy for CRS patients. Purpose: To review recent studies on the microbiota profile in sinonasal mucosa of CRS patients, and its potential as an indicator for therapeutic outcome. Literature review: Recent data from several studies has documented increased microbiota richness and diversity in post-operative CRS patients’ sinonasal mucosa, as well as good post-operative outcomes. Increased genus Corynebacterium abundance was also consistently associated with good post-operative outcomes. Conclusion: There was a difference in microbiota profiles in pre and post-operative CRS patients, indicating an association with clinical improvement. Corynebacterium was associated with better post-operative outcomes. Thus, the presence of these bacteria potentially could be used as an indicator for therapeutic outcome.Keywords: chronic rhinosinusitis, microbiota, endoscopic sinus surgery, therapeutic outcomeABSTRAKLatar belakang: Rinosinusitis kronis (RSK) merupakan kondisi inflamasi yang menetap pada mukosa sinonasal dan sering memerlukan operasi dan terapi tambahan pasca-operasi. Kondisi disbiosis mikrobiota akibat ketidakseimbangan bakteri komensal dan patogen diduga memengaruhi proses inflamasi pada mukosa sinonasal dan luaran terapi. Diperlukan pengetahuan tentang profil mikrobiota pada RSK sehingga diharapkan dapat meningkatkan strategi penanganan pasien RSK. Tujuan: Mempelajari studi terkini tentang profil mikrobiota pada mukosa sinonasal pasien RSK, dan potensinya sebagai indikator luaran terapi. Tinjauan pustaka: Data terkini dari beberapa penelitian menemukan peningkatan kekayaan dan keragaman mikrobiota pada mukosa sinonasal pasien RSK pasca-operasi dan memiliki hubungan dengan luaran operasi yang baik. Peningkatan kelimpahan genus Corynebacterium ditemukan secara konsisten berkaitan dengan luaran operasi yang baik. Kesimpulan: Terdapat perbedaan profil mikrobiota pada pasien RSK pra dan pasca-operasi yang mengindikasikan kaitannya dengan perbaikan klinis. Corynebacterium adalah bakteri yang ditemukan memiliki hubungan dengan luaran operasi yang lebih baik, sehingga keberadaan bakteri ini berpotensi untuk dapat dimanfaatkan sebagai indikator luaran terapi.Kata kunci: rinosinusitis kronis, mikrobiota, operasi sinus endoskopik, luaran terapi

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