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All Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Neurona
Basuki, Mudjiani
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Risk Factors and Complications in Herpes Zoster Patients at Dr. Soetomo General Academic Hospital, Surabaya Nadiva, Shafa Karin; Hidayati, Afif Nurul; Basuki, Mudjiani; Machin, Abdulloh
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 15 No. 2 (2024): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V15I22024.106-112

Abstract

Highlights: The highest distribution of herpes zoster patients’ age and gender was between 46-55 years old and females. The highest distribution of herpes zoster patients’ complications was post-herpetic neuralgia. Abstract Introduction: Herpes zoster (HZ) is a painful rash confined to a dermatome resulting from the reactivation of the varicella-zoster virus (VZV). Factors that increase the risk of HZ include age, sex, prior varicella infection, immunocompromised conditions, SARS-CoV-2 infection, and varicella vaccination. Potential complications of Herpes zoster may encompass post-herpetic neuralgia (PHN), Ramsay Hunt syndrome, meningoencephalitis, vasculopathy, and varicella pneumonia. This study aimed to identify risk factors and complications associated with Herpes zoster and to enhance preventive measures to decrease the incidence of Herpes zoster at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Methods: This descriptive, retrospective analysis utilized secondary data from the medical records of Herpes zoster patients at the Dermatology Clinic of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from 2019 to 2021. Data analysis used the International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) version 25.0. Results: Out of 105 cases, Herpes zoster was more frequently observed in females (61 patients, 58.1%), with the highest occurrence found in the 46–55 years old age group (33 patients, 31.04%). The thoracic nerve was the most frequently involved (58 patients, 55.2%). Hypertension emerged as the most prevalent risk factor (26 patients, 24.7%), followed by diabetes mellitus/DM (15 patients, 14.3%) and autoimmune disorders (7 patients, 6.7%). Most patients had no comorbidities (33 patients, 31.4%). Post-herpetic neuralgia was the most frequent complication (19 patients, 18.1%), while 78 patients (74.3%) reported no complications. Conclusion: Herpes zoster was more prevalent among females, with hypertension being the most significant risk factor and post-herpetic neuralgia the most common complication.
ANALISIS KORELASI SKOR GEJALA TOTAL, NYERI, DAN KUALITAS HIDUP SETELAH PENGOBATAN VITAMIN B1, B6, DAN B12 DOSIS TINGGI PADA NEUROPATI PERIFER Hakim, Manfaluthy; Kurniani, Nani; Pinzon, Rizaldy; Tugasworo, Dodik; Basuki, Mudjiani; Haddani, Hasnawi; Pambudi, Pagan; Fithrie, Aida; Wuysang, Audry Devisanty
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 35 No 2 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i2.3

Abstract

CORRELATION ANALYSIS OF TOTAL SYMPTOM SCORE, PAIN, AND QUALITY OF LIFE POST HIGH DOSE VITAMIN B1, B6, DAN B12 TREATMENT IN PERIPHERAL NEUROPATHYABSTRACTIntroduction: Peripheral neuropathy (PN) is a clinical condition in which nerves of the peripheral nervous system are damaged and is associated with various symptoms affecting the patients’ quality of life (QoL).Aims: To understand the  effect of Vitamin B1, B6, and B12 combination in mild to moderate PN.Methods: This is a prospective, open label, multicenter, single arm observational study involved 399 subjects with PN of different etiology. Subjects received the vitamin B1, B6, and B12 combination tablet orally once daily and were observed for 3 months. Total symptom score (TSS), visual analog score (VAS) and QoL were assessed, and the correlation between these parameters was analyzed.Results: Clinically significant reductions were observed from baseline to subsequent visits for TSS and VAS. Positive correlation  was observed between TSS and components of VAS. The study treatment was associated with a significant improvement in QoL parameters. Inverse correlation was observed between QoL and TSS as well as QoL and components of VAS. The study treatment was found to be well tolerated.Discussion: The correlation  analysis between different outcome measures demonstrated the beneficial effect of combination of vitamin B1, B6, and B12 in relief from symptoms and improvement in QoL of PN.Keyword: Correlation analysis, peripheral neuropathy, SF-8, TSS, VAS, vitamin B1, B6, and B12ABSTRAKPendahuluan: Neuropati perifer (NP) merupakan kondisi klinis akibat kerusakan pada sistem saraf tepi yang memengaruhi kualitas hidup (quality of life/QoL) pasien.Tujuan: Mengetahui efek pemberian kombinasi vitamin B1, B6, and B12 pada NP ringan hingga sedang.Metode: Penelitian observasional dan prospektif secara open label, multisenter, dan single arm, yang melibatkan 399 subjek penderita neuropati perifer dengan etiologi yang berbeda-beda. Subjek mengonsumsi tablet kombinasi vitamin B1, B6, and B12 secara oral satu kali sehari dan diamati selama 3 bulan. Dilakukan penilaian skor gejala total (total symptom score/TSS), visual analog scale (VAS), dan QoL, serta korelasi antara parameter-parameter tersebut.Hasil: Terdapat penurunan TSS dan VAS yang bermakna secara klinis antara baseline (awal) dengan kunjungan berikutnya. Terdapat korelasi yang positif antara TSS dengan komponen-komponen VAS. Pemberian perlakuan dalam penelitian berkorelasi secara bermakna dengan perbaikan parameter dalam QoL. Teramati juga adanya hubungan terbalik antara QoL dengan TSS serta QoL dan komponen VAS. Pengobatan pada penelitian ini juga terbukti dapat ditoleransi dengan baik.Diskusi: Analisis korelasi antara berbagai macam metode pengukuran yang berbeda menunjukkan manfaat dari pemberian kombinasi vitamin B1, B6, and B12 dalam mengurangi gejala dan perbaikan QoL pada pasien PN.Kata kunci: Analisis korelasi, neuropati perifer, kualitas hidup, SF-8, TSS, VAS, vitamin B1, B6, and B12
Co-Authors Achmad Firdaus Sani, Achmad Firdaus Adrianto, Yudhi Afif Nurul Hidayati, Afif Nurul Dodik Tugasworo Fadil Fidiana, Fidiana Fithrie, Aida Hakim, Manfaluthy Hanifah, Anny Machin, Abdulloh Muhammad Faizi, Muhammad Muhammad Hasnawi Haddani Nadiva, Shafa Karin Nani Kurniani Pagan Pambudi Rizaldy Pinzon Wuysang, Audry Devisanty